JP6890311B2 - 擬ベーマイト系アルミナのモリブデン吸着剤及びそれを用いた99Mo/99mTcジェネレータ - Google Patents
擬ベーマイト系アルミナのモリブデン吸着剤及びそれを用いた99Mo/99mTcジェネレータ Download PDFInfo
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- JP6890311B2 JP6890311B2 JP2016172617A JP2016172617A JP6890311B2 JP 6890311 B2 JP6890311 B2 JP 6890311B2 JP 2016172617 A JP2016172617 A JP 2016172617A JP 2016172617 A JP2016172617 A JP 2016172617A JP 6890311 B2 JP6890311 B2 JP 6890311B2
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- Prior art keywords
- alumina
- pseudo
- boehmite
- molybdenum
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- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 title claims description 80
- VXAUWWUXCIMFIM-UHFFFAOYSA-M aluminum;oxygen(2-);hydroxide Chemical compound [OH-].[O-2].[Al+3] VXAUWWUXCIMFIM-UHFFFAOYSA-M 0.000 title claims description 32
- 229910052750 molybdenum Inorganic materials 0.000 title claims description 22
- 239000011733 molybdenum Substances 0.000 title claims description 22
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 title claims description 21
- 239000003463 adsorbent Substances 0.000 title claims description 17
- ZOKXTWBITQBERF-AKLPVKDBSA-N Molybdenum Mo-99 Chemical compound [99Mo] ZOKXTWBITQBERF-AKLPVKDBSA-N 0.000 title description 2
- 229950009740 molybdenum mo-99 Drugs 0.000 title description 2
- 238000001179 sorption measurement Methods 0.000 claims description 21
- 238000000034 method Methods 0.000 claims description 20
- 239000013078 crystal Substances 0.000 claims description 11
- 239000000243 solution Substances 0.000 description 15
- 238000010828 elution Methods 0.000 description 13
- 238000004519 manufacturing process Methods 0.000 description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 9
- 238000010304 firing Methods 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 8
- 239000002504 physiological saline solution Substances 0.000 description 6
- 239000000047 product Substances 0.000 description 6
- 239000008213 purified water Substances 0.000 description 5
- 239000002994 raw material Substances 0.000 description 5
- 229910001593 boehmite Inorganic materials 0.000 description 4
- 230000007423 decrease Effects 0.000 description 4
- FAHBNUUHRFUEAI-UHFFFAOYSA-M hydroxidooxidoaluminium Chemical class O[Al]=O FAHBNUUHRFUEAI-UHFFFAOYSA-M 0.000 description 4
- 238000001095 inductively coupled plasma mass spectrometry Methods 0.000 description 4
- 239000002245 particle Substances 0.000 description 4
- 239000011148 porous material Substances 0.000 description 4
- 238000002441 X-ray diffraction Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000004992 fission Effects 0.000 description 3
- 230000005855 radiation Effects 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 229910052770 Uranium Inorganic materials 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 239000012670 alkaline solution Substances 0.000 description 2
- VSCWAEJMTAWNJL-UHFFFAOYSA-K aluminium trichloride Chemical compound Cl[Al](Cl)Cl VSCWAEJMTAWNJL-UHFFFAOYSA-K 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 238000009616 inductively coupled plasma Methods 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000005245 sintering Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- JFALSRSLKYAFGM-UHFFFAOYSA-N uranium(0) Chemical compound [U] JFALSRSLKYAFGM-UHFFFAOYSA-N 0.000 description 2
- 238000004438 BET method Methods 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000001354 calcination Methods 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 239000000032 diagnostic agent Substances 0.000 description 1
- 229940039227 diagnostic agent Drugs 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- KJZYNXUDTRRSPN-UHFFFAOYSA-N holmium atom Chemical compound [Ho] KJZYNXUDTRRSPN-UHFFFAOYSA-N 0.000 description 1
- 238000010191 image analysis Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 150000002751 molybdenum Chemical class 0.000 description 1
- VLAPMBHFAWRUQP-UHFFFAOYSA-L molybdic acid Chemical compound O[Mo](O)(=O)=O VLAPMBHFAWRUQP-UHFFFAOYSA-L 0.000 description 1
- 238000009206 nuclear medicine Methods 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002901 radioactive waste Substances 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 230000003439 radiotherapeutic effect Effects 0.000 description 1
- 239000011684 sodium molybdate Substances 0.000 description 1
- 235000015393 sodium molybdate Nutrition 0.000 description 1
- TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940126585 therapeutic drug Drugs 0.000 description 1
- 238000005979 thermal decomposition reaction Methods 0.000 description 1
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- Compounds Of Alkaline-Earth Elements, Aluminum Or Rare-Earth Metals (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Description
1.アルミナの製造方法
2.アルミナの製造と特性評価
a) ベーマイト(Boehmite) → γ(Gamma) → δ(Delta)
b) p-ベーマイト(p-Boehmite) → p-γ(p-Gamma) → θ(Theta)
と構造変化する系列が混在していると推定できる。
3.アルミナのMo吸着試験及びMo溶離試験
(1)Mo吸着試験
(2)Mo溶離試験
4.モリブデン(Mo)回収試験
1)放射化法((n,γ)法)により製造した比放射能の低い99Moでも使用可能である。
2)現行医療用アルミナと同等の高純度99mTc溶液を得ることが可能である。
3)高価な98Mo濃縮原料をアルミナから回収し、98Mo濃縮モリブデン原料は再利用が可能である。
4)安価で大量製造が可能である。
Claims (2)
- モリブデン(Mo)の比表面積換算吸着量が、0.273mg/m2から0.368mg/m2の範囲にあり、「δ」または「θ」の結晶構造を含むことを特徴とする擬ベーマイト系アルミナから成るモリブデン吸着剤。
- 天然同位体もしくは98Mo濃縮Moから(n,γ)法を利用して99mTcを得る99Mo/99mTcジェネレータにおいて、モリブデン(Mo)の比表面積換算吸着量が、0.273mg/m2から0.368mg/m2の範囲にあり、「δ」または「θ」の結晶構造を含む擬ベーマイト系アルミナから成るモリブデン吸着剤を用いた99Mo/99mTcジェネレータ。
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JP2016172617A JP6890311B2 (ja) | 2016-09-05 | 2016-09-05 | 擬ベーマイト系アルミナのモリブデン吸着剤及びそれを用いた99Mo/99mTcジェネレータ |
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JP2016172617A JP6890311B2 (ja) | 2016-09-05 | 2016-09-05 | 擬ベーマイト系アルミナのモリブデン吸着剤及びそれを用いた99Mo/99mTcジェネレータ |
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JP6890311B2 true JP6890311B2 (ja) | 2021-06-18 |
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Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57135721A (en) * | 1981-02-09 | 1982-08-21 | Mitsubishi Chem Ind Ltd | Molded particle of porous active alumina |
JPS5969424A (ja) * | 1982-10-08 | 1984-04-19 | Chiyoda Chem Eng & Constr Co Ltd | 低嵩密度アルミナの製造方法 |
KR100755933B1 (ko) * | 2006-11-08 | 2007-09-06 | 한국원자력연구원 | 진단용 및 치료용 방사성 동위원소 흡착제 및 이의제조방법 |
NL2007951C2 (en) * | 2011-12-12 | 2013-06-13 | Univ Delft Tech | A column material and a method for adsorbing mo-99 in a 99mo/99mtc generator. |
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- 2016-09-05 JP JP2016172617A patent/JP6890311B2/ja active Active
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