JP6843741B2 - アクリル系ポリマーおよび経皮吸収型ドラッグデリバリーにおけるその使用 - Google Patents
アクリル系ポリマーおよび経皮吸収型ドラッグデリバリーにおけるその使用 Download PDFInfo
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- JP6843741B2 JP6843741B2 JP2017511241A JP2017511241A JP6843741B2 JP 6843741 B2 JP6843741 B2 JP 6843741B2 JP 2017511241 A JP2017511241 A JP 2017511241A JP 2017511241 A JP2017511241 A JP 2017511241A JP 6843741 B2 JP6843741 B2 JP 6843741B2
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- 239000002023 wood Substances 0.000 description 1
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- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/12—Esters of monohydric alcohols or phenols
- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
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- A61F13/00—Bandages or dressings; Absorbent pads
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- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
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- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- C08F22/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals each having only one carbon-to-carbon double bond, and at least one being terminated by a carboxyl radical and containing at least one other carboxyl radical in the molecule; Salts, anhydrides, esters, amides, imides or nitriles thereof
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- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
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- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
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- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1804—C4-(meth)acrylate, e.g. butyl (meth)acrylate, isobutyl (meth)acrylate or tert-butyl (meth)acrylate
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- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
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- C08F220/16—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms
- C08F220/18—Esters of monohydric alcohols or phenols of phenols or of alcohols containing two or more carbon atoms with acrylic or methacrylic acids
- C08F220/1808—C8-(meth)acrylate, e.g. isooctyl (meth)acrylate or 2-ethylhexyl (meth)acrylate
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- C08K5/00—Use of organic ingredients
- C08K5/0008—Organic ingredients according to more than one of the "one dot" groups of C08K5/01 - C08K5/59
- C08K5/005—Stabilisers against oxidation, heat, light, ozone
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- C09J133/00—Adhesives based on homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Adhesives based on derivatives of such polymers
- C09J133/04—Homopolymers or copolymers of esters
- C09J133/06—Homopolymers or copolymers of esters of esters containing only carbon, hydrogen and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C09J133/08—Homopolymers or copolymers of acrylic acid esters
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00544—Plasters form or structure
- A61F2013/00646—Medication patches, e.g. transcutaneous
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00655—Plasters adhesive
- A61F2013/00659—Plasters adhesive polymeric base
- A61F2013/00663—Plasters adhesive polymeric base acrylic
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- C09J2301/40—Additional features of adhesives in the form of films or foils characterized by the presence of essential components
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Description
126.0gのn−ブチルアクリレート、54.0gのメチルメタクリレート、120.0gのエチルアセテート(溶媒)、および0.12gの2,2’−アゾビスイソブチロニトリル(AIBN)(重合開始剤)を含有する初期投入物を調製し、ステンレス鋼スターラー、温度計、コンデンサー、ウォーターバスおよび添加漏斗を備えた2Lの4首丸底フラスコに投入した。初期投入物を撹拌しながら加熱して還流させた。還流開始から15分で、84.0gのn−ブチルアクリレートおよび12.0gのメチルメタクリレートを含有するモノマー混合物を1.0時間かけて同時に均一に添加した。再度の還流開始から15分で、30.0gの酢酸エチルおよび1.2gのAIBNを3時間かけて同時に均一に添加した。この添加後、フラスコの内容物を2.0時間還流して保持した。保持期間後に、30.0gの酢酸エチルおよび1.5gのt−アミルパーオキシピバレートを1時間かけて添加した。添加後、内容物を1時間還流して保持した。保持期間後、内容物を室温まで冷却し、60gの酢酸エチルを添加して、溶解ポリマーを析出させた。最終的なポリマーは、全固形分55.46%、および相対粘度2.76であった(酢酸エチル、2.0重量%溶液)。
139.5gのn−ブチルアクリレート、40.5gのメチルメタクリレート、120.0gの酢酸エチル(溶媒)、および0.12gの2,2’−アゾビスイソブチロニトリル(AIBN)(重合開始剤)を含有する初期投入物を調製し、ステンレス鋼スターラー、温度計、コンデンサー、ウォーターバスおよび添加漏斗を備えた2Lの4首丸底フラスコに投入した。初期投入物を撹拌しながら加熱して還流させた。還流開始から15分で、93.0gのn−ブチルアクリレートおよび27.0gのメチルメタクリレートを含有するモノマー混合物を1.0時間かけて同時に均一に添加した。再度の還流開始から15分で、30.0gの酢酸エチルおよび1.2gのAIBNを3時間かけて同時に均一に添加した。この添加後、フラスコの内容物を2.0時間還流して保持した。保持期間後に、30.0gの酢酸エチルおよび1.5gのt−アミルパーオキシピバレートを1時間かけて添加した。添加後、内容物を1時間還流して保持した。保持期間後、内容物を室温まで冷却し、60gの酢酸エチルを添加して、溶解ポリマーを析出させた。最終的なポリマーは、全固形分55.07%、および相対粘度2.75であった(酢酸エチル、2.0重量%溶液)。
本開示のポリマーを調製し、その特性を他のポリマーと比較した。結果を表1に示す。
Claims (12)
- ブチルアクリレートモノマー、2−エチルヘキシルアクリレートモノマー、オクチルアクリレートモノマー、またはイソオクチルアクリレートモノマーである、ランダムコポリマーの重量を基準にして少なくとも70重量%の第1のモノマーと、メチルメタクリレートモノマー、ブチルメタクリレート、またはイソブチルメタクリレートである、ランダムコポリマーの重量を基準にして少なくとも18重量%の第2のモノマーとを、重合開始剤の存在下で重合する工程により調製されるランダムコポリマーと、
治療薬と、
酸化防止剤と、
を含む組成物。 - ランダムコポリマーが、第1のモノマーおよび第2のモノマーのみからなるモノマーから調製される、請求項1に記載の組成物。
- ランダムコポリマーのFox方程式に基づいて計算されるTgが−18℃〜−50℃である、請求項1または2に記載の組成物。
- エンハンサー、可塑剤、粘着付与剤、粘度調整剤、賦形剤、希釈剤、皮膚軟化剤、抗刺激剤、乳白剤、顔料、および防腐剤から成る群より選択される少なくとも1つの成分を含む、請求項1〜3のいずれか1項に記載の組成物。
- 酸化防止剤が、ブチル化ヒドロキシアニソール(BHA)、またはブチル化ヒドロキシトルエン(BHT)である、請求項1〜4のいずれか1項に記載の組成物。
- 20重量%、22.5重量%、または30重量%の第2のモノマーを含む、請求項1〜5のいずれか1項に記載の組成物。
- 重合開始剤が、2,2’−アゾジ(2−メチルブチロニトリル)(AMBN)、ジベンゾイルパーオキサイド、ラウロイルパーオキサイド、または2,2’−アゾビスイソブチロニトリル(AIBN)である、請求項1〜6のいずれか1項に記載の組成物。
- 有機溶媒を含む、請求項1〜7のいずれか1項に記載の組成物。
- 有機溶媒が、酢酸エチル、アセトン、ヘキサン、シクロヘキサン、へプタン、トルエン、エタノール、イソプロピルアルコール、またはこれらの組み合わせである、請求項8に記載の組成物。
- 治療薬がランダムコポリマーに溶解している、請求項1〜9のいずれか1項に記載の組成物。
- 治療薬がランダムコポリマーに分散している、請求項1〜10のいずれか1項に記載の組成物。
- 経皮吸収パッチである、請求項1〜11のいずれか1項に記載の組成物。
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---|---|---|---|---|
US3994764A (en) * | 1975-06-13 | 1976-11-30 | Pratt & Lambert, Inc. | Adhesive compositions |
ATE126434T1 (de) * | 1991-06-10 | 1995-09-15 | Sanol Arznei Schwarz Gmbh | Nitroglycerin-pflaster und verfahren zu seiner herstellung. |
FR2716201B1 (fr) * | 1994-02-16 | 1996-04-12 | Atochem Elf Sa | Copolymères statistiques vivants (méth)acryliques, copolymères préparés à partir de ces copolymères vivants et les procédés d'obtention correspondants par copolymérisation anionique. |
FR2793689B1 (fr) * | 1999-05-19 | 2001-08-24 | Pf Medicament | Dispositif transdermique pour l'administration de testosterone ou d'un de ses derives |
KR100452972B1 (ko) * | 2000-05-16 | 2004-10-14 | 주식회사 삼양사 | 경피투여용 하이드로젤 조성물 |
US20020119187A1 (en) * | 2000-09-29 | 2002-08-29 | Cantor Adam S. | Composition for the transdermal delivery of fentanyl |
RU2708563C2 (ru) * | 2001-03-16 | 2019-12-10 | Алза Корпорейшн | Трансдермальный пластырь для введения фентанила |
JP3884995B2 (ja) * | 2002-05-29 | 2007-02-21 | 日東電工株式会社 | 皮膚貼着用粘着シート |
US8343538B2 (en) * | 2004-10-08 | 2013-01-01 | Noven Pharmaceuticals, Inc. | Compositions and methods for controlling the flux of a drug from a transdermal drug delivery systems |
US20070098772A1 (en) * | 2005-09-23 | 2007-05-03 | Westcott Tyler D | Transdermal norelgestromin delivery system |
JP5137503B2 (ja) * | 2006-09-15 | 2013-02-06 | 株式会社日本触媒 | 化粧料用紫外線カット剤およびそれを用いた化粧料 |
WO2008067164A2 (en) * | 2006-11-15 | 2008-06-05 | Abbott Laboratories | Solid pharmaceutical dosage formulations |
WO2011010556A1 (ja) * | 2009-07-23 | 2011-01-27 | ニプロパッチ株式会社 | 経皮吸収型製剤 |
JP2011074034A (ja) * | 2009-09-30 | 2011-04-14 | Sekisui Medical Co Ltd | 貼付剤 |
CN102090983B (zh) * | 2010-12-02 | 2012-05-23 | 天津大学 | 一种丙烯酸丁酯-甲基丙烯酸甲酯共聚物基义齿基托材料及其制备方法和应用 |
RU2586068C2 (ru) * | 2011-01-14 | 2016-06-10 | Эйвери Деннисон Корпорейшн | Легкоудаляемая композиция, содержащая полимерные микросферы |
FR2987561B1 (fr) * | 2012-03-02 | 2014-04-11 | Pf Medicament | Dispositif transdermique comprenant des micro-particules poreuses |
JP2014051467A (ja) * | 2012-09-07 | 2014-03-20 | Nipro Patch Co Ltd | 貼付剤 |
JP6169372B2 (ja) * | 2013-02-28 | 2017-07-26 | ジャパンコーティングレジン株式会社 | 凝集粒子及びそれを用いた化粧料 |
JP6434218B2 (ja) * | 2014-03-31 | 2018-12-05 | 株式会社コーセー | アイライナー化粧料 |
JP6327665B2 (ja) * | 2014-03-31 | 2018-05-23 | 株式会社コーセー | スキンケア化粧料 |
JP6434220B2 (ja) * | 2014-03-31 | 2018-12-05 | 株式会社コーセー | 乳化型メイクアップ化粧料 |
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KR20170045225A (ko) | 2017-04-26 |
BR112017003248B1 (pt) | 2022-10-11 |
JP2017526783A (ja) | 2017-09-14 |
CN106659591B (zh) | 2021-06-04 |
US10849859B2 (en) | 2020-12-01 |
RU2700032C2 (ru) | 2019-09-12 |
BR112017003248A2 (pt) | 2017-11-28 |
RU2017109811A3 (ja) | 2019-03-13 |
EP3185826B1 (en) | 2020-08-19 |
RU2017109811A (ru) | 2018-10-01 |
CN106659591A (zh) | 2017-05-10 |
WO2016032924A1 (en) | 2016-03-03 |
EP3185826A4 (en) | 2018-02-14 |
US20170165205A1 (en) | 2017-06-15 |
EP3185826A1 (en) | 2017-07-05 |
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