JP6827691B2 - Cosmetics - Google Patents
Cosmetics Download PDFInfo
- Publication number
- JP6827691B2 JP6827691B2 JP2015232536A JP2015232536A JP6827691B2 JP 6827691 B2 JP6827691 B2 JP 6827691B2 JP 2015232536 A JP2015232536 A JP 2015232536A JP 2015232536 A JP2015232536 A JP 2015232536A JP 6827691 B2 JP6827691 B2 JP 6827691B2
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- JP
- Japan
- Prior art keywords
- extract
- acid
- solution
- bergamot
- citrus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011787 zinc oxide Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- 229910001928 zirconium oxide Inorganic materials 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
Description
本発明は、ミカン科ミカン属に属する植物から得られ、すぐれた生理活性及び生体安全性を有する機能性素材、並びに当該機能性素材を配合してなる化粧料及び経口組成物に関する。 The present invention relates to a functional material obtained from a plant belonging to the genus Citrus of the Rutaceae family and having excellent physiological activity and biosafety, and a cosmetic and an oral composition containing the functional material.
皮膚は、加齢に伴う細胞増殖・分化の不活化、ホルモン分泌の低下、細胞外マトリックス成分の量的低下等の内的要因と、太陽光(紫外線)に誘発される活性酸素、大気汚染物質や環境ホルモン等の化学物質、花粉等のアレルギー物質、環境ストレス等の外的要因とが複雑に絡み合って、老化現象や肌荒れ、色調の変化が生じる。 The skin has internal factors such as inactivation of cell proliferation and differentiation with aging, decreased hormone secretion, and quantitative decrease of extracellular matrix components, as well as active oxygen induced by sunlight (ultraviolet rays) and air pollutants. And chemical substances such as environmental hormones, allergic substances such as pollen, and external factors such as environmental stress are intricately intertwined, causing aging, rough skin, and changes in color tone.
例えば、皮膚細胞内には種々のマトリックスメタプロテアーゼと呼ばれる酵素が存在し、これが活性化すると、皮膚を構成する基底膜成分(コラーゲン、ラミニン等)や、真皮マトリック成分であるエラスチン等を分解し、その結果、皮膚のシワ、タルミの原因となる。 For example, various enzymes called matrix metaprotease exist in skin cells, and when activated, they decompose the basement membrane components (collagen, laminin, etc.) that make up the skin, elastin, which is a dermis matrix component, and so on. As a result, it causes wrinkles and tarmi on the skin.
また、外的要因である紫外線、化学物質、アレルギー物質は、皮膚の細胞や組織、細胞にダメージを与えて生体成分を変質させたり、又は活性酸素を発生させたりすることで、皮膚内に抗原を発生させて、これにより皮膚の炎症が生じる。さらにはメラニン色素の異常沈着を誘発してシミ、ソバカス、肝斑等を生じさせる。 In addition, ultraviolet rays, chemical substances, and allergens, which are external factors, damage cells, tissues, and cells of the skin to alter biological components or generate active oxygen, thereby causing antigens in the skin. This causes skin irritation. Furthermore, it induces abnormal deposition of melanin pigment and causes spots, freckles, chloasma and the like.
以上のような皮膚の老化、不健全化を防ぎ、かつ、若々しい状態に保持するため、従来、種々の活性成分の使用が提案され、それら活性成分を配合した化粧品や経口組成物が上市されている。例えば、ビタミンC、ビタミンE、カタラーゼ等の抗酸化剤;グリチルリチン酸又はその塩、アラントイン等の抗炎症剤;各種紫外線吸収剤;α−ヒドロキシカルボン酸、胎盤抽出液、γ−アミノ−β−ヒドロキシ酪酸等の細胞賦活成分;コラーゲン、エラスチン、ヒアルロン酸又はその塩等の細胞外マトリックス成分;尿素等の保湿剤;アミノグアニジン等のタンパク質糖化抑制剤が挙げられる。また、皮膚のシミ、ソバカス、肝斑等の色素沈着の発生を抑制する物質としては、コウジ酸やリノール酸等が知られており、美白剤の有効成分として広く使用されている。 In order to prevent the above-mentioned aging and unhealthy skin and keep it in a youthful state, the use of various active ingredients has been proposed, and cosmetics and oral compositions containing these active ingredients have been put on the market. Has been done. For example, antioxidants such as vitamin C, vitamin E and catalase; anti-inflammatory agents such as glycyrrhizic acid or salts thereof, allantin; various ultraviolet absorbers; α-hydroxycarboxylic acid, placenta extract, γ-amino-β-hydroxy Cell-activating components such as butyric acid; extracellular matrix components such as collagen, elastin, hyaluronic acid or salts thereof; moisturizers such as urea; protein glycation inhibitors such as aminoguanidine. Further, kojic acid, linoleic acid and the like are known as substances that suppress the occurrence of pigmentation such as skin spots, freckles and chloasma, and are widely used as active ingredients of whitening agents.
以上のように、従来、様々な皮膚老化現象や不健全化のメカニズムに基づいて、抗老化剤及び美白剤が提案されているが、皮膚等に対する安全性、また、実際に皮膚への適用又は服用に際しての有効性の観点で問題が存在する。従って、かかる点が改善された機能性素材が求められている。 As described above, anti-aging agents and whitening agents have been conventionally proposed based on various skin aging phenomena and unhealthy mechanisms, but they are safe for the skin and the like, and are actually applied to the skin or applied to the skin. There is a problem in terms of efficacy when taking. Therefore, there is a demand for a functional material having improved such points.
本発明者らは、かかる従来技術の問題点に鑑みて、生体安全性の観点から天然物由来の新たな機能性素材を見出すべく鋭意研究を行った。その結果、ミカン科ミカン属に属するベルガモット(Citrus aurantium L.subsp. bergamia[Risso & Poit.] Wight & Arn. 以下、「Citrus bergamia」という)の抽出物が、すぐれたコラーゲンゲル収縮促進作用、コラーゲン合成促進活作用、デコリン合成促進作用、メラノソーム取り込み抑制作用、抗酸化作用及び脂質蓄積抑制作用を有し、これらの相互作用により、当該抽出物を配合することですぐれた皮膚(頭皮も含む)の健全化効果、抗老化効果、美白効果、髪質改善効果及び育毛効果を奏し、かつ、生体安全性にすぐれた化粧料や美容用経口組成物の提供が可能になることを見出した。 In view of the problems of the prior art, the present inventors have conducted diligent research to find a new functional material derived from a natural product from the viewpoint of biosafety. As a result, the extract of bergamot (Citrus aurantium L.subsp. Bergamia [Risso & Poit.] Wight & Arn. Hereinafter referred to as "Citrus bergamia") belonging to the genus Citrus of the Rutaceae family has an excellent collagen gel contraction promoting action, collagen. It has a synthesis-promoting activity, a decorin synthesis-promoting action, a melanosomes uptake inhibitory action, an antioxidant action, and a lipid accumulation inhibitory action, and due to these interactions, the skin (including the scalp) excellent by blending the extract. It has been found that it is possible to provide cosmetics and oral cosmetic compositions which have a healthening effect, an anti-aging effect, a whitening effect, a hair quality improving effect and a hair growing effect, and are also excellent in biosafety.
従来、ミカン科ミカン属に属する植物の抽出物を化粧料等の皮膚外用剤に利用されることについては特許文献1〜4により知られているが、ベルガモットの搾汁液又は抽出物を化粧料や美容用経口組成物に利用することについては、知られていなかった。 Conventionally, it is known from Patent Documents 1 to 4 that an extract of a plant belonging to the genus Citrus of the Rutaceae family is used as an external preparation for skin such as cosmetics, but bergamot juice or extract can be used as cosmetics. It was not known for use in cosmetic oral compositions.
本発明は、ミカン科ミカン属に属するベルガモット(Citrus bergamia)の搾汁液又は抽出物を有効成分として含有する化粧料である。
本発明は、ミカン科ミカン属に属するベルガモット(Citrus bergamia)の搾汁液又は抽出物を有効成分として含有する経口用組成物である。
なお、本明細書において化粧料なる文言は、所謂化粧料のほかに医薬部外品までも含む広義で用いる。
The present invention is a cosmetic containing a juice or extract of bergamot (Citrus bergamia) belonging to the genus Citrus of the Rutaceae family as an active ingredient.
The present invention is an oral composition containing a squeezed juice or an extract of bergamot (Citrus bergamia) belonging to the genus Citrus of the Rutaceae family as an active ingredient.
In this specification, the term cosmetics is used in a broad sense to include not only so-called cosmetics but also quasi-drugs.
本発明は、ミカン科ミカン属に属するベルガモットの抽出物を有効成分とする化粧料又は経口用組成物であって、当該抽出物が奏するコラーゲンゲル収縮作用、コラーゲン合成促進作用、デコリン合成促進作用、メラノソーム取り込み抑制作用、抗酸化作用及び脂質蓄積抑制作用により、格段にすぐれた皮膚の肌荒れ(炎症、乾燥肌、ニキビ等);老化現象(シワ、タルミ、ハリやキメの低下等)の予防・改善効果;毛穴のくすみ、黒ずみ、開き、詰まり、タルミ等の予防・改善;並びに皮膚のシミ、ソバカス、肝斑等の色素沈着の予防・改善効果を有する化粧料や美容用経口組成物を提供することができる。さらに、上記作用に基づき毛髪を保護し、かつ、頭皮を健全化する効果を有する化粧料や経口組成物も提供できる。 The present invention is a cosmetic or oral composition containing an extract of freckles belonging to the genus Melasma of the family Chloasma as an active ingredient, and the collagen gel contraction action, collagen synthesis promoting action, decorin synthesis promoting action, which the extract exerts. Remarkably excellent rough skin (inflammation, dry skin, acne, etc.); prevention / improvement of aging phenomenon (wrinkles, age spots, reduction of firmness and texture, etc.) due to melanosomes uptake inhibitory action, antioxidant action and lipid accumulation inhibitory action Effect; Preventing / improving dullness, darkening, opening, clogging, tarmi, etc. of pores; and providing cosmetics and oral cosmetic compositions having an effect of preventing / improving pigmentation such as skin stains, freckles, and chloasma. be able to. Further, it is possible to provide a cosmetic or an oral composition having the effect of protecting the hair and sounding the scalp based on the above action.
以下、本発明の好ましい実施の形態について詳細に説明する。
本発明の化粧料や経口組成物には、ミカン科ミカン属に属するベルガモット(Citrus bergamia)のエキス「搾汁液(果汁)又は抽出物」を有効成分として配合される。ベルガモットの搾汁液は果実をそのまま圧搾するか、或いは果実を破砕したのち、その破砕物を圧搾することにより調製することができる。また、ベルガモットの抽出物の調製は、全草又は果実を、必要に応じてこれに予め水洗、乾燥処理等を施した上、浸漬法、向流抽出法等適宜の手段により抽出溶媒と接触させることによって行うことができる。また、超臨界抽出法や水蒸気蒸留法を用いてもよい。なお、果実の抽出物の調製に当たっては、果皮及び/又は種子を含むものを用いてもよい。また、ベルガモットの搾汁液、抽出物、及び水蒸気蒸留物又は精油のいずれか2以上の混合物を使用しても良い。
Hereinafter, preferred embodiments of the present invention will be described in detail.
The cosmetic or oral composition of the present invention contains an extract "juice (fruit juice) or extract" of bergamot (Citrus bergamia) belonging to the genus Citrus of the Rutaceae family as an active ingredient. The bergamot juice can be prepared by squeezing the fruit as it is, or by crushing the fruit and then squeezing the crushed product. To prepare the bergamot extract, the whole plant or fruit is previously washed with water, dried, etc., if necessary, and then brought into contact with the extraction solvent by an appropriate means such as a dipping method or a countercurrent extraction method. Can be done by Further, a supercritical extraction method or a steam distillation method may be used. In preparing the fruit extract, those containing pericarp and / or seeds may be used. In addition, a mixture of any two or more of bergamot juice, extract, and steam distillation or essential oil may be used.
抽出溶媒としては、水;メタノール、エタノール、プロパノール等の低級アルコール類;エチレングリコール、プロピレングリコール、1,3−ブチレングリコール、グリセリン等の多価アルコール類;酢酸エチル、酢酸ブチル、プロピオン酸メチル等のエステル類;アセトン、メチルエチルケトン等のケトン類;エチルエーテル、イソプロピルエーテル等のエーテル類;n−ヘキサン、トルエン、クロロホルム等の炭化水素系溶媒等が挙げられ、それらは単独で又は二種以上を混合して用いられる。 As the extraction solvent, water; lower alcohols such as methanol, ethanol and propanol; polyhydric alcohols such as ethylene glycol, propylene glycol, 1,3-butylene glycol and glycerin; ethyl acetate, butyl acetate, methyl propionate and the like. Esters; ketones such as acetone and methyl ethyl ketone; ethers such as ethyl ether and isopropyl ether; hydrocarbon solvents such as n-hexane, toluene and chloroform, etc., which may be used alone or in admixture of two or more. Is used.
それら抽出溶媒のうちでも、得られる抽出物の有効性、さらには、皮膚刺激性の観点から、又化粧料等への幅広い適用が可能であるという点からも、本発明においては、水、低級アルコール類又は多価アルコール類等の親水性溶媒が好適である。この親水性溶媒を用いる場合の好ましい例としては、例えば、水、低級アルコール類(例えば、エタノール)、又は多価アルコール(例えば、1,3−ブチレングリコール、プロパンジオール、グリセリン)の単独使用、或いは、水と低級アルコール類(特にエタノール)との混合溶媒、又は水と多価アルコール類(例えば、1,3−ブチレングリコール、グリセリン)との混合溶媒の使用等が挙げられるが、なかでも水単独、又は水と1,3−ブチレングリコール若しくはプロパンジオールの混合溶媒が特に好ましい。 Among these extraction solvents, water and lower grades are used in the present invention from the viewpoint of the effectiveness of the obtained extract, skin irritation, and the fact that it can be widely applied to cosmetics and the like. Hydrophilic solvents such as alcohols or polyhydric alcohols are suitable. Preferred examples of using this hydrophilic solvent include, for example, water, lower alcohols (eg, ethanol), or polyhydric alcohols (eg, 1,3-butylene glycol, propanediol, glycerin) alone, or , The use of a mixed solvent of water and lower alcohols (particularly ethanol), or a mixed solvent of water and polyhydric alcohols (for example, 1,3-butylene glycol, glycerin), etc., among which water alone is used. , Or a mixed solvent of water and 1,3-butylene glycol or propanediol is particularly preferable.
混合溶媒を用いる場合の混合比は、例えば水と1,3−ブチレングリコール若しくはプロパンジオールとの混合溶媒であれば、容量比(以下同じ)で1:1〜20:1、水とエタノールとの混合溶媒であれば、1:1〜25:1、水とグリセリンとの混合溶媒であれば1:1〜20:1の範囲とすることが好ましい。 When a mixed solvent is used, for example, in the case of a mixed solvent of water and 1,3-butylene glycol or propanediol, the volume ratio (hereinafter the same applies) is 1: 1 to 20: 1, and water and ethanol are mixed. The range is preferably 1: 1 to 25: 1 for a mixed solvent and 1: 1 to 20: 1 for a mixed solvent of water and glycerin.
また、ベルガモットの乾燥部位と抽出溶媒との重量比は好ましくは1:1〜1:80の範囲であり、より好ましくは、1:5〜1:50の範囲である。 The weight ratio of the dried portion of bergamot to the extraction solvent is preferably in the range of 1: 1 to 1:80, more preferably in the range of 1: 5 to 1:50.
抽出物の調製に際して、そのpHに特に限定はないが、一般には3〜9の範囲とすることが好ましい。かかる意味で、必要であれば、前記抽出溶媒に、水酸化ナトリウム、炭酸ナトリウム、水酸化カリウム等のアルカリ性調整剤、又はクエン酸、塩酸、リン酸、硫酸等の酸性調整剤を配合し、所望のpHとなるように調整してもよい。 When preparing the extract, the pH is not particularly limited, but is generally preferably in the range of 3 to 9. In this sense, if necessary, an alkali adjusting agent such as sodium hydroxide, sodium carbonate, potassium hydroxide or the like, or an acid adjusting agent such as citric acid, hydrochloric acid, phosphoric acid, sulfuric acid, etc. is added to the extraction solvent, which is desired. The pH may be adjusted to the above.
抽出温度、抽出時間等の抽出条件は、用いる溶媒の種類やpHによっても異なるが、例えば、水もしくは1,3−ブチレングリコール、又は水と1,3−ブチレングリコールとの混液を溶媒とする場合であれば、抽出温度は一般的には4℃〜85℃の範囲であり、又抽出時間は一般的には0.5時間〜3日間の範囲である。 Extraction conditions such as extraction temperature and extraction time differ depending on the type and pH of the solvent used, but for example, when water or 1,3-butylene glycol or a mixed solution of water and 1,3-butylene glycol is used as the solvent. If so, the extraction temperature is generally in the range of 4 ° C. to 85 ° C., and the extraction time is generally in the range of 0.5 hours to 3 days.
なお、ベルガモットの果実の搾汁液又は抽出物には、安定性を向上する目的や、化粧料や経口組成物の成分として好ましくない不純物等を除去する目的で、活性炭処理や、非イオン交換樹脂等の合成吸着剤による吸着処理を行っても良い。さらに、ベルガモットの果実の搾汁液又は抽出物に含まれる成分を濃縮する目的で、活性炭処理、非イオン交換樹脂等の合成吸着剤による濃縮処理を行っても良い。 The bergamot fruit juice or extract is treated with activated carbon, non-ion exchange resin, etc. for the purpose of improving stability and removing impurities that are not desirable as components of cosmetics and oral compositions. You may perform the adsorption treatment with the synthetic adsorbent of. Further, for the purpose of concentrating the components contained in the squeezed liquid or extract of bergamot fruit, activated carbon treatment or concentration treatment with a synthetic adsorbent such as a non-ion exchange resin may be performed.
活性炭としては、松等の木、竹、椰子殻、胡桃殻等の植物質のほか、石炭質、石油質等を原材料として、それらの原材料に水蒸気や二酸化炭素、空気等のガスを使う高温炭化法等の物理的な方法や塩化亜鉛等の化学薬品を使って処理した上で加熱し、多孔質にする化学的な方法による活性化処理を施して得られる活性炭等何れを用いても良い。 Activated carbon includes trees such as pine, bamboo, coconut husks, peach husks, and other vegetable substances, as well as coal and petroleum husks, and high-temperature carbonization that uses gas such as water vapor, carbon dioxide, and air as the raw materials. Either a physical method such as a method or activated carbon obtained by treating with a chemical such as zinc chloride and then heating to make it porous by a chemical method may be used.
また、非イオン性多孔性樹脂吸着剤としては、スチレン/ジビニルベンゼン共重合体、メタクリル酸エステル重合体等の非イオン性樹脂からなり、比表面積が一般に100〜2000m2/gの範囲の合成吸着剤(芳香族系無置換型等)が挙げられる。例えばスチレン/ジビニルベンゼン系のダイヤイオンHP10、同20、同21、セパビーズSP800、同SP850、同SP700、同SP207(以上、三菱化学株式会社)、アンバーライトXAD4、同16、デュオライトS874、同877(ローム・アンド・ハース社)、メタクリル酸エステル系のダイヤイオンHP1MG、同2MG(三菱化学株式会社)、アンバーライトXAD7(ローム・アンド・ハース社)等が挙げられる。本発明に用いることができる合成吸着剤はこれに限るものではなく、不純物の除去や濃縮の目的に合わせて適宜選択することができる。 The nonionic porous resin adsorbent is composed of a nonionic resin such as a styrene / divinylbenzene copolymer and a methacrylic acid ester polymer, and has a specific surface area generally in the range of 100 to 2000 m 2 / g for synthetic adsorption. Agents (aromatic unsubstituted type, etc.) can be mentioned. For example, styrene / divinylbenzene-based Diaion HP10, 20, 21, Sepabeads SP800, SP850, SP700, SP207 (above, Mitsubishi Chemical Corporation), Amberlite XAD4, 16, Duolite S874, 877. (Rohm and Haas), methacrylic acid ester-based benzene HP1MG, 2MG (Mitsubishi Chemical Co., Ltd.), Amberlite XAD7 (Rohm and Haas) and the like. The synthetic adsorbent that can be used in the present invention is not limited to this, and can be appropriately selected according to the purpose of removing impurities and concentrating.
また、本発明の抽出処理に先立って、又は抽出処理と並行して、必要に応じて抽出部位に加水分解処理を施してもよい。これによって、当該抽出物の保存安定性等を改善できる可能性がある。 Further, the extraction site may be subjected to a hydrolysis treatment, if necessary, prior to the extraction treatment of the present invention or in parallel with the extraction treatment. Thereby, there is a possibility that the storage stability of the extract can be improved.
抽出物に酵素加水分解処理を施す場合、酵素としては、アクチナーゼ、パパイン、ペプシン等の蛋白分解酵素、グルコアミラーゼ、α−アミラーゼ、β−アミラーゼ等の澱粉分解酵素、セルラーゼ、ヘミセルラーゼ、ペクチナーゼ等の繊維素分解酵素、及びリパーゼ等の脂肪分解酵素のいずれかの酵素群から選ばれた1種又は2種以上を用いてもよいが、それらの酵素群からそれぞれ選ばれた1種又は2種以上の酵素を組み合わせて用いることがより好ましい。 When the extract is subjected to enzyme hydrolysis treatment, the enzymes include proteolytic enzymes such as actinase, papaine and pepsin, starch degrading enzymes such as glucoamylase, α-amylase and β-amylase, and cellulase, hemicellase and pectinase. One or more selected from any of the enzyme groups of fibrinolytic enzyme and lipolytic enzyme such as lipase may be used, but one or more selected from those enzyme groups, respectively. It is more preferable to use the above enzymes in combination.
酵素の添加量は、ベルガモットの使用部位の固形分に対して、合計で0.001〜50重量%の範囲とすることが好ましい。 The amount of the enzyme added is preferably in the range of 0.001 to 50% by weight in total with respect to the solid content of the site where the bergamot is used.
上述のように調製した抽出物は、一般にはpHを3〜9に調製した上で、これをそのままの状態で使用しても良く、又減圧濃縮等により所望の濃度として使用しても良い。また、抽出物はスプレードライ法等の常法により乾燥物としても良い。 The extract prepared as described above may generally have a pH adjusted to 3 to 9 and then used as it is, or may be used as a desired concentration by concentration under reduced pressure or the like. Further, the extract may be a dried product by a conventional method such as a spray-drying method.
また、上述のように調製した抽出物は、保存安定性等を高めるために、一定時間冷蔵保存した上で、上清を使用しても良い。 In addition, the extract prepared as described above may be refrigerated for a certain period of time and then the supernatant may be used in order to improve storage stability and the like.
本発明に係る抽出物を含む化粧料(医薬部外品も含む)としては、例えば、乳液、クリーム、ローション、エッセンス、パック、口紅、ファンデーション、リクイドファンデーション、メイクアッププレスパウダー、ほほ紅、白粉、洗顔料、ボディシャンプー、毛髪用シャンプー、石けん等が挙げられ、また、育毛剤、さらには浴剤等も挙げられるが、勿論これらに限定されるものではない。また、美容用経口組成物としては、美容飲料、栄養ドリンク、スポーツドリンク、ニアウォーター、ビタミン飲料、ミネラル飲料、アルコール飲料等の飲料;各種スープ類(粉末スープも含む)、乳製品、ゼリー、キャンディ、錠菓、ガム等の食品;錠剤、液状、顆粒状又はゼリー状の健康食品・飲料等に配合することができるが、本発明はこれに限るものではなく、経口摂取できる飲食品等に配合することができる。 Cosmetics (including non-medicinal products) containing the extract according to the present invention include, for example, milky lotion, cream, lotion, essence, pack, lipstick, foundation, liquid foundation, make-up press powder, blusher, white powder, etc. Examples thereof include facial cleansers, body shampoos, shampoos for hair, soaps, etc., and hair growth agents, bathing agents, etc., but of course, are not limited thereto. In addition, as oral cosmetic compositions, beverages such as beauty beverages, energy drinks, sports drinks, near water, vitamin beverages, mineral beverages, alcoholic beverages; various soups (including powdered soups), dairy products, jellies, candy , Tablets, gums and other foods; can be blended in tablets, liquid, granular or jelly-like health foods / beverages, etc., but the present invention is not limited to this, and can be blended in foods and drinks that can be taken orally. can do.
化粧料における本発明の抽出物の配合量は、抽出物の固形分として、基礎化粧料の場合は、一般に0.002〜1.0重量%(固形分重量%、以下同じ)、好ましくは0.02〜0.2重量%の範囲、メイクアップ化粧料の場合は、一般に0.002〜1.0重量%、好ましくは0.02〜0.2重量%の範囲、又清浄用化粧料の場合は、一般に0.002〜10.0重量%、好ましくは0.02〜7.0重量%の範囲である。また、毛髪用化粧料の場合は、抽出物の固形分として、一般的には0.0001〜5.0重量%であり、好ましくは、0.001〜3.0重量%である。また、美容用経口組成物における本発明の抽出物の配合量は、抽出物の固形分として、0.1〜15重量%の範囲が好ましい。 The blending amount of the extract of the present invention in cosmetics is generally 0.002 to 1.0% by weight (solid content weight%, the same applies hereinafter), preferably 0, as the solid content of the extract in the case of basic cosmetics. In the range of .02 to 0.2% by weight, in the case of make-up cosmetics, generally in the range of 0.002 to 1.0% by weight, preferably in the range of 0.02 to 0.2% by weight, and for cleaning cosmetics. In the case, it is generally in the range of 0.002 to 10.0% by weight, preferably 0.02 to 7.0% by weight. In the case of hair cosmetics, the solid content of the extract is generally 0.0001 to 5.0% by weight, preferably 0.001 to 3.0% by weight. The blending amount of the extract of the present invention in the cosmetological oral composition is preferably in the range of 0.1 to 15% by weight as the solid content of the extract.
化粧料には、必須成分である抽出物のほかに、通常化粧料や経口組成物に用いられる成分、例えば油性成分、界面活性剤(合成系、天然物系)、保湿剤、増粘剤、防腐・殺菌剤、粉体成分、紫外線吸収剤、抗酸化剤、色素、香料等を必要に応じて適宜配合することができる。また、当該抽出物の有効性、特長を損なわない限り、他の生理活性成分を組み合わせて配合することも何ら差し支えない。 In cosmetics, in addition to extracts, which are essential ingredients, ingredients usually used in cosmetics and oral compositions, such as oily ingredients, surfactants (synthetic and natural products), moisturizers, thickeners, etc. Preservatives / bactericides, powder components, ultraviolet absorbers, antioxidants, pigments, fragrances and the like can be appropriately blended as needed. Further, as long as the effectiveness and characteristics of the extract are not impaired, other physiologically active ingredients may be combined and blended at all.
ここで、油性成分としては、例えばベルガモット油、オリーブ油、ホホバ油、ヒマシ油、大豆油、米油、米糠油、米胚芽油、ヤシ油、カミツレ油、パーム油、カカオ油、メドウフォーム油、ローズヒップ油、ランベンダー油、シアーバター、ティーツリー油、アボガド油、マカデミアナッツ油、植物由来スクワラン等の植物由来の油脂類;ミンク油、タートル油等の動物由来の油脂類;ミツロウ、カルナウバロウ、ライスワックス、ラノリン等のロウ類;流動パラフィン、ワセリン、パラフィンワックス、スクワラン等の炭化水素類;ミリスチン酸、パルミチン酸、ステアリン酸、オレイン酸、イソステアリン酸、エイコセン酸等の脂肪酸類;ラウリルアルコール、セタノール、ステアリルアルコール等の高級アルコール類;ミリスチン酸イソプロピル、パルミチン酸イソプロピル、オレイン酸ブチル、2−エチルヘキシルグリセライド、高級脂肪酸オクチルドデシル(ステアリン酸オクチルドデシル等)等の合成エステル類及び合成トリグリセライド類等が挙げられる。 Here, examples of the oily component include bergamot oil, olive oil, jojoba oil, paraffin oil, soybean oil, rice oil, rice bran oil, rice germ oil, palm oil, chamomile oil, palm oil, cacao oil, meadowfoam oil, and rose. Plant-derived fats and oils such as hip oil, lanbender oil, sheer butter, tea tree oil, avocado oil, macadamia nut oil, and plant-derived squalane; animal-derived fats and oils such as mink oil and turtle oil; honey wax, carnauba wax, rice wax , Lanorin and other waxes; liquid paraffin, vaseline, paraffin wax, squalane and other hydrocarbons; myristic acid, palmitic acid, stearic acid, oleic acid, isostearic acid, eicosenoic acid and other fatty acids; lauryl alcohol, cetanol, stearyl Higher alcohols such as alcohols; synthetic esters such as isopropyl myristate, isopropyl palmitate, butyl oleate, 2-ethylhexyl glyceride, higher fatty acid octyldodecyl (octyldodecyl stearate, etc.) and synthetic triglycerides can be mentioned.
界面活性剤としては、例えばポリオキシエチレンアルキルエーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビトール脂肪酸エステル等の非イオン界面活性剤;脂肪酸塩、アルキル硫酸塩、アルキルベンゼンスルホン酸塩、ポリオキシエチレンアルキルエーテル硫酸塩、ポリオキシエチレン脂肪アミン硫酸塩、ポリオキシエチレンアルキルフェニルエーテル硫酸塩、ポリオキシエチレンアルキルエーテル燐酸塩、α−スルホン化脂肪酸アルキルエステル塩、ポリオキシエチレンアルキルフェニルエーテル燐酸塩等のアニオン界面活性剤;第四級アンモニウム塩、第一級〜第三級脂肪アミン塩、トリアルキルベンジルアンモニウム塩、アルキルピリジニウム塩、2−アルキル−1−アルキル−1−ヒドロキシエチルイミダゾリニウム塩、N,N−ジアルキルモルフォルニウム塩、ポリエチレンポリアミン脂肪酸アミド塩等のカチオン界面活性剤;N,N−ジメチル−N−アルキル−N−カルボキシメチルアンモニオベタイン、N,N,N−トリアルキル−N−アルキレンアンモニオカルボキシベタイン、N−アシルアミドプロピル−N′,N′−ジメチル−N′−β−ヒドロキシプロピルアンモニオスルホベタイン等の両性界面活性剤等を使用することができる。 Examples of the surfactant include polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene hydrogenated castor oil, and poly. Nonionic surfactants such as oxyethylene sorbitol fatty acid ester; fatty acid salt, alkyl sulfate, alkylbenzene sulfonate, polyoxyethylene alkyl ether sulfate, polyoxyethylene fatty amine sulfate, polyoxyethylene alkyl phenyl ether sulfate, Anionic surfactants such as polyoxyethylene alkyl ether phosphate, α-sulfonated fatty acid alkyl ester salt, polyoxyethylene alkyl phenyl ether phosphate; quaternary ammonium salt, primary to tertiary fatty amine salt, tri Cationic surfactants such as alkylbenzylammonium salt, alkylpyridinium salt, 2-alkyl-1-alkyl-1-hydroxyethylimidazolinium salt, N, N-dialkylmorphonium salt, polyethylene polyamine fatty acid amide salt; N, N-dimethyl-N-alkyl-N-carboxymethylammoniobetaine, N, N, N-trialkyl-N-alkylene ammoniocarboxybetaine, N-acylamide propyl-N', N'-dimethyl-N'- Amphoteric surfactants such as β-hydroxypropylammoniosulfobetaine can be used.
乳化剤又は乳化助剤としては、酵素処理ステビア等のステビア誘導体、サポニン又はその誘導体、カゼイン又はその塩(ナトリウム等)、糖と蛋白質の複合体、ショ糖又はそのエステル、ラクトース、大豆由来の水溶性多糖、大豆由来蛋白質と多糖の複合体、ラノリン又はその誘導体、コレステロール、ステビア誘導体(ステビア酵素処理物等)、ケイ酸塩(アルミニウム、マグネシウム等)、炭酸塩(カルシウム、ナトリウム等)、サポニン及びその誘導体、レシチン及びその誘導体(水素添加レシチン等)、乳酸菌醗酵米、乳酸菌醗酵発芽米、乳酸菌醗酵穀類(麦類、豆類、雑穀等)等を配合することもできる。 Examples of emulsifiers or emulsifying aids include stevia derivatives such as enzyme-treated stevia, saponin or derivatives thereof, casein or salts thereof (sodium, etc.), sugar-protein complexes, sucrose or esters thereof, lactic acid, and water-soluble soybeans. Polysaccharide, complex of soybean-derived protein and polysaccharide, lanolin or its derivative, cholesterol, stevia derivative (stevia enzyme treated product, etc.), silicate (aluminum, magnesium, etc.), carbonate (calcium, sodium, etc.), saponin and its Derivatives, lecithin and its derivatives (hydrogenated lecithin, etc.), lactic acid bacteria fermented rice, lactic acid bacteria fermented germinated rice, lactic acid bacteria fermented grains (wheat, beans, miscellaneous grains, etc.) and the like can also be blended.
保湿剤としては、例えばグリセリン、プロピレングリコール、ジプロピレングリコール、1,3−ブチレングリコール、ポリエチレングリコール、ソルビトール、キシリトール、ピロリドンカルボン酸ナトリウム等があり、さらにトレハロース等の糖類、ムコ多糖類(例えば、ヒアルロン酸及びその誘導体、コンドロイチン及びその誘導体、ヘパリン及びその誘導体等)、エラスチン及びその誘導体、コラーゲン及びその誘導体、NMF関連物質、乳酸、尿素、高級脂肪酸オクチルドデシル、海藻抽出物、シラン根(白及)抽出物、各種アミノ酸及びそれらの誘導体が挙げられる。 Examples of the moisturizing agent include glycerin, propylene glycol, dipropylene glycol, 1,3-butylene glycol, polyethylene glycol, sorbitol, xylitol, sodium pyrrolidone carboxylate and the like, and saccharides such as trehalose and mucopolysaccharides (for example, hyalurone). Acids and their derivatives, chondroitin and its derivatives, heparin and its derivatives, etc.), elastin and its derivatives, collagen and its derivatives, NMF-related substances, lactic acid, urea, higher fatty acids octyldodecyl, seaweed extract, silane roots (white) Examples include extracts, various amino acids and derivatives thereof.
増粘剤としては、例えばアルギン酸、寒天、カラギーナン、フコイダン等の褐藻、緑藻又は紅藻由来成分;シラン根(白及)抽出物;ペクチン、ローカストビーンガム、アロエ多糖体、アルカリゲネス産生多糖体等の多糖類;キサンタンガム、トラガントガム、グアーガム等のガム類;カルボキシメチルセルロース、ヒドロキシエチルセルロース等のセルロース誘導体;ポリビニルアルコール、ポリビニルピロリドン、カルボキシビニルポリマー、アクリル酸・メタクリル酸共重合体等の合成高分子類;ヒアルロン酸及びその誘導体;ポリグルタミン酸及びその誘導体等が挙げられる。 Examples of the thickener include ingredients derived from brown algae such as alginic acid, agar, carrageenan, and fucoidan, green algae or red algae; silane root (white and) extract; pectin, locust bean gum, aloe polysaccharide, alkaligenes-producing polysaccharide and the like. Polysaccharides; gums such as xanthan gum, tragant gum, guar gum; cellulose derivatives such as carboxymethyl cellulose and hydroxyethyl cellulose; synthetic polymers such as polyvinyl alcohol, polyvinyl pyrrolidone, carboxyvinyl polymer, alginic acid / methacrylic acid copolymer; hyaluronic acid And derivatives thereof; examples thereof include polyglutamic acid and derivatives thereof.
防腐・殺菌剤としては、例えば尿素;パラオキシ安息香酸メチル、パラオキシ安息香酸エチル、パラオキシ安息香酸プロピル、パラオキシ安息香酸ブチル等のパラオキシ安息香酸エステル類;フェノキシエタノール、ジクロロフェン、ヘキサクロロフェン、塩酸クロルヘキシジン、塩化ベンザルコニウム、サリチル酸、エタノール、ウンデシレン酸、フェノール類、ジャマール(イミダゾデイニールウレア)、プロパンジオール、1,2−ペンタンジオール、各種精油類、樹皮乾留物、大根発酵液、サトウキビ等の植物由来のエタノール又は1,3−ブチレングリコール等がある。 Examples of preservatives and bactericides include urea; paraoxybenzoic acid esters such as methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, and butyl paraoxybenzoate; phenoxyethanol, dichlorophenol, hexachlorophene, chlorhexidine hydrochloride, and benza chloride. Plant-derived ethanol such as luconium, salicylic acid, ethanol, undecyleneic acid, phenols, jamar (imidazodeinylurea), propanediol, 1,2-pentanediol, various essential oils, bark dry distillate, radish fermented liquid, sugar cane Alternatively, there are 1,3-butylene glycol and the like.
粉体成分としては、例えばセリサイト、酸化チタン、タルク、カオリン、ベントナイト、酸化亜鉛、炭酸マグネシウム、酸化マグネシウム、酸化ジルコニウム、硫酸バリウム、無水ケイ酸、雲母、ナイロンパウダー、ポリエチレンパウダー、シルクパウダー、セルロース系パウダー、穀類(米、麦、トウモロコシ、キビ等)のパウダー、豆類(大豆、小豆等)のパウダー等がある。 Examples of powder components include cericite, titanium oxide, talc, kaolin, bentonite, zinc oxide, magnesium carbonate, magnesium oxide, zirconium oxide, barium sulfate, silicic anhydride, mica, nylon powder, polyethylene powder, silk powder, and cellulose. There are system powders, grain powders (rice, wheat, corn, talc, etc.), beans (soybeans, talc, etc.) powders, etc.
紫外線吸収剤としては、例えばパラアミノ安息香酸エチル、パラジメチルアミノ安息香酸エチルヘキシル、サリチル酸アミル及びその誘導体、パラメトキシ桂皮酸2−エチルヘキシル、桂皮酸オクチル、オキシベンゾン、2,4−ジヒドロキシベンゾフェノン、2−ヒドロキシ−4−メトキシベンゾフェノン−5−スルホン酸塩、4−ターシャリーブチル−4−メトキシベンゾイルメタン、2−(2−ヒドロキシ−5−メチルフェニル)ベンゾトリアゾール、ウロカニン酸、ウロカニン酸エチル、アロエ抽出物等がある。 Examples of the ultraviolet absorber include ethyl paraaminobenzoate, ethylhexyl paradimethylaminobenzoate, amyl salicylate and its derivatives, 2-ethylhexyl paramethoxycinnamate, octyl silicate, oxybenzone, 2,4-dihydroxybenzophenone, 2-hydroxy-4. -Methoxybenzophenone-5-sulfonate, 4-tershally butyl-4-methoxybenzoylmethane, 2- (2-hydroxy-5-methylphenyl) benzotriazole, urocanic acid, ethyl urocanate, aloe extract, etc. ..
抗酸化剤としては、例えばブチルヒドロキシアニソール、ブチルヒドロキシトルエン、没食子酸プロピル、ビタミンE及びその誘導体(例えば、ビタミンEニコチネート、ビタミンEリノレート等)等がある。 Examples of the antioxidant include butylhydroxyanisole, butylhydroxytoluene, propyl gallate, vitamin E and its derivatives (for example, vitamin E nicotinate, vitamin E linoleate, etc.).
美白剤としては、t−シクロアミノ酸誘導体、コウジ酸及びその誘導体、アスコルビン酸及びその誘導体、ハイドロキノン又はその誘導体、エラグ酸及びその誘導体、ニコチン酸及びその誘導体、レゾルシノール誘導体、トラネキサム酸及びその誘導体、4−メトキシサリチル酸カリウム塩、マグノリグナン(5,5'−ジプロピル−ビフェニル−2,2’−ジオール)、ヒドロキシ安息香酸及びその誘導体、ビタミンE及びその誘導体、α−ヒドロキシ酸、AMP(アデノシンモノホスフェイト、アデノシン1リン酸)が挙げられ、これらを単独で配合しても、複数を組み合わせて配合しても良い。 Whitening agents include t-cycloamino acid derivatives, kodiic acid and its derivatives, ascorbic acid and its derivatives, hydroquinone or its derivatives, ellagic acid and its derivatives, nicotinic acid and its derivatives, resorcinol derivatives, tranexamic acid and its derivatives, 4 -Polish potassium methoxysalicylate, magnolignan (5,5'-dipropyl-biphenyl-2,2'-diol), hydroxybenzoic acid and its derivatives, vitamin E and its derivatives, α-hydroxyic acid, AMP (adenosine monophosphate) , Adenosine monophosphate), and these may be blended alone or in combination of two or more.
上記のコウジ酸誘導体としては、例えばコウジ酸モノブチレート、コウジ酸モノカプレート、コウジ酸モノパルミテート、コウジ酸ジブチレート等のコウジ酸エステル類、コウジ酸エーテル類、コウジ酸グルコシド等のコウジ酸糖誘導体等が、アスコルビン酸誘導体としては、例えばL−アスコルビン酸−2−リン酸エステルナトリウム、L−アスコルビン酸−2−リン酸エステルマグネシウム、L−アスコルビン酸−2−硫酸エステルナトリウム、L−アスコルビン酸−2−硫酸エステルマグネシウム等のアスコルビン酸エステル塩類、L−アスコルビン酸−2−グルコシド、L−アスコルビン酸−5−グルコシド、アスコルビルトコフェリルマレイン酸、アスコルビルトコフェリルリン酸K、ミリスチル3−グリセリルアスコルビン酸、カプリリル2−グリセリルアスコルビン酸等のアスコルビン酸糖誘導体、それらアスコルビン酸糖誘導体の6位アシル化物(アシル基は、ヘキサノイル基、オクタノイル基、デカノイル基等)、L−アスコルビン酸テトライソパルミチン酸エステル、L−アスコルビン酸テトララウリン酸エステル等のL−アスコルビン酸テトラ脂肪酸エステル類、3−O−エチルアスコルビン酸、L−アスコルビン酸−2−リン酸−6−O−パルミテートナトリウム、グリセリルアスコルビン酸又はそのアシル化誘導体、ビスグリセリルアスコルビン酸等のアスコルビン酸グルセリン誘導体、L−アスコルビン酸リン酸アミノプロピル、L−アスコルビン酸のヒアルロン酸誘導体、3−O−Dラクトース−L−アスコルビン酸、イソステアリルアスコルビルリン酸塩等が、ハイドロキノン誘導体としては、アルブチン(ハイドロキノン−β−D−グルコピラノシド)、α−アルブチン(ハイドロキノン−α−D−グルコピラノシド)等が、トラネキサム酸誘導体としては、トラネキサム酸エステル(例えば、トラネキサム酸ラウリルエステル、トラネキサム酸ヘキサデシルエステル、トラネキサム酸セチルエステル又はその塩)、トラネキサム酸のアミド体(例えば、トラネキサム酸メチルアミド)等が挙げられ、レゾルシノール誘導体としては、例えば、4−n−ブチルレゾルシノール、4−イソアミルレゾルシノール等が、2,5−ジヒドロキシ安息香酸誘導体としては、例えば2,5−ジアセトキシ安息香酸、2−アセトキシ−5−ヒドロキシ安息香酸、2−ヒドロキシ−5−プロピオニルオキシ安息香酸等が、ニコチン酸誘導体としては、例えばニコチン酸アミド、ニコチン酸ベンジル等が、α−ヒドロキシ酸としては、例えば乳酸、リンゴ酸、コハク酸、クエン酸、α−ヒドロキシオクタン酸等がある。 Examples of the ascorbic acid derivative include ascorbic acid esters such as ascorbic acid monobutyrate, ascorbic acid monocaplate, ascorbic acid monopalmitate, and ascorbic acid dibutyrate, ascorbic acid ethers, and ascorbic acid sugar derivatives such as ascorbic acid glucoside. However, examples of the ascorbic acid derivative include L-ascorbic acid-2-phosphate ester sodium, L-ascorbic acid-2-phosphate ester magnesium, L-ascorbic acid-2-sulfate sodium ester, and L-ascorbic acid-2. -Ascorbic acid ester salts such as magnesium sulfate, L-ascorbic acid-2-glucoside, L-ascorbic acid-5-glucoside, ascorbic acidcopheryl maleic acid, ascorbic acidcopheryl phosphate K, myristyl 3-glyceryl ascorbic acid, caprylyl Ascorbic acid sugar derivatives such as 2-glyceryl ascorbic acid, 6-position acylated products of those ascorbic acid sugar derivatives (acyl groups are hexanoyl group, octanoyl group, decanoyle group, etc.), L-ascorbic acid tetraisopalmitic acid ester, L- L-ascorbic acid tetrafatty acid esters such as ascorbic acid tetralauric acid ester, 3-O-ethylascorbic acid, L-ascorbic acid-2-phosphate-6-O-palmitate sodium, glyceryl ascorbic acid or acylation thereof Derivatives, glycerin ascorbic acid derivatives such as bisglyceryl ascorbic acid, aminopropyl L-ascorbic acid phosphate, hyaluronic acid derivatives of L-ascorbic acid, 3-OD lactose-L-ascorbic acid, isostearyl ascorbic acid, etc. However, as the hydroquinone derivative, albutin (hydroquinone-β-D-glucopyranoside), α-arbutin (hydroquinone-α-D-glucopyranoside) and the like are used, and as the tranexamic acid derivative, a tranexamic acid ester (for example, tranexamic acid lauryl ester, etc.) Examples thereof include tranexamic acid hexadecyl ester, tranexamic acid cetyl ester or a salt thereof), an amide form of tranexamic acid (for example, methylamide tranexamic acid), and examples of the resorcinol derivative include 4-n-butylresorcinol and 4-isoamylresorsinol. As the 2,5-dihydroxybenzoic acid derivative, for example, 2,5-diacetoxybenzoic acid, 2-acetoxy-5-hydroxybenzoic acid, 2-hydroxy-5-propionilo, etc. Xybenzoic acid and the like, nicotinic acid derivatives such as nicotinamide and benzyl nicotinate, and α-hydroxy acids include, for example, lactic acid, malic acid, succinic acid, citric acid, α-hydroxyoctanoic acid and the like. ..
生理活性成分としては、例えば、胎盤抽出液、ソウハクヒ抽出物、ユキノシタ抽出物、シソ抽出物、米糠抽出物又はその加水分解物、白芥子抽出物又はその加水分解物、白芥子の発酵物、シャクヤク抽出物又はその加水分解物、乳酸菌醗酵米、ムラサキシキブ抽出物、ハス種子抽出物又はその加水分解物、ハス種子発酵物、党参抽出物又はその加水分解物、ハトムギ加水分解物、ハトムギ種子発酵物、ローヤルゼリー発酵物、酒粕抽出物又はそれに含まれるセラミド、酒粕発酵物、パンダヌス・アマリリフォリウス(Pandanus amaryllifolius Roxb.)抽出物、アルカンジェリシア・フラバ(Arcangelicia flava Merrilli)抽出物、カミツレ抽出物等が挙げられる。また、サンゴ草抽出物、イネの葉の抽出物又はその加水分解物、ナス(ベルガモット、長ナス、賀茂ナス、米ナス等)抽出物又はその加水分解物、アンズ果実の抽出物、カタメンキリンサイ等の海藻の抽出物、アマモ等の海産顕花植物の抽出物、豆乳発酵物、クラゲ水、米抽出物又はその加水分解物、米醗酵エキス、発芽米抽出物又はその加水分解物、発芽米発酵物、黒豆抽出物又はその加水分解物、ダマスクバラの花の抽出物、タケノコの皮の抽出物、リノール酸及びその誘導体もしくは加工物(例えばリポソーム化リノール酸等)、動物又は魚由来のコラーゲン及びその誘導体、エラスチン及びその誘導体、グリチルリチン酸及びその誘導体(ジカリウム塩等)、t−シクロアミノ酸誘導体、ビタミンA及びその誘導体、アラントイン、ジイソプロピルアミンジクロロアセテート、γ−アミノ−β−ヒドロキシ酪酸、ゲンチアナ抽出物、甘草抽出物、ニンジン抽出物、オタネニンジン抽出物又はその発酵物、紅参抽出物、ミツイシコンブ抽出物、ヘチマ抽出物、アナアオサ抽出物、モモ抽出物、桃仁抽出物、キウイ抽出物、ヒマワリ抽出物、ジュアゼイロ(Zizyphus joazeiro)抽出物、パウダルコ樹皮抽出物、萱草(デイリリー)抽出物または発酵物、ハイビスカスの花抽出物または発酵物、ハゴロモグサ抽出物、チェリモヤ抽出物、マンゴー抽出物、マンゴスチン抽出物、フノリ抽出物、烏龍茶抽出物、紅富貴抽出物、紫蘭抽出物、山椒果皮又は種皮の抽出物または加水分解物、ベニバナ花抽出物、カサブランカ抽出物、甘藷抽出物又はその発酵物、グアバ葉抽出物、ドクダミ抽出物、晩白柚抽出物、アロエ抽出物、イチジク花抽出物、リンゴ抽出物、ホワイトアスパラガス抽出物等がある。 Physiologically active ingredients include, for example, placental extract, soybean extract, yukinoshita extract, perilla extract, rice bran extract or its hydrolyzate, white potato extract or its hydrolyzate, white potato fermented product, shakyaku. Extract or its hydrolyzate, lactic acid fungus fermented rice, purple kib extract, lotus seed extract or its hydrolyzate, lotus seed fermented product, ginseng extract or its hydrolyzate, honeybee hydrolyzate, honeybee seed fermented product, Royal jelly fermented product, liquor lees extract or ceramide contained therein, liquor lees fermented product, Pandanus amaryllifolius Roxb. Extract, Arcangelicia flava Merrilli extract, chamomile extract, etc. Be done. In addition, coral grass extract, rice leaf extract or its hydrolyzate, eggplant (bergamot, Naga eggplant, Kamo eggplant, rice eggplant, etc.) extract or its hydrolyzate, apricot fruit extract, catamen giraffe, etc. Seaweed extract, marine flowering plant extract such as amamo, soymilk fermented product, jellyfish water, rice extract or its hydrolyzate, fermented rice extract, sprouted rice extract or its hydrolyzate, sprouted rice fermentation Products, black bean extract or its hydrolyzate, damask rose flower extract, bamboo shoot skin extract, linoleic acid and its derivatives or processed products (eg, liposomal linoleic acid, etc.), animal or fish-derived collagen and Its derivatives, elastin and its derivatives, glycyrrhizic acid and its derivatives (dipotassium salt, etc.), t-cycloamino acid derivatives, vitamin A and its derivatives, allantin, diisopropylamine dichloroacetate, γ-amino-β-hydroxybutyric acid, gentian extract , Lantern extract, Carrot extract, Otane carrot extract or fermented product thereof, Red ginseng extract, Mitsuishikonbu extract, Hechima extract, Anaaosa extract, Peach extract, Peach seed extract, Kiwi extract, Sunflower extract, Zizyphus joazeiro extract, paudalco bark extract, daily extract or fermented product, hibiscus flower extract or fermented product, hagoromogusa extract, cherimoya extract, mango extract, mangostin extract, funori extract Thing, Karyu tea extract, Benifuki extract, Purple orchid extract, Sansho peel or seed coat extract or hydrolyzate, Benibana flower extract, Casablanca extract, Sweet potato extract or its fermented product, Guava leaf extract, Dokudami There are extracts, evening white yuzu extract, aloe extract, fig flower extract, apple extract, white asparagus extract and the like.
次に、製造例、処方例及び試験例によって本発明をさらに具体的に説明するが、本発明はそれらに限定されるものではない。なお、以下において、部はすべて重量部を、また%はすべて重量%を意味する。 Next, the present invention will be described in more detail with reference to Production Examples, Formulation Examples, and Test Examples, but the present invention is not limited thereto. In the following, all parts mean parts by weight, and% means all parts by weight.
製造例1.ベルガモットエキス(搾汁液)の調製
ベルガモットの果実3000gを搾汁し、果汁1000gを得た。果汁をろ過し、微黄色の透明液体900gを得た。果汁に芳香族系無置換型の合成吸着剤9gを加え、1時間攪拌後、ろ過し、微黄色透明の搾汁液880gを得た。なお、後述する試験例に示す評価を行う際には当該搾汁液をその固形分濃度が1.0%になるように調整した。
Production example 1. Preparation of bergamot extract (juice juice) 3000 g of bergamot fruit was squeezed to obtain 1000 g of fruit juice. The juice was filtered to obtain 900 g of a slightly yellow transparent liquid. 9 g of an aromatic-unsubstituted synthetic adsorbent was added to the fruit juice, and the mixture was stirred for 1 hour and then filtered to obtain 880 g of a slightly yellow transparent juice. When performing the evaluation shown in the test example described later, the juice was adjusted so that its solid content concentration was 1.0%.
製造例2.ベルガモットエキス(搾汁液)の調製
製造例1と同様の操作により、搾汁液880gを得た。これに芳香族系無置換型の高比表面積処理品である合成吸着剤8.8gを加え、2時間攪拌後、合成吸着剤を回収した。1,3−ブチレングリコール水溶液に回収した合成吸着剤を加え、攪拌し、ろ過し、微黄色透明の搾汁液400gを得た(固形分濃度 0.1%)。
Production example 2. Preparation of bergamot extract (squeezed liquid) 880 g of squeezed liquid was obtained by the same operation as in Production Example 1. To this, 8.8 g of a synthetic adsorbent, which is an aromatic-unsubstituted high specific surface area treated product, was added, and after stirring for 2 hours, the synthetic adsorbent was recovered. The recovered synthetic adsorbent was added to an aqueous solution of 1,3-butylene glycol, and the mixture was stirred and filtered to obtain 400 g of a slightly yellow transparent juice (solid content concentration: 0.1%).
製造例3.ベルガモットエキス(抽出物)の調製
ベルガモット果実の乾燥物粉末40gに1,3−ブチレングリコールを200gと精製水150gの混合溶媒を添加した後、80℃で抽出した。得られた粗抽出液を濾過して、褐色透明のベルガモット果実の抽出物溶液284gを得た(固形分濃度2.30%)。
Production example 3. Preparation of bergamot extract (extract) After adding 200 g of 1,3-butylene glycol and 150 g of purified water to 40 g of dried bergamot fruit powder, the mixture was extracted at 80 ° C. The obtained crude extract was filtered to obtain 284 g of a brown transparent bergamot fruit extract solution (solid content concentration 2.30%).
製造例4.ベルガモットエキス(抽出物)の調製
ベルガモット果実の乾燥物粉末40gにプロパンジオールを200gと精製水150gの混合溶媒を添加した後、40℃で抽出した。得られた粗抽出液を濾過して、褐色透明のベルガモット果実の抽出物溶液278gを得た(固形分濃度2.21%)。
Production example 4. Preparation of bergamot extract (extract) After adding a mixed solvent of 200 g of propanediol and 150 g of purified water to 40 g of dried bergamot fruit powder, extraction was performed at 40 ° C. The obtained crude extract was filtered to obtain 278 g of a brown transparent bergamot fruit extract solution (solid content concentration: 2.21%).
製造例5.ベルガモットエキス(抽出物)の調製
ベルガモット果実の乾燥物粉末40gに50%エタノール水溶液を350gの混合溶媒を添加した後、20℃で抽出した。得られた粗抽出液を濾過して、褐色透明のベルガモット果実の抽出物溶液289gを得た(固形分濃度2.38%)。
Production example 5. Preparation of bergamot extract (extract) After adding 350 g of a 50% ethanol aqueous solution to 40 g of dried bergamot fruit powder, extraction was performed at 20 ° C. The obtained crude extract was filtered to obtain 289 g of a brown transparent bergamot fruit extract solution (solid content concentration: 2.38%).
製造例6.ベルガモットエキス(抽出物)の調製
ベルガモットの全草(果実、果皮及び種子を含む)の乾燥物粉末80gに1,3−ブチレングリコールを400gと精製水300gの混合溶媒を添加した後、40℃で抽出した。得られた粗抽出液を濾過して、褐色透明のベルガモットの抽出物溶液270gを得た(固形分濃度2.09%)。
Production example 6. Preparation of bergamot extract (extract) After adding a mixed solvent of 400 g of 1,3-butylene glycol and 300 g of purified water to 80 g of dried powder of bergamot whole plant (including fruits, peels and seeds), at 40 ° C. Extracted. The obtained crude extract was filtered to obtain 270 g of a brown transparent bergamot extract solution (solid content concentration 2.09%).
処方例1.化粧水
[A成分] 部
オリーブ油 1.0
ポリオキシエチレン(5.5)セチルアルコール 5.0
ブチルパラベン 0.1
[B成分]
製造例1の搾汁液 5.0
エタノール 5.0
グリセリン 5.0
1,3−ブチレングリコール 5.0
水酸化カリウム 適量
精製水 全量が100部となる量
[C成分]
香料 適量
A成分及びB成分をそれぞれ80℃以上に加温後、A成分にB成分を加えて攪拌し、さらにヒスコトロン(5000rpm)で2分間ホモジナイズを行った。これを50℃まで冷却した後、C成分を加えて攪拌混合し、さらに30℃以下まで冷却して化粧水を得た。
Prescription example 1. Toner [A component] Part Olive oil 1.0
Polyoxyethylene (5.5) cetyl alcohol 5.0
Butylparaben 0.1
[B component]
Juice liquid of Production Example 1 5.0
Ethanol 5.0
Glycerin 5.0
1,3-butylene glycol 5.0
Potassium hydroxide Appropriate amount Purified water 100 parts in total [C component]
Appropriate amount of fragrance After heating each of the A component and the B component to 80 ° C. or higher, the B component was added to the A component and stirred, and further homogenized with hiscotron (5000 rpm) for 2 minutes. After cooling this to 50 ° C., component C was added, stirred and mixed, and further cooled to 30 ° C. or lower to obtain a lotion.
処方例2.化粧水
処方例1のB成分に含まれる製造例1の搾汁液に代えて、製造例2の搾汁液5.0部を用いるほかは、処方例1と同様にして化粧水を得た。
Prescription example 2. Toner A lotion was obtained in the same manner as in Formulation 1, except that 5.0 parts of the juice of Production Example 2 was used instead of the juice of Production Example 1 contained in the B component of Formulation Example 1.
処方例3.化粧水
処方例1のB成分に含まれる製造例1の搾汁液に代えて、製造例3の抽出物5.0部を用いるほかは、処方例1と同様にして化粧水を得た。
Prescription example 3. Toner Toner was obtained in the same manner as in Formulation Example 1 except that 5.0 parts of the extract of Production Example 3 was used instead of the juice squeezed liquid of Production Example 1 contained in the B component of Formulation Example 1.
処方例4.化粧水
処方例1のB成分に含まれる製造例1の搾汁液に代えて、製造例4の抽出物5.0部を用いるほかは、処方例1と同様にして化粧水を得た。
Prescription example 4. Toner Toner was obtained in the same manner as in Formulation Example 1 except that 5.0 parts of the extract of Production Example 4 was used instead of the juice of Production Example 1 contained in the B component of Formulation Example 1.
処方例5.化粧水
処方例1のB成分に含まれる製造例1の搾汁液に代えて、製造例5の抽出物5.0部を用いるほかは、処方例1と同様にして化粧水を得た。
Prescription example 5. Toner Toner was obtained in the same manner as in Formulation Example 1 except that 5.0 parts of the extract of Production Example 5 was used instead of the squeezed liquid of Production Example 1 contained in the B component of Formulation Example 1.
処方例6.化粧水
処方例1のB成分に含まれる製造例1の搾汁液に代えて、製造例6の抽出物5.0部を用いるほかは、処方例1と同様にして化粧水を得た。
Prescription example 6. Toner Toner was obtained in the same manner as in Formulation Example 1 except that 5.0 parts of the extract of Production Example 6 was used in place of the juice of Production Example 1 contained in the B component of Formulation Example 1.
処方例7.乳液
[A成分] 部
流動パラフィン 6.0
ヘキサラン 4.0
ホホバ油 1.0
ベルガモット精油 0.025
ポリオキシエチレン(20)ソルビタンモノステアレート 1.0
親油型ステアリン酸グリセリル 1.0
大豆レシチン 1.5
[B成分]
製造例1の搾汁液 3.0
L−アスコルビン酸−2−グルコシド 2.0
水酸化カリウム 0.5
グリセリン 3.0
1,3−ブチレングリコール 2.0
カルボキシメチルセルロース 0.3
ヒアルロン酸ナトリウム 0.01
水溶性コラーゲン 0.1
精製水 全量が100部となる量
[C成分]
香料 適量
上記のA成分とB成分をそれぞれ80℃以上に加熱した後、攪拌混合した。これを50℃まで冷却した後、C成分を加えてさらに攪拌混合して乳液を得た。
Prescription example 7. Emulsion [Component A] Part Liquid paraffin 6.0
Hexalan 4.0
Jojoba oil 1.0
Bergamot essential oil 0.025
Polyoxyethylene (20) sorbitan monostearate 1.0
Oil-based glyceryl stearate 1.0
Soy lecithin 1.5
[B component]
Juice liquid of Production Example 1 3.0
L-ascorbic acid-2-glucoside 2.0
Potassium hydroxide 0.5
Glycerin 3.0
1,3-butylene glycol 2.0
Carboxymethyl cellulose 0.3
Sodium hyaluronate 0.01
Water-soluble collagen 0.1
Amount of purified water totaling 100 parts [C component]
Appropriate amount of fragrance The above components A and B were heated to 80 ° C. or higher, and then stirred and mixed. After cooling this to 50 ° C., component C was added and further stirred and mixed to obtain a milky lotion.
処方例8.乳液
処方例7のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてトラネキサム酸2.0部を用いるほかは処方例7と同様にして乳液を得た。
Prescription example 8. Emulsion Emulsion in the same manner as in Formulation 7, except that 2.0 parts of tranexamic acid is used instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide in the B component of Formulation Example 7. Got
処方例9.乳液
処方例7のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてアルブチン3.0部を用いるほかは処方例7と同様にして乳液を得た。
Prescription example 9. Emulsion Emulsion was prepared in the same manner as in Formulation 7, except that 3.0 parts of arbutin was used instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 part of potassium hydroxide in the B component of Formulation Example 7. Obtained.
処方例10.乳液
処方例7のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてニコチン酸アミド3.0部を用いるほかは処方例7と同様にして乳液を得た。
Prescription example 10. Emulsion Same as in Formulation 7, except that 3.0 parts of nicotinamide is used instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide in the B component of Formulation Example 7. Emulsion was obtained.
処方例11.乳液
処方例7のB成分中、L−アスコルビン酸−2−グルコシド2.0部及び水酸化カリウム0.5部に代えてソウハクヒ抽出物5.0部を用いるほかは処方例7と同様にして乳液を得た。
Prescription example 11. Emulsion Same as in Formulation Example 7 except that 5.0 parts of Sohakuhi extract is used instead of 2.0 parts of L-ascorbic acid-2-glucoside and 0.5 parts of potassium hydroxide in the B component of Formulation Example 7. Emulsion was obtained.
処方例12.乳液
[A成分] 部
スクワラン 3.0
ベヘニルアルコール 3.0
ヘキサラン 4.0
ホホバ油 1.0
ポリオキシエチレン(20)ソルビタンモノステアレート 1.0
グリセリン脂肪酸エステル 1.0
大豆レシチン 1.5
[B成分]
製造例1の搾汁液 2.5
製造例2の搾汁液 2.5
L−アスコルビン酸−2−グルコシド 2.0
水酸化カリウム 0.5
グリチルリチン酸ジカリウム 0.1
グリセリン 3.0
1,3−ブチレングリコール 2.0
水溶性コラーゲン 0.1
ヒアルロン酸ナトリウム 0.01
精製水 全量が100部となる量
Prescription example 12. Emulsion [A component] Part Squalene 3.0
Behenyl alcohol 3.0
Hexalan 4.0
Jojoba oil 1.0
Polyoxyethylene (20) sorbitan monostearate 1.0
Glycerin fatty acid ester 1.0
Soy lecithin 1.5
[B component]
Juice liquid of Production Example 1 2.5
Juice liquid of Production Example 2 2.5
L-ascorbic acid-2-glucoside 2.0
Potassium hydroxide 0.5
Dipotassium glycyrrhizinate 0.1
Glycerin 3.0
1,3-butylene glycol 2.0
Water-soluble collagen 0.1
Sodium hyaluronate 0.01
Amount of purified water totaling 100 parts
処方例13.ローション
[成分] 部
製造例2の搾汁液 10.0
エタノール 10.0
グリセリン 3.0
1、3−ブチレングリコール 2.0
メチルパラベン 0.2
クエン酸 0.1
クエン酸ナトリウム 0.3
カルボキシビニルポリマー 0.1
キサンタンガム 0.1
香料 適量
水酸化カリウム 適量
精製水 全量が100部となる量
上記の成分を混合してローションを得た。
Prescription example 13. Lotion [Ingredients] Part Production Example 2 Juice Liquid 10.0
Ethanol 10.0
Glycerin 3.0
1,3-butylene glycol 2.0
Methylparaben 0.2
Citric acid 0.1
Sodium citrate 0.3
Carboxyvinyl polymer 0.1
Xanthan gum 0.1
Perfume Appropriate amount Potassium hydroxide Appropriate amount Purified water 100 parts in total The above components were mixed to obtain a lotion.
処方例14.ローション
処方例13の成分中製造例2の搾汁液に代えて製造例3の抽出物10.0部を用いるほかは処方例13と同様にしてローションを得た。
Prescription example 14. Lotion A lotion was obtained in the same manner as in Formulation 13 except that 10.0 parts of the extract of Production Example 3 was used instead of the juice of Production Example 2 in the components of Formulation Example 13.
処方例15.エッセンス
[成分] 部
エタノール 2.0
グリセリン 5.0
1,3−ブチレングリコール 5.0
メチルパラベン 0.1
ヒアルロン酸 0.1
加水分解ヒアルロン酸液 0.1
製造例1の搾汁液 5.0
クエン酸 0.3
クエン酸ナトリウム 0.6
精製水 全量が100部となる量
精製水にヒアルロン酸を溶解させた後、残りの原料を順次加えて攪拌溶解させ、透明のエッセンスを得た。
Prescription example 15. Essence [Ingredients] Part Ethanol 2.0
Glycerin 5.0
1,3-butylene glycol 5.0
Methylparaben 0.1
Hyaluronic acid 0.1
Hydrolyzed hyaluronic acid solution 0.1
Juice liquid of Production Example 1 5.0
Citric acid 0.3
Sodium citrate 0.6
Amount of purified water totaling 100 parts Hyaluronic acid was dissolved in purified water, and the remaining raw materials were sequentially added and dissolved by stirring to obtain a transparent essence.
実施例16.リキッドファンデーション
[A成分] 部
ステアリン酸 2.4
モノステアリン酸プロピレングリコール 2.0
セトステアリルアルコール 0.2
液状ラノリン 2.0
流動パラフィン 3.0
ミリスチン酸イソプロピル 8.5
プロピルパラベン 0.05
[B成分]
製造例1の搾汁液 5.0
カルボキシメチルセルロースナトリウム 0.2
ベントナイト 0.5
プロピレングリコール 4.0
トリエタノールアミン 1.1
メチルパラベン 0.1
精製水 全量が100部となる量
[C成分]
酸化チタン 8.0
タルク 4.0
着色顔料 適量
上記のA成分とB成分をそれぞれ加温した後混合攪拌した。これを再加温し、上記のC成分を添加して型に流し込み、室温になるまで攪拌してリキッドファンデーションを得た。
Example 16. Liquid foundation [Component A] Part Stearic acid 2.4
Propylene glycol monostearate 2.0
Setostearyl alcohol 0.2
Liquid lanolin 2.0
Liquid paraffin 3.0
Isopropyl myristate 8.5
Propylparaben 0.05
[B component]
Juice liquid of Production Example 1 5.0
Sodium Carboxymethyl Cellulose 0.2
Bentonite 0.5
Propylene glycol 4.0
Triethanolamine 1.1
Methylparaben 0.1
Amount of purified water totaling 100 parts [C component]
Titanium oxide 8.0
Talc 4.0
Appropriate amount of color pigment The above components A and B were heated and then mixed and stirred. This was reheated, the above C component was added and poured into a mold, and the mixture was stirred until it reached room temperature to obtain a liquid foundation.
処方例17.ボディシャンプー
[A成分] 部
N−ラウロイルメチルアラニンナトリウム 25.0
ヤシ油脂肪酸カリウム液(40%) 26.0
ヤシ油脂肪酸ジエタノールアミド 3.0
メチルパラベン 0.1
[B成分]
製造例2の搾汁液 5.0
1,3−ブチレングリコール 2.0
精製水 全量が100部となる量
A成分及びB成分をそれぞれ80℃に加温して均一に溶解した後、A成分にB成分を加え、攪拌を続けて室温まで冷却してボディシャンプーを得た。
Prescription example 17. Body shampoo [Ingredient A] Part N-lauroylmethylalanine sodium 25.0
Coconut oil fatty acid potassium solution (40%) 26.0
Coconut oil fatty acid diethanolamide 3.0
Methylparaben 0.1
[B component]
Juice liquid of Production Example 2 5.0
1,3-butylene glycol 2.0
Amount of purified water totaling 100 parts A component and B component are each heated to 80 ° C and uniformly dissolved, then B component is added to A component, and stirring is continued to cool to room temperature to obtain a body shampoo. It was.
処方例18.育毛用化粧料
[成分] 部
グリチルリチン酸ジカリウム 0.1
モノニトログアヤコールナトリウム 0.02
塩酸ピリドキシン 0.03
l−メントール 0.8
タマサキツヅラフジ根エキス 0.3
褐藻エキス 0.3
オタネニンジンエキス 0.3
センブリエキス 2.0
製造例1の搾汁液 3.5
トリメチルグリシン 0.5
乳酸 0.2
1,3−ブチレングリコール 10.0
フェノキシエタノール 0.2
ポリオキシエチレン硬化ヒマシ油 0.4
L−アルギニン 適量
エタノール 20.0
精製水 全量が100部となる量
上記の成分を十分攪拌混合して育毛料を得た。
Prescription example 18. Hair growth cosmetics [Ingredients] Part Dipotassium glycyrrhizinate 0.1
Mononitroguaiacol Sodium 0.02
Pyridoxine hydrochloride 0.03
l-Menthol 0.8
Menispermaceae root extract 0.3
Brown algae extract 0.3
Panax ginseng extract 0.3
Swertia japonica extract 2.0
Juice liquid of Production Example 1 3.5
Trimethylglycine 0.5
Lactic acid 0.2
1,3-butylene glycol 10.0
Phenoxyethanol 0.2
Polyoxyethylene hardened castor oil 0.4
L-Arginine Appropriate amount Ethanol 20.0
Amount of purified water totaling 100 parts The above components were sufficiently stirred and mixed to obtain a hair restorer.
処方例19.ヘアシャンプー
[A成分] 部
N−ヤシ油脂肪酸メチルタウリンナトリウム 10.0
ポリオキシエチレン(3)アルキルエーテル硫酸ナトリウム 20.0
ラウリルジメチルアミノ酢酸ベタイン 10.0
ヤシ油脂肪酸ジエタノールアミド 4.0
メチルパラベン 0.1
[B成分]
クエン酸 0.1
製造例1の搾汁液 2.0
1,3−ブチレングリコール 2.0
精製水 全量が100部となる量
A成分及びB成分をそれぞれ80℃に加温して均一に溶解した後、A成分にB成分を加え、攪拌を続けて室温まで冷却してヘアシャンプーを得た。
Prescription example 19. Hair shampoo [Ingredient A] Part N-coconut oil fatty acid methyl taurine sodium 10.0
Polyoxyethylene (3) Alkylation Ether Sodium Sulfate 20.0
Betaine Lauryldimethylaminoacetic Acid 10.0
Coconut oil fatty acid diethanolamide 4.0
Methylparaben 0.1
[B component]
Citric acid 0.1
Juice liquid of Production Example 1 2.0
1,3-butylene glycol 2.0
Amount of purified water that makes up 100 parts A component and B component are each heated to 80 ° C and uniformly dissolved, then B component is added to A component, and stirring is continued to cool to room temperature to obtain a hair shampoo. It was.
実施例20.ヘアコンディショナー
[A成分] 部
ポリオキシエチレン(10)硬化ヒマシ油 1.0
塩化ジステアリルジメチルアンモニウム 1.5
塩化ステアリルトリメチルアンモニウム 2.0
2−エチルヘキサン酸グリセリル 1.0
セタノール 3.2
ステアリルアルコール 1.0
メチルパラベン 0.1
[B成分] 部
製造例2の搾汁液 2.0
1,3−ブチレングリコール 5.0
精製水 全量が100部となる量
A成分及びB成分をそれぞれ80℃に加温して均一に溶解した後、A成分にB成分を加え、攪拌を続けて室温まで冷却してヘアリンスを得た。
Example 20. Hair conditioner [Component A] Part Polyoxyethylene (10) Hardened castor oil 1.0
Distearyldimethylammonium chloride 1.5
Stearyltrimethylammonium chloride 2.0
Glyceryl 2-ethylhexanoate 1.0
Cetanol 3.2
Stearyl alcohol 1.0
Methylparaben 0.1
[B component] Part Production example 2 juice juice 2.0
1,3-butylene glycol 5.0
Amount of purified water totaling 100 parts A component and B component were each heated to 80 ° C. to dissolve them uniformly, then B component was added to A component, and stirring was continued to cool to room temperature to obtain a hair rinse. ..
試験例1.コラーゲンゲル収縮促進効果の評価試験
まず、コラーゲンゲルは以下の通りにして作製した。すなわち、氷冷下コラーゲンゲル溶液(新田ゼラチン社製、CellmatrixType I-A)に200mMのHEPES、2.2%NaHCO3含有の0.05Nの水酸化ナトリウム溶液、及びイーグルMEM(ニッスイ)10倍濃縮溶液(NaHCO3不含)を8:1:1の比率で加え、十分に攪拌中和した。そこに0.5%NCS含有イーグルMEMで5×105個/mLに調整したヒト皮膚線維芽細胞NB1RGBの懸濁液を8:2の比率で加えて十分に攪拌し、24穴プレートに各穴0.5mLずつ注入し、直ちに37℃でゲル化させた。1時間後、0.5%NCS含有イーグルMEMに本発明に係る製造例2のエキスを添加して調製した試料含有培地を1mL添加し、さらにゲルの周囲を剥離し、3日間培養を行った。ここで、試料溶液は培地全量に対して溶液としての終濃度が0.5%、1.0%となるように調製した。ゲル面積計測は以下の通りに行った。すなわち、透過光ユニットをセットしたスキャナの上に評価を行っている24穴プレートを置き、スキャンを行って全てのウェルのコラーゲンゲルの影像を電子画像化した。その画像をコンピューターに取り込み、画像解析ソフト(ImageJ)を用いて各コラーゲンゲルの面積を数値化した。上記試料の代わりに30% 1,3−ブチレングリコールを添加した区をコントロールとし、得られたコントロール区のコラーゲンゲルの面積を100とした各試料添加区のコラーゲンゲル面積の相対値を求めた。また、試験系が正常に機能しているかを確認するために、試料の代わりに陽性対照として10%NCS含有イーグルMEMを添加した場合についても、同様の試験を行った。
Test example 1. Evaluation test of collagen gel shrinkage promoting effect First, collagen gel was prepared as follows. That is, a collagen gel solution under ice-cooling (CellmatrixType IA manufactured by Nitta Gelatin Co., Ltd.), a 0.05 N sodium hydroxide solution containing 200 mM HEPES and 2.2% NaHCO 3 , and an Eagle MEM (Nissui) 10-fold concentrated solution. (NaHCO 3 -free) was added in a ratio of 8: 1: 1 and sufficiently stirred and neutralized. A suspension of human skin fibroblasts NB1RGB adjusted to 5 × 10 5 cells / mL with Eagle MEM containing 0.5% NCS was added thereto at a ratio of 8: 2, and the mixture was sufficiently stirred, and each was placed on a 24-well plate. 0.5 mL of each hole was injected and immediately gelled at 37 ° C. After 1 hour, 1 mL of a sample-containing medium prepared by adding the extract of Production Example 2 according to the present invention to Eagle's MEM containing 0.5% NCS was added, and the periphery of the gel was further peeled off and cultured for 3 days. .. Here, the sample solution was prepared so that the final concentration as a solution was 0.5% and 1.0% with respect to the total amount of the medium. The gel area was measured as follows. That is, the 24-hole plate being evaluated was placed on the scanner in which the transmitted light unit was set, and scanning was performed to electronically image the images of collagen gel in all wells. The image was taken into a computer, and the area of each collagen gel was quantified using image analysis software (ImageJ). The group to which 30% 1,3-butylene glycol was added instead of the above sample was used as a control, and the relative value of the collagen gel area of each sample-added group was determined with the area of the collagen gel in the obtained control group as 100. In addition, in order to confirm whether the test system is functioning normally, the same test was performed when Eagle MEM containing 10% NCS was added as a positive control instead of the sample.
試験例1の結果を表1に示す。
[表1]
The results of Test Example 1 are shown in Table 1.
[Table 1]
表1に示すように、本発明に係るベルガモットエキスは格段にすぐれたコラーゲンゲル収縮促進効果を有することが示された。 As shown in Table 1, it was shown that the bergamot extract according to the present invention has a remarkably excellent collagen gel contraction promoting effect.
試験例2.コラーゲン合成促進効果の評価試験
ヒト真皮由来線維芽細胞NB1RGBを、0.5%NCS含有イーグル最少必須培地を入れた96穴マイクロプレートに1×104個/穴播種し、37℃、5.0%CO2の条件下に1日間プレ培養した後、試料溶液として本発明に係る製造例2のエキスを培地に添加し、同条件でさらに5日間培養した。ここで、試料溶液は培地全量に対して溶液として終濃度が0.5%、1.0%となるように調製した。次に、培地を除去し、冷メタノール、冷エタノールで細胞を固定した後、0.1%シリウスレッド含有飽和ピクリン酸水溶液で染色を行った。精製水で洗浄後、0.1%NaOH:メタノール=1:1溶液にて抽出を行い、マイクロプレートリーダー(Model680、バイオラッド社製)を用いて波長540nmでコラーゲン量を測定した。試料溶液に代えて30%1,3−ブチレングリコールを添加した試料無添加の場合(対照)についても上記と同様の操作を行い、ここに得られたコラーゲン量に対する各試料添加時のコラーゲン量の相対値を求め、線維芽細胞コラーゲン合成率(%)とした。
Test example 2. Evaluation test of collagen synthesis promoting effect Human dermis-derived fibroblast NB1RGB was seeded at 1 × 10 4 cells / hole in a 96-well microplate containing 0.5% NCS-containing eagle minimum essential medium, and seeded at 37 ° C., 5.0. After pre-culturing under the condition of% CO 2 for 1 day, the extract of Production Example 2 according to the present invention was added to the medium as a sample solution, and the cells were cultured under the same conditions for another 5 days. Here, the sample solution was prepared so that the final concentration of the solution was 0.5% or 1.0% with respect to the total amount of the medium. Next, the medium was removed, cells were fixed with cold methanol and cold ethanol, and then stained with a saturated aqueous picric acid solution containing 0.1% silius red. After washing with purified water, extraction was performed with a 0.1% NaOH: methanol = 1: 1 solution, and the amount of collagen was measured at a wavelength of 540 nm using a microplate reader (Model 680, manufactured by Biorad). In the case of no sample addition (control) in which 30% 1,3-butylene glycol was added instead of the sample solution, the same operation as above was performed, and the amount of collagen at the time of addition of each sample to the amount of collagen obtained here was calculated. The relative value was calculated and used as the fibroblast collagen synthesis rate (%).
[表2]
[Table 2]
表2に示すように、本発明に係るベルガモットエキスは、濃度依存的に格段にすぐれたコラーゲン合成促進効果を有することが示された。 As shown in Table 2, it was shown that the bergamot extract according to the present invention has a remarkably excellent collagen synthesis promoting effect in a concentration-dependent manner.
試験例3.デコリン合成促進効果の評価試験
本発明に関し、線維芽細胞で合成されるプロテオグリカンの一種で、真皮のコラーゲンの網目構造を構成の形成に重要な役割を果たすデコリンの合成促進効果を評価した。
正常ヒト皮膚由来線維芽細胞(NB1RGB)を0.5容量%NCS含有イーグルMEM(日水製薬社製)にて1×105個/mLに調製し、96穴マイクロプレートに100μLずつ播種して、5%炭酸ガス、飽和水蒸気下、37℃で培養した。24時間後、その培養液全量に対して溶液としての終濃度が2%となるように本発明に係る製造例2のエキスを含んだ培養液を追添加しさらに培養した。また、対照として終濃度2%となるように50%1,3−ブチレングリコールを含んだ培養液を追添加した試験区を設定した。48時間後、培養上清を回収して培養上清中に分泌されたデコリン量を、デコリン測定キット(BOSTER社製)を用いて抗デコリン抗体によるELISA法により測定した。
Test example 3. Evaluation test of decolin synthesis promoting effect In the present invention, the synthesis promoting effect of decolin, which is a kind of proteoglycan synthesized in fibroblasts and plays an important role in the formation of the collagen network structure of the dermis, was evaluated.
Normal human skin-derived fibroblasts (NB1RGB) were prepared at 1 × 10 5 cells / mL with 0.5% by volume NCS-containing Eagle MEM (manufactured by Nissui Pharmaceutical Co., Ltd.), and 100 μL was seeded on a 96-well microplate. The cells were cultured at 37 ° C. under 5% carbon dioxide and saturated steam. After 24 hours, the culture solution containing the extract of Production Example 2 according to the present invention was added and further cultured so that the final concentration as a solution was 2% with respect to the total amount of the culture solution. In addition, as a control, a test group was set in which a culture solution containing 50% 1,3-butylene glycol was additionally added so that the final concentration was 2%. After 48 hours, the culture supernatant was collected, and the amount of decorin secreted in the culture supernatant was measured by the ELISA method using an anti-decolin antibody using a decorin measurement kit (manufactured by BOSTER).
[表3]
[Table 3]
表3に示すように本発明に係るベルガモットエキスは、格段にすぐれたデコリン合成促進効果を有することが示された。 As shown in Table 3, the bergamot extract according to the present invention was shown to have a remarkably excellent effect of promoting decorin synthesis.
試験例4.メラノソーム取り込み抑制効果の評価試験
ヒト表皮細胞NHEKを、HuMedia KG2培地(クラボウ社製)を入れた96穴マイクロプレートに1×104個/穴播種し、37℃,5.0%CO2の条件下に1日間プレ培養した後、上清を除去して本発明に係る製造例1,3〜5のエキスを試料溶液として含むHuMedia KB2培地(クラボウ社製)を添加し、同条件でさらに2日間培養した。ここで、試料溶液は培地全量に対して溶液としての終濃度が1.0%、2.0%となるように調製した。その後、7.2×108個/mLの蛍光ビーズ(FluoSpheres(登録商標) Fluorescent Microspheres(Invitrogen社))を添加して37℃に1時間保持した。その後、上清を除去しPBS(−)で2回洗浄後、PBS(−)で100倍希釈したhoechst33342試薬を100μL/穴添加し、37℃で15分間インキュベートしてDNAを蛍光染色した。そして、蛍光強度(励起:542nm、放射:590nm、及び励起:355nm、放射:460nm/蛍光マイクロプレートリーダー(フルオロスキャンアセント、Thermo Fisher Scientific社製))を測定し、DNA当たりの蛍光ビーズの取り込み量を求めた。試料溶液に代えて30%1,3−ブチレングルコールを添加した試料無添加の場合(Control)についても上記と同様の操作を行い、ここに得られた値に対する各試料添加時の値の相対値を求め、表皮細胞のDNA当たりの蛍光ビーズ取り込み率(%)とした。
Test example 4. Evaluation test of melanosome uptake inhibitory effect Human epidermal cell NHEK was seeded in 1 × 10 4 cells / hole in a 96-well microplate containing HuMedia KG2 medium (manufactured by Kurabo) under the conditions of 37 ° C. and 5.0% CO 2 . After pre-culturing for 1 day underneath, the supernatant is removed, and HuMedia KB2 medium (manufactured by Kurabo) containing the extracts of Production Examples 1 and 3 to 5 according to the present invention as a sample solution is added, and further 2 under the same conditions. Incubated for days. Here, the sample solution was prepared so that the final concentration as a solution was 1.0% and 2.0% with respect to the total amount of the medium. Then, 7.2 × 10 8 cells / mL fluorescent beads (FluoSpheres (registered trademark) Fluorescent Microspheres (Invitrogen)) were added and kept at 37 ° C. for 1 hour. Then, the supernatant was removed, washed twice with PBS (−), 100 μL / hole of hoechst33342 reagent diluted 100-fold with PBS (−) was added, and the mixture was incubated at 37 ° C. for 15 minutes to fluorescently stain the DNA. Then, the fluorescence intensity (excitation: 542 nm, radiation: 590 nm, and excitation: 355 nm, radiation: 460 nm / fluorescent microplate reader (Fluoroscan Ascent, manufactured by Thermo Fisher Scientific)) was measured, and the amount of fluorescent beads taken up per DNA. Asked. In the case of no sample addition (Control) in which 30% 1,3-butylene glucol was added instead of the sample solution, the same operation as above was performed, and the relative value of each sample was added to the value obtained here. The value was determined and used as the fluorescent bead uptake rate (%) per DNA of epidermal cells.
[表4]
[Table 4]
表4に示すように、本発明に係るベルガモットエキスは、濃度依存的に格段にすぐれたメラノソーム取り込み抑制効果を有することが示された。 As shown in Table 4, it was shown that the bergamot extract according to the present invention has a remarkably excellent effect of suppressing melanosomes uptake in a concentration-dependent manner.
試験例5.DPPHラジカル消去効果の評価試験
DPPH2.4部をエタノール20部に溶解し、これに精製水20部を加えてDPPH溶液を調製した。このDPPH溶液24部に対して、18v/v%エタノール溶液を19.2部、2M酢酸-酢酸ナトリウム緩衝液(pH5.5)を4.8部加えて、DPPH添加溶液として調製した。また、抽出液そのものの色調が試験に及ぼす影響を差し引くため、DPPH溶液の代わりに50v/v%エタノール溶液を用いて、18v/v%エタノール溶液と2M酢酸−酢酸ナトリウム緩衝液を混合した液を対照液とした。次に、本発明に係る製造例1〜5のエキス(搾汁液又は抽出物)を精製水で希釈して試料溶液を調製した。ここで、試料溶液としては、その全量に対する溶液としての終濃度がそれぞれ1.0%、2.0%となるように調製した2種の濃度のものを使用した。この試料溶液とDPPH添加溶液又は対照液とを1:3の割合で混合し、室温で10分静置後、各試験溶液をDPPH添加溶液と混合した場合の550nmにおける吸光度と、同じく各試験溶液を対照液と混合した場合の550nmにおける吸光度との差を測定し、DPPHラジカルの残存量を確認した。また、同時にコントロールとして本発明に係る製造例1,2の搾汁液の代わりに、30%1,3-ブチレングリコール水溶液を用いて上記と同様の操作を行い、ここに得られる DPPHラジカル残存率に対する各試料添加時のDPPHラジカル残存率の相対値を求めた。また、試験系が正常に機能しているかを確認するために、試料溶液の代わりに陽性対照として水溶性ビタミンE(終濃度25μM)を添加した場合についても、同様の試験を行った。
Test example 5. Evaluation test of DPPH radical scavenging effect 2.4 parts of DPPH was dissolved in 20 parts of ethanol, and 20 parts of purified water was added thereto to prepare a DPPH solution. To 24 parts of this DPPH solution, 19.2 parts of an 18v / v% ethanol solution and 4.8 parts of a 2M sodium acetate-sodium acetate buffer (pH 5.5) were added to prepare a DPPH-added solution. In addition, in order to subtract the influence of the color tone of the extract itself on the test, a 50v / v% ethanol solution was used instead of the DPPH solution, and a mixture of an 18v / v% ethanol solution and a 2M sodium acetate-sodium acetate buffer solution was used. It was used as a control solution. Next, the extract (squeezed liquid or extract) of Production Examples 1 to 5 according to the present invention was diluted with purified water to prepare a sample solution. Here, as the sample solution, two kinds of concentrations prepared so that the final concentrations of the solution as a solution with respect to the total amount were 1.0% and 2.0%, respectively, were used. This sample solution is mixed with the DPPH-added solution or the control solution at a ratio of 1: 3, and after allowing to stand at room temperature for 10 minutes, the absorbance at 550 nm when each test solution is mixed with the DPPH-added solution and each test solution are also obtained. The difference from the absorbance at 550 nm when mixed with the control solution was measured, and the residual amount of DPPH radical was confirmed. At the same time, the same operation as above was performed using a 30% 1,3-butylene glycol aqueous solution instead of the juices of Production Examples 1 and 2 according to the present invention as a control, and the DPPH radical residual ratio obtained here was obtained. The relative value of the DPPH radical residual rate at the time of adding each sample was determined. Further, in order to confirm whether the test system is functioning normally, the same test was conducted when water-soluble vitamin E (final concentration 25 μM) was added as a positive control instead of the sample solution.
試験例5の結果を表5に示す。
[表5]
The results of Test Example 5 are shown in Table 5.
[Table 5]
表5に示すように、本発明に係るベルガモットエキスは、濃度依存的に格段にすぐれたDPPHラジカル消去作用を有することが示された。 As shown in Table 5, it was shown that the bergamot extract according to the present invention has a remarkably excellent DPPH radical scavenging effect in a concentration-dependent manner.
試験例6.SOD様活性の評価試験
[試験方法]
0.2Mトリス塩酸緩衝液50μL、1mMエチレンジアミン四酢酸(EDTA)二ナトリウム溶液20μL、0.75mMニトロブルーテトラゾリウムクロリド(NBT)溶液10μL、1mMキサンチン溶液20μL、0.06U/mLキサンチンオキシターゼ溶液50μL、本発明に係る製造例1〜5のエキスの50μL(その終濃度が1.0%及び2.0%になるように調製した)を混合して試料溶液を調製した。この試料溶液を37℃、5分間インキュベートし、スーパーオキシドを発生させた。そして、NBTがスーパーオキシドによって還元されて生成するホルマザン量を560nmにおける吸光度を測定した。また、コントロールとして製造例1,2の搾汁液の代わりに、30%1,3−ブチレングリコール溶液を用いて上記と同様の操作を行い、ここに得られる吸光度に対する各試料添加時の吸光度の相対値を求め、スーパーオキシド残存率(%)とした。また、試験系が正常に機能しているかを確認するために、試料溶液の代わりに陽性対照として、スーパーオキシドジスムターゼ(SOD)8.75units/mLを添加した場合についても、同様の試験を行った。
Test example 6. Evaluation test of SOD-like activity [Test method]
0.2 M Tris-hydrochloric acid buffer 50 μL, 1 mM ethylenediamine tetraacetic acid (EDTA) disodium solution 20 μL, 0.75 mM nitroblue tetrazolium chloride (NBT) solution 10 μL, 1 mM xanthin solution 20 μL, 0.06 U / mL xanthin oxidase solution 50 μL, A sample solution was prepared by mixing 50 μL of the extracts of Production Examples 1 to 5 according to the present invention (adjusted so that their final concentrations were 1.0% and 2.0%). The sample solution was incubated at 37 ° C. for 5 minutes to generate superoxide. Then, the absorbance at 560 nm was measured for the amount of formazan produced by reducing NBT with superoxide. Further, as a control, a 30% 1,3-butylene glycol solution was used instead of the juices of Production Examples 1 and 2 and the same operation as above was performed, and the absorbance at the time of addition of each sample was relative to the absorbance obtained here. The value was calculated and used as the residual rate of superoxide (%). A similar test was also performed when superoxide dismutase (SOD) 8.75 units / mL was added as a positive control instead of the sample solution to confirm that the test system was functioning normally. ..
試験例6の結果を表6に示す。
[表6]
The results of Test Example 6 are shown in Table 6.
[Table 6]
表6に示すように、本発明に係るベルガモットエキスは、濃度依存的に格段にすぐれたSOD様活性を有することが示された。 As shown in Table 6, the bergamot extract according to the present invention was shown to have remarkably excellent SOD-like activity in a concentration-dependent manner.
試験例7.脂質蓄積抑制効果の評価試験
正常ハムスター皮脂腺細胞(Ha-SE)を、HuMedia−BG(クラボウ社製)を入れた96穴マイクロプレートに8×103個/穴播種し、37℃、5.0%CO2の条件下にて7日間培養した。培養後、本発明に係る製造例1,3〜5のエキスを試料溶液として含む分化誘導培地(インスリンの代わりに2μMテストステロンを含むHuMedia-BD(クラボウ社製))に交換し、同条件でさらに14日間培養した。ここで、試料溶液は培地全量に対して溶液として終濃度が0.5%、1.0%になるように調製した。培養後、培地を除き、PBS(−)で洗浄した後、10%ホルマリン溶液を添加することで細胞を固定した。次にPBS(−)で洗浄し、60%イソプロパノールを加えて1分間静置した。その後、0.18%オイルレッド染色液を添加し、室温で30分間静置した。次に60%イソプロパノールで洗浄した後、イソプロパノールを加えた後、マイクロプレートリーダー(Model 680、バイオラッド社製)を用いて波長540nmで蓄積された脂質量を測定した。また、試験系が正常に機能しているかを確認するために、試料溶液の代わりに陽性対照として13-シスレチノイン酸(2μM)を添加した場合についても、同様の試験を行った。
Test example 7. Evaluation test of lipid accumulation inhibitory effect Normal hamster sebaceous gland cells (Ha-SE) were seeded at 8 × 10 3 cells / hole on a 96-well microplate containing HuMedia-BG (manufactured by Kurabo) at 37 ° C., 5.0. The cells were cultured for 7 days under the condition of% CO 2 . After culturing, the medium was replaced with a differentiation-inducing medium containing the extracts of Production Examples 1, 3 to 5 according to the present invention as a sample solution (HuMedia-BD (manufactured by Kurabou) containing 2 μM testosterone instead of insulin), and further under the same conditions. Incubated for 14 days. Here, the sample solution was prepared so that the final concentration of the solution was 0.5% or 1.0% with respect to the total amount of the medium. After culturing, the medium was removed, the cells were washed with PBS (-), and the cells were fixed by adding a 10% formalin solution. The cells were then washed with PBS (-), 60% isopropanol was added, and the mixture was allowed to stand for 1 minute. Then, 0.18% oil red stain solution was added, and the mixture was allowed to stand at room temperature for 30 minutes. Next, after washing with 60% isopropanol, isopropanol was added, and then the amount of accumulated lipid at a wavelength of 540 nm was measured using a microplate reader (Model 680, manufactured by Bio-Rad). A similar test was also performed when 13-cisretinoic acid (2 μM) was added as a positive control instead of the sample solution in order to confirm whether the test system was functioning normally.
[表7]
[Table 7]
表7に示すように、本発明に係るベルガモットエキスは、濃度依存的に格段にすぐれた脂質蓄積抑制効果を有することが示された。 As shown in Table 7, it was shown that the bergamot extract according to the present invention has a significantly excellent lipid accumulation inhibitory effect in a concentration-dependent manner.
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