JP6820246B2 - 免疫活性化剤の製造方法および免疫活性化用飲食品の製造方法 - Google Patents
免疫活性化剤の製造方法および免疫活性化用飲食品の製造方法 Download PDFInfo
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- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
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- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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Description
(1) Gynura procumbensを0℃以上40℃以下で乾燥する乾燥工程と、前記乾燥工程により乾燥したGynura procumbensを0℃以上40℃以下に保ちながら裁断または粉砕する裁断・粉砕工程とを含む免疫活性化剤の製造方法、
(2) 前記Gynura procumbensとして、Gynura procumbensの葉または茎の少なくとも一方を用いる(1)記載の免疫活性化剤の製造方法、
(3) さらにビタミン類、オリーブまたはその抽出物およびドクダミまたはその抽出物のうちの少なくとも1つを添加する工程を含む(1)または(2)に記載の免疫活性化剤の製造方法、
(4) (1)〜(3)の何れかに記載の免疫活性化剤の製造方法により得られる免疫活性化剤を食品または飲料に配合させる工程を含む免疫活性化用飲食品の製造方法、
が提供される。
Gynura procumbensとしては、葉、茎、根などのいずれを用いてもよいが、葉または茎を用いることが好ましく、葉を用いることがより好ましい。
なお、ギヌラの保存状態を良好に保つ観点から、ギヌラをジューサー等にかけて水分を含む状態で保存することは好ましくない。本発明のようにギヌラを乾燥させた状態で保存することが好ましい。
上述のようにして処理されたギヌラは、免疫活性化剤として用いることができる。
(1) 免疫誘導反応の検討
(検体の調製)
免疫誘導反応の検討に用いるギヌラの葉の検体としては下記の4種類を調製した。
検体D.検体Bを凍結し、その後解凍し、検体とした。
また、ビワの葉、クマ笹の葉、明日葉の葉、ドクダミの葉については、葉のまま検体として用いた。
検体A〜D、ビワの葉、クマ笹の葉、明日葉の葉及びドクダミの葉の検体をそれぞれ1/10000に希釈し、マウス脾臓細胞に添加し、その際のサイトカイン−mRNA量の変動を定量PCR法により検討した。
(検体の調製)
自然免疫反応及び獲得免疫反応の検討に用いるギヌラの葉の検体は、上記免疫誘導反応の検討に用いる検体Aを用いた(以下、この項においては、「ギヌラの葉の検体」という)。
マウスからマクロファージを単離し、各検体をそれぞれ1/100、1/1000、1/10000および1/100000に希釈し添加した後、一定量の蛍光ビーズを添加し8時間培養した。そして、培養したマクロファージを蛍光顕微鏡で観察し、取り込まれた蛍光ビーズ量を蛍光量として数値化した。
マウス脾臓リンパ球(CD4+T細胞)を単離し、各検体をそれぞれ1/100、1/1000および1/10000に希釈し添加した後、1週間培養した。T細胞がIFN−γを産生するようになるとTh1細胞に、T細胞がIL−4を産生するようになるとTh2細胞に分化したことがそれぞれ示される。
(検体の調製)
がん細胞への細胞障害活性の検討に用いるギヌラの葉の検体は、上記免疫誘導反応の検討における検体Aを用いた。(以下、この項においては、「ギヌラの葉の検体」という)
がん細胞を培養し、直接それぞれの検体を添加した際の細胞を死滅させる殺細胞効果を検討した。がん細胞としては3種類について検討を行い、固形がん、血液系がん、表皮がんの代表的なマウスがん細胞株を用いた(CT−26;大腸がん、EL−4;リンパ腫、B16 mel;メラノーマ)。なお、検体としては、ギヌラの葉、ドクダミの葉、オリーブの葉およびフコイダンの検体、さらに前記4種の混合検体を用いた。結果を図6に示す。
マウス脾臓から単離したリンパ球に各種検体を添加し、1週間培養した。その後、別途培養した3種のがん細胞をそれぞれ培養したリンパ球と併せて培養を継続した。ここで、キラー活性が誘導されると、リンパ球はがん細胞を障害する。このことを測定するために、細胞障害活性測定キット(Takara製 LDH Cytoxicity Detection Kit)を用いて測定した。
なお、4種の混合検体では、フコイダンが他検体の効果を阻害するような結果となった。
Claims (5)
- Gynura procumbensを0℃以上40℃以下、かつ、相対湿度10%以下で低温除湿乾燥する乾燥工程と、
前記乾燥工程により乾燥したGynura procumbensを0℃以上40℃以下に保ちながら裁断または粉砕する裁断・粉砕工程と
を含む免疫活性化剤の製造方法。 - 前記Gynura procumbensとして、Gynura procumbensの葉または茎の少なくとも一方を用いる請求項1に記載の免疫活性化剤の製造方法。
- さらにビタミン類、オリーブまたはその抽出物およびドクダミまたはその抽出物のうちの少なくとも1つを添加する工程を含む請求項1または2に記載の免疫活性化剤の製造方法。
- 請求項1〜3の何れか一項に記載の免疫活性化剤の製造方法であって、
前記免疫活性化剤は、田七人参またはその抽出物を含むものを除く、免疫活性化剤の製造方法。 - 請求項1〜4の何れか一項に記載の免疫活性化剤の製造方法により得られる免疫活性化剤を食品または飲料に配合させる工程を含む免疫活性化用飲食品の製造方法。
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