JP6785796B2 - 浸透圧保護剤としてのリポ酸およびタウリンの組み合わせ - Google Patents
浸透圧保護剤としてのリポ酸およびタウリンの組み合わせ Download PDFInfo
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- JP6785796B2 JP6785796B2 JP2017560794A JP2017560794A JP6785796B2 JP 6785796 B2 JP6785796 B2 JP 6785796B2 JP 2017560794 A JP2017560794 A JP 2017560794A JP 2017560794 A JP2017560794 A JP 2017560794A JP 6785796 B2 JP6785796 B2 JP 6785796B2
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- Prior art keywords
- lipoic acid
- composition
- taurine
- combination
- eye
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Description
医薬また化粧品組成物で使用されるヒアルロン酸およびその塩の種々の形態は、当該技術分野において周知であり、本発明による組成物に使用することができる。特にこれらの中でも1から2.5m3/ kgの固有粘度を有するヒアルロン酸ナトリウムである。
試験は、ヒト結膜(WKD)および角膜(HCE)細胞に高浸透圧性ストレスをかけ、リポ酸ナトリウム(A)の浸透圧保護活性を定めることで行った。
実施例4の手順を、リポ酸ナトリウム(A)とタウリン(B)の11の組み合わせ(1Mから11M)について繰り返した。得られた細胞生存率の結果は、実施例4の混合物について観察された浸透圧保護の増加を確認するものである。
− US 5,817,630
− US 6,162,393
− US 2004/265345
− US 2005/192229
− US 2006/188492
− WO 01/93824
− WO 02098345
− DE10229995
− BR PI0 800 818
− CN 103 860 625
− JP 2013 241398
− Masami Kojima et al., Japanese Journal of Ophthalmology, January 2007, Volume 51, Issue
Claims (5)
- ドライアイに関連する眼の状態または眼浮腫の予防または治療に用いるための、局所適用に適した医薬または化粧品組成物であって、(a)当該組成物の総重量に対し、0.0050から1.00重量%の範囲のリポ酸、(b)当該組成物の総重量に対し、0.10から1.00重量%の範囲のタウリン、および薬学的または化粧品的に許容される担体を含んでなり、前記リポ酸:前記タウリンの重量比が、0.005から0.5の範囲にあることを特徴とする、組成物。
- 眼への適用に適したものである、請求項1に記載の組成物。
- 前記ドライアイが、マイボーム腺の機能不全、高蒸発性症候群、または涙欠乏症の徴候である、請求項1または2に記載の組成物。
- 前記眼浮腫が角膜浮腫である、請求項1〜3のいずれか一項に記載の組成物。
- 浸透圧の不均衡に関連した粘膜、眼の疾患の予防または治療のための浸透圧保護剤として用いられる、請求項1〜4のいずれか一項に記載の組成物。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR1554590 | 2015-05-21 | ||
FR1554590A FR3036284B1 (fr) | 2015-05-21 | 2015-05-21 | Acide lipoique en tant qu'agent osmoprotecteur |
FR1650372A FR3046727B3 (fr) | 2016-01-18 | 2016-01-18 | Association d'acide lipoique et de taurine en tant qu'agent osmoprotecteur |
FR1650372 | 2016-01-18 | ||
PCT/EP2016/061358 WO2016184998A1 (fr) | 2015-05-21 | 2016-05-20 | Association d'acide lipoique et de taurine en tant qu'agent osmoprotecteur |
Publications (3)
Publication Number | Publication Date |
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JP2018515575A JP2018515575A (ja) | 2018-06-14 |
JP2018515575A5 JP2018515575A5 (ja) | 2019-05-16 |
JP6785796B2 true JP6785796B2 (ja) | 2020-11-18 |
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JP2017560794A Active JP6785796B2 (ja) | 2015-05-21 | 2016-05-20 | 浸透圧保護剤としてのリポ酸およびタウリンの組み合わせ |
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US (1) | US11224588B2 (ja) |
EP (1) | EP3297733A1 (ja) |
JP (1) | JP6785796B2 (ja) |
CN (1) | CN107864623A (ja) |
BR (1) | BR112017024805B1 (ja) |
CA (1) | CA2985013C (ja) |
RU (1) | RU2726978C2 (ja) |
WO (1) | WO2016184998A1 (ja) |
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AU6141498A (en) * | 1997-02-04 | 1998-08-25 | John V. Kosbab | Compositions and methods for prevention and treatment of vascular degenerative diseases |
US5817630A (en) * | 1997-03-18 | 1998-10-06 | Austin Nutriceutical Corporation | Glutathione antioxidant eye drops |
IT1299623B1 (it) * | 1998-02-23 | 2000-03-24 | Gen Topics Srl | Composizione per uso cosmetico o farmaceutico a base di acido lipoico e acido piruvico |
US6162393A (en) | 1998-08-06 | 2000-12-19 | Ndt, Inc. | Contact lens and ophthalmic solutions |
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- 2016-05-20 EP EP16726819.2A patent/EP3297733A1/fr active Pending
- 2016-05-20 RU RU2017142379A patent/RU2726978C2/ru active
- 2016-05-20 CA CA2985013A patent/CA2985013C/fr active Active
- 2016-05-20 WO PCT/EP2016/061358 patent/WO2016184998A1/fr active Application Filing
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WO2016184998A1 (fr) | 2016-11-24 |
CA2985013A1 (fr) | 2016-11-24 |
EP3297733A1 (fr) | 2018-03-28 |
RU2017142379A (ru) | 2019-06-24 |
US11224588B2 (en) | 2022-01-18 |
RU2017142379A3 (ja) | 2019-09-30 |
CN107864623A (zh) | 2018-03-30 |
US20180092878A1 (en) | 2018-04-05 |
JP2018515575A (ja) | 2018-06-14 |
BR112017024805B1 (pt) | 2021-09-14 |
BR112017024805A2 (ja) | 2018-08-21 |
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RU2726978C2 (ru) | 2020-07-17 |
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