JP6741774B2 - 慢性閉塞性肺疾患の急性増悪の治療のための投与レジメン - Google Patents
慢性閉塞性肺疾患の急性増悪の治療のための投与レジメン Download PDFInfo
- Publication number
- JP6741774B2 JP6741774B2 JP2018547431A JP2018547431A JP6741774B2 JP 6741774 B2 JP6741774 B2 JP 6741774B2 JP 2018547431 A JP2018547431 A JP 2018547431A JP 2018547431 A JP2018547431 A JP 2018547431A JP 6741774 B2 JP6741774 B2 JP 6741774B2
- Authority
- JP
- Japan
- Prior art keywords
- cyanobenzoyl
- methylbenzamide
- amino
- cyclopropyl
- pyrazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/GB2016/050636 WO2017153702A1 (en) | 2016-03-08 | 2016-03-08 | Dosage regimen for the treatment of acute exacerbations of chronic obstructive pulmonary disease |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2019507786A JP2019507786A (ja) | 2019-03-22 |
JP2019507786A5 JP2019507786A5 (ko) | 2019-05-09 |
JP6741774B2 true JP6741774B2 (ja) | 2020-08-19 |
Family
ID=55586330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2018547431A Active JP6741774B2 (ja) | 2016-03-08 | 2016-03-08 | 慢性閉塞性肺疾患の急性増悪の治療のための投与レジメン |
Country Status (9)
Country | Link |
---|---|
US (2) | US10603306B2 (ko) |
JP (1) | JP6741774B2 (ko) |
KR (2) | KR20240101698A (ko) |
AU (1) | AU2016397047B2 (ko) |
BR (1) | BR112018067454A2 (ko) |
CA (1) | CA3016488C (ko) |
MX (1) | MX2018010782A (ko) |
RU (1) | RU2713203C1 (ko) |
WO (1) | WO2017153702A1 (ko) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6741774B2 (ja) * | 2016-03-08 | 2020-08-19 | メレオ バイオファーマ 1 リミテッド | 慢性閉塞性肺疾患の急性増悪の治療のための投与レジメン |
GB201612240D0 (en) | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide |
GB201612238D0 (en) | 2016-07-14 | 2016-08-31 | Mereo Biopharma 1 Ltd | Method for producing a polymorphic form of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-Yl]-n-cyclopropyl-4-methylbenzamide |
WO2019116022A1 (en) | 2017-12-11 | 2019-06-20 | Mereo Biopharma 1 Limited | Use of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide in the prevention or reduction of acute exacerbations of chronic obstructive pulmonary disease |
PT3585382T (pt) | 2017-12-11 | 2021-08-19 | Mereo Biopharma 1 Ltd | Utilização de 3-[5-amino-4-(3-cianobenzoil)-pirazol-1-il]-n-ciclopropil-4-metilbenzamida no tratamento de exacerbações agudas da doença pulmonar obstrutiva crónica |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9501841D0 (en) | 1995-01-31 | 1995-03-22 | Co Ordinated Drug Dev | Improvements in and relating to carrier particles for use in dry powder inhalers |
US6598603B1 (en) | 1997-12-31 | 2003-07-29 | Astra Aktiebolag | Method for treating respiratory diseases |
JP4838121B2 (ja) | 2003-06-26 | 2011-12-14 | ノバルティス アーゲー | 5員ヘテロ環を基礎とするp38キナーゼ阻害剤 |
TW201705980A (zh) | 2004-04-09 | 2017-02-16 | 艾伯維生物技術有限責任公司 | 用於治療TNFα相關失調症之多重可變劑量療法 |
GB0409703D0 (en) | 2004-04-30 | 2004-06-02 | Vectura Ltd | Pharmaceutical compositions |
US20050277602A1 (en) | 2004-05-21 | 2005-12-15 | Grunstein Michael M | Methods employing agonists of P38 map kinase for the treatment of asthma |
US20090270350A1 (en) | 2006-02-10 | 2009-10-29 | Pfizer Inc. | Pyridinone Pyrazole Urea and Pyrimidinone Pyrazole Urea Derivatives |
GB0603684D0 (en) | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
HUE032004T2 (en) * | 2012-03-20 | 2017-08-28 | Mereo Biopharma 1 Ltd | Use of a pyrazole derivative for the treatment of acute severe conditions of chronic obstructive airways disease |
JP6741774B2 (ja) * | 2016-03-08 | 2020-08-19 | メレオ バイオファーマ 1 リミテッド | 慢性閉塞性肺疾患の急性増悪の治療のための投与レジメン |
AU2016397046B2 (en) * | 2016-03-08 | 2022-05-12 | Mereo Biopharma 1 Limited | Dosage regimen for the treatment of acute exacerbations of inflammatory conditions |
-
2016
- 2016-03-08 JP JP2018547431A patent/JP6741774B2/ja active Active
- 2016-03-08 CA CA3016488A patent/CA3016488C/en active Active
- 2016-03-08 MX MX2018010782A patent/MX2018010782A/es unknown
- 2016-03-08 KR KR1020247020223A patent/KR20240101698A/ko unknown
- 2016-03-08 US US16/082,765 patent/US10603306B2/en active Active
- 2016-03-08 BR BR112018067454A patent/BR112018067454A2/pt not_active Application Discontinuation
- 2016-03-08 KR KR1020187026084A patent/KR20180118667A/ko not_active IP Right Cessation
- 2016-03-08 AU AU2016397047A patent/AU2016397047B2/en active Active
- 2016-03-08 RU RU2018132047A patent/RU2713203C1/ru active
- 2016-03-08 WO PCT/GB2016/050636 patent/WO2017153702A1/en active Application Filing
-
2020
- 2020-02-18 US US16/793,922 patent/US11129810B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
JP2019507786A (ja) | 2019-03-22 |
RU2713203C1 (ru) | 2020-02-04 |
MX2018010782A (es) | 2019-01-10 |
AU2016397047A1 (en) | 2018-09-06 |
US20200281896A1 (en) | 2020-09-10 |
BR112018067454A2 (pt) | 2019-01-15 |
WO2017153702A1 (en) | 2017-09-14 |
US20190060279A1 (en) | 2019-02-28 |
CA3016488C (en) | 2023-04-11 |
KR20240101698A (ko) | 2024-07-02 |
US10603306B2 (en) | 2020-03-31 |
CA3016488A1 (en) | 2017-09-14 |
US11129810B2 (en) | 2021-09-28 |
AU2016397047B2 (en) | 2022-04-07 |
KR20180118667A (ko) | 2018-10-31 |
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JP6741773B2 (ja) | 炎症状態の急性増悪の治療のための投与レジメン | |
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EP3585383B1 (en) | Use of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide in the prevention of acute exacerbations of chronic obstructive pulmonary disease | |
EP3585382B1 (en) | Use of 3-[5-amino-4-(3-cyanobenzoyl)-pyrazol-1-yl]-n-cyclopropyl-4-methylbenzamide in the treatment of acute exacerbations of chronic obstructive pulmonary disease |
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