JP6625986B2 - カカオポリフェノール及び好酸球性食道炎の治療又は予防におけるその使用 - Google Patents
カカオポリフェノール及び好酸球性食道炎の治療又は予防におけるその使用 Download PDFInfo
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- JP6625986B2 JP6625986B2 JP2016543426A JP2016543426A JP6625986B2 JP 6625986 B2 JP6625986 B2 JP 6625986B2 JP 2016543426 A JP2016543426 A JP 2016543426A JP 2016543426 A JP2016543426 A JP 2016543426A JP 6625986 B2 JP6625986 B2 JP 6625986B2
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- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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Description
本発明の組成物は、いくつかの成分、特にポリフェノールを含み得る。好ましい成分は、少なくとも1種のプロシアニジンである。プロシアニジンは、カカオ抽出物又は濃縮物中に含まれ得る。特に、本発明の組成物は、カカオ抽出物又は濃縮物を含み得、これはまた少なくともプロシアニジンを含むポリフェノールを含む。特定の実施形態において、組成物は、少なくとも1種のプロシアニジンを含むポリフェノール及び別のポリフェノールを含む。更なる好ましい実施形態において、ポリフェノールは、カカオ抽出物又は濃縮物において見いだされ得る抽出物又は濃縮物中の濃度又は/及び比で存在する。
組成物は、少なくとも1種の植物ポリフェノールを含む。植物ポリフェノールは、少なくとも2、3、4、5、又は6個のフェノール基を含む。特に好ましいのは、2個のフェノール基を含む植物フェノールである。植物フェノールは、優先的には、水素、炭素及び酸素だけからなる。植物フェノールは、優先的には、少なくとも1つのシクロヘキサン基、フェノール基、H−基、OH−基、C=基、CO2H−基、エチル基、−O−基からなる群から選択される基を含むか、又はそれらからなる。
上記の組成物は、液体又は固体形態で製剤化することができる。液体形態は、噴霧に好適な形態に、すなわちスプレーの形態に製剤化することができる。これは、組成物を収容するコンパートメントをスプレーノズルに接続することによって達成することができる。液体は、スプレーノズルを通って移送されるときに霧化され、得られた液滴は表面上に均等に分布することができる。スプレーノズルを通して液体を移送するための様々な方法が当業者に公知である。例えば、組成物を収容する容器は、周囲の大気圧と比較して加圧下にあってもよい。あるいは、ポンプ機構によりノズルを通してスプレーを移送してもよい。スプレーの使用により、例えば、口腔を介して食道内に組成物を噴霧し、それにより組成物を食道粘膜に直接接触させることが可能になる。その後、組成物は粘膜に吸収され、次いで体内の全身への分布を達成することができる。
本明細書において使用する場合、「栄養組成物」という用語は、完全栄養組成物、部分的又は不完全栄養組成物、及び疾患又は状態に特化した栄養組成物を含むがこれらに限定されない。完全栄養組成物(すなわち、必須の主要栄養素及び微量栄養素をすべて含有するもの)は、患者のための唯一の栄養供給源として使用することができる。患者は、その栄養所要量の100%をそのような完全栄養組成物から得ることができる。部分的又は不完全栄養組成物は、必須の主要及び微量栄養素をすべて含有するわけではなく、患者のための唯一の栄養供給源として使用することはできない。部分的又は不完全栄養組成物は、栄養補助食品として使用することができる。経口栄養補助組成物は、特許請求されている組成物の必須の活性成分(植物フェノール)を主に又はそれだけを含有し、患者の通常の栄養食に加えて摂取され得る。
上記の組成物はまた、キットとして提供されてもよい。それらのキットにおいて、上記組成物の成分のすべて又は一部は、別々の(すなわち混合されていない)形態で提供される。本発明のキットは、一方では植物フェノールを、他方ではすべての残りの成分を、別々の形態で含むことができる。本発明のキットは、別々の形態で提供される少なくとも2種又は3種の植物フェノールを含むことができる。代替の実施形態において、キットは、上記組成物の成分のそれぞれを別々の形態で含むことができる。
本発明の組成物又はキットは、好酸球性食道炎の治療若しくは予防、又は特に上皮における、特に食道の上皮における好酸球数の減少において使用することができる。本発明の組成物又はキットはまた、好酸球性食道炎の治療若しくは予防、又は特に上皮における、特に食道の上皮における好酸球数の減少のための方法においても使用することができる。
上記組成物を製造するための方法が提供され、これは、上記植物フェノールのうちの少なくとも1種を用意する工程、例えば1種若しくはそれ以上のアミノ酸、脂肪、又は炭水化物からなる群から選択される、少なくとも1つの更なる成分を任意に添加する工程、少なくとも1種の栄養素又は微量栄養素を任意に添加する工程、担体又は/及び水を添加する工程を含む。
5〜8週齢の雌のBalb/cマウスを、200μgのアレルギー性抽出物を皮膚上に適用することによって感作させた。マウスの背部の小領域を剃毛した。アレルゲンを含む滅菌ガーゼのパッチ(1×1cm)を、バイオ密封透明包帯(bio-occlusive transparent dressing)2461(Johnson and Johnson)及びBand−Aidを用いて皮膚に固定した。パッチは、反応が現れるまで、連続する4〜7日間の感作期間にわたって皮膚に貼り付けたままとし、又は8日目に除去した。最後の感作日(21〜28日目)から数日後、マウスを30日目に麻酔下で経鼻チャレンジ(100μg)に曝露し、32日目にマウスを採取した。
好酸球性食道炎に罹患している18〜60歳の20〜30人の7つのコホート(食道胃十二指腸内視鏡検査の間に得られた粘膜生検材料において最高倍率での1視野あたり15個を超える好酸球が存在することによって示される)に、下記表において示す抽出物を更に含有するアミノ酸ベースの組成物VIVONEX(登録商標)PEDIATRICを投与する。
Claims (12)
- 好酸球性食道炎の予防又は治療において使用するための、少なくとも1種のプロシアニジンB1又は/及び1種若しくはそれ以上のその多量体、及び
少なくとも1種のプロシアニジンB2又は/及び1種若しくはそれ以上のその多量体、及び
プロシアニジンB1でもB2でもない少なくとも1種のプロシアニジン又は/及び1種若しくはそれ以上の2量体〜10量体であるその多量体、及び
カテキン
を含むカカオポリフェノール抽出物を含む、組成物。 - 前記組成物が、0.01%〜0.5%、又は0.02%〜0.1%、又は0.04%〜0.07%(w/w)のプロシアニジンB1又は該プロシアニジンの多量体を含む、請求項1に記載の組成物。
- 前記組成物が、0.01%〜1.0%、又は0.1%〜0.9%、又は0.2%〜0.3%(w/w)のプロシアニジンB2又は該プロシアニジンの多量体を含む、請求項1又は2に記載の組成物。
- 前記組成物が、0.5%〜10%、又は1%〜5%、又は1.5%〜2%(w/w)の、プロシアニジンB1でもB2でもないプロシアニジン、又は該プロシアニジンの多量体を含む、請求項1〜3のいずれか一項に記載の組成物。
- 経口的又は局所経口的に投与されるための、請求項1〜4のいずれか一項に記載の組成物。
- スプレーの形態で投与される、請求項1〜5のいずれか一項に記載の組成物。
- ヒト又は愛玩動物、特にネコ若しくはイヌに投与されるための、請求項1〜6のいずれか一項に記載の組成物。
- 前記ヒトが、1ヶ月から6歳の間の低年齢の小児、6歳から18歳の間の年長の小児、又は大人である、請求項7に記載の組成物。
- 前記組成物が、栄養組成物、経口栄養補助食品又は医薬品である、請求項1〜8のいずれか一項に記載の組成物。
- 前記栄養組成物が、乳幼児用栄養補給組成物、アミノ酸ベースの飲料若しくはフォーミュラ、フォローアップフォーミュラ、グローイングアップミルク、乳幼児用シリアル、又は乳児用栄養組成物からなる群から選択される、請求項9に記載の組成物。
- 前記栄養組成物が、飲料製品、ヨーグルト製品、発酵乳、フルーツジュース、小袋入りの乾燥粉末又はシリアルバーからなる群から選択される、請求項9に記載の組成物。
- 前記栄養組成物が、経口栄養補給のためのヘルスケア栄養組成物、経腸栄養補給のための栄養製品、又は非経口栄養補給製品などの特定医療用食品である、請求項9に記載の組成物。
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