JP6618358B2 - 下流フロー制御を有する臓器灌流装置 - Google Patents
下流フロー制御を有する臓器灌流装置 Download PDFInfo
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- JP6618358B2 JP6618358B2 JP2015521688A JP2015521688A JP6618358B2 JP 6618358 B2 JP6618358 B2 JP 6618358B2 JP 2015521688 A JP2015521688 A JP 2015521688A JP 2015521688 A JP2015521688 A JP 2015521688A JP 6618358 B2 JP6618358 B2 JP 6618358B2
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- 210000000056 organ Anatomy 0.000 title claims description 123
- 230000010412 perfusion Effects 0.000 title claims description 37
- 239000012530 fluid Substances 0.000 claims description 69
- 238000000034 method Methods 0.000 claims description 18
- 238000011835 investigation Methods 0.000 claims 1
- 210000002767 hepatic artery Anatomy 0.000 description 22
- 210000003240 portal vein Anatomy 0.000 description 19
- 238000003860 storage Methods 0.000 description 18
- 239000002826 coolant Substances 0.000 description 14
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 13
- 239000001301 oxygen Substances 0.000 description 13
- 229910052760 oxygen Inorganic materials 0.000 description 13
- 230000008859 change Effects 0.000 description 11
- 210000004185 liver Anatomy 0.000 description 8
- 239000007789 gas Substances 0.000 description 7
- 238000010926 purge Methods 0.000 description 7
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- 230000000875 corresponding effect Effects 0.000 description 3
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- 230000005484 gravity Effects 0.000 description 2
- 239000005457 ice water Substances 0.000 description 2
- 239000000082 organ preservation Substances 0.000 description 2
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- 210000005166 vasculature Anatomy 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 description 1
- 230000005355 Hall effect Effects 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
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- 239000011362 coarse particle Substances 0.000 description 1
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- 230000002596 correlated effect Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 230000002828 effect on organs or tissue Effects 0.000 description 1
- 230000002255 enzymatic effect Effects 0.000 description 1
- 230000036512 infertility Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
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- URGAHOPLAPQHLN-UHFFFAOYSA-N sodium aluminosilicate Chemical compound [Na+].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O URGAHOPLAPQHLN-UHFFFAOYSA-N 0.000 description 1
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Images
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0247—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components for perfusion, i.e. for circulating fluid through organs, blood vessels or other living parts
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0242—Apparatuses, i.e. devices used in the process of preservation of living parts, such as pumps, refrigeration devices or any other devices featuring moving parts and/or temperature controlling components
- A01N1/0252—Temperature controlling refrigerating apparatus, i.e. devices used to actively control the temperature of a designated internal volume, e.g. refrigerators, freeze-drying apparatus or liquid nitrogen baths
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Thermal Sciences (AREA)
- Physics & Mathematics (AREA)
- Dentistry (AREA)
- Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- External Artificial Organs (AREA)
Description
Claims (2)
- 臓器又は組織を灌流する装置に配置された臓器又は組織を灌流する方法において、
導管を臓器又は組織に接続するステップであって、前記導管は複数個のチューブを備え、2個の前記チューブのそれぞれにおける第1端部が前記臓器又は組織に接続される、ステップと、
流体原動力を、当該流体原動力を印加する手段によって、2個の前記チューブ内の灌流流体に印加して、前記流体を強制的に前記2個のチューブから前記臓器又は組織内に送給し、前記臓器又は組織を灌流する、ステップと、
前記流体原動力と前記灌流されている前記臓器又は組織によって生ずる背圧とによって、前記2個のチューブ間にフローバランスの確立を得る、ステップと、
次に、少なくとも1個のバルブによって前記2個のチューブのうち少なくとも一方を抑制させることによって、前記印加される前記流体原動力を変更せずに、前記2個のチューブ間の前記フローバランスを変更する、ステップと、
前記2個のチューブ間の前記フローバランスを変更した後、新たなフローバランスの確立を得るステップと、
前記新たなフローバランスを確立するのにかかる時間を測定するステップと、
を有する、方法。 - 臓器又は組織を灌流する装置に配置された臓器又は組織を灌流する方法において、
導管を臓器又は組織に接続するステップであって、前記導管は複数個のチューブを備え、2個の前記チューブのそれぞれにおける第1端部が前記臓器又は組織に接続される、ステップと、
流体原動力を、当該流体原動力を印加する手段によって、2個の前記チューブ内の灌流流体に印加して、前記流体を強制的に前記2個のチューブから前記臓器又は組織内に送給し、前記臓器又は組織を灌流する、ステップと、
前記流体原動力と前記灌流されている前記臓器又は組織によって生ずる背圧とによって、前記2個のチューブ間にフローバランスの確立を得る、ステップと、
次に、少なくとも1個のバルブによって前記2個のチューブのうち少なくとも一方を抑制させることによって、前記印加される前記流体原動力を変更せずに、前記2個のチューブ間の前記フローバランスを変更する、ステップと、
前記2個のチューブ間の前記フローバランスを変更することから生ずる、前記臓器又は組織に対する検査及び調査を行う、ステップと、
を有する、方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13/545,281 US10602740B2 (en) | 2012-07-10 | 2012-07-10 | Organ perfusion apparatus with downstream flow control |
US13/545,281 | 2012-07-10 | ||
PCT/US2013/049573 WO2014011547A2 (en) | 2012-07-10 | 2013-07-08 | Organ perfusion apparatus with downstream flow control |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2015527320A JP2015527320A (ja) | 2015-09-17 |
JP2015527320A5 JP2015527320A5 (ja) | 2019-07-18 |
JP6618358B2 true JP6618358B2 (ja) | 2019-12-11 |
Family
ID=48856963
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015521688A Active JP6618358B2 (ja) | 2012-07-10 | 2013-07-08 | 下流フロー制御を有する臓器灌流装置 |
Country Status (9)
Country | Link |
---|---|
US (2) | US10602740B2 (ja) |
EP (3) | EP3513654B1 (ja) |
JP (1) | JP6618358B2 (ja) |
CN (2) | CN104619170A (ja) |
BR (1) | BR112015000496B1 (ja) |
CA (2) | CA3070650C (ja) |
ES (2) | ES2872935T3 (ja) |
PL (2) | PL3513654T3 (ja) |
WO (1) | WO2014011547A2 (ja) |
Families Citing this family (22)
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US12010987B2 (en) | 2004-10-07 | 2024-06-18 | Transmedics, Inc. | Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status |
IL311989A (en) | 2004-10-07 | 2024-06-01 | Transmedics Inc | Methods and systems for extracorporeal organ treatment |
US9078428B2 (en) | 2005-06-28 | 2015-07-14 | Transmedics, Inc. | Systems, methods, compositions and solutions for perfusing an organ |
US9457179B2 (en) | 2007-03-20 | 2016-10-04 | Transmedics, Inc. | Systems for monitoring and applying electrical currents in an organ perfusion system |
US9247728B2 (en) | 2008-01-31 | 2016-02-02 | Transmedics, Inc. | Systems and methods for ex vivo lung care |
WO2012142487A1 (en) | 2011-04-14 | 2012-10-18 | Transmedics, Inc. | Organ care solution for ex-vivo machine perfusion of donor lungs |
CN106659151B (zh) * | 2014-06-02 | 2021-06-08 | 特兰斯迈迪茨公司 | 离体器官护理*** |
CA2970117A1 (en) | 2014-12-12 | 2016-06-16 | Darren FREED | Apparatus and method for organ perfusion |
CN112933394B (zh) | 2015-09-09 | 2023-10-24 | 特兰斯迈迪茨公司 | 用于在离体器官护理***中使用的主动脉插管 |
CN105660604B (zh) * | 2016-02-04 | 2019-03-15 | 杭州莱普晟医疗科技有限公司 | 一种离体肝脏灌流***和离体肝脏灌流方法 |
CN109688811B (zh) | 2016-07-22 | 2022-06-03 | 苏黎世联邦理工学院 | 用于离体肝灌注的灌注回路组件和肝腔室组件 |
DE102016117901A1 (de) | 2016-09-22 | 2018-03-22 | Technische Universität Dresden | System und Verfahren zur extrakorporalen Perfusion von Organen |
CN107467011B (zh) * | 2017-08-14 | 2020-04-10 | 武汉大学 | 一种肝脏携氧机械灌注装置 |
WO2019141809A1 (en) * | 2018-01-19 | 2019-07-25 | ETH Zürich | Perfusion loop assembly for an ex-vivo liver perfusion and a method for ex-vivo liver perfusion |
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CN109479872B (zh) * | 2018-11-28 | 2020-03-10 | 广东丁沃生医疗器械有限公司 | 一种肝脏灌注耗材组件 |
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JP2024029908A (ja) * | 2022-08-23 | 2024-03-07 | 株式会社Screenホールディングス | 接続配管、灌流装置の準備方法、および灌流方法 |
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-
2012
- 2012-07-10 US US13/545,281 patent/US10602740B2/en active Active
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2013
- 2013-07-08 WO PCT/US2013/049573 patent/WO2014011547A2/en active Search and Examination
- 2013-07-08 EP EP19160027.9A patent/EP3513654B1/en active Active
- 2013-07-08 CA CA3070650A patent/CA3070650C/en active Active
- 2013-07-08 PL PL19160027T patent/PL3513654T3/pl unknown
- 2013-07-08 CN CN201380046850.9A patent/CN104619170A/zh active Pending
- 2013-07-08 ES ES19160027T patent/ES2872935T3/es active Active
- 2013-07-08 PL PL13740121T patent/PL2871944T3/pl unknown
- 2013-07-08 ES ES13740121T patent/ES2869963T3/es active Active
- 2013-07-08 EP EP19160037.8A patent/EP3510866A1/en not_active Withdrawn
- 2013-07-08 CN CN201811441279.1A patent/CN109362711A/zh active Pending
- 2013-07-08 CA CA2917823A patent/CA2917823C/en active Active
- 2013-07-08 BR BR112015000496A patent/BR112015000496B1/pt active IP Right Grant
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- 2013-07-08 JP JP2015521688A patent/JP6618358B2/ja active Active
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Also Published As
Publication number | Publication date |
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EP2871944B1 (en) | 2021-02-24 |
BR112015000496B1 (pt) | 2020-06-09 |
US10602740B2 (en) | 2020-03-31 |
CN104619170A (zh) | 2015-05-13 |
EP2871944A2 (en) | 2015-05-20 |
CA3070650A1 (en) | 2014-01-16 |
EP3513654B1 (en) | 2021-02-24 |
WO2014011547A3 (en) | 2014-03-27 |
WO2014011547A2 (en) | 2014-01-16 |
US20200187490A1 (en) | 2020-06-18 |
CA2917823A1 (en) | 2014-01-16 |
CN109362711A (zh) | 2019-02-22 |
CA2917823C (en) | 2020-09-22 |
EP3510866A1 (en) | 2019-07-17 |
ES2872935T3 (es) | 2021-11-03 |
PL3513654T3 (pl) | 2021-09-06 |
PL2871944T3 (pl) | 2021-09-06 |
EP3513654A1 (en) | 2019-07-24 |
JP2015527320A (ja) | 2015-09-17 |
US20140017662A1 (en) | 2014-01-16 |
ES2869963T3 (es) | 2021-10-26 |
WO2014011547A9 (en) | 2015-02-26 |
CA3070650C (en) | 2023-05-02 |
BR112015000496A2 (pt) | 2017-06-27 |
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