JP6462918B2 - 減量食事療法後の体重の安定化に使用するためのフィトエクジソン - Google Patents
減量食事療法後の体重の安定化に使用するためのフィトエクジソン Download PDFInfo
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- JP6462918B2 JP6462918B2 JP2018023066A JP2018023066A JP6462918B2 JP 6462918 B2 JP6462918 B2 JP 6462918B2 JP 2018023066 A JP2018023066 A JP 2018023066A JP 2018023066 A JP2018023066 A JP 2018023066A JP 6462918 B2 JP6462918 B2 JP 6462918B2
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- phytoecdysone
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Description
‐キノア種子の水抽出;
‐固体/液体分離及び水性抽出物の遠心分離;
‐タンパク質を沈殿させるための上澄みの加熱;
‐上澄みをフィトエクジソンで富化するためのクロマトグラフィーによる精製
を含む。
まず、キノア種子を挽いて、種子のふすまから粉末を分離する。続いて4000Lの水を400kgのふすまに加えることにより、抽出を行う。水性の抽出物を固体/液体分離及びそれに続いて遠心分離に供する。結果として得られた上澄みを90℃の熱に曝露して、タンパク質を沈殿させる。続いて、この水性の抽出物をフィトエクジソンで富化するために、この水性の抽出物を食品用樹脂のカラムを通過させることにより精製する。続いて、20‐ヒドロキシエクジソン(20E)の2±02重量%の含有量を調整するのに適切な少量のマルトデキストリンを添加した後に、エタノール溶出液をスプレー乾燥を用いて乾かす。
プロトコル
抽出物Aの効果を、MBI27〜38の男性18人及び女性42人からなる60人の体重過多及び肥満の協力者への二重盲式臨床試験の一部として調査した。協力者は、女性1200kcal、男性1500kcalの低カロリーの食事を6週間与えられた。低カロリー食事療法の後には、低カロリー食事療法よりも20%カロリーの高い6週間の安定食事療法が続く。インスリン濃度、体重変化、脂肪細胞の直径、筋力等のパラメータを、調査の間、低カロリー及び安定段階の開始時及び終了時において測定した。
低カロリー食事療法の間の抽出物Aの効果を、体重変化に基づいて調査した(図1A、図1B)。
低カロリー食事療法の間の抽出物Aの効果を、脂肪細胞の直径の変化に基づいて調査した(図2A、図2B)。
低カロリー食事療法の間の抽出物Aの効果を、インスリン濃度及びインスリン抵抗性に基づいて調査した(図3A、図3B)。HOMA−IR(インスリン抵抗性指数、図4A、図4B)指数は、インスリン抵抗性のマーカである。
抽出物Aの投与により、低カロリー減量食事療法の安定段階と呼ばれる第2の段階の間に、対象となる被験者の体重の再増加を回避できる。
Claims (6)
- 低カロリー減量食事療法後の哺乳類の体重の再増加を防ぐための、フィトエクジソンを含む薬剤であって、
前記フィトエクジソンは、キノア由来の植物抽出物の形態で提供される薬剤。 - 低カロリー減量食事療法後の脂肪細胞の直径を安定させるための、請求項1に記載の薬剤。
- 低カロリー減量食事療法によって以前に改善されたインスリン感受性を安定させるための、請求項1又は2に記載の薬剤。
- 前記フィトエクジソンは、20-ヒドロキシエクジソン、マキステロンA、24‐エピ‐マキステロンA、24(28)‐デヒドロマキステロンA、20,26‐ジヒドロキシエクジソン、及び前記成分のうち2つ以上の組み合わせから選択される、請求項1〜3のいずれか1項に記載の薬剤。
- 前記抽出物は、少なくとも1重量%のフィトエクジソンを含む、請求項1〜4のいずれか1項に記載の薬剤。
- 経口投与できる組成物に組み込まれる、請求項1〜5のいずれか1項に記載の薬剤。
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FR1160280A FR2982489B1 (fr) | 2011-11-10 | 2011-11-10 | Phytoecdysones pour leur utilisation dans la stabilisation du poids apres un regime amaigrissant |
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FR3021318B1 (fr) | 2014-05-20 | 2017-04-28 | Inst Biophytis | Produits derives de la 20-hydroxyecdysone et leur utilisation dans la preparation de medicaments |
FR3078252B1 (fr) * | 2018-02-28 | 2020-08-14 | Biophytis | Phytoecdysones pour leur utilisation dans la prevention de la perte de force musculaire lors d’une immobilisation |
JP7107368B2 (ja) | 2018-06-06 | 2022-07-27 | 株式会社島津製作所 | 分析方法 |
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US5688772A (en) * | 1994-08-01 | 1997-11-18 | University Of Saskatchewan | Quinoa saponin compositions and methods of use |
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US6355249B2 (en) * | 1998-04-17 | 2002-03-12 | Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food Canada | Process for recovery and purification of saponins and sapogenins from quinoa (Chenopodium quinoa) |
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US20070196517A1 (en) * | 2005-07-13 | 2007-08-23 | Dictuc S.A. | Modified Saponin Molluscicide |
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PL2775859T3 (pl) | 2017-07-31 |
HUE031953T2 (en) | 2017-08-28 |
JP2014533256A (ja) | 2014-12-11 |
US20170071955A1 (en) | 2017-03-16 |
US20200100534A1 (en) | 2020-04-02 |
JP2018109023A (ja) | 2018-07-12 |
CN103957727A (zh) | 2014-07-30 |
HRP20170260T1 (hr) | 2017-06-16 |
US20140309203A1 (en) | 2014-10-16 |
PT2775859T (pt) | 2017-03-10 |
WO2013068704A1 (fr) | 2013-05-16 |
JP6346094B2 (ja) | 2018-06-20 |
FR2982489B1 (fr) | 2013-12-27 |
EP2775859B1 (fr) | 2017-01-18 |
CN103957727B (zh) | 2016-09-14 |
FR2982489A1 (fr) | 2013-05-17 |
EP2775859A1 (fr) | 2014-09-17 |
ES2618023T3 (es) | 2017-06-20 |
DK2775859T3 (en) | 2017-03-06 |
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