JP6382995B2 - コントラスト強調超音波撮像を用いた頸動脈プラークの評価 - Google Patents
コントラスト強調超音波撮像を用いた頸動脈プラークの評価 Download PDFInfo
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- 238000002607 contrast-enhanced ultrasound Methods 0.000 title claims description 7
- 238000011156 evaluation Methods 0.000 title claims description 4
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- 230000010412 perfusion Effects 0.000 claims description 50
- 238000002604 ultrasonography Methods 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 28
- 230000033001 locomotion Effects 0.000 claims description 17
- 210000001715 carotid artery Anatomy 0.000 claims description 15
- 230000002123 temporal effect Effects 0.000 claims description 15
- 239000000523 sample Substances 0.000 claims description 13
- 238000002059 diagnostic imaging Methods 0.000 claims description 11
- 239000000700 radioactive tracer Substances 0.000 claims description 6
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- 238000011002 quantification Methods 0.000 claims description 5
- 238000012285 ultrasound imaging Methods 0.000 claims description 4
- 230000006870 function Effects 0.000 description 13
- 238000009826 distribution Methods 0.000 description 8
- 208000006011 Stroke Diseases 0.000 description 6
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- 210000005166 vasculature Anatomy 0.000 description 4
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 208000037260 Atherosclerotic Plaque Diseases 0.000 description 2
- 208000007536 Thrombosis Diseases 0.000 description 2
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- 210000004556 brain Anatomy 0.000 description 2
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- 238000012360 testing method Methods 0.000 description 2
- 201000001320 Atherosclerosis Diseases 0.000 description 1
- 206010029113 Neovascularisation Diseases 0.000 description 1
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- 230000000740 bleeding effect Effects 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
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- 238000002347 injection Methods 0.000 description 1
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- 230000007246 mechanism Effects 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000013618 particulate matter Substances 0.000 description 1
- 230000007406 plaque accumulation Effects 0.000 description 1
- 230000007505 plaque formation Effects 0.000 description 1
- 238000004451 qualitative analysis Methods 0.000 description 1
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- 238000007619 statistical method Methods 0.000 description 1
- 238000000528 statistical test Methods 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
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- G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
- G06T7/00—Image analysis
- G06T7/0002—Inspection of images, e.g. flaw detection
- G06T7/0012—Biomedical image inspection
- G06T7/0014—Biomedical image inspection using an image reference approach
- G06T7/0016—Biomedical image inspection using an image reference approach involving temporal comparison
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/06—Measuring blood flow
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4444—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device related to the probe
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/44—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device
- A61B8/4483—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer
- A61B8/4494—Constructional features of the ultrasonic, sonic or infrasonic diagnostic device characterised by features of the ultrasound transducer characterised by the arrangement of the transducer elements
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/46—Ultrasonic, sonic or infrasonic diagnostic devices with special arrangements for interfacing with the operator or the patient
- A61B8/461—Displaying means of special interest
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/52—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/5215—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data
- A61B8/5223—Devices using data or image processing specially adapted for diagnosis using ultrasonic, sonic or infrasonic waves involving processing of medical diagnostic data for extracting a diagnostic or physiological parameter from medical diagnostic data
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- H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
- H04N23/00—Cameras or camera modules comprising electronic image sensors; Control thereof
- H04N23/60—Control of cameras or camera modules
- H04N23/68—Control of cameras or camera modules for stable pick-up of the scene, e.g. compensating for camera body vibrations
- H04N23/682—Vibration or motion blur correction
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- G06T2207/30101—Blood vessel; Artery; Vein; Vascular
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- G06T2207/30004—Biomedical image processing
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- G06T2207/30104—Vascular flow; Blood flow; Perfusion
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Description
Claims (13)
- コントラスト強調超音波によるプラークの評価のための超音波診断撮像システムであって、
造影剤の供給の間において頸動脈のプラーク領域の一連の超音波画像を取得するアレイ状トランスジューサを備えた超音波撮像プローブと、
前記プラーク領域における灌流の度合いを表示するディスプレイと、
を有する、超音波診断撮像システムにおいて、
前記一連の超音波画像の前記プラーク領域における造影剤が存在する各ピクセルに関して時間輝度曲線を形成する時間輝度曲線計算器と、
前記プラーク領域におけるピクセルに関する前記時間輝度曲線に基づいて、前記プラーク領域における灌流が存在するピクセルを識別する比較器と、
前記プラーク領域における灌流を示すピクセルのパーセンテージを定量化する灌流定量化装置と、
を更に有することを特徴とする、超音波診断撮像システム。 - 何処に灌流が存在するかを示す前記プラーク領域の解剖学的マップを生成する画像プロセッサを更に有する、請求項1に記載の超音波診断撮像システム。
- 前記取得された一連の超音波画像を記憶するフレームメモリを更に有する、請求項1に記載の超音波診断撮像システム。
- フレーム間の動きを補償する画像安定器を更に有する、請求項3に記載の超音波診断撮像システム。
- 頸動脈画像内のプラークの輪郭を描くプラークトレーサを更に有する、請求項1に記載の超音波診断撮像システム。
- 前記プラークトレーサが超音波システム制御パネルのユーザ制御子を更に有する、請求項5に記載の超音波診断撮像システム。
- 前記比較器が更に前記プラーク領域への造影剤の到達前後のピクセル輝度値を比較する、請求項1に記載の超音波診断撮像システム。
- コントラスト強調超音波によりプラークを評価する方法であって、
造影剤の供給の間においてプラークを有する頸動脈の一連の超音波画像を取得するステップと、
前記一連の超音波画像内のプラーク領域を識別するステップと、
前記プラーク領域における灌流の度合いを表示するステップと、
を有する、方法において、
前記プラーク領域における造影剤が存在する各ピクセルに関する時間輝度曲線を形成するステップと、
前記プラーク領域におけるピクセルに関する前記時間輝度曲線に基づいて、前記プラーク領域における灌流が存在する1以上のピクセルを識別するステップと、
前記プラーク領域における灌流を示すピクセルのパーセンテージを定量化するステップと、
を特徴とする、方法。 - 前記プラーク領域を識別するステップが、前記超音波画像のうちの1つにおいてプラークの領域の輪郭を描くステップを更に有する、請求項8に記載の方法。
- 灌流が識別されたピクセルを示す前記プラーク領域の解剖学的マップを形成するステップを更に有する、請求項8に記載の方法。
- 前記一連の超音波画像におけるフレーム間の動きを補償するステップを更に有する、請求項8に記載の方法。
- 前記プラーク領域の画像における灌流が識別されたピクセルを、前記プラーク領域の画像における動きが存在するピクセルに相関させるステップを更に有する、請求項8に記載の方法。
- 前記プラーク領域内からの平均信号の時間輝度曲線を形成して、該プラーク領域への前記造影剤の到達を識別するステップを更に有する、請求項8に記載の方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201461930655P | 2014-01-23 | 2014-01-23 | |
US61/930,655 | 2014-01-23 | ||
PCT/IB2015/050452 WO2015110961A1 (en) | 2014-01-23 | 2015-01-21 | Evaluation of carotid plaque using contrast enhanced ultrasonic imaging |
Publications (3)
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JP2017503603A JP2017503603A (ja) | 2017-02-02 |
JP2017503603A5 JP2017503603A5 (ja) | 2018-07-26 |
JP6382995B2 true JP6382995B2 (ja) | 2018-08-29 |
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JP2016547943A Active JP6382995B2 (ja) | 2014-01-23 | 2015-01-21 | コントラスト強調超音波撮像を用いた頸動脈プラークの評価 |
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US (2) | US10163208B2 (ja) |
EP (1) | EP3097538B1 (ja) |
JP (1) | JP6382995B2 (ja) |
CN (1) | CN105940431B (ja) |
RU (1) | RU2690445C2 (ja) |
WO (1) | WO2015110961A1 (ja) |
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JP6382995B2 (ja) * | 2014-01-23 | 2018-08-29 | コーニンクレッカ フィリップス エヌ ヴェKoninklijke Philips N.V. | コントラスト強調超音波撮像を用いた頸動脈プラークの評価 |
CN107506791B (zh) * | 2017-08-07 | 2020-11-10 | 哈尔滨医科大学 | 一种对动脉粥样硬化斑块进行分类的*** |
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