JP6371762B2 - Oct血管造影データの解析および可視化 - Google Patents
Oct血管造影データの解析および可視化 Download PDFInfo
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
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- G01B9/00—Measuring instruments characterised by the use of optical techniques
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- G01B9/0209—Low-coherence interferometers
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Description
特許参考文献
米国特許第6,549,801号明細書 チェン他(Chen et al.)“Phase−resolved optical coherence tomography and optical Doppler tomography for imaging fluid flow in tissue with fast scanning speed and high velocity sensitivity”
米国特許第7,301,644号明細書 ナイトン他(Knighton et al.)“Enhanced optical coherence tomography for anatomical mapping”
米国特許第7,359,062号明細書 チェン他(Chen et al.)“High speed spectral domain functional optical coherence tomography and optical Doppler tomography for in vivo blood flow dynamics and tissue structure”
米国特許8,079,711号明細書 ステットソン他(Stetson et al.)“Method for finding the lateral position of the fovea in an SD−OCT image volume”
米国公開第2008/0025570号明細書 フィングラー他(Fingler et al.)“Dynamic motion contrast and transverse flow estimation using OCT”,
米国特許公開第2008/0100612号明細書 ダストマルチ他(Dastmalchi et al.)“User interface for efficiently displaying relevant OCT imaging data”
米国特許公開第2011/0034803号明細書 ステットソン他(Stetson et al.)“Non−linear projections of 3−D medical imaging data”
米国公開第2010/0027857号明細書 ワン(Wang)“In vivo structural and flow imaging”
米国特許公開第2012/0249956号明細書 アイヤー他(Iyer et al.)“Systems and methods for efficiently obtaining measurements of the human eye using tracking”
米国特許公開第2012/0277579号明細書 シャルマ他(Sharma et al.)“Inter−frame complex OCT data analysis techniques”
WO 2010/129494 明細書 ワン他(Wang et al)“Method and apparatus for quantitative imaging of blood perfusion in living tissue”
WO 2011/097631 明細書 ワン(Wang)“Method and apparatus for ultrahigh sensitive optical microangiography”
非特許文献
アル−ディリ他(Al−Diri et al.)“Automated analysis of retinal vascular network connectivity”,Computerized Medical Imaging and Graphics,34,462−470(2010).
アン他(An et al.)“Optical microangiography provides correlation between microstructure and microvasculature of optic nerve head in human subjects”,J.Biomed.Opt.17,116018(2012).
アヴァキアン他(Avakian, et al.),“Fractal analysis of region−based vascular change in the normal and nonproliferative diabetic retina”,Curr.Eye Res.24,274−280(2002).
フィングラー他(Fingler et al.)“Mobility and transverse flow visualization using phase variance contrast with spectral domain optical coherence tomography”Optics Express.Vol.15,No.20.pp 12637−12653(2007).
フィングラー他(Fingler et al.)“Volumetric microvascular imaging of human retina using optical coherence tomography with a novel motion contrast technique”Optics Express.Vol.17,No.24,pp 22190−22200(2009).
ガネサン他(Ganesan et al.)“Development of an Image−Based Network Model of Retinal Vasculature”,Annals of Biomedical Engineering 38(4)1566−1585(2010).
ジア他(Jia et al.),“Quantitative OCT angiography of optic nerve head blood flow”,Biomed.Opt.Express 3,3127−3137(2012).
キム他(Kim et al.)“In vivo volumetric imaging of human retinal circulation with phase variance OCT”,Biomedical Optics Express,2(6),1504−1513(2011).
キム他(Kim et al.)“Noninvasive Imaging of the Foveal Avascular Zone with High−Speed, Phase−Variance Optical Coherence Tomography”Investigative Ophthalmology & Visual Science,53(1),85−92(2012)
マキタ他(Makita et al.),“Optical Coherence Angiography”,Optics Express,14(17),7821−7840(2006).
マキタ他(Makita et al.),“Comprehensive in vivo micro−vascular imaging of the human eye by dual−beam−scan Doppler optical coherence angiography”Optics Express 19(2) 1271−1283(2011).
マリアンピライ他(Mariampillai et al.),“Optimized speckle variance OCT imaging of microvasculature”,Optics Letters 35,1257−1259(2010).
ライトゲープ(Leitgeb),“Imaging of the parafoveal capillary network and its integrity analysis using fractal dimension”,Biomed. Opt.Express 2,1159−1168(2011).
ライトゲープ他(Leitgeb et al.),“Real−time assessment of retinal blood flow with ultrafast acquisition by color Doppler FDOCT”,Optics Express,11,3116−3121(2003).
ライトゲープ他(Leitgeb et al.)“Ultrahigh resolution Fourier domain optical coherence tomography”,Optics Express 12(10):2156(2004)
リウ他(Liu et al.),“Intensity−based modified Doppler variance algorithm:application to phase instable and phase stable optical coherence tomography systems”Optics Express 19(12),11429−11440(2011).
シュモール他(Schmoll et al.)“Imaging of the parafoveal capillary network and its integrity analysis using fractal dimension”Biomed.Opt.Express 2,1159−1168(2011).
ワン他(Wang et al.),“Frequency domain phase−resolved optical Doppler and Doppler variance tomography”Optics Communications 242 345−350(2004).
ワン他(Wang et al.),“Three dimensional optical angiography”,Optics Express 15,4083−4097(2007).
ワン他(Wang et al.),“Depth−resolved imaging of capillary networks in retina and choroid using ultrahigh sensitive optical microangiography”,Optics Letters,35(9),1467−1469(2010).
ワン他(Wang et al.)“Imaging Retinal Capillaries Using Ultrahigh−Resolution Optical Coherence Tomography and Adaptive Optics”Invest.Ophthalmol.Vis.Sci.52.6292−6299 2011
ホワイト他(White et al.),“In vivo dynamic human retinal blood flow imaging using ultra−high−speed spectral domain optical Doppler tomography”,Optics Express,11(25),3490−3497(2003).
ヤズダンファ(Yazdanfar)“Imaging and velocimetry of the human retinal circulation with color Doppler OCT”,Optics Letters 25,1448−1450(2000).
ヨン他(Yong et al.)“Novel Noninvasive Detection of the Fovea Avascular Zone Using Confocal Red−Free Imaging in Diabetic Retinopathy and Retinal Vein Occlusion”Retina.52:2649−2655 2011
ジャオ他(Zhao et al.),“Doppler standard deviation imaging for clinical monitoring of in vivo human skin blood flow”,Optics Letters 25,1358−1360(2000).
ジャン他(Zheng et al.)“Automated segmentation of foveal avascular zone in fundus fluorescein angiography”Retina.51(7):3653−3659 2010
Claims (14)
- 眼の光干渉断層撮影(OCT)画像データ内において、関心対象のエリアを特定するための、自動化された方法であって、
患者の眼の複数の横断方向の所在にわたってOCT画像データを収集することであって、少なくとも2つのOCT測定値が、事前に求められた間隔だけ時間において分離されて、ほぼ同じ横断方向の所在において得られる、前記収集すること、
データを処理してほぼ同じ横断方向の所在において得られた少なくとも2つのOCT測定値における変化を決定することであって、前記変化は、前記事前に求められた間隔の間に生じた血液の流れに関連している、前記決定すること、
処理されたデータから、2次元の正面血管系画像を生成すること、
該正面血管系画像の強度内容の統計的特性を解析して、特定のエリアのサイズおよび形状を特定すること、
特定されたエリアを表示または格納すること
を含む、方法。 - 前記特定されたエリアが、中心窩無血管性域(FAZ)である、請求項1に記載の方法。
- 前記特定されたエリアが、網膜虚血の領域である、請求項1に記載の方法。
- 網膜内の層を特定すること、これらの層を、前記正面血管系画像を生成する際に境界として使用することをさらに含む、請求項1に記載の方法。
- 前記正面血管系画像の解析が、前記正面血管系画像から強度ヒストグラムを生成すること、該強度ヒストグラム内のピークに対応する強度を特定すること、前記特定されたエリアと血管系の残りの部分との間の推移を、これらの強度の組み合わせとして求めること、前記正面血管系画像内に、これらの強度値に対応する領域を位置付けることを含む、請求項1に記載の方法。
- 前記正面血管系画像を、セクタに分割すること、強度を使用して、背景に関してセクタ内の脈管の割合を求めることをさらに含む、請求項1に記載の方法。
- 網膜血管系の3次元表現を生成することをさらに含む、請求項1に記載の方法。
- 強度に加えて、前記正面血管系画像の付加的な特性を使用して、前記特定のエリアを特定することをさらに含む、請求項1に記載の方法。
- 光干渉断層撮影(OCT)画像データ内において疾病を解析するための方法であって、
患者の眼の複数の横断方向の所在にわたってOCT画像データを収集することであって、少なくとも2つのOCT測定値が、事前に求められた間隔だけ時間において分離されて、ほぼ同じ横断方向の所在において得られる、前記収集すること、
データを処理してほぼ同じ横断方向の所在において得られた少なくとも2つのOCT測定値における変化を決定することであって、前記変化は、前記事前に求められた間隔の間に生じた血液の流れに関連している、前記決定すること、
処理されたデータの3D可視化を生成することであって、前記3D可視化は、特定の血管と、収集されたOCT画像データ内にある、選択された脈管に連絡された他の血管のみとをハイライト表示する、前記生成すること
を含む、方法。 - 特定の脈管が、ユーザによって選択される、請求項9に記載の方法。
- 連絡している脈管が、オペレータが選んだ点から伝播しながらハイライト表示される、請求項9に記載の方法。
- ハイライト表示の際の伝播速度が、脈管径によって決定される、請求項9に記載の方法。
- ボリューム内の軸方向深さ情報を使用して、3D脈管マップから立体画像対を生成すること、該立体画像対を、可視化用にユーザに提示することをさらに含む、請求項9に記載の方法。
- 異なる時間に撮られた、同じ患者の2つの3D可視化を位置合わせすること、該同じ患者の2つの3D可視化を比較して、毛細血管範囲が増大したか、または、縮小した領域を求めることをさらに含む、請求項9記載の方法。
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US201261645513P | 2012-05-10 | 2012-05-10 | |
US61/645,513 | 2012-05-10 | ||
US201261691219P | 2012-08-20 | 2012-08-20 | |
US61/691,219 | 2012-08-20 | ||
US13/781,375 | 2013-02-28 | ||
US13/781,375 US9357916B2 (en) | 2012-05-10 | 2013-02-28 | Analysis and visualization of OCT angiography data |
PCT/EP2013/059560 WO2013167641A1 (en) | 2012-05-10 | 2013-05-08 | Analysis and visualization of oct angiography data |
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Publication number | Priority date | Publication date | Assignee | Title |
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WO2021241564A1 (ja) | 2020-05-29 | 2021-12-02 | 国立大学法人筑波大学 | 画像生成装置、プログラム及び画像生成方法 |
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WO2013167641A1 (en) | 2013-11-14 |
EP2852317B1 (en) | 2022-07-27 |
EP2852317A1 (en) | 2015-04-01 |
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CN104271031B (zh) | 2017-08-08 |
JP2018175888A (ja) | 2018-11-15 |
JP2015515894A (ja) | 2015-06-04 |
EP4122377A1 (en) | 2023-01-25 |
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