JP6353454B2 - 感知トランジスタアレイを備えた集積回路、感知装置及び測定方法 - Google Patents
感知トランジスタアレイを備えた集積回路、感知装置及び測定方法 Download PDFInfo
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Description
REPEAT
IF(Vmedium>Vset)THEN Vbias:=Vbias−x
IF(Vmedium<Vset)THEN Vbias:=Vbias+x
UNTIL Vmedium=Vset
ここで、Vmediumは媒体の電位であり、Vsetは媒体の目標電位であり、Vbiasはバイアス電圧生成器150によって基板110に印加されるバイアス電圧であり、xはVbiasが調節される量を定義する正の数である。量xは一定の、即ち予め定義された量であっても良いし、又はVmediumとVsetとの間の差に基づいて動的に決定される量であっても良い。以上のアルゴリズムから明らかであるように、バイアス電圧生成器150により生成されるバイアス電圧は徐々に調節され、即ちVsetがVmediumと等しくなるまで、VmediumがVsetを超えている場合に低減させられ、又はVmediumがVsetを超えている場合には増大させられる。媒体が一定の電荷を保持しているという仮定が依然として成り立つことを確実にするのに十分に迅速に、検体測定が完了し得ることを確実にするのに十分にステップ周波数が高い限り(特に、以上に説明されたように、測定の時間スケールにおいて、測定空間が閉じた副系とみなされるような開いた流体系に重要である)、いずれの適切な調節ステップ周波数が利用されても良い。典型的には、上述の仮定は、ミリ秒又はそれ以下の範囲で実行されるいずれの測定についても成り立つ。
Claims (15)
- 半導体基板と、
前記基板上の絶縁層と、
前記絶縁層上の第1のトランジスタであって、ソース領域とドレイン領域との間に露出させられた機能化チャネル領域を有し、前記機能化チャネル領域は、媒体中の検体を感知するよう構成された、第1のトランジスタと、
前記絶縁層上の第2のトランジスタであって、ソース領域とドレイン領域との間に露出させられたチャネル領域を有し、前記チャネル領域は、前記媒体の電位を感知するよう構成された、前記ドレイン領域は、前記第1のトランジスタ及び前記第2のトランジスタに共通である、第2のトランジスタと、
前記第1のトランジスタ及び前記第2のトランジスタにバイアス電圧を供給するため前記半導体基板に導電的に結合された電圧バイアス生成器であって、前記第2のトランジスタに応答する、電圧バイアス生成器と、
を有する集積回路。 - 前記機能化チャネル領域は、対象検体を結合するための結合層により機能化された、請求項1に記載の集積回路。
- 前記機能化チャネル領域は、前記チャネル領域の化学修飾により機能化された、請求項1に記載の集積回路。
- トランジスタのアレイを更に有し、前記アレイは、複数の前記第1のトランジスタ及び複数の前記第2のトランジスタを有する、請求項1又は2に記載の集積回路。
- 前記第1のトランジスタの各々が別個に機能化された、請求項4に記載の集積回路。
- 各前記チャネル領域がナノワイヤ又はナノチューブを有する、請求項1乃至5のいずれか一項に記載の集積回路。
- 前記ナノワイヤは、シリコンナノワイヤを有するか又はシリコンナノワイヤから成る、請求項6に記載の集積回路。
- 前記ナノチューブは、カーボンナノチューブを有するか又はカーボンナノチューブから成る、請求項6に記載の集積回路。
- 各前記チャネル領域は、酸化物膜により被覆された、請求項1乃至8のいずれか一項に記載の集積回路。
- サンプル区画及び請求項1乃至9のいずれか一項に記載の集積回路を有し、前記第1のトランジスタ及び前記第2のトランジスタが前記サンプル区画に露出させられた、感知装置。
- 前記サンプル区画が流路を有する、請求項10に記載の感知装置。
- それぞれの前記第1及び第2のトランジスタに個別に結合された信号プロセッサを更に有する、請求項10又は11に記載の感知装置。
- 媒体中の検体を測定する方法であって、
請求項1乃至9のいずれか一項に記載の集積回路を備えるステップと、
前記第1のトランジスタ及び前記第2のトランジスタを前記検体を潜在的に含む媒体に露出させるステップと、
前記第2のトランジスタを用いて前記媒体の電位を感知するステップと、
前記感知された前記媒体の電位に応じて、前記基板に供給されるバイアス電圧を調節するステップと、
を有する方法。 - 前記バイアス電圧を調節するステップに後続して、前記第1のトランジスタを流れるドレイン−ソース電流を測定するステップと、
前記測定されたドレイン−ソース電流から、前記検体の存在を導出するステップと、
を更に有する、請求項13に記載の方法。 - 前記測定するステップは、前記媒体の電位が一定となるような期間の間に実行される、請求項14に記載の方法。
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PCT/IB2013/059296 WO2014060916A1 (en) | 2012-10-16 | 2013-10-11 | Integrated circuit with sensing transistor array, sensing apparatus and measuring method |
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CN109414936B (zh) * | 2016-09-23 | 2021-04-02 | 惠普发展公司,有限责任合伙企业 | 流体喷射装置和颗粒检测器 |
US10447202B2 (en) * | 2017-02-08 | 2019-10-15 | Texas Instruments Incorporated | Apparatus for communication across a capacitively coupled channel |
JP6740949B2 (ja) * | 2017-03-31 | 2020-08-19 | 日立金属株式会社 | ガスセンサ |
US11531027B2 (en) * | 2017-12-01 | 2022-12-20 | University Of Florida Research Foundation, Inc. | Low cost disposable medical sensor fabricated on glass, paper or plastics |
FR3077926B1 (fr) * | 2018-02-15 | 2023-04-14 | St Microelectronics Crolles 2 Sas | Dispositif de detection, en particulier incorpore dans un ph-metre, et procede de realisation correspondant. |
AU2019345325A1 (en) * | 2018-09-21 | 2021-04-15 | Teralytic Holdings Inc. | Extensible, multimodal sensor fusion platform for remote, proximal terrain sensing |
CN114674897B (zh) * | 2022-03-28 | 2023-06-06 | 深圳大学 | 一种用于检测单细胞外pH值的探针型有机电化学晶体管传感器及其制备方法、检测方法 |
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IL189576A0 (en) | 2008-02-18 | 2008-12-29 | Technion Res & Dev Foundation | Chemically sensitive field effect transistors for explosive detection |
WO2009124111A2 (en) * | 2008-04-01 | 2009-10-08 | Trustees Of Boston University | Glucose sensor employing semiconductor nanoelectronic device |
EP2335061B1 (en) * | 2008-08-25 | 2019-02-27 | Nxp B.V. | Reducing capacitive charging in an electrode comprising a heater |
TWI383144B (zh) | 2008-09-23 | 2013-01-21 | Univ Nat Chiao Tung | 感測元件、製造方法及其生物檢測系統 |
US20100219085A1 (en) | 2009-02-27 | 2010-09-02 | Edwards Lifesciences Corporation | Analyte Sensor Offset Normalization |
WO2010120297A1 (en) | 2009-04-15 | 2010-10-21 | Hewlett-Packard Development Company, L.P | Nanowire sensor having a nanowire and electrically conductive film |
KR101217576B1 (ko) | 2009-09-22 | 2013-01-03 | 한국전자통신연구원 | 바이오 센서 및 그의 구동 방법 |
US8368123B2 (en) * | 2009-12-23 | 2013-02-05 | Nokia Corporation | Apparatus for sensing an event |
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2013
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- 2013-10-11 RU RU2015118418A patent/RU2650087C2/ru active
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EP2909616A1 (en) | 2015-08-26 |
RU2015118418A (ru) | 2016-12-10 |
RU2650087C2 (ru) | 2018-04-06 |
CN104737008B (zh) | 2017-06-09 |
BR112015008211A2 (pt) | 2017-07-04 |
BR112015008211B1 (pt) | 2020-05-19 |
WO2014060916A1 (en) | 2014-04-24 |
US20150276667A1 (en) | 2015-10-01 |
US10302590B2 (en) | 2019-05-28 |
JP2016502644A (ja) | 2016-01-28 |
CN104737008A (zh) | 2015-06-24 |
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