JP6321668B2 - 効率的変調撮像 - Google Patents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
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- A—HUMAN NECESSITIES
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
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- A—HUMAN NECESSITIES
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- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
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- A61B5/0077—Devices for viewing the surface of the body, e.g. camera, magnifying lens
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Description
1) 図9bに示されるように、構造化光源16は、オンにされ、米国特許第6958815号に簡単に説明されるように、1つまたは少数の高SNR波長(例えば、λj S=λ1 S,λ2 S,λ3 S)において、組織サンプル30上に走査される。構造化光は、いくつかの空間周波数を伴うこれらの波長において、サンプル30を照射し、サンプル30から反射および散乱された光は、カメラ18によって収集される。本データは、次いで、生物学的組織中の光の散乱に関する物理的モデル、あるいは一連の測定またはシミュレーションに基づく実験的データルックアップのいずれかを使用して、サンプルの変調伝達関数および/または光学特性情報、例えば、空間分解吸収および等価散乱(μa(λj S)およびμs´(λj S)マップを得るために分析されることができる。サンプル混濁性を考慮する、物理的モデルの実施例は、光伝達の標準拡散方程式および放射伝達モデルである。
2) 次に、空間構造化波長λj Sにおける測定は、着目サンプル中の光学特性の波長依存特徴に基づいて、非構造化波長λk Pに内挿または外挿されることができる。例えば、近赤外線領域では、導出された散乱係数μs´(λj S)は、μs´(λ)=A*λ―b、またはより一般的には、
3) 図9cに示されるように、高SNR波長における構造化光源16は、次いで、オフにされ、低SNR波長である、平面光源12が、次いで、オンにされ、サンプル30を照射するために使用される。サンプル30から反射された光は、カメラシステム18によって検出され、拡散反射率係数、Rdλk P等の所望の波長において再放出された光を提供する。例証的実施例のように、拡散反射率は、970nmにおいて測定され、ctH2O感度を判定する。本ステップは、代替として、ステップ1の前に行われる、またはステップ1内の測定に差し挟むことができることに留意されたい。
4) 分析の最後のステップでは、低SNR波長λk Pにおける光学特性が、平面および外挿または内挿された構造化光源測定の組み合わせを使用することによって計算される。例えば、λk P、すなわち、μs´(λk P)=A*(λk P)―b)において評価された拡散反射率値(Rd(λk P))および適合散乱係数μs´(λ)=A*λ―b)が、1パラメータ適合または生物学的組織に関する物理的散乱/反射モデルを使用するルックアップテーブル計算と組み合わせられ、故に、μa(λk P)をもたらすことができる。
5) 本段階において、光学特性(例えば、散乱および吸収)係数は、構造化照射波長(すなわち、高SNR)から導出されたデータおよび非構造化平面照射波長(すなわち、低SNR)から導出された光データに関して、直接、変調伝達関数から測定された全波長に対して、完全に判定される。
6) 発色団濃度および生理学指標は、ここで、完全波長依存散乱および吸収係数から導出されることができる。
Claims (26)
- 混濁サンプルの測定のための装置であって、
空間構造を有していない光を用いて、混濁サンプルの標的面積を照射するように構成される複数の光源を有する、照射装置と、
空間構造を有する光を用いて、混濁サンプルの前記標的面積を照射するように構成される、投射システムと、
前記混濁サンプルの標的面積から光を収集するように構成される、センサと、
前記センサによって捕捉されたデータを分析し、前記混濁サンプルの散乱および吸収係数を求めるように構成される、プロセッサと
を備え、
空間構造を伴わない前記光の波長は、空間構造を有する前記光の波長と異なる、装置。 - 前記光源は、前記照射装置の周縁上に配置される空間構造を有していない光を用いて、前記サンプルを照射するように構成される、請求項1に記載の装置。
- 前記照射装置は、光リングアセンブリを備える、請求項1に記載の装置。
- 前記光リングアセンブリは、リング体とともに、前記リング体の周縁を中心として形成されるソケットを含み、前記光源は、前記ソケット内に可撤性に搭載される、請求項3に記載の装置。
- 前記光源は、LEDモジュールを備える、請求項4に記載の装置。
- 前記センサは、カメラである、請求項1に記載の装置。
- 前記センサは、前記照射装置および前記投射システムに対して軸外に位置付けられる、請求項1に記載の装置。
- 前記光源は、ビームホモジナイザを含む、請求項1に記載の装置。
- ビームホモジナイザは、集光ロッドである、請求項1に記載の装置。
- 前記投射システムは、いくつかの切替可能光源を備える、請求項1に記載の装置。
- 前記切替可能光源は、異なる波長を有するLEDを含む、請求項10に記載の装置。
- 混濁サンプルの測定のための装置であって、
平面光源と、
空間構造化光源と、
前記平面光源および前記空間構造化光源によって別個に照射される、混濁サンプルの標的面積から光を収集するように構成される、センサと、
前記センサによって捕捉されたデータを分析し、前記混濁サンプルの散乱および吸収係数を求めるように構成される、プロセッサと
を備え、
前記平面光源によって放出される光の波長は、前記空間構造化光源から放出される光の波長と異なる、装置。 - 前記平面光源は、空間構造を有していない光を用いて、前記サンプルを照射するように構成される、請求項12に記載の装置。
- 前記平面光源は、光リングアセンブリを備える、請求項12に記載の装置。
- 前記光リングアセンブリは、リング体とともに、前記リング体の周縁を中心として形成される複数のソケットと、前記ソケット内に可撤性に搭載された複数の非空間構造化光源とを含む、請求項14に記載の装置。
- 前記複数の非空間構造化光源の個々の1つは、LEDモジュールを備える、請求項15に記載の装置。
- 前記センサは、カメラである、請求項12に記載の装置。
- 前記センサは、前記平面光源および前記空間構造化光源に対して軸外に位置付けられる、請求項12に記載の装置。
- 前記複数の非空間構造化光源の個々の1つは、ビームホモジナイザを備える、請求項16に記載の装置。
- 前記ビームホモジナイザは、集光ロッドである、請求項19に記載の装置。
- 前記空間構造化光源は、投射システムを備える、請求項12に記載の装置。
- 前記空間構造化光源は、いくつかの切替可能光源を備える、請求項12に記載の装置。
- 前記切替可能光源は、異なる波長を有するLEDを含む、請求項22に記載の装置。
- 混濁サンプルの測定のための方法であって、
空間構造を有する光を用いて、混濁サンプルを照射するステップと、
前記混濁サンプルから反射された光を収集し、いくつかの波長λjにおける前記サンプルの再放出された光を得るステップと、
空間構造を有していない光を用いて、前記混濁サンプルを照射するステップと、
前記サンプルから反射された光を収集し、いくつかの波長λkにおける前記サンプルの再放出された光を得るステップと、
空間構造を有する光および空間構造を有していない光から得られた測定を組み合わせ、適合パラメータを得るステップであって、前記適合パラメータは、いくつかの波長λjにおける前記混濁サンプルの光学特性および吸収または蛍光分子の濃度のうちの1つ以上を含む、ステップと
を含み、
空間構造を伴わない前記光の波長λ k は、空間構造を有する前記光の波長λ j と異なる、方法。 - 混濁サンプルの測定のための方法であって、
空間構造を有する光を用いて、混濁サンプルを照射するステップと、
前記混濁サンプルから反射された光を収集し、いくつかの波長λ j における前記サンプルの再放出された光を得るステップと、
空間構造を有していない光を用いて、前記混濁サンプルを照射するステップと、
前記サンプルから反射された光を収集し、いくつかの波長λ k における前記サンプルの再放出された光を得るステップと、
空間構造を有する光および空間構造を有していない光から得られた測定を組み合わせ、適合パラメータを得るステップであって、前記適合パラメータは、いくつかの波長λ j における前記混濁サンプルの光学特性および吸収または蛍光分子の濃度のうちの1つ以上を含む、ステップと
を含み、
前記得られた測定を組み合わせるステップは、空間構造を有していない光を使用して得られた波長λ k における散乱に関する推定値を得るために、波長への散乱の依存性を記述する散乱関数を使用して、空間構造を有する光を使用して得られた離散波長λ j における測定を内挿または外挿することによって行われる、方法。 - 前記波長の散乱関数は、
として記述される冪関数である、請求項25に記載の方法。
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US201261723721P | 2012-11-07 | 2012-11-07 | |
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US201361793331P | 2013-03-15 | 2013-03-15 | |
US61/793,331 | 2013-03-15 | ||
PCT/US2013/068956 WO2014074720A1 (en) | 2012-11-07 | 2013-11-07 | Efficient modulated imaging |
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US (3) | US8892192B2 (ja) |
EP (2) | EP2898326B1 (ja) |
JP (2) | JP6321668B2 (ja) |
KR (1) | KR102251749B1 (ja) |
CN (1) | CN105190308B (ja) |
AU (2) | AU2013341165B2 (ja) |
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CA (1) | CA2889489C (ja) |
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MX2018016101A (es) | 2012-11-07 | 2022-05-19 | Modulated Imaging Inc | Eficiente formacion modulada de imagenes. |
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