JP6306097B2 - 細胞破壊装置、及び、細胞破壊装置の作動方法 - Google Patents
細胞破壊装置、及び、細胞破壊装置の作動方法 Download PDFInfo
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Description
本願は、2011年3月7日に出願された米国仮出願第61/450,038号に対して優先権を主張するものであり、本明細書にその全体を参照により援用する。
エキシランプ技術例としては、シベリアのトムスクにあるIHCE(the Institute of High Current Electronics)で開発された概念例(例えば、ソスニン・イーエー(Sosnin EA),オッペンランダー・ティー(Oppenlander T),タラセンコ・ブイエフ(Tarasenko VF),「光科学における容量性及び障壁放電エキシランプの応用(Applications of capacitive and barrier discharge excilamps in photoscience)」,J. Photochem. Photobiol C:Photochem. Rev. 2006;7:145−63参照)が利用できる。本開示の実施例に利用可能な別の例示的エキシランプとしては、ドイツのヘレウス社(Heraues Noblelight)製のものがある。IHCEランプの実施例であるランプ302を図3に示す。IHCEランプは、小型、頑丈で、価格は1000ドル以下であり、様々な単一波長のUV放射線を発生させることができる。以上に基づき、本開示の実施例では、例えば、約207nmでUVを発生可能なクリプトン−臭素ランプ又は約222nmでUVを発生可能なクリプトン−塩素ランプ(図3)を使用できる。別の例示的エキシランプでは、約206nmでUVを発生できる。これらのランプのスペクトル例を図4のグラフに示す。図4に示すように、スペクトル分布402はクリプトン−臭素ランプで発生でき、スペクトル分布404はクリプトン−塩素ランプで発生した。更に、本開示の更なる実施例によると、ある特徴例を含むことにより(例えば、多層誘電体フィルタや化学フィルタ等のスペクトルフィルタ素子)、不要な波長や、好ましい波長域外の波長を除去できる。例えば、吸収及び/又は反射素子をランプと照射面の間に設けることで、不要な波長をフィルタリングできる(例えば、帯域通過フィルタや長波長阻止フィルタ等)。ある実施例では、吸収材に蛍光材を用いて、UV放射線を吸収したら可視光を発してランプが動作中であることを示してもよい。別法として、あるいは更に、別のガスをランプに添加して、不要な波長を抑制してもよい。例えば、クリプトン−塩素ランプにアルゴンを添加すると、228nmのUVの発生を抑制できる。
以下、本開示のある実施例を実現するある実験例を説明する。これらの実験例は、例えば、例示的フィルタ付きエキシランプからのUVに、正常なヒト細胞を害することなくバクテリアを殺菌する効果があるかを調べたものである。
Claims (16)
- 少なくとも1つの放射線を発生する細胞破壊装置であって、
約190ナノメートル(nm)〜約230nmの範囲内で提供される1つ又は複数の波長を有する前記少なくとも1つの放射線を発生する放射線源第1装置と、
前記少なくとも1つの放射線が前記範囲外の波長を有することを実質的に防止する少なくとも1つの第2装置と、
を備え、
前記少なくとも1つの放射線は、直径1μm未満のバクテリアに選択的に作用し、若しくは破壊することを特徴とする細胞破壊装置。 - 請求項1の細胞破壊装置において、前記少なくとも1つの放射線は、身体の細胞への危害を実質的に回避することを特徴とする細胞破壊装置。
- 請求項1の細胞破壊装置において、前記放射線源第1装置は、更に、エキシランプを含むことを特徴とする細胞破壊装置。
- 請求項3の細胞破壊装置において、前記エキシランプは、クリプトン−臭素ランプ及び/又はクリプトン−塩素ランプを含むことを特徴とする細胞破壊装置。
- 請求項1の細胞破壊装置において、前記放射線源第1装置は、更に、前記範囲内で提供される単一波長を有する前記少なくとも1つの放射線を発生するとともに、前記少なくとも1つの第2装置は、更に、前記少なくとも1つの放射線が前記単一波長以外の波長を有することを防止することを特徴とする細胞破壊装置。
- 請求項5の細胞破壊装置において、前記単一波長は、207nmであることを特徴とする細胞破壊装置。
- 請求項5の細胞破壊装置において、前記単一波長は、222nmであることを特徴とする細胞破壊装置。
- 請求項1の細胞破壊装置において、前記少なくとも1つの第2装置は、化学フィルタ及び/又は誘電体を含むことを特徴とする細胞破壊装置。
- 放射線源第1装置と、第2装置とを備え、少なくとも1つのバクテリアを選択的に破壊する細胞破壊装置の作動方法であって、
約190ナノメートル(nm)〜約230nmの範囲内の少なくとも1つの波長を有する少なくとも1つの放射線を発生する前記放射線源第1装置が動作し、
前記少なくとも1つの前記第2装置が、前記少なくとも1つの放射線が前記範囲外の波長を有することがないように前記範囲外の波長を実質的に防止し、
前記細胞破壊装置は、前記少なくとも1つの放射線を所定の領域へ出射して少なくとも1つの直径1μm未満のバクテリアに対し選択的に作用し、若しくは破壊することを特徴とする細胞破壊装置の作動方法。 - 請求項9の方法において、前記少なくとも1つの放射線は、身体の細胞への危害を実質的に回避することを特徴とする細胞破壊装置の作動方法。
- 請求項9の方法において、前記少なくとも1つの放射線は、エキシランプから出射されることを特徴とする細胞破壊装置の作動方法。
- 請求項11の方法において、前記エキシランプは、クリプトン−臭素ランプ及び/又はクリプトン−塩素ランプを含むことを特徴とする細胞破壊装置の作動方法。
- 請求項9の方法において、前記少なくとも1つの放射線は、前記範囲内で提供される単一波長を有するとともに、前記防止は、前記少なくとも1つの放射線が前記単一波長以外の波長を有することを防止することを特徴とする細胞破壊装置の作動方法。
- 請求項13の方法において、前記単一波長は、207nmであることを特徴とする細胞破壊装置の作動方法。
- 請求項13の方法において、前記単一波長は、222nmであることを特徴とする細胞破壊装置の作動方法。
- 請求項9の方法において、前記第2装置は、化学フィルタ及び/又は誘電体を含むことを特徴とする細胞破壊装置の作動方法。
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