JP6300864B2 - 外面に表面増感分光法要素を有する装置 - Google Patents
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/65—Raman scattering
- G01N21/658—Raman scattering enhancement Raman, e.g. surface plasmons
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
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- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Biochemistry (AREA)
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- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Description
表面増感ラマン分光法(surface-enhanced Raman spectroscopy:SERS)のような表面増感分光法(surface-enhancedspectroscopy:SES)において、被分析物の振動励起レベルが調査される。光子のエネルギーは、光子により励起された振動レベルの量に等しい量だけ移動(シフト)することができる(ラマン散乱)。調査されている被分析物に特有の分子振動に対応する帯域の波長分布からなるラマンスペクトルが検出されて、被分析物が同定され得る。SERSにおいて、被分析物の分子は、誘電体(例えば、二酸化ケイ素、窒化ケイ素、及びポリマー)でコーティングされても、されていなくても良い金属ナノ粒子に接触または近接(例えば、数十ナノメートル未満)し、当該金属ナノ粒子は、ひとたび光により励起されると、当該金属ナノ粒子の周囲に強い近接場を生成する、プラズモンモード(自由電子密度の集団振動)をサポートする。これらの場は、近接場の領域において被分析物分子に結合し、被分析物の分子からの散乱信号の放出を強めることができる。
簡略化および例示の目的のために、本開示は、主としてその例を参照することにより説明される。以下の説明において、本開示の完全な理解を与えるために、多くの特定の細部が記載される。しかしながら、本開示がこれら特定の細部に制限されずに実施され得ることは容易に明らかであろう。また、幾つかの方法および構造は、本開示を不必要に曖昧にしないように、詳細に説明されない。
Claims (15)
- 分光法を行うための装置であって、
検体へ挿入されることができる形状およびサイズを有する細長い基体であって、第1の端部および第2の端部を有する、細長い基体と、
前記細長い基体の前記第1の端部と前記第2の端部との間の場所において前記細長い基体の外面に配置された複数の表面増感分光法(SES)要素と、
前記細長い基体を前記検体へ挿入中に前記複数のSES要素を保護するために、前記複数のSES要素を覆うカバー層とを含み、
前記カバー層が、前記細長い基体の前記検体への挿入後に前記複数のSES要素を曝露するために取り除かれるように構成されている、装置。 - 前記装置は、前記検体へ挿入した後に、生体内で分光法を行うための装置である、請求項1に記載の装置。
- 前記細長い基体が、鍼灸針からなる、請求項1又は2に記載の装置。
- 前記細長い基体が円形の断面からなり、前記複数のSES要素が、前記細長い基体の前記第1の端部と前記第2の端部との間の場所において、前記細長い基体が前記検体へ挿入される回転配向に関係なく照射ビームを受け取るように前記細長い基体の外周の周りに配置されている、請求項1〜3の何れかに記載の装置。
- 前記細長い基体の外面から延びる複数のナノフィンガを更に含み、前記複数のSES要素が、前記複数のナノフィンガの先端部に配置されている、請求項1〜4の何れかに記載の装置。
- 隣接するナノフィンガの先端部がお互いに対して近接し、前記隣接するナノフィンガの少なくとも幾つかの先端部にある前記複数のSES要素がお互いに接触するように、前記複数のナノフィンガは、前記複数のナノフィンガの隣接するナノフィンガ上に部分的に倒れる、請求項5に記載の装置。
- 前記カバー層が、前記検体の流体に溶解可能、光分解可能、及び外部刺激を受けることによって除去可能の少なくとも1つである、請求項1〜6の何れかに記載の装置。
- 前記カバー層は、特定の粒子が前記複数のSES要素に接触することを実質的に阻止することができる多孔質膜からなる、請求項1〜7の何れかに記載の装置。
- 前記複数のSES要素の複数のグループが、前記細長い基体の前記第1の端部と前記第2の端部との間の複数の異なる場所において前記細長い基体の表面に配置されている、請求項1〜8の何れかに記載の装置。
- 前記カバー層が、
前記複数のSES要素の第1のグループを覆う第1のカバー層と、
前記複数のSES要素の第2のグループを覆う第2のカバー層とからなり、
前記第1のカバー層および前記第2のカバー層が、お互いに対して別個に除去可能である、請求項9に記載の装置。 - 前記第1のカバー層および前記第2のカバー層が、異なる速度で又は異なる時間に除去されるようになっている、請求項10に記載の装置。
- 前記細長い基体上に設けられた薬材料を更に含み、前記薬材料が、前記カバー層の除去後に、前記検体へ導入されることができる、請求項1〜11の何れかに記載の装置。
- 請求項1〜12の何れかに記載の装置を用いて分光法を行うためのシステムであって、
前記複数のSES要素を照明するための照明光源と、
前記複数のSES要素の近くに配置された被分析物から放出された光を検出するためのスペクトロメータとを含む、システム。 - 請求項1〜12の何れかに記載の装置を用いて分光法を行うための方法であって、
ターゲット粒子を含有する前記検体の流体内において、前記ターゲット粒子の少なくとも幾つかを前記複数のSES要素に接触させ、
照射ビームを前記複数のSES要素および前記ターゲット粒子に送り、前記ターゲット粒子に散乱信号を放出させ、
前記ターゲット粒子により放出された前記散乱信号を測定することを含む、方法。 - 請求項1〜12の何れかに記載の装置を製造するための方法であって、
前記細長い基体の前記外面に前記複数のSES要素を設け、
前記細長い基体上に前記カバー層を設けることを含む、方法。
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