JP6298145B2 - 高速のターンオン時間をもつ電流検出複数出力電流刺激装置 - Google Patents
高速のターンオン時間をもつ電流検出複数出力電流刺激装置 Download PDFInfo
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- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
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- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
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Description
例えば、本願発明は以下の項目を提供する。
(項目1)
基準電圧を供給するための基準電圧源と、
複数の入力側トランジスタと、
複数の出力側トランジスタの電流ミラーが前記入力側トランジスタのそれぞれに連結された複数の出力側トランジスタであって、前記出力側トランジスタが共通検出電圧を供給するように一緒に連結され、前記出力側トランジスタのそれぞれ1つがそれぞれの出力電流を供給するための電流出力端子を有する、複数の出力側トランジスタと、
それぞれの入力側トランジスタと所定の電圧ポートとの間でカスコード構成で切り替え可能に連結された供給トランジスタと、
前記基準電圧に連結された第1の入力、前記共通検出電圧に連結された第2の入力、及び前記基準電圧と前記共通検出電圧との間の差の関数として、前記供給トランジスタを駆動するように構成された出力、を含む差動増幅器と、
前記対応する入力側トランジスタの電流にしたがって、前記対応する電流ミラー出力側トランジスタにそれぞれの出力電流を供給させるように、前記入力側トランジスタのそれぞれ1つを選択的に作動させるように構成されるスイッチング制御回路と、を備える複数出力電流刺激装置回路。
(項目2)
電流源と、前記電流源に連結され、前記基準電圧を供給するための第1の抵抗器とを更に備える項目1に記載の刺激装置回路。
(項目3)
電圧源と前記出力側トランジスタとの間に連結され、それにより前記共通検出電圧を供給する第2の抵抗器を更に備える、項目2に記載の刺激装置回路。
(項目4)
前記電圧源と前記入力側トランジスタとの間に連結され、電流をそれぞれの入力側トランジスタに供給するための第3の抵抗器を更に備える、項目3に記載の刺激装置回路。
(項目5)
前記それぞれの出力電流の合計は前記電流源によって供給される電流に定数Kを乗算したものに等しく、定数Kは前記第1の抵抗器と前記第2の抵抗器の比に等しい、項目3に記載の刺激装置回路。
(項目6)
前記入力側トランジスタ及び前記出力側トランジスタは、幅(W)と長さ(L)を有するMOSFETトランジスタであり、それぞれのトランジスタのW/L比は1:Lに等しく構成され、前記第3の抵抗器と前記第2の抵抗器の前記抵抗値の比が、L:1に等しく構成され、それによって供給トランジスタにLで除算した記第1及び第2の抵抗器の前記比を、前記電流源電流に乗算したものに等しい電流を供給する、項目3に記載の刺激装置。
(項目7)
前記所定の電圧ポートは接地を含む、項目1に記載の刺激装置。
(項目8)
前記所定の電圧ポートは電圧源を含む、項目1に記載の刺激装置。
(項目9)
第1の複数のスイッチを含み、前記第1の複数のスイッチのそれぞれのスイッチが前記供給トランジスタとそれぞれの入力側トランジスタとの間に接続され、前記スイッチング制御回路は、前記対応する電流ミラーされた出力側トランジスタにそれぞれの出力電流を供給させるように、刺激プロトコロにしたがって前記第1の複数のスイッチを作動させるように構成される、項目1に記載の刺激装置。
(項目10)
第2の複数のスイッチを含み、前記第2の複数のスイッチのそれぞれのスイッチが前記電圧源とそれぞれの入力側トランジスタとの間に接続され、前記スイッチング制御回路は、対応する電流ミラーされた出力側トランジスタにそれぞれの出力電流の供給を停止させるように、刺激プロトコロにしたがって前記第2の複数のスイッチを作動させるように構成される、項目9に記載の刺激装置。
(項目11)
前記第1の複数のスイッチ内のスイッチが作動するとき、前記第2の複数のスイッチ内の対応するスイッチが作動しないようにし、前記第1の複数のスイッチのうちのスイッチが作動しないとき、前記第2の複数のスイッチの対応するスイッチが作動するように、前記スイッチング制御回路が前記第1の複数のスイッチと前記第2の複数のスイッチの状態を相補的な方法で制御する、項目10に記載の刺激装置。
(項目12)
前記第1の複数のスイッチの少なくとも1つのスイッチが作動すると、前記基準電圧が供給され、それによって前記少なくとも1つの事前に選択されるスイッチに対応する前記出力側トランジスタに関連する静電容量を放電するように、前記スイッチング制御回路が前記基準電圧源を制御する、項目11に記載の刺激装置。
(項目13)
前記基準電圧を供給すると、前記少なくとも1つの事前に選択されるスイッチに対応する前記出力側トランジスタに関連する静電容量を放電するように前記差動増幅器が前記供給トランジスタを駆動する、項目12に記載の刺激装置。
(項目14)
基準電圧を供給するための基準電圧源と、
少なくとも1つの入力側トランジスタと、
少なくとも1つの出力側トランジスタの電流ミラーが前記少なくとも1つの入力側トランジスタに連結された少なくとも1つの出力側トランジスタであって、共通検出電圧を供給し、出力電流を供給するための電流出力端子を有する、少なくとも1つの出力側トランジスタと、
前記少なくとも1つの入力側トランジスタと電圧ポートとの間でカスコード構成で切り替え可能に連結された供給トランジスタと、
前記基準電圧に連結された第1の入力、前記共通検出電圧に連結された第2の入力、及び前記基準電圧と前記共通検出電圧との間の差の関数として、前記供給トランジスタを駆動するように構成された出力、を含む差動増幅器と、
前記対応する少なくとも1つの入力側トランジスタ電流にしたがって、前記電流ミラーされた少なくとも1つの出力側トランジスタに出力電流を供給させるように、前記少なくとも1つの入力側トランジスタを作動させるように構成されるスイッチング制御回路と、を備える複数出力電流刺激装置回路。
(項目15)
前記電圧ポートは接地している、項目14に記載の刺激装置。
(項目16)
前記所定の電圧ポートは電圧源である、項目14に記載の刺激装置。
(項目17)
末梢移植可能な神経刺激システムであって、
電流源と、
前記電流源と連結され、基準電圧を供給するための第1の抵抗器と、
出力電流を供給するための電流出力端子を有する少なくとも1つの出力側トランジスタと、
電圧源と前記少なくとも1つの出力側トランジスタとの間に連結され、それによって共通検出電圧を提供する第2の抵抗器と、
前記基準電圧に連結された第1の入力、前記共通検出電圧に連結された第2の入力、及び前記基準電圧と前記共通検出電圧との間の差の関数として、前記少なくとも1つの出力側トランジスタを駆動するように構成された出力、を含む差動増幅器と、を含む複数出力電流刺激装置回路を含むパルス発生器を備える、末梢移植可能な神経刺激システム。
(項目18)
前記パルス発生器と接続されるリード線を更に含み、前記リード線が複数の導電性電極と複数の非導電性領域とを備える、項目17に記載の末梢移植可能な神経刺激システム。
(項目19)
前記パルス発生器が複数の電気パルスプログラムを含む、項目17に記載の末梢移植可能な神経刺激システム。
(項目20)
前記複数の電気パルスプログラムは前記パルス発生器によって生成される電気パルスの周波数及び強度に影響を与える、項目19に記載の末梢移植可能な神経刺激システム。
(項目21)
前記複数の電気パルスプログラムの1つを作成するために前記パルス発生器と通信することができる制御装置を更に含む、項目20に記載の末梢移植可能な神経刺激システム。
(項目22)
前記複数の電気パルスプログラムの1つを選択するために前記パルス発生器と通信することができる制御装置を更に含む、項目20に記載の末梢移植可能な神経刺激システム。
(項目23)
前記差動増幅器の出力と前記出力側トランジスタとの間に位置する第1のスイッチを更に含み、前記第1のスイッチは前記複数の電気パルスプログラムの1つに応じて閉じられる、項目19に記載の末梢移植可能な神経刺激システム。
(項目24)
末梢移植可能な神経刺激システムであって、1つ又はいくつかの電気パルスを生成するように構成されるパルス発生器であって、前記パルス発生器が、
基準電流を生成するように構成される電流発生器と、
第1の抵抗器と第2の抵抗器の抵抗比に応じて、前記基準電流を増幅する刺激装置回路を含む刺激装置と、を含む、パルス発生器と、
前記パルス発生器に接続され、1つ以上の電極を含む1つ以上のリード線であって、前記パルス発生器から前記1つ以上の電極に前記1つ又はいくつかの電気パルスを伝導するように構成される、1つ以上のリード線と、を含む末梢移植可能な神経刺激システム。
(項目25)
前記刺激装置回路が、第1の入力と第2の入力を有する差動増幅器を含み、前記第1の抵抗器が前記第1の入力に連結され、前記第2の抵抗器が前記第2の入力に連結される、項目24に記載の末梢移植可能な神経刺激システム。
(項目26)
前記第2の抵抗器と電気的に接続される複数の出力を更に含む、項目24に記載の末梢移植可能な神経刺激システム。
(項目27)
前記第2の抵抗器を流れる刺激装置出力電流が前記出力を流れる電流の合計に等しい、項目26に記載の末梢移植可能な神経刺激システム。
(項目28)
前記第1の抵抗器が複数の抵抗器を含む、項目24に記載の末梢移植可能な神経刺激システム。
(項目29)
前記第2の抵抗器が複数の抵抗器を含む、項目28に記載の末梢移植可能な神経刺激システム。
(項目30)
前記第1の抵抗器の前記複数の抵抗器が直列に構成されている、項目29に記載の末梢移植可能な神経刺激システム。
(項目31)
前記第2の抵抗器の前記複数の抵抗器が並列に構成されている、項目30に記載の末梢移植可能な神経刺激システム。
(項目32)
末梢移植可能な神経刺激システムであって、
1つ又はいくつかの電気パルスを生成するように構成されるパルス発生器であって、
基準電流を生成するように構成される電流発生器と、
1つ又はいくつかの出力トランジスタの1つ又はいくつかのゲートに接続される出力を有する供給トランジスタを備える刺激装置回路を含む刺激装置と、を含む、パルス発生器と、
前記パルス発生器に接続され、1つ以上の電極を含む1つ以上のリード線であって、前記パルス発生器から前記1つ以上の電極に前記1つ又はいくつかの電気パルスを伝導するように構成される、1つ以上のリード線と、を含む末梢移植可能な神経刺激システム。
(項目33)
前記供給トランジスタのドレインが、1つ又はいくつかの出力トランジスタの1つ又はいくつかのゲートに接続されている、項目32に記載の末梢移植可能な神経刺激システム。
(項目34)
差動増幅器を更に含み、前記差動増幅器の出力が前記供給トランジスタを駆動するように構成される、項目33に記載の末梢移植可能な神経刺激システム。
(項目35)
1つ又はいくつかの電気パルスを生成するように構成され、刺激装置回路を含むパルス発生器を体の末梢部に移植する工程であって、前記刺激装置回路が第1の抵抗器と第2の抵抗器の抵抗の比に応じて基準電流を増幅する、工程と、
前記体の末梢部内に、1つ以上の電極を含むリード線を移植する工程と、
前記末梢神経に近接して前記リード線の1つ以上の電極を配置する工程と、
前記リード線を前記パルス発生器に接続する工程と、を含む神経障害性疼痛を治療する方法。
(項目36)
前記パルス発生器で電気パルスを生成する工程と、前記電気パルスを前記リード線で前記末梢神経に伝導する工程と、を更に含む、項目35に記載の神経障害性疼痛を治療する方法。
(項目37)
1つ又はいくつかの電気パルスを生成するように構成され、刺激装置回路を含むパルス発生器を体の末梢部に移植する工程であって、前記刺激装置回路が1つ又はいくつかの出力トランジスタの1つ又はいくつかのゲートに接続される出力を有する供給トランジスタを含む、工程と、
前記体の末梢部内に、1つ以上の電極を含むリード線を移植する工程と、
前記末梢神経に近接して前記リード線の1つ以上の電極を配置する工程と、
前記リード線を前記パルス発生器に接続する工程と、を含む神経障害性疼痛を治療する方法。
(項目38)
前記パルス発生器で電気パルスを生成する工程と、前記電気パルスを前記リード線で前記末梢神経に伝導する工程と、を更に含む、項目31に記載の神経障害性疼痛を治療する方法。
(項目39)
末梢移植可能な神経刺激システムであって、
1つ又はいくつかの電気パルスを生成するように構成されるパルス発生器であって、
電流発生器と、
50mA未満の出力電流に対して5us未満のターンオン時間と、を有する刺激装置回路を含む刺激装置と、を含むパルス発生器と、
前記パルス発生器に接続され、1つ以上の電極を含む1つ以上のリード線であって、前記パルス発生器から前記1つ以上の電極に前記1つ又はいくつかの電気パルスを伝導するように構成される、1つ以上のリード線と、を含む、末梢移植可能な神経刺激システム。
(項目40)
前記ターンオン時間が、200uA〜25mAの出力電流に対して2us未満である、項目33に記載の末梢移植可能な神経刺激システム。
(項目41)
前記ターンオン時間が、200uA〜25mAの出力電流に対して0.5〜2usである、項目33に記載の末梢移植可能な神経刺激システム。
(項目42)
前記パルス発生器が、50usのパルス幅を有する少なくとも1つの電気パルスを生成するように構成される、項目33に記載の末梢移植可能な神経刺激システム。
(項目43)
神経刺激システムであって、
移植可能なパルス発生器であって、
第1の抵抗、
前記第1の抵抗間を延在する基準電圧、又は前記第1の抵抗を流れる基準電流のうちの少なくとも1つである基準信号を生成するように構成される基準信号発生器、
第2の抵抗、
複数の電極出力、及び
前記基準信号を、前記第2の抵抗間に延在する全出力電圧又は、前記第2の抵抗を流れる全出力電流の少なくとも1つである全出力信号に増幅するように構成され、前記全出力信号を複数の電極出力の少なくともいくつかに分配するように構成される複数出力刺激装置であって、
前記複数出力刺激装置による増幅の利得値が前記第1の抵抗及び前記第2の抵抗に基づいている、複数出力刺激装置、を含む、移植可能なパルス発生器と、
前記複数の電極出力に連結されるように構成される複数の電極を含む1つ以上のリード線と、を含む、神経刺激システム。
(項目44)
前記複数出力刺激装置による増幅の利得値が前記第2の抵抗により除算される前記第1の抵抗に等しい、項目43に記載の神経刺激システム。
(項目45)
前記第1の抵抗器が直列の複数の抵抗器を含む、項目44に記載の神経刺激システム。
(項目46)
前記第2の抵抗器が並列の複数の抵抗器を含む、項目45に記載の神経刺激システム。
(項目47)
前記移植可能なパルス発生器は人体の末梢部内の移植のために寸法決めされる、項目43に記載の神経刺激システム。
(項目48)
前記人体の末梢部が、腕、脚、手及び、足の1つを含む、項目47に記載の神経刺激システム。
Claims (17)
- 基準電圧を供給するための基準電圧源と、
少なくとも1つの入力側トランジスタと、
少なくとも1つの出力側トランジスタの電流ミラーが前記少なくとも1つの入力側トランジスタに連結された少なくとも1つの出力側トランジスタであって、共通検出電圧を供給し、出力電流を供給するための電流出力端子を有する、少なくとも1つの出力側トランジスタと、
前記少なくとも1つの入力側トランジスタと電圧ポートとの間でカスコード構造で切り替え可能に結合された供給トランジスタと、
前記基準電圧に連結された第1の入力、前記共通検出電圧に連結された第2の入力、及び前記基準電圧と前記共通検出電圧との間の差の関数として、前記供給トランジスタを駆動するように構成された出力、を含む差動増幅器と、
前記対応する少なくとも1つの入力側トランジスタ電流にしたがって、前記電流ミラーされた少なくとも1つの出力側トランジスタに出力電流を供給させるように、前記少なくとも1つの入力側トランジスタを作動させるように構成されるスイッチング制御回路と、を備える複数出力電流刺激装置回路。 - 前記電圧ポートは接地している、請求項1に記載の複数出力電流刺激装置回路。
- 前記電圧ポートは電圧源である、請求項1に記載の複数出力電流刺激装置回路。
- 神経刺激システムであって、
電流源と、
前記電流源と連結され、基準電圧を供給するための第1の抵抗器と、
出力電流を供給するための電流出力端子及びゲートを有する少なくとも1つの出力側トランジスタと、
電圧源と前記少なくとも1つの出力側トランジスタとの間に連結され、共通検出電圧を出力する第2の抵抗器と、
前記少なくとも1つの出力側トランジスタの前記ゲートに接続される出力を有する供給トランジスタと、
前記基準電圧に連結された第1の入力、前記共通検出電圧に連結された第2の入力、及び前記基準電圧と前記共通検出電圧との間の差の関数として、前記少なくとも1つの出力側トランジスタを前記供給トランジスタを介して制御するように構成された出力、を含む差動増幅器と、を含む複数出力電流刺激装置回路を含むパルス発生器を備える神経刺激システム。 - 前記パルス発生器と接続されるリード線を更に含み、前記リード線が複数の導電性電極と複数の非導電性領域とを備える、請求項4に記載の神経刺激システム。
- 前記パルス発生器が複数の電気パルスプログラムを含む、請求項4に記載の神経刺激システム。
- 前記複数の電気パルスプログラムは前記パルス発生器によって生成される電気パルスの周波数及び強度に影響を与える、請求項6に記載の神経刺激システム。
- 前記複数の電気パルスプログラムの1つを作成するために前記パルス発生器と通信することができる制御装置を更に含む、請求項7に記載の神経刺激システム。
- 前記複数の電気パルスプログラムの1つを選択するために前記パルス発生器と通信することができる制御装置を更に含む、請求項7に記載の神経刺激システム。
- 前記差動増幅器の出力と前記出力側トランジスタとの間に位置する第1のスイッチを更に含み、前記第1のスイッチは前記複数の電気パルスプログラムの1つに応じて閉じられる、請求項6に記載の神経刺激システム。
- 神経刺激システムであって、
1つ又はいくつかの電気パルスを生成するように構成されるパルス発生器であって、
基準電流を生成するように構成される電流発生器と、
刺激装置回路を含む刺激装置であって、前記刺激装置回路は、
前記生成された電流と連結され、前記基準電流に基づいて基準電圧を供給するための第1の抵抗器と、
1つ又はいくつかの出力トランジスタの1つ又はいくつかのゲートに接続される出力を有する供給トランジスタと、
前記基準電圧に連結された第1の入力、共通検出電圧に連結された第2の入力、及び前記供給トランジスタに連結された出力、を有する差動増幅器であって、前記1つ又はいくつかの出力トランジスタが前記共通検出電圧を供給する、差動増幅器と、を含む、刺激装置と、を含む、パルス発生器と、
前記パルス発生器に接続され、1つ以上の電極を含む1つ以上のリード線であって、前記パルス発生器から前記1つ以上の電極に前記1つ又はいくつかの電気パルスを伝導するように構成される、1つ以上のリード線と、を含む神経刺激システム。 - 前記供給トランジスタのドレインが、1つ又はいくつかの出力トランジスタの1つ又はいくつかのゲートに接続されている、請求項11に記載の神経刺激システム。
- 1つ又はいくつかの入力側トランジスタを更に含み、前記1つ又はいくつかの出力トランジスタは、前記1つ又はいくつかの入力側トランジスタにミラー連結されている、請求項12に記載の神経刺激システム。
- 前記差動増幅器の出力が、前記供給トランジスタのゲートに結合されている、請求項1に記載の複数出力電流刺激装置回路。
- 前記供給トランジスタが、前記少なくとも1つの出力側トランジスタのゲートと電圧ポートとの間で切り替え可能に結合されている、請求項4に記載の神経刺激システム。
- 前記差動増幅器の出力が、前記供給トランジスタのゲートに結合されている、請求項15に記載の神経刺激システム。
- 前記差動増幅器の出力が、前記供給トランジスタのゲートに結合されている、請求項11に記載の神経刺激システム。
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