JP6189037B2 - 治療用ビタミンd日焼け止め製剤およびそれを使用するための方法 - Google Patents
治療用ビタミンd日焼け止め製剤およびそれを使用するための方法 Download PDFInfo
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Description
概して、本発明は、ビタミンD欠乏およびビタミンD不足の哺乳動物を治療するための、ならびにビタミンD欠乏およびビタミンD不足に伴う障害および疾患を予防および治療するための、製剤の日焼け止め成分(1つまたは複数)に起因するビタミンD生成の低減の理由からビタミンDを補うのに治療上有効な量のビタミンDを含む、局所用日焼け止め製剤を提供することによって、当技術分野におけるある種の問題および必要性に取り組むものである。
少なくとも1つの日焼け止め剤を、皮膚に対する太陽光の曝露が低減しても最適なビタミンDレベルを維持するために治療上有効な量のビタミンDと組み合わせて有するように、日焼け止め製剤を当技術分野で認められた技術にしたがって調製する。
少なくとも1つの日焼け止め剤を、ビタミンD欠乏またはビタミンD不足の個体を治療するのに治療上有効な量のビタミンDと組み合わせて有し、それによってこのような個体におけるビタミンDレベルの増大をもたらし、同時に皮膚への太陽光の曝露に対する必要性を除去または低減し、それによって低ビタミンDレベルに伴う様々な疾患状態の発症を予防し得る日焼け止め製剤を、当技術分野で認められた技術にしたがって調製する。
少なくとも1つの日焼け止め剤を、ビタミンD欠乏および/またはビタミンD不足に伴う障害および/または疾患を治療するのに治療上有効な量のビタミンDと組み合わせて有するように、当技術分野で認められた技術にしたがって、日焼け止め製剤を調製する。本明細書において論じる通り、本発明の製剤を用いて治療され得るこのような障害および/または疾患は、例えば、制限なく、カルシウム取込みの低下に伴う障害および疾患;骨減少症、骨軟化症、骨粗鬆症およびくる病を含む骨関連障害および疾患;冠動脈疾患、高血圧および末梢動脈疾患を含む血管障害および疾患;多発性硬化症、線維筋症、関節リウマチ、グレーブス病および狼瘡を含む自己免疫障害および疾患;結核;歯周性の障害および疾患;慢性疼痛;季節的情動障害;認知障害;うつ病;I型糖尿病;慢性腎疾患;副甲状腺機能低下症;パーキンソン病、ならびに乳癌、前立腺癌、大腸癌および皮膚癌を含むあるタイプの癌を含む。
本明細書に提供する教示より、当業者であれば、1つまたは複数の日焼け止め剤および治療上有効な量のビタミンDを有する本発明の製剤を作成することができ、確立された動物モデル(例えば、制限なく、経皮的な薬物送達に適する動物モデル)において、慣例的な薬物動態分析および技術を用いてこのような本発明の製剤の安全性および有効性を試験することができ、また、このような本発明の製剤を特定の個体によって使用するのに、特定の活動の間に使用するのに、および/または特定の環境条件に曝露した場合に使用するのに適するようにする成分を用いて調製することができる。
本発明は、概ね上記で教示される通りであるが日焼け止め剤を含まない治療用ビタミンD製剤も含む。本実施例による製剤は、個体に(好ましくは1つまたは複数の適用において経皮的に)投与した場合に、個体の血清ビタミンDレベルを増大させるために治療上有効である量で存在するビタミンD化合物を含む。
Claims (11)
- (a)少なくとも1つの日焼け止め剤;(b)ビタミンD2又はビタミンD3[前記ビタミンD2又はビタミンD3は、哺乳動物に局所投与した場合に、前記哺乳動物の皮膚を介して吸収され、前記哺乳動物の血清ビタミンDレベルの測定可能な増大を生じるように、前記ビタミンD 2 またはビタミンD 3 は皮膚に送達され、血清中の、ビタミンD欠乏およびビタミンD不足に伴う障害及び疾患を予防および治療するのに治療上有効な量で治療用日焼け止め組成物中に存在する];並びに(c)前記少なくとも1つの日焼け止め剤および前記ビタミンD2又はビタミンD3の経皮投与を同時に局所投与するのに有効な医薬担体を含む、治療用日焼け止め組成物であって、
前記ビタミンD2又はビタミンD3は、アルコール担体の不存在下で、前記哺乳動物の皮膚を介して吸収されることが可能であり、光線への曝露をせずに、前記哺乳動物の血清ビタミンDレベルの測定可能な増大を生じる、治療用日焼け止め組成物。 - 前記ビタミンD2又はビタミンD3が、前記少なくとも1つの日焼け止め剤に起因する太陽光への曝露の低減による前記哺乳動物の天然のビタミンD生成の低減を補う量で存在する、請求項1に記載の治療用日焼け止め組成物。
- ビタミンD欠乏である、またはビタミンD不足である前記哺乳動物が、20ng/mL未満の血清(25−ヒドロキシ)ビタミンD濃度を有する、請求項1に記載の治療用日焼け止め組成物。
- ビタミンD欠乏である、またはビタミンD不足である前記哺乳動物が、30ng/mL未満の血清(25−ヒドロキシ)ビタミンD濃度を有する、請求項1に記載の治療用日焼け止め組成物。
- ビタミンD欠乏である、またはビタミンD不足である前記哺乳動物が、40ng/mL未満の血清(25−ヒドロキシ)ビタミンD濃度を有する、請求項1に記載の治療用日焼け止め組成物。
- ビタミンD欠乏である、またはビタミンD不足である前記哺乳動物が、100ng/mL未満の血清(25−ヒドロキシ)ビタミンD濃度を有する、請求項1に記載の治療用日焼け止め組成物。
- 前記ビタミンD2又はビタミンD3の前記哺乳動物への投与が、前記哺乳動物における20ng/mL〜100ng/mLの範囲での血清(25−ヒドロキシ)ビタミンD濃度をもたらす、請求項1に記載の治療用日焼け止め組成物。
- 前記ビタミンD2又はビタミンD3が、0.1IU/cm2〜1000IU/cm2の濃度の前記ビタミンD2又はビタミンD3の前記哺乳動物の皮膚への投与をもたらす濃度で前記組成物中に存在する、請求項1に記載の治療用日焼け止め組成物。
- 前記ビタミンD2又はビタミンD3が、0.1IU/cm2〜10.0IU/cm2の濃度の前記ビタミンD2又はビタミンD3の前記哺乳動物の皮膚への投与をもたらす濃度で前記組成物中に存在する、請求項1に記載の治療用日焼け止め組成物。
- 前記少なくとも1つの日焼け止め剤が、アミノ安息香酸、アボベンゾン、ベンゾフェノン、ベンゾフェノン−3、シンナメート、シノキセート、ジオキシベンゾン、エカムスル(ecamsule)、エンスリゾール(ensulizole)、エチルヘキシルp−メトキシシンナメート、ホモサレート、アントラニル酸メンチル、メラジメート(meradimate)、オクチノキサート、オクチサレート、オクトクリレン、オクチルジメチルpaba、メトキシケイヒ酸オクチル(OMC)、サリチル酸オクチル(OCS)、オキシベンゾン、パジメート−O、パラアミノ安息香酸(PABA)、parsol(登録商標)1789、サリチレート、スルイソベンゾン、スルイソベンゾン、二酸化チタン、トロラミンサリチレート、UV線吸収剤および酸化亜鉛からなる群から選択される、請求項1に記載の治療用日焼け止め組成物。
- さらに、1つ以上の以下のもの:少なくとも1つの皮膚軟化剤;少なくとも1つの皮膚コンディショニング剤;少なくとも1つの安定化剤;少なくとも1つの湿潤剤;少なくとも1つの乳化剤;少なくとも1つのコンディショニング剤;少なくとも1つの増粘剤;少なくとも1つの抗酸化剤;少なくとも1つのUV線吸収剤;またはこれらの混合物を含む、請求項1に記載の治療用日焼け止め組成物。
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US12/535,660 US8470304B2 (en) | 2009-08-04 | 2009-08-04 | Therapeutic vitamin D sun-protecting formulations and methods for their use |
US12/535,660 | 2009-08-04 | ||
PCT/US2010/044319 WO2011017380A1 (en) | 2009-08-04 | 2010-08-03 | Therapeutic vitamin d sun-protecting formulations and methods for their use |
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JP6189037B2 true JP6189037B2 (ja) | 2017-08-30 |
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CN (1) | CN102695418A (ja) |
AU (1) | AU2010279524A1 (ja) |
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US8470304B2 (en) | 2009-08-04 | 2013-06-25 | Avidas Pharmaceuticals Llc | Therapeutic vitamin D sun-protecting formulations and methods for their use |
US20110189114A1 (en) * | 2010-01-29 | 2011-08-04 | Nyangenya Maniga | minoxidil composition and non-aerosol, non-spray foam method of delivery therefor |
KR20140031227A (ko) * | 2011-03-24 | 2014-03-12 | 레오 파마 에이/에스 | 지질 나노입자들 및 코르티코스테로이드 또는 비타민 d 유도체를 포함하는 조성물 |
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CN102695418A (zh) | 2012-09-26 |
JP2013501067A (ja) | 2013-01-10 |
EP2461691A1 (en) | 2012-06-13 |
EP2461691A4 (en) | 2014-08-13 |
WO2011017380A1 (en) | 2011-02-10 |
CA2807463C (en) | 2018-07-10 |
US8709387B2 (en) | 2014-04-29 |
AU2010279524A1 (en) | 2012-03-29 |
BR112012002553A8 (pt) | 2017-10-31 |
JP2016041707A (ja) | 2016-03-31 |
US20130344014A1 (en) | 2013-12-26 |
US8470304B2 (en) | 2013-06-25 |
CA2807463A1 (en) | 2011-02-10 |
BR112012002553B1 (pt) | 2018-05-08 |
US20150050226A1 (en) | 2015-02-19 |
BR112012002553A2 (pt) | 2017-06-13 |
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