JP6122134B2 - 化粧品組成物及びメラニン合成を抑制するための方法 - Google Patents
化粧品組成物及びメラニン合成を抑制するための方法 Download PDFInfo
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- JP6122134B2 JP6122134B2 JP2015542056A JP2015542056A JP6122134B2 JP 6122134 B2 JP6122134 B2 JP 6122134B2 JP 2015542056 A JP2015542056 A JP 2015542056A JP 2015542056 A JP2015542056 A JP 2015542056A JP 6122134 B2 JP6122134 B2 JP 6122134B2
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- cosmetic composition
- skin
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- bisabolol
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- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 229940102398 methyl anthranilate Drugs 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000012184 mineral wax Substances 0.000 description 1
- 229910052901 montmorillonite Inorganic materials 0.000 description 1
- 235000011929 mousse Nutrition 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229960004738 nicotinyl alcohol Drugs 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical class C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- YAGMLECKUBJRNO-UHFFFAOYSA-N octyl 4-(dimethylamino)benzoate Chemical compound CCCCCCCCOC(=O)C1=CC=C(N(C)C)C=C1 YAGMLECKUBJRNO-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- BARWIPMJPCRCTP-UHFFFAOYSA-N oleic acid oleyl ester Natural products CCCCCCCCC=CCCCCCCCCOC(=O)CCCCCCCC=CCCCCCCCC BARWIPMJPCRCTP-UHFFFAOYSA-N 0.000 description 1
- BARWIPMJPCRCTP-CLFAGFIQSA-N oleyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCCOC(=O)CCCCCCC\C=C/CCCCCCCC BARWIPMJPCRCTP-CLFAGFIQSA-N 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000011368 organic material Substances 0.000 description 1
- 125000005702 oxyalkylene group Chemical group 0.000 description 1
- 229940101267 panthenol Drugs 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 235000020957 pantothenol Nutrition 0.000 description 1
- 239000011619 pantothenol Substances 0.000 description 1
- 125000001232 pantothenyl group Chemical group C(CCNC([C@H](O)C(C)(C)CO)=O)(=O)* 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical compound OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 239000013500 performance material Substances 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000013503 personal care ingredient Substances 0.000 description 1
- 229940057874 phenyl trimethicone Drugs 0.000 description 1
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 description 1
- 239000000419 plant extract Substances 0.000 description 1
- 229920002401 polyacrylamide Polymers 0.000 description 1
- 229920000570 polyether Polymers 0.000 description 1
- 238000006116 polymerization reaction Methods 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 229940100498 polysilicone-15 Drugs 0.000 description 1
- 229920002282 polysilicones-15 Polymers 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229940078491 ppg-15 stearyl ether Drugs 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- XLCIFRJORZNGEV-UHFFFAOYSA-N propan-2-yl 2-[dodecanoyl(methyl)amino]acetate Chemical compound CCCCCCCCCCCC(=O)N(C)CC(=O)OC(C)C XLCIFRJORZNGEV-UHFFFAOYSA-N 0.000 description 1
- 235000013772 propylene glycol Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229960003581 pyridoxal Drugs 0.000 description 1
- 235000008164 pyridoxal Nutrition 0.000 description 1
- 239000011674 pyridoxal Substances 0.000 description 1
- 235000008151 pyridoxamine Nutrition 0.000 description 1
- 239000011699 pyridoxamine Substances 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 201000004700 rosacea Diseases 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 238000007493 shaping process Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 230000009759 skin aging Effects 0.000 description 1
- 230000037075 skin appearance Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 125000004079 stearyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 210000000434 stratum corneum Anatomy 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 230000035882 stress Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000037072 sun protection Effects 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- BORJONZPSTVSFP-UHFFFAOYSA-N tetradecyl 2-hydroxypropanoate Chemical compound CCCCCCCCCCCCCCOC(=O)C(C)O BORJONZPSTVSFP-UHFFFAOYSA-N 0.000 description 1
- 235000019157 thiamine Nutrition 0.000 description 1
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
- 229960003495 thiamine Drugs 0.000 description 1
- 239000011721 thiamine Substances 0.000 description 1
- 230000008719 thickening Effects 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 150000003627 tricarboxylic acid derivatives Chemical class 0.000 description 1
- LINXHFKHZLOLEI-UHFFFAOYSA-N trimethyl-[phenyl-bis(trimethylsilyloxy)silyl]oxysilane Chemical compound C[Si](C)(C)O[Si](O[Si](C)(C)C)(O[Si](C)(C)C)C1=CC=CC=C1 LINXHFKHZLOLEI-UHFFFAOYSA-N 0.000 description 1
- 238000009281 ultraviolet germicidal irradiation Methods 0.000 description 1
- 238000002371 ultraviolet--visible spectrum Methods 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 238000001429 visible spectrum Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 239000003021 water soluble solvent Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000001052 yellow pigment Substances 0.000 description 1
Classifications
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
- A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Medical Informatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Description
化粧品組成物は、哺乳類のケラチン性組織、特にヒトの皮膚に塗布することができる。化粧品組成物はさまざまな形をとり得る。例えば、そうした形態の非限定的な例をいくつか挙げると、溶液、懸濁液、ローション、クリーム、ゲル、化粧水、スティック、ペンシル、スプレー、エアゾル、軟膏、クレンジング洗剤液およびクレンジング棒状固形物、シャンプー及びヘアコンディショナー、ペースト、フォーム、パウダー、ムース、髭剃りクリーム、ティッシュ、細片、パッチ、電気駆動パッチ、創傷被覆材及び粘着性包帯、ヒドロゲル、フィルム形成製品、顔面及び皮膚マスク、化粧品(例えば、ファンデーション、アイライナー及びアイシャドウ)等が含まれる。
バチルアルコールは次のような化学式で表され得る:
既に説明した成分に加えて、本明細書で説明される化粧品組成物は、1種類又は複数の他の成分も含み得る。化粧品組成物に一般に用いられる他の成分(例えば、スキンケア用活性物質)の非限定的な例、スキンケア用活性物質識別する方法、及び/又は化粧品組成物を処方する方法が、米国特許出願公開第2002/0022040号、同2003/0049212号、同2007/0196344号、同2008/0181956号、同2010/00092408号、同2008/0206373号、同2010/0239510号、同2010/0189669号、同2011/0262025号、同2011/0097286号、同2012/0197016号、同2012/0128683号、同2012/0148515号、同2012/0156146号、及び同2013/0022557号、並びに米国特許第5,939,082号、同5,872,112号、同6,492,326号、同6,696,049号、同6,524,598号、同5,972,359号、及び同6,174,533号に記載されている。
R3SiO[R2SiO]xSiR3
(式中、Rは、独立して、水素又はC1〜30直鎖又は分岐鎖、飽和又は不飽和アルキル、フェニル又はアリール、トリアルキルシロキシから選択され;xは、所望の分子量を得るために選択された0〜約10,000の整数である。)Rの非限定的な例は、水素、メチル、及びエチルを含む。市販のポリシロキサンとしては、ジメチコーンとしても既知である、ポリジメチルシロキサンが挙げられ、その例としては、Shin−Etsu社から販売されているDM−Fluidシリーズ、Momentive Performance Materials Inc.から販売されているVicasil(登録商標)シリーズ、及びDow Corning社から販売されるDow Corning(登録商標)200シリーズが挙げられる。好適なポリジメチルシロキサンの具体例としては、Dow Corning(登録商標)200流体(Xiameter(登録商標)PMX−200シリコーン流体としても市販)の粘度が0.65、1.5、50、100、350、10,000、12,500、100,000、及び300,000mm2/s(0.65、1.5、50、100、350、10,000、12,500、100,000、及び300,000センチストークス)のものが挙げられる。
R3SiO[R2SiO]x[RR’SiO]ySiR3
式中、R及びR’は、それぞれ独立して、水素又はC1〜30直鎖若しくは分岐鎖飽和若しくは不飽和アルキル、アリール若しくはトリアルキルシロキシであり、x及びyは、それぞれ、所望の分子量を得るために選択される1〜1,000,000の整数である。ジメチコンの非制限的例としては、フェニルジメチコン(Botanigenics,Inc.のBotansil(商標)PD−151)、ジフェニルジメチコン(Shin−Etsu社のKF−53及びKF−54)、フェニルトリメチコン(Dow Corning社の556コスメチックグレードフルイド)、又はトリメチルシロキシフェニルジメチコン(Wacker−BelsilのPDM−20、PDM−200、又はPDM−1000)が挙げられる。他の非制限的例としては、少なくともR’が脂肪族アルキル(例えば、C12〜22)であるアルキルジメチコンが挙げられる。好適なアルキルジメチコンは、R’がC16直鎖であり、Rがメチルである、セチルジメチコンである。セチルジメチコンは、2502コスメチック・フルイドとしてDow Corning社から、又はAbil Wax 9801若しくは9814としてEvonik Goldschmidt GmbHから入手可能である。
B16−F1マウス黒色腫細胞ラインが、メラニン合成を測定するためのアッセイとして用いられ得る。B16−F1細胞は、American Tissue Culture Collection,バージニア州、米国から入手できる。アッセイに使用できる細胞培養液には、500mLのDulbecco改変イーグル培地(DMEM)、50mLのウシ胎児血清(FBS)、及び5mLのペニシリン−ストレプトマイシン液を含みうる。この培地中で培養され、90%を越えるコンフルエンシーに増殖したB16−F1細胞は、メラニンを合成する。いかなる理論によっても縛られずに言えば、メラニン合成は培養液及び/又は高いコンフルエンシーへの増殖により誘導されるストレスにより刺激されると仮定される。DMEM及びFBSはAmerican Tissue culture Collectionから入手でき、ペニシリン−ストレプトマイシン液はInvitrogen,Inc.,カリフォルニア州、米国から入手できる。このアッセイで使用する機器は、Therma Scientific,マサチューセッツ州、米国によるForma Series Model 3110等のCO2インキュベーター、Hauser Scientific,ペンシルバニア州、米国によるBright Lineモデル等の血球計、及びMolecular Devices,カリフォルニア州、米国からのSpectraMax250等の紫外線可視スペクトルプレートリーダーを含む。アッセイのステップは、以下のものを含み得る:
第0日−細胞増殖。細胞培養液を摂氏37度に温め、29mLをT−150フラスコ内に配置する。T−150フラスコにおよそ1×106のB16−F1継代1マウス細胞を加え、摂氏37度、5%のCO2、90%の相対湿度で、約80%のコンフルエンシー迄、3日間インキュベートする。
第3日−96ウェルプレートの開始。第3日にT−150フラスコからの細胞をトリプシン処理し、血球計数器を使用して細胞濃度を測定する。96ウェルプレートを1ウェル当たり2,500細胞、細胞培養液100μLで開始する。プレートを摂氏37度で、5%のCO2、90%の相対湿度で、少なくとも20%〜40%のコンフルエンシー迄、2日間インキュベートする。
第5日−プレートから細胞培養液を除去し、新鮮な培養液(100μL/ウェル)で置き換える。[水又はDSMO]溶媒で希釈した[試験化合物]1μLを添加する。複数の希釈比を試験して用量応答曲線を生成してもよく、好ましくは3つのウェルを各希釈比で処理する。対照は、細胞培養培地、B16−F1細胞と、溶媒(対照#1)とを含むウェル;細胞培養培地と溶媒とを含むウェル(対照#2);並びに、細胞培養培地と、溶媒と、[試験化合物]のバックグラウンド色を制御する必要がある場合には[試験化合物]とを含む任意的なウェル(対照#3)とから構成される。
7日目−メラニン生成を測定する:細胞は集密度が約90%超の状態であるべきである。そうでない場合、このデータ点を使用しない。各ウェルに100μLの0.75%水酸化ナトリウム溶液を加える。UV−Visプレートリーダーを使用して、96ウェルプレートを410nmにて読み取り、[試験化合物]で処理されたウェルと、試験化合物で処理されなかった対照ウェルとの間で、生成されたメラニンの量を光学的に測定する。メラニンが生成されたウェルは、通常、茶色がかって見える。メラニンが殆ど生成されなかったウェルは、通常、透明から薄紫色に見える。メラニン合成阻害の百分率は、以下の式により計算する。
本明細書に開示される化粧品組成物は、1つ又は複数の皮膚表面及び/又は1つ又は複数の哺乳類のケラチン性組織表面に、使用者の毎日のルーティン又はレジメンの一部として塗布されてよい。更に又はあるいは、本明細書における化粧品組成物は、「必要に応じて」方式で用いてよい。いくつかの例においては、有効な量の化粧品組成物が、ケラチン性組織又は皮膚の標的部位に塗布されてよい。いくつかの例においては、化粧品組成物は、適用のレジメンを詳しく説明した説明書とともにパッケージに入れて提供され得る。
Claims (28)
- a.N−ウンデシレノイル−L−フェニルアラニンと、
b.ヘキシルデカノールと、
c.ビサボロールと、及び
d.バチルアルコールとを含む、化粧品組成物。 - メラニン合成を減らす方法であって、
a.メラニンを減らすことが必要なケラチン性組織の標的部位を識別するステップと、及び
b.前記ケラチン性組織の前記標的部位に、有効な量の化粧品組成物を局所的に塗布するステップとを含み、該化粧品組成物は、
i.N−ウンデシレノイル−L−フェニルアラニンと、
ii.ヘキシルデカノールと、
iii.ビサボロールと、及び
iv.バチルアルコールとを含む、方法。 - 前記組成物が、ビタミンB化合物を更に含む、請求項1に記載の化粧品組成物。
- 前記ビタミンB化合物がナイアシンアミドを含む、請求項3に記載の化粧品組成物。
- 前記ナイアシンアミドは、前記化粧品組成物の、11重量%未満の濃度である、請求項4に記載の化粧品組成物。
- 前記ヘキシルデカノールは、前記化粧品組成物の、0.01重量%〜8重量%、好ましくは0.05重量%〜5重量%の濃度である、請求項1および3〜5のいずれか1項に記載の化粧品組成物。
- 前記バチルアルコールは、前記化粧品組成物の、0.03重量%〜5重量%、好ましくは0.03重量%〜2重量%の濃度である、請求項1および3〜6のいずれか1項に記載の化粧品組成物。
- 前記ビサボロールは、前記化粧品組成物の、0.003重量%〜2重量%の濃度である、請求項1および3〜7のいずれか1項に記載の化粧品組成物。
- 前記N−ウンデシレノイル−L−フェニルアラニンは、前記化粧品組成物の、0.01重量%〜2重量%の濃度である、請求項1および3〜8のいずれか1項に記載の化粧品組成物。
- 前記化粧品組成物が、紫外線活性物質を更に含む、請求項1および3〜9のいずれか1項に記載の化粧品組成物。
- 前記化粧品組成物が、グリセリンを更に含む、請求項1および3〜10のいずれか1項に記載の化粧品組成物。
- 前記化粧品組成物が、ヒドロキシ桂皮酸、イノシトール、カンゾウ抽出物、グリチルレチン酸、グラブリジン、ビタミンEのコハク酸塩、サリチル酸、カラフトコンブ抽出物、ベンガルボダイジュ抽出物、N−アセチルグルコサミン、及びそれらの組み合わせよりなる群から選択される物質を更に含む、請求項1および3〜11のいずれか1項に記載の化粧品組成物。
- 前記化粧品組成物は、油中水型乳液、水中油型乳液、又はシリコーン中水型乳液の形で提供される、請求項1および3〜12のいずれか1項に記載の化粧品組成物。
- 前記化粧品組成物がパッケージで提供され、該パッケージが、前記化粧品組成物を適用するためのレジメンの指示書を更に含む、請求項1および3〜13のいずれか1項に記載の化粧品組成物。
- 前記適用のレジメンは、少なくとも毎日1回である、請求項14に記載の化粧品組成物。
- 前記組成物が、ビタミンB化合物を更に含む、請求項2に記載の方法。
- 前記ビタミンB化合物がナイアシンアミドを含む、請求項16に記載の方法。
- 前記ナイアシンアミドは、前記化粧品組成物の、11重量%未満の濃度である、請求項17に記載の方法。
- 前記ヘキシルデカノールは、前記化粧品組成物の、0.01重量%〜8重量%、好ましくは0.05重量%〜5重量%の濃度である、請求項2および16〜18のいずれか1項に記載の方法。
- 前記バチルアルコールは、前記化粧品組成物の、0.03重量%〜5重量%、好ましくは0.03重量%〜2重量%の濃度である、請求項2および16〜19のいずれか1項に記載の方法。
- 前記ビサボロールは、前記化粧品組成物の、0.003重量%〜2重量%の濃度である、請求項2および16〜20のいずれか1項に記載の方法。
- 前記N−ウンデシレノイル−L−フェニルアラニンは、前記化粧品組成物の、0.01重量%〜2重量%の濃度である、請求項2および16〜21のいずれか1項に記載の方法。
- 前記化粧品組成物が、紫外線活性物質を更に含む、請求項2および16〜22のいずれか1項に記載の方法。
- 前記化粧品組成物が、グリセリンを更に含む、請求項2および16〜23のいずれか1項に記載の方法。
- 前記化粧品組成物が、ヒドロキシ桂皮酸、イノシトール、カンゾウ抽出物、グリチルレチン酸、グラブリジン、ビタミンEのコハク酸塩、サリチル酸、カラフトコンブ抽出物、ベンガルボダイジュ抽出物、N−アセチルグルコサミン、及びそれらの組み合わせよりなる群から選択される物質を更に含む、請求項2および16〜24のいずれか1項に記載の方法。
- 前記化粧品組成物は、油中水型乳液、水中油型乳液、又はシリコーン中水型乳液の形で提供される、請求項2および16〜25のいずれか1項に記載の方法。
- 前記化粧品組成物がパッケージで提供され、該パッケージが、前記化粧品組成物を適用するためのレジメンの指示書を更に含む、請求項2および16〜26のいずれか1項に記載の方法。
- 前記適用のレジメンは、少なくとも毎日1回である、請求項27に記載の方法。
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