JP5996837B2 - インフルエンザウイルスの感染抑制剤 - Google Patents
インフルエンザウイルスの感染抑制剤 Download PDFInfo
- Publication number
- JP5996837B2 JP5996837B2 JP2010122582A JP2010122582A JP5996837B2 JP 5996837 B2 JP5996837 B2 JP 5996837B2 JP 2010122582 A JP2010122582 A JP 2010122582A JP 2010122582 A JP2010122582 A JP 2010122582A JP 5996837 B2 JP5996837 B2 JP 5996837B2
- Authority
- JP
- Japan
- Prior art keywords
- influenza virus
- infection
- pectin
- nucleic acid
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/732—Pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
以下に、ペクチンと核酸とを含むインフルエンザウイルスの感染抑制剤の一実施例を示す。図1及び2は、赤血球凝集抑制試験の結果を示している。図1及び2において、ペクチンには、柑橘類の果皮由来のペクチン(CP Kelo社製:GENU pectin(citrus) type USP-L、ガラクツロン酸74%以上、メトキシル基率6.7以上)を用いた。核酸には、サケ白子由来のDNA(大和化成社製:DNA−Na、Lot:DN-JD0603)を用いた。感染抑制剤中におけるペクチンとDNAとの質量比は、1:1とした。
Claims (2)
- ペクチンと、
核酸と
を含む混合物を含み、
前記ペクチンと核酸との混合物の濃度は、0.04%以上であり、前記ペクチンの濃度は0.01%以上であり、前記核酸の濃度は0.01%以上であり、
前記ペクチンは、分子量が50000 Da以上であり、前記核酸は、分子量が10000 Da以上であり、
鼻若しくは口腔の粘膜細胞に作用させるための、ヘマグルチニンの機能を阻害してインフルエンザウイルスの細胞への侵入を阻害する、インフルエンザウイルスの細胞侵入阻害剤。 - 前記核酸が、デオキシリボ核酸であることを特徴とする、請求項1に記載の細胞侵入阻害剤。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010122582A JP5996837B2 (ja) | 2010-05-28 | 2010-05-28 | インフルエンザウイルスの感染抑制剤 |
EP11786351.4A EP2578220A4 (en) | 2010-05-28 | 2011-05-27 | INHIBITOR OF INFLUENZA VIRUS INFECTION |
US13/700,343 US20130137757A1 (en) | 2010-05-28 | 2011-05-27 | Inhibitor of influenza virus infection |
PCT/JP2011/002973 WO2011148648A1 (ja) | 2010-05-28 | 2011-05-27 | インフルエンザウイルスの感染抑制剤 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010122582A JP5996837B2 (ja) | 2010-05-28 | 2010-05-28 | インフルエンザウイルスの感染抑制剤 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015030727A Division JP6211023B2 (ja) | 2015-02-19 | 2015-02-19 | インフルエンザウイルスの感染抑制剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011246409A JP2011246409A (ja) | 2011-12-08 |
JP5996837B2 true JP5996837B2 (ja) | 2016-09-21 |
Family
ID=45003646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010122582A Active JP5996837B2 (ja) | 2010-05-28 | 2010-05-28 | インフルエンザウイルスの感染抑制剤 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20130137757A1 (ja) |
EP (1) | EP2578220A4 (ja) |
JP (1) | JP5996837B2 (ja) |
WO (1) | WO2011148648A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1625851A4 (en) * | 2003-05-16 | 2007-12-26 | Bbk Bio Corp | PREPARATION FOR PREVENTING CONTACT OF PATHOGEN BROOMS WITH A LIVING ORGANISM |
JP6211023B2 (ja) * | 2015-02-19 | 2017-10-11 | 小林製薬株式会社 | インフルエンザウイルスの感染抑制剤 |
AU2018356377A1 (en) | 2017-10-23 | 2020-05-07 | Nutrileads B.V. | Enzymatically hydrolysed pectic polysaccharides for treating or preventing infections |
AU2017441954A1 (en) | 2017-12-04 | 2020-07-16 | Nutrileads B.V. | Composition for use in the prevention or treatment of salmonellosis |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01199915A (ja) * | 1986-11-29 | 1989-08-11 | Ueno Seiyaku Oyo Kenkyusho:Kk | ウイルス性疾患処置剤 |
JP3201812B2 (ja) * | 1992-01-20 | 2001-08-27 | 日本たばこ産業株式会社 | 低分子ペクチン及びこれを配合してなる飲食品 |
FR2745980B1 (fr) * | 1996-03-15 | 1998-06-05 | Utilisation de pectines depolymerisees d'agrumes et de pommes a titre d'agents emulsifiants et stabilisants d'emulsions | |
WO1998048626A1 (en) * | 1997-04-30 | 1998-11-05 | Emory University | Methods and compositions for administering dna to mucosal surfaces |
JPH10298082A (ja) * | 1997-04-30 | 1998-11-10 | Snow Brand Milk Prod Co Ltd | 骨強化剤 |
US6362225B1 (en) * | 1999-01-21 | 2002-03-26 | George Andreakos | Target therapies for treating common viral infections |
US7494669B2 (en) * | 2001-02-28 | 2009-02-24 | Carrington Laboratories, Inc. | Delivery of physiological agents with in-situ gels comprising anionic polysaccharides |
KR20040073438A (ko) * | 2001-11-19 | 2004-08-19 | 벡톤 디킨슨 앤드 컴퍼니 | 입자 형태의 약제학적 조성물 |
JP4216013B2 (ja) | 2002-07-26 | 2009-01-28 | 株式会社ロッテ | 抗インフルエンザウイルス剤 |
WO2004073652A2 (en) * | 2003-02-20 | 2004-09-02 | Becton Dickinson And Company | Powder formulations of recombinant staphylococcal enterotoxin b (rseb) made by atmospheric spray-freeze drying for improved vaccination |
US7786279B2 (en) * | 2003-02-27 | 2010-08-31 | Yeda Research And Development Co. Ltd. | Nucleic acid molecules, polypeptides, antibodies and compositions for treating and detecting influenza virus infection |
EP1625851A4 (en) * | 2003-05-16 | 2007-12-26 | Bbk Bio Corp | PREPARATION FOR PREVENTING CONTACT OF PATHOGEN BROOMS WITH A LIVING ORGANISM |
JP4669670B2 (ja) | 2004-06-04 | 2011-04-13 | 株式会社ロッテ | 抗インフルエンザウイルス剤及びこれを吸着、含浸、添加させてなるインフルエンザ感染抑制用品 |
EP1634599A1 (en) * | 2004-08-20 | 2006-03-15 | N.V. Nutricia | Iimmune stimulatory infant nutrition |
JP2007223970A (ja) | 2006-02-24 | 2007-09-06 | Morinaga & Co Ltd | トリインフルエンザウイルス感染阻害剤 |
JP5114173B2 (ja) * | 2007-11-30 | 2013-01-09 | 株式会社マルハニチロ食品 | 飲料への配合に適した核酸素材及びその製造方法 |
-
2010
- 2010-05-28 JP JP2010122582A patent/JP5996837B2/ja active Active
-
2011
- 2011-05-27 WO PCT/JP2011/002973 patent/WO2011148648A1/ja active Application Filing
- 2011-05-27 EP EP11786351.4A patent/EP2578220A4/en not_active Withdrawn
- 2011-05-27 US US13/700,343 patent/US20130137757A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP2011246409A (ja) | 2011-12-08 |
WO2011148648A1 (ja) | 2011-12-01 |
EP2578220A1 (en) | 2013-04-10 |
EP2578220A4 (en) | 2013-11-20 |
US20130137757A1 (en) | 2013-05-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Yong et al. | RIG-I-like receptors as novel targets for pan-antivirals and vaccine adjuvants against emerging and re-emerging viral infections | |
JP5996837B2 (ja) | インフルエンザウイルスの感染抑制剤 | |
AU2017224113B2 (en) | Compositions and methods for protecting against airborne pathogens and irritants | |
CN101616687B (zh) | 非特异性免疫刺激剂 | |
JP2012176990A5 (ja) | ||
EP2846767B1 (en) | Polyinosinic-polycytidylic acid (poly (i:c)) formulations for the treatment of upper respiratory tract infections | |
WO2019046426A1 (en) | COMPOSITIONS AND METHODS FOR PROTECTING PATHOGENS AND IRRITANTS IN AIR SUSPENSION | |
WO2015039010A2 (en) | Deoxynojirimycin derivatives and methods of their using | |
JP2016065037A (ja) | 抗ウイルス剤の製法及び該製法によって得られた抗ウイルス剤 | |
US20230270802A1 (en) | Antiviral pharmaceutical composition | |
JP6317798B2 (ja) | インフルエンザウイルスの感染抑制剤 | |
JP6211023B2 (ja) | インフルエンザウイルスの感染抑制剤 | |
WO2010147472A1 (en) | Inhibition of nfk-b mediated virus replication with specific oligosaccharides | |
R Aghasadeghi et al. | Lamivudine-PEGylated chitosan: A novel effective nanosized antiretroviral agent | |
WO2017201030A1 (en) | Methods of treating viral infection | |
US20220125827A1 (en) | Application of Sulfated Polysaccharides in Resisting novel Coronavirus | |
TW201110978A (en) | Arabinogalactan for enhancing the adaptive immune response | |
EP2486931B1 (en) | Therapeutic agent for influenza virus infectious diseases | |
US20060154896A1 (en) | Phosphorylated dextrans | |
JP2006036666A (ja) | ケモカイン受容体ccr10の発現誘導剤 | |
Bălan | Integrative bioinformatic analysis of SARs-CoV-2 data | |
Lundahl | The Immunomodulatory Properties of L-Rhamnose | |
WO2021171225A1 (en) | Antimicrobial agents based on beta-glucans, methods for producing and use thereof | |
JP2005060288A (ja) | 免疫賦活剤及び抗腫瘍剤 | |
JP2024508368A (ja) | 新規なシアロシド及び治療におけるそれらの使用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20130520 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20140729 |
|
A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20140730 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20140730 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20140929 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20141119 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150219 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20150305 |
|
A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20150403 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160509 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160707 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20160825 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 5996837 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |