JP2011246409A - インフルエンザウイルスの感染抑制剤 - Google Patents
インフルエンザウイルスの感染抑制剤 Download PDFInfo
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- JP2011246409A JP2011246409A JP2010122582A JP2010122582A JP2011246409A JP 2011246409 A JP2011246409 A JP 2011246409A JP 2010122582 A JP2010122582 A JP 2010122582A JP 2010122582 A JP2010122582 A JP 2010122582A JP 2011246409 A JP2011246409 A JP 2011246409A
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- Prior art keywords
- influenza virus
- infection
- nucleic acid
- pectin
- infection inhibitor
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/732—Pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
【解決手段】インフルエンザウイルスの感染抑制剤は、ペクチンと核酸とを含む混合物である。
【選択図】なし
Description
以下に、ペクチンと核酸とを含むインフルエンザウイルスの感染抑制剤の一実施例を示す。図1及び2は、赤血球凝集抑制試験の結果を示している。図1及び2において、ペクチンには、柑橘類の果皮由来のペクチン(CP Kelo社製:GENU pectin(citrus) type USP-L、ガラクツロン酸74%以上、メトキシル基率6.7以上)を用いた。核酸には、サケ白子由来のDNA(大和化成社製:DNA−Na、Lot:DN-JD0603)を用いた。感染抑制剤中におけるペクチンとDNAとの質量比は、1:1とした。
Claims (4)
- ペクチンと、
核酸とを含む混合物であることを特徴とするインフルエンザウイルスの感染抑制剤。 - 前記ペクチンと核酸との混合物の濃度は、0.04%以上であり、
前記ペクチンの濃度は0.01%以上であり、
前記核酸の濃度は0.01%以上であることを特徴とする請求項1に記載の感染抑制剤。 - 前記ペクチンは、分子量が50000Da以上であり、
前記核酸は、分子量が10000Da以上であることを特徴とする請求項1又は2に記載の感染抑制剤。 - 前記核酸は、デオキシリボ核酸であることを特徴とする請求項1〜3のいずれか1項に記載の感染抑制剤。
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010122582A JP5996837B2 (ja) | 2010-05-28 | 2010-05-28 | インフルエンザウイルスの感染抑制剤 |
EP11786351.4A EP2578220A4 (en) | 2010-05-28 | 2011-05-27 | INHIBITOR OF INFLUENZA VIRUS INFECTION |
US13/700,343 US20130137757A1 (en) | 2010-05-28 | 2011-05-27 | Inhibitor of influenza virus infection |
PCT/JP2011/002973 WO2011148648A1 (ja) | 2010-05-28 | 2011-05-27 | インフルエンザウイルスの感染抑制剤 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2010122582A JP5996837B2 (ja) | 2010-05-28 | 2010-05-28 | インフルエンザウイルスの感染抑制剤 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2015030727A Division JP6211023B2 (ja) | 2015-02-19 | 2015-02-19 | インフルエンザウイルスの感染抑制剤 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011246409A true JP2011246409A (ja) | 2011-12-08 |
JP5996837B2 JP5996837B2 (ja) | 2016-09-21 |
Family
ID=45003646
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2010122582A Active JP5996837B2 (ja) | 2010-05-28 | 2010-05-28 | インフルエンザウイルスの感染抑制剤 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20130137757A1 (ja) |
EP (1) | EP2578220A4 (ja) |
JP (1) | JP5996837B2 (ja) |
WO (1) | WO2011148648A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015096558A (ja) * | 2015-02-19 | 2015-05-21 | 小林製薬株式会社 | インフルエンザウイルスの感染抑制剤 |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4851185B2 (ja) * | 2003-05-16 | 2012-01-11 | ジェレックスインターナショナル株式会社 | アレルギー症状抑制剤及び空気濾過フィルター |
CA3079933A1 (en) | 2017-10-23 | 2019-05-02 | Nutrileads B.V. | Enzymatically hydrolysed pectic polysaccharides for treating or preventing infections |
WO2019112418A1 (en) | 2017-12-04 | 2019-06-13 | Nutrileads B.V. | Composition for use in the prevention or treatment of salmonellosis |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH01199915A (ja) * | 1986-11-29 | 1989-08-11 | Ueno Seiyaku Oyo Kenkyusho:Kk | ウイルス性疾患処置剤 |
JPH05252972A (ja) * | 1992-01-20 | 1993-10-05 | Japan Tobacco Inc | 低分子ペクチン及びこれを配合してなる飲食品 |
JPH104894A (ja) * | 1996-03-15 | 1998-01-13 | Syst Bio Ind | 低分子化した柑橘類の果実やリンゴのペクチンの乳化剤および乳化安定剤としての使用 |
JPH10298082A (ja) * | 1997-04-30 | 1998-11-10 | Snow Brand Milk Prod Co Ltd | 骨強化剤 |
WO2004100966A1 (ja) * | 2003-05-16 | 2004-11-25 | Bbk Bio Corporation | 病態起因物質の生体への接触防止用製剤 |
JP2005518430A (ja) * | 2001-11-19 | 2005-06-23 | ベクトン・ディキンソン・アンド・カンパニー | 微粒子形態の薬剤組成物 |
JP2006518748A (ja) * | 2003-02-20 | 2006-08-17 | ベクトン・ディキンソン・アンド・カンパニー | 改良されたワクチン接種のための大気圧噴霧凍結乾燥によって作製される組換えブドウ球菌エンテロトキシンb(<sb>r</sb>seb)の粉末処方物 |
JP2007504129A (ja) * | 2003-08-29 | 2007-03-01 | デルサイト バイオテクノロジーズ, インコーポレイテッド | 陰イオン性多糖類を含むインサイチュゲルでの生理学的な薬剤の送達 |
JP2008510689A (ja) * | 2004-08-20 | 2008-04-10 | ナムローゼ フェンノートシャップ ヌトリシア | 免疫刺激性乳児用栄養 |
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AU7563798A (en) * | 1997-04-30 | 1998-11-24 | Emory University | Methods and compositions for administering dna to mucosal surfaces |
US6362225B1 (en) * | 1999-01-21 | 2002-03-26 | George Andreakos | Target therapies for treating common viral infections |
JP4216013B2 (ja) | 2002-07-26 | 2009-01-28 | 株式会社ロッテ | 抗インフルエンザウイルス剤 |
WO2004076621A2 (en) * | 2003-02-27 | 2004-09-10 | Yeda Research And Development Co. Ltd. | Compositions of nucleic acids for treating and detecting influenza virus |
JP4669670B2 (ja) | 2004-06-04 | 2011-04-13 | 株式会社ロッテ | 抗インフルエンザウイルス剤及びこれを吸着、含浸、添加させてなるインフルエンザ感染抑制用品 |
JP2007223970A (ja) | 2006-02-24 | 2007-09-06 | Morinaga & Co Ltd | トリインフルエンザウイルス感染阻害剤 |
JP5114173B2 (ja) * | 2007-11-30 | 2013-01-09 | 株式会社マルハニチロ食品 | 飲料への配合に適した核酸素材及びその製造方法 |
-
2010
- 2010-05-28 JP JP2010122582A patent/JP5996837B2/ja active Active
-
2011
- 2011-05-27 EP EP11786351.4A patent/EP2578220A4/en not_active Withdrawn
- 2011-05-27 WO PCT/JP2011/002973 patent/WO2011148648A1/ja active Application Filing
- 2011-05-27 US US13/700,343 patent/US20130137757A1/en not_active Abandoned
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH01199915A (ja) * | 1986-11-29 | 1989-08-11 | Ueno Seiyaku Oyo Kenkyusho:Kk | ウイルス性疾患処置剤 |
JPH05252972A (ja) * | 1992-01-20 | 1993-10-05 | Japan Tobacco Inc | 低分子ペクチン及びこれを配合してなる飲食品 |
JPH104894A (ja) * | 1996-03-15 | 1998-01-13 | Syst Bio Ind | 低分子化した柑橘類の果実やリンゴのペクチンの乳化剤および乳化安定剤としての使用 |
JPH10298082A (ja) * | 1997-04-30 | 1998-11-10 | Snow Brand Milk Prod Co Ltd | 骨強化剤 |
JP2005518430A (ja) * | 2001-11-19 | 2005-06-23 | ベクトン・ディキンソン・アンド・カンパニー | 微粒子形態の薬剤組成物 |
JP2005532987A (ja) * | 2001-11-19 | 2005-11-04 | ベクトン・ディキンソン・アンド・カンパニー | 微粒子形態の薬剤組成物 |
JP2006518748A (ja) * | 2003-02-20 | 2006-08-17 | ベクトン・ディキンソン・アンド・カンパニー | 改良されたワクチン接種のための大気圧噴霧凍結乾燥によって作製される組換えブドウ球菌エンテロトキシンb(<sb>r</sb>seb)の粉末処方物 |
WO2004100966A1 (ja) * | 2003-05-16 | 2004-11-25 | Bbk Bio Corporation | 病態起因物質の生体への接触防止用製剤 |
JP2007504129A (ja) * | 2003-08-29 | 2007-03-01 | デルサイト バイオテクノロジーズ, インコーポレイテッド | 陰イオン性多糖類を含むインサイチュゲルでの生理学的な薬剤の送達 |
JP2008510689A (ja) * | 2004-08-20 | 2008-04-10 | ナムローゼ フェンノートシャップ ヌトリシア | 免疫刺激性乳児用栄養 |
Non-Patent Citations (1)
Title |
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JPN6014031018; The Journal of Experimental Medicine 86, 1947, 55-64 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2015096558A (ja) * | 2015-02-19 | 2015-05-21 | 小林製薬株式会社 | インフルエンザウイルスの感染抑制剤 |
Also Published As
Publication number | Publication date |
---|---|
JP5996837B2 (ja) | 2016-09-21 |
EP2578220A4 (en) | 2013-11-20 |
US20130137757A1 (en) | 2013-05-30 |
EP2578220A1 (en) | 2013-04-10 |
WO2011148648A1 (ja) | 2011-12-01 |
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