JP5983908B2 - 抗炎症剤および皮膚外用品 - Google Patents
抗炎症剤および皮膚外用品 Download PDFInfo
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- JP5983908B2 JP5983908B2 JP2007341983A JP2007341983A JP5983908B2 JP 5983908 B2 JP5983908 B2 JP 5983908B2 JP 2007341983 A JP2007341983 A JP 2007341983A JP 2007341983 A JP2007341983 A JP 2007341983A JP 5983908 B2 JP5983908 B2 JP 5983908B2
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- Prior art keywords
- skin
- acid
- camellia
- inflammation
- defatted
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Landscapes
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Description
長崎県五島産ヤブツバキ(C.japonica var.japonica)の乾燥種子を粗粉砕して蒸煮後、圧搾して圧搾油を分離した圧搾粕を得、次いで圧搾粕にノルマルヘキサンを加えて常法により抽出処理し、抽出液を分離して抽出粕を採取した。この抽出粕をノルマルヘキサンで洗浄して油分を取り除き脱脂粕を採取した。この脱脂粕100gに水400mLを加え、常圧下、85℃に加熱して1時間適宜に撹拌した後、室温まで冷却し、濾過して濾液を分離した。この濾過残渣に再度水200mLを加えて同様に加熱し、冷却後、濾過して濾液を採取した。両濾液を合わせて減圧下に濃縮し、凍結乾燥及び粉砕して、本発明に係る水性成分を含む粉末(試料1とする)15.8gを得た。この粉末は、これを加水分解してHPLC分析したところ、サポニンのアグリコンであるサポゲニンを15.2%、フラボノールの一種であるケンフェロールを2.8%含むものであった。
屋久島産リンゴツバキ(C.japonica var.macrocarpa)の乾燥種子を製造例1に記載の方法で脱脂して脱脂粕を採取した。この脱脂粕100gに水400mLを加え、2気圧の加圧下、120℃で25分間加熱した後、室温まで冷却し、濾過して濾液を分離した。この濾過残渣に再度水200mLを加えて同様に加熱し、冷却後、濾過して濾液を採取した。両濾液を合わせて減圧下に濃縮し、凍結乾燥及び粉砕して、本発明に係る水性成分を含む粉末(試料2とする)16.4gを得た。該粉末を製造例1と同様に加水分解してHPLC分析した結果、サポゲニン含量は13.7%であり、ケンフェロール含量は2.2%であった。
製造例1に記載の方法で得た脱脂粕100gに含水エタノール(含水率35%)300mLを加え、80℃で1時間加熱還流した後、室温まで冷却し、濾過して濾液を分離した。この濾過残渣に再度含水エタノール(含水率35%)200mLを加えて同様に加熱し、冷却後、濾過して濾液を採取した。両濾液を合わせて減圧下に濃縮し、凍結乾燥及び粉砕して、本発明に係る水性成分を含む粉末(試料3とする)11.3gを得た。該粉末を製造例1と同様に加水分解してHPLC分析した結果、サポゲニン含量は11.3%であり、ケンフェロール含量は2.7%』であった。
製造例2に記載の方法で得た脱脂粕100gにエタノール(純度99.5%)300mLを加え、80℃で1時間加熱還流した後、室温まで冷却し、濾過して濾液を分離した。この濾過残渣に再度エタノール(純度99.5%)200mLを加えて同様に加熱し、冷却後、濾過して濾液を採取した。両濾液を合わせて減圧下に濃縮し、凍結乾燥及び粉砕して、本発明に係る水性成分を含む粉末(試料4とする)4.5gを得た。該粉末を製造例1と同様に加水分解してHPLC分析した結果、サポゲニン含量は13.0%であり、ケンフェロール含量は2.7%であった。
本発明に係る水性成分を含む粉末(試料1〜試料4)が、紫外線暴露によって生じる皮膚の炎症の軽減に及ぼす影響を以下の方法で調べた。すなわち、ヘアレスマウス(HR−1/Hos、雄性、7週齢、36匹(1群6匹))を用い、その背部の一定面積部位に紫外線照射(UV−B、強度:30mJ/cm2、ATTO社製UVランプ使用)を1日1回、1回につき1分間の割合で7日間行った。この間毎日、紫外線照射直後に0.1%の濃度で精製水に溶かした被験物質(試料1〜試料4)水溶液又は精製水の各0.5mlを5×4cmの滅菌ガーゼに染み込ませ背部に塗布した。
スクワラン:10部、ステアリン酸:5部、セタノール:3部及びステアリン酸モノグリセリド:3部からなる油相成分を80℃にて加熱溶解し、一方、グリセリン:15部、パラオキシ安息香酸メチル:0.1部、カルボキシビニルポリマー(1%水溶液):10部、ポリグリセリン(平均重合度4)モノオレアート:3部、アルギニン(20%水溶液):15部、試料2:1部及び精製水:34.9部からなる水相成分を80℃にて加熱溶解した。この水相成分に前記油相成分を撹拌しながら加え、ホモジナイザーにより均一に乳化して試験用クリームを調製した。又、このクリームにおいて、試料2を配合しない比較用クリーム(精製水で調整)を調製した。ボランティアの健康な成人女性10名(22歳〜54歳、平均年齢:31.0歳)の左手に試験用クリームを、右手に比較用クリームをそれぞれ1日2回塗布して2ヵ月間(7月〜8月)日常生活をしてもらい、皮膚への影響をアンケート調査(3段階評価)した。
以下に示す処方(数値は全て重量%)を用いて各種皮膚外用品を試作した。
(1)ローション
(a)ソルビット 2
(b)1,3−ブチレングリコール 4
(c)ポリエチレングリコール1000 2
(d)エタノール 10
(e)試料1 1
(f)防腐剤(メチルパラベン) 適量
(g)精製水 残量
(a)〜(f)を80℃に加熱した(g)に加え、撹拌して溶解した後、室温まで冷却して容器に充填した。
(a)スクワラン 4
(b)ワセリン 1
(c)ステアリルアルコール 0.5
(d)ソルビタンモノステアラート 1.5
(e)ポリオキシエチレン(20)ソルビタンモノオレアート 3
(f)1,3−ブチレングリコール 5
(g)試料2 0.1
(h)茶カテキン 0.1
(i)精製水 残量
(a)〜(d)を80℃で加熱溶解して油相成分とし、(e)〜(i)を80℃で加熱溶解して水相成分とした。同温度にて、水相成分に油相成分を撹拌しながら加え、ホモジナイザーにより均一に乳化した後、室温まで冷却、脱気して容器に充填した。この乳液は肌の炎症を抑制するために利用できる。
(a)スクワラン 20
(b)ミツロウ 5
(c)ホホバ油 5
(d)ソルビタンモノステアラート 1
(e)グリセリンモノオレアレート 3
(f)ポリオキシエチレン(20)ソルビタンモノステアラート 3
(g)グリセリン 5
(h)試料3 5
(i)N−アセチルグルコサミン 2
(j)精製水 残量
(a)〜(e)を80℃で加熱溶解して油相成分とし、(f)〜(j)を80℃で加熱溶解して水相成分とした。同温度にて、水相成分に油相成分を撹拌しながら加え、ホモジナイザーにより均一に乳化した後、室温まで冷却、脱気して容器に充填した。このクリームは抗炎症用の皮膚外用品として利用できる。
(a)ラウリン酸カリウム 13
(b)ミリスチン酸カリウム 5
(c)プロピレングリコール 7
(d)試料4 10
(e)ハイビスカス花抽出物 3
(f)pH調整剤(クエン酸) 適量
(g)防腐剤(メチルパラベン) 適量
(h)精製水 残量
(a)及び(b)を予め80℃で加熱溶解した(c)〜(h)の溶液に撹拌しながら加え、ホモジナイザーにより均一に混合した後、室温まで冷却、脱気して容器に充填した。このボディーソープは皮膚の炎症軽減や肌荒れ防止用の皮膚外用品として利用できる。
(a)ラウリン酸ジエタノールアミド 2
(b)ラウリル硫酸トリエタノールアミン 5
(c)ポリオキシエチレンラウリルエーテル硫酸ソーダ 12
(d)1,3−ブチレングリコール 4
(e)エデト酸二ナトリウム 0.1
(f)試料2 0.05
(g)防腐剤及び香料 各適量
(h)精製水 残量
(b)〜(h)を加熱溶解して70℃とし、(a)を添加してホモミキサーにより乳化後、冷却、脱気して容器に充填した。
(a)オレイン酸エチル 1
(b)エタノール 45
(c)ポリオキシエチレン(40)硬化ヒマシ油 2
(d)試料1 15
(e)精製水 残量
(c)〜(e)を加熱溶解して60℃とし、同温度に加熱した(a)及び(b)の混合物を添加してホモミキサーにより可溶化後、冷却、脱気して容器に充填した。
(a)炭酸水素ナトリウム 50
(b)無水硫酸ナトリウム 35
(c)ホウ砂 3
(d)試料3 7
(e)カミツレ抽出末 4
(f)着色料及び香料 各適量
(a)〜(f)を粉体混合機で混合して容器に充填した。この粉末浴用剤は入浴時に使用して肌の紅斑やほてり感を鎮めるために利用できる。
Claims (3)
- ツバキ科ツバキ属に属するツバキ(Camellia Japonica)の種子の脱脂粕の常圧又は加圧下における熱水(85℃以上)抽出物を有効成分として配合することを特徴とする、紫外線照射により引き起こされる皮膚の炎症を抑制するためのTGF−β1増強剤の製造方法。
- 熱水抽出物は、その加水分解物が少なくともサポゲニン及びケンフェロールを含有するものである請求項1に記載のTGF−β1増強剤の製造方法。
- 請求項1又は2に記載の製造方法を経た後、当該製造方法により得られたTGF−β1増強剤を配合することを特徴とする、紫外線照射により引き起こされる皮膚の炎症を抑制するための皮膚外用品の製造方法。
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