JP5953376B2 - エマルション化されたハイドロゲル組成物及びその製造方法 - Google Patents
エマルション化されたハイドロゲル組成物及びその製造方法 Download PDFInfo
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- JP5953376B2 JP5953376B2 JP2014535641A JP2014535641A JP5953376B2 JP 5953376 B2 JP5953376 B2 JP 5953376B2 JP 2014535641 A JP2014535641 A JP 2014535641A JP 2014535641 A JP2014535641 A JP 2014535641A JP 5953376 B2 JP5953376 B2 JP 5953376B2
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Description
。
ネバナ、ドクダミ、シーバックソーン、ユズ(シトロン)、アルブミン、卵黄及びミルクプロテインの抽出物からなる群より選択され得る。
acid)及びニトリロ三酢酸(nitrilotriacetic acid)からなる群より選択される1種または2種以上が挙げられる。
ン、セチルエチルヘキサノエート、イソプロピルミリステート、及びオクチルドデカノールなどのエステル系オイル;リキッドイソパラフィン、ワセリン、パラフィン及び水添ポリデセンなどの炭化水素系オイル;マイクロクリスタリンワックス、ビーズワックス及びラノリンワックスなどのワックス;スクワラン、ミネラルオイル、ホホバオイル、アボカドオイル、アーモンドオイル、オリーブオイル、カカオバター、ゴマ油、小麦胚芽油、サフラワー油、シアバター、ツバキ油、ヒマシ油、ブドウ種子油、緑茶種子油、マカダミアナッツオイル、ヤシ油、ローズヒップ油、硬化油、アルガンオイル、シーバックソーンオイル、アルガンツリーカーネルオイル及びラベンダーオイルなどの天然オイル;並びに、シクロメチコン、フェニルトリメチコン、シクロペンタシロキサン及びジメチコンなどのシリコーンオイルからなる群より選択される1種または2種以上が挙げられる。
ル、1,3−プロパンジオール、3−クロロ−1,2−プロパンジオール、2−クロロ−1,3−プロパンジオール及びグリセリンからなる群より選択される1種または2種以上が挙げられるが、グリセリンを使用することが好ましい。
容器に精製水89.78質量%、EDTA 2ナトリウム0.03質量%、メチルパラベン0.32質量%、ベタイン1.87質量%、及びブチレングリコール8質量%を添加し、これを撹拌して水相部を製造した。
容器にグリセリルステアレート7.4質量%、ポリソルベート60.9質量%、ソルビタンセスキオレエート6.4質量%、カプリル酸/カプリン酸トリグリセリド33.16質量%、ジメチコン15質量%、シクロペンタシロキサン15質量%、トコフェリルアセテート(酢酸トコフェロール)7.02質量%、及びレチニルパルミテート7.02質量%を添加し、これを撹拌して油相部を製造した。
容器に、グリセリン87.8質量%、カラギーナン3.51質量%及びローカストビンゴム8.69質量%を添加し、これを撹拌してゲル化溶液を製造した。
上記製造例1で製造した水相部を75℃に加熱し、上記製造例2で製造された油相部を温度75℃に加熱した。加熱した水相部55質量%及び油相部20質量%を混合した後、温度75℃で、ホモミキサーで5分間乳化して、エマルションを製造した。製造したエマルションにゲル化溶液25質量%を添加した後、温度75℃で保持しながら30分間撹拌して、ハイドロゲル組成物を製造した。
水相部の含量を45質量%とし、そして油相部の含量を30質量%としたことを除き、上記実施例1と同様に実施してハイドロゲル組成物を製造した。
水相部の含量を55質量%とし、油相部の含量を20質量%とし、そしてゲル化溶液の
含量を20質量%としたことを除き、上記実施例1と同様に実施してハイドロゲル組成物を製造した。
水相部の含量を45質量%とし、油相部の含量を30質量%とし、そしてゲル化溶液の含量を20質量%としたことを除き、上記実施例1と同様に実施してハイドロゲル組成物を製造した。
油相部を添加せず、水相部の含量を75質量%としたことを除き、上記実施例1と同様に実施してハイドロゲル組成物を製造した。
予め水相部にゲル化溶液を添加してから、油相部を添加したことを除き、上記実施例1と同様に実施してハイドロゲル組成物を製造した。
水相部の含量を40質量%とし、油相部の含量を45質量%とし、そしてゲル化溶液の含量を15質量%としたことを除き、上記実施例1と同様に実施してハイドロゲル組成物を製造した。
水相部の含量を30質量%とし、油相部の含量を30質量%とし、そしてゲル化溶液の含量を40質量%としたことを除き、上記実施例1と同様に実施してハイドロゲル組成物を製造した。
上記実施例及び比較例で製造したハイドロゲル組成物を用いて製造されたハイドロゲルの物性を測定し、その結果を表1に示した。
の腕の内側に付着し、24時間後に剥がし、肉眼で皮膚の状態を観察し、以下の評価基準に基づいて評価した。
◎:刺激なし
○:弱い刺激
□:紅斑
△:紅斑及び浮腫
×:紅斑、浮腫及び水疱
◎:性状保持
○:全面積の10%未満に変色、ゲルの流動化、乾燥
□:全面積の30%未満に変色、ゲルの流動化、乾燥
△:全面積の50%未満に変色、ゲルの流動化、乾燥
×:全面積の80%未満に変色、ゲルの流動化、乾燥
を行った。直径15.0mmの皮膚の表面に、実施例1、2、3と比較例1の試料を48マイクロリットル塗布し、経皮吸収機器(Hanson Microette)を用いて、透過されたトコフェリルアセテート量を24時間後に液体クロマトグラフィーで秤量し、表2に示した。表2から、実施例の経皮吸収効率は、比較例と比べて優れていることが分かる。
Claims (7)
- 水相部45〜60質量%及び油相部15〜30質量%が混合されたエマルション、及びゲル化溶液20〜30質量%、を含み、
前記水相部は、ブチレングリコール、ジプロピレングリコール、ヒアルロン酸ナトリウム、ベタイン、トレハロース、プロピレングリコール、乳酸ナトリウム、ソルビトール及び1,2−ヘキサンジオールからなる群より選択される1種以上の保湿剤と、精製水と、添加剤とを含み、
前記油相部は、エマルション化剤、皮膚柔軟化剤及び皮膚コンディショニング剤を含み、
前記ゲル化溶液は、ガラクトマンナン、グルコマンナン、グアーガム、ローカストビーンガム、寒天、アルギン、カラギーナン、キサンタンガム及びジェランからなる群より選択される1種以上のゲル化高分子と、1,2−エタンジオール、1,2−プロパンジオール、1,3−プロパンジオール、3−クロロ−1,2−プロパンジオール、2−クロロ−1,3−プロパンジオール及びグリセリンからなる群より選択される1種以上の多価アルコールとを含み、前記多価アルコールの含量はゲル化溶液の総質量に基づき80〜95質量%であることを特徴とする、エマルション化されたハイドロゲル組成物。 - 上記水相部は、水相部の総質量に基づき、保湿剤1〜20質量%、精製水78〜98質量%及び添加剤0.1〜3質量%を含むことを特徴とする、請求項1に記載のエマルション化されたハイドロゲル組成物。
- 上記油相部は、油相部の総質量に基づき、エマルション化剤15〜25質量%、皮膚柔軟化剤60〜83質量%及び皮膚コンディショニング剤0.1〜15質量%を含むことを特徴とする、請求項1に記載のエマルション化されたハイドロゲル組成物。
- 上記エマルション化剤は、グリセリルステアレート、レシチン、ソルビタンステアレート、ソルビタンセスキオレエート、ソルビタンオレエート、ソルビタンパルミテート、C14−22アルコール/C12−20アルキルグルコシド、セテアリルアルコール/セテアリルグルコシド、ポリソルベート60、PEG−100ステアレート/グリセリルステアレート、PEG−4オレエート、ソルビタンオリベート(sorbitan olivate)、ポリグリセリル−3メチルグルコースジステアレート、PEG−8ジメチコン、PEG−10ジメチコン、PEG−9メチルエーテルジメチコン、PEG−3ジメチコン、PEG−11メチルエーテルジメチコン、PEG/PPG−20/20ブチルエーテルジメチコン、PEG/PPG−20/20ジメチコン、セチルPEG/PPG−10/1−ジメチコン、ラウリルPEG−9ポリジメチルシロキシエチルジメチコン及びビス−PEG/PPG−20/5 PEG/PPG−20/5ジメチコンからなる群より選択される1種以上であることを特徴とする、請求項1に記載のエマルション化されたハイドロゲル組成物。
- 上記皮膚柔軟化剤は、エステル系オイル、炭化水素系オイル、ワックス、天然オイル及びシリコーンオイルからなる群より選択される1種以上であることを特徴とする、請求項1に記載のエマルション化されたハイドロゲル組成物。
- 上記油相部に添加される皮膚コンディショニング剤は、レチニルパルミテート、トコフェロールアセテート、セラミド、α−ビサボロール、コエンザイムQ10並びにビタミンA、D及びEからなる群より選択される1種以上であることを特徴とする、請求項1に記載のエマルション化されたハイドロゲル組成物。
- エマルション化されたハイドロゲル組成物の製造方法であって、
水相部45〜60質量%及び油相部15〜30質量%を温度70〜80℃に加熱する工程、
上記加熱した油相部と水相部を温度70〜80℃で混合し、エマルションを製造する工程、及び
上記エマルションにゲル化溶液20〜30質量%を添加して混合した後、温度70〜80℃にて20〜40分間撹拌する工程、を含み、
前記水相部は、ブチレングリコール、ジプロピレングリコール、ヒアルロン酸ナトリウム、ベタイン、トレハロース、プロピレングリコール、乳酸ナトリウム、ソルビトール及び1,2−ヘキサンジオールからなる群より選択される1種以上の保湿剤と、精製水と、添加剤とを含み、
前記油相部は、エマルション化剤、皮膚柔軟化剤及び皮膚コンディショニング剤を含み、
前記ゲル化溶液は、ガラクトマンナン、グルコマンナン、グアーガム、ローカストビーンガム、寒天、アルギン、カラギーナン、キサンタンガム及びジェランからなる群より選択される1種以上のゲル化高分子と、1,2−エタンジオール、1,2−プロパンジオール、1,3−プロパンジオール、3−クロロ−1,2−プロパンジオール、2−クロロ−1,3−プロパンジオール及びグリセリンからなる群より選択される1種以上の多価アルコールとを含み、前記多価アルコールの含量はゲル化溶液の総質量に基づき80〜95質量%であることを特徴とする、製造方法。
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KR100654062B1 (ko) * | 2005-01-06 | 2006-12-05 | 주식회사 코리아나화장품 | 고형 타입의 유중수형 부분 메이크업 화장료 조성물 |
US20060246098A1 (en) * | 2005-03-16 | 2006-11-02 | Srinivasa Rao | Stable aqueous-based emulsion formulation comprising urea and salicylic acid and method of using same |
JP4685536B2 (ja) * | 2005-06-22 | 2011-05-18 | サンスター株式会社 | 乳化組成物およびそれを含有した化粧料 |
JP4982101B2 (ja) * | 2006-03-31 | 2012-07-25 | 花王株式会社 | 剥離型パック化粧料 |
KR100789345B1 (ko) * | 2006-08-21 | 2007-12-28 | 주식회사 엘지생활건강 | 유중수형 고형 스틱화장료 조성물 |
JP2009108007A (ja) * | 2007-10-31 | 2009-05-21 | Fujifilm Corp | ゲルシートおよびそれを用いたシート状化粧料 |
ES2336995B1 (es) * | 2008-10-13 | 2011-02-09 | Lipotec, S.A. | Composicion cosmetica o dermofarmaceutica para el cuidado de la piel,cuero cabelludo y uñas. |
JP5222708B2 (ja) * | 2008-12-11 | 2013-06-26 | 花王株式会社 | 皮膚外用剤 |
JP5588630B2 (ja) * | 2009-06-04 | 2014-09-10 | 花王株式会社 | 容器入り歯磨剤 |
KR101367608B1 (ko) * | 2011-10-11 | 2014-03-05 | 주식회사 제닉 | 에멀젼화된 하이드로겔 조성물 및 이의 제조방법 |
-
2011
- 2011-10-11 KR KR20110103494A patent/KR101367608B1/ko active IP Right Grant
-
2012
- 2012-09-12 US US14/350,425 patent/US20140271596A1/en not_active Abandoned
- 2012-09-12 EP EP12839933.4A patent/EP2772270A4/en not_active Withdrawn
- 2012-09-12 JP JP2014535641A patent/JP5953376B2/ja active Active
- 2012-09-12 CN CN201280049568.1A patent/CN103857412A/zh active Pending
- 2012-09-12 WO PCT/KR2012/007313 patent/WO2013055041A1/ko active Application Filing
Also Published As
Publication number | Publication date |
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KR20130039058A (ko) | 2013-04-19 |
US20140271596A1 (en) | 2014-09-18 |
KR101367608B1 (ko) | 2014-03-05 |
CN103857412A (zh) | 2014-06-11 |
EP2772270A4 (en) | 2015-03-25 |
EP2772270A1 (en) | 2014-09-03 |
WO2013055041A1 (ko) | 2013-04-18 |
JP2014528471A (ja) | 2014-10-27 |
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