JP5881682B2 - 無菌極低温液体を製造するための方法 - Google Patents
無菌極低温液体を製造するための方法 Download PDFInfo
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- JP5881682B2 JP5881682B2 JP2013510108A JP2013510108A JP5881682B2 JP 5881682 B2 JP5881682 B2 JP 5881682B2 JP 2013510108 A JP2013510108 A JP 2013510108A JP 2013510108 A JP2013510108 A JP 2013510108A JP 5881682 B2 JP5881682 B2 JP 5881682B2
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- cryogenic
- sterile
- heat exchanger
- fluid
- gas
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- 239000007788 liquid Substances 0.000 title claims description 45
- 238000004519 manufacturing process Methods 0.000 title description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 74
- 239000012530 fluid Substances 0.000 claims description 39
- 229910052757 nitrogen Inorganic materials 0.000 claims description 34
- 238000000034 method Methods 0.000 claims description 31
- 239000007789 gas Substances 0.000 claims description 28
- 230000001954 sterilising effect Effects 0.000 claims description 27
- 238000004659 sterilization and disinfection Methods 0.000 claims description 23
- 230000001276 controlling effect Effects 0.000 claims description 6
- 229910001873 dinitrogen Inorganic materials 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 230000001105 regulatory effect Effects 0.000 claims description 5
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 claims description 4
- 238000009835 boiling Methods 0.000 claims description 3
- 229910052786 argon Inorganic materials 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 238000007599 discharging Methods 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 description 6
- 238000001816 cooling Methods 0.000 description 4
- 102100024209 CD177 antigen Human genes 0.000 description 3
- 101000980845 Homo sapiens CD177 antigen Proteins 0.000 description 3
- 230000008016 vaporization Effects 0.000 description 3
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 238000009833 condensation Methods 0.000 description 2
- 230000005494 condensation Effects 0.000 description 2
- 239000002826 coolant Substances 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 238000012546 transfer Methods 0.000 description 2
- 238000009834 vaporization Methods 0.000 description 2
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 238000010926 purge Methods 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
- 238000013022 venting Methods 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/022—Filtration
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Separation By Low-Temperature Treatments (AREA)
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
Description
[0024]排出孔は様々な形状のものであってよく、例えばオリフィス、ノズル、スプレーノズル、特定の長さの小径のパイプ、または同類のものである。無菌液体を様々な位置へ分配するようにした、単一の排出パイプから出る複数の排出孔、または複数の分岐したパイプから出る複数の排出孔としてもよい。
Claims (13)
- 極低温ガスを滅菌して無菌極低温流れを生成し、そしてその滅菌された極低温流れを熱交換器へ供給して無菌極低温流れを液化することにより無菌極低温流体を製造する方法であって、当該熱交換器は無菌極低温流体の排出孔を具備し、当該排出孔はオリフィスであり、当該排出孔の寸法を規制して、そして前記流体の所定の圧力を設定することによって、無菌極低温流体の排出量を制御することを特徴とする、前記方法。
- 前記極低温流体は−50℃未満の標準沸点を有する液体の群から選択される、請求項1に記載の方法。
- 前記極低温流体は窒素、酸素、液体空気およびアルゴンからなる群から選択される、請求項2に記載の方法。
- 前記滅菌はろ過による加温滅菌である、請求項1〜3のいずれかに記載の方法。
- 前記熱交換器と排出孔の蒸気滅菌をさらに含む、請求項1〜4のいずれかに記載の方法。
- 前記排出孔は無菌極低温流体の流れの制限を与える、請求項1〜5のいずれかに記載の方法。
- 前記極低温ガスの圧力は前記熱交換器の中で液化を起こすのに十分な大きさである、請求項1〜6のいずれかに記載の方法。
- 前記熱交換器は前記極低温ガスを凝縮させるのに十分な表面積を有する、請求項1〜7のいずれかに記載の方法。
- 前記所定の圧力は大気圧よりも大きい、請求項1〜8のいずれかに記載の方法。
- 極低温ガスを滅菌して無菌極低温流れを生成し、そしてその滅菌された極低温流れを熱交換器へ供給して無菌極低温流れを液化することにより、無菌極低温流体を製造する装置であって、当該熱交換器は無菌極低温流体の排出孔を具備し、当該排出孔はオリフィスであることを特徴とする、前記装置。
- 前記熱交換器は前記極低温ガスを凝縮させるのに十分な表面積を有する、請求項10に記載の装置。
- 前記熱交換器は、滅菌窒素ガスを受け入れて液化された滅菌窒素流体を排出する配管としてのコイルを具備し、
前記排出孔は、当該コイルの排出先端部に設けられている
ことを特徴とする請求項10又は11に記載の装置。 - 前記熱交換器は、滅菌窒素ガスを受け入れて液化された滅菌窒素流体を排出する配管として、トラップを含まず、下流に向けての傾斜を有する配管を具備し、
前記排出孔は、当該配管の排出先端部に設けられている
ことを特徴とする請求項10又は11に記載の装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12/778,299 US20110277499A1 (en) | 2010-05-12 | 2010-05-12 | Method for producing sterile cryogenic liquid |
US12/778,299 | 2010-05-12 | ||
PCT/US2011/033202 WO2011142945A1 (en) | 2010-05-12 | 2011-04-20 | Method for producing sterile cryogenic liquid |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013531212A JP2013531212A (ja) | 2013-08-01 |
JP5881682B2 true JP5881682B2 (ja) | 2016-03-09 |
Family
ID=44910514
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013510108A Active JP5881682B2 (ja) | 2010-05-12 | 2011-04-20 | 無菌極低温液体を製造するための方法 |
Country Status (12)
Country | Link |
---|---|
US (1) | US20110277499A1 (ja) |
EP (1) | EP2569570B1 (ja) |
JP (1) | JP5881682B2 (ja) |
CN (1) | CN102884360B (ja) |
AU (1) | AU2011253417B2 (ja) |
BR (1) | BR112012028771A2 (ja) |
CA (1) | CA2790474C (ja) |
CL (1) | CL2012003005A1 (ja) |
IL (1) | IL221513A (ja) |
MY (1) | MY161921A (ja) |
WO (1) | WO2011142945A1 (ja) |
ZA (1) | ZA201207088B (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20180015721A (ko) * | 2016-06-24 | 2018-02-13 | 가부시키가이샤 아루박 | 무균 액화가스 제조 장치 |
JP6968525B2 (ja) * | 2016-09-27 | 2021-11-17 | 岩谷産業株式会社 | 液体窒素供給システム |
WO2019092934A1 (ja) | 2017-11-07 | 2019-05-16 | 株式会社アルバック | 無菌液化ガス装置、及び無菌液化ガス装置の取り合い管 |
CN112728398B (zh) * | 2020-12-28 | 2023-04-28 | 江西新节氢能源科技有限公司 | 一种氢气生产用加压装罐设备及氢气生产工艺 |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4277950A (en) * | 1980-02-29 | 1981-07-14 | Union Carbide Corporation | Cryogenic liquid transfer termination apparatus |
JPS58161300U (ja) * | 1982-04-22 | 1983-10-27 | テイサン株式会社 | 低温液化ガス流出装置 |
JPS58184396A (ja) * | 1982-04-22 | 1983-10-27 | Teisan Kk | 低温液化ガス流出装置 |
US4620962A (en) * | 1985-03-04 | 1986-11-04 | Mg Industries | Method and apparatus for providing sterilized cryogenic liquids |
JPS6261614A (ja) * | 1985-09-10 | 1987-03-18 | Aoki Kensetsu:Kk | 滅菌フイルタ− |
US4865088A (en) * | 1986-09-29 | 1989-09-12 | Vacuum Barrier Corporation | Controller cryogenic liquid delivery |
JPH0616810B2 (ja) * | 1988-09-19 | 1994-03-09 | 株式会社ピュアロンジャパン | 流体用フィルタ |
JPH0884919A (ja) * | 1994-09-14 | 1996-04-02 | Toshiba Corp | 極低温液体の注入方法 |
US5557924A (en) * | 1994-09-20 | 1996-09-24 | Vacuum Barrier Corporation | Controlled delivery of filtered cryogenic liquid |
US5533341A (en) * | 1995-06-07 | 1996-07-09 | Air Liquide America Corporation | Apparatus and method for producing and injecting sterile cryogenic liquids |
US5749232A (en) * | 1996-12-18 | 1998-05-12 | Air Liquide America Corporation | Apparatus and method for producing and injecting sterile cryogenic liquids |
US6631621B2 (en) * | 2001-07-03 | 2003-10-14 | Thermo King Corporation | Cryogenic temperature control apparatus and method |
US20030110781A1 (en) * | 2001-09-13 | 2003-06-19 | Zbigniew Zurecki | Apparatus and method of cryogenic cooling for high-energy cutting operations |
EP1707866A1 (en) * | 2005-04-02 | 2006-10-04 | Linde Aktiengesellschaft | Method and apparatus for sterilization |
JP2010538236A (ja) * | 2007-08-30 | 2010-12-09 | リンデ・エルエルシー | 滅菌低温流体を製造する方法 |
CN101433885A (zh) * | 2008-12-02 | 2009-05-20 | 西安交通大学 | 均匀连续式液滴产生装置 |
-
2010
- 2010-05-12 US US12/778,299 patent/US20110277499A1/en not_active Abandoned
-
2011
- 2011-04-20 AU AU2011253417A patent/AU2011253417B2/en not_active Ceased
- 2011-04-20 EP EP11780996.2A patent/EP2569570B1/en active Active
- 2011-04-20 WO PCT/US2011/033202 patent/WO2011142945A1/en active Application Filing
- 2011-04-20 MY MYPI2012700909A patent/MY161921A/en unknown
- 2011-04-20 BR BR112012028771A patent/BR112012028771A2/pt active Search and Examination
- 2011-04-20 CN CN201180023296.3A patent/CN102884360B/zh active Active
- 2011-04-20 JP JP2013510108A patent/JP5881682B2/ja active Active
- 2011-04-20 CA CA2790474A patent/CA2790474C/en not_active Expired - Fee Related
-
2012
- 2012-08-16 IL IL221513A patent/IL221513A/en active IP Right Grant
- 2012-09-20 ZA ZA2012/07088A patent/ZA201207088B/en unknown
- 2012-10-26 CL CL2012003005A patent/CL2012003005A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
IL221513A (en) | 2017-05-29 |
WO2011142945A1 (en) | 2011-11-17 |
JP2013531212A (ja) | 2013-08-01 |
BR112012028771A2 (pt) | 2017-12-12 |
CL2012003005A1 (es) | 2013-04-01 |
EP2569570A4 (en) | 2014-08-20 |
CA2790474C (en) | 2019-09-10 |
AU2011253417B2 (en) | 2016-08-25 |
CN102884360A (zh) | 2013-01-16 |
MY161921A (en) | 2017-05-15 |
AU2011253417A1 (en) | 2012-09-13 |
EP2569570B1 (en) | 2018-08-15 |
CN102884360B (zh) | 2015-11-25 |
EP2569570A1 (en) | 2013-03-20 |
ZA201207088B (en) | 2013-05-29 |
CA2790474A1 (en) | 2011-11-17 |
US20110277499A1 (en) | 2011-11-17 |
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