JP5847723B2 - 経口摂取用皮膚賦活剤、及びその製造方法 - Google Patents
経口摂取用皮膚賦活剤、及びその製造方法 Download PDFInfo
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- JP5847723B2 JP5847723B2 JP2012536576A JP2012536576A JP5847723B2 JP 5847723 B2 JP5847723 B2 JP 5847723B2 JP 2012536576 A JP2012536576 A JP 2012536576A JP 2012536576 A JP2012536576 A JP 2012536576A JP 5847723 B2 JP5847723 B2 JP 5847723B2
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Description
(1)酸性リン脂質の含有量が40質量%以上であることを特徴とする経口摂取用皮膚賦活剤。
(2)酸性リン脂質がホスファチジン酸及び/又はリゾホスファチジン酸であることを特徴とする(1)の経口摂取用皮膚賦活剤。
(3)コラーゲン類と併用可能であることを特徴とする(1)又は(2)の経口摂取用皮膚賦活剤。
(4)スフィンゴ糖脂質と併用可能であることを特徴とする(1)〜(3)のいずれかの経口摂取用皮膚賦活剤。
(5)(1)〜(4)のいずれかの経口摂取用皮膚賦活剤を含有してなる飲食品。
(6)(1)〜(4)のいずれかの経口摂取用皮膚賦活剤を製造する方法であって、中性リン脂質を含有する脂質混合物にホスホリパーゼを作用させる工程と、該脂質混合物中に含まれる中性脂質を除去する工程を含むことを特徴とする経口摂取用皮膚賦活剤の製造方法。
本発明の経口摂取用皮膚賦活剤は、皮膚組織の新陳代謝を活発にすることによって、肌のハリやツヤの低下を防ぎ、小ジワ又はくすみなどを改善するものである。特に、紫外線が繰り返し暴露されることによる光老化を効果的に防ぐ効果を有する。さらに、本発明の経口摂取用皮膚賦活剤は、コラーゲン産生促進効果及び美容効果以外の効果、つまり創傷の治癒を促進する効果なども有する。
本発明の経口摂取用皮膚賦活剤の製造方法は、中性リン脂質を含有する脂質混合物にホスホリパーゼを作用させる工程(以下、「酵素作用工程」と称する場合がある)と、該脂質混合物中に含まれる中性脂質を除去する工程(以下、「中性脂質除去工程」と称する場合がある)を含むものである。
各種リン脂質の皮膚賦活効果の比較
創傷を作製したモデル動物を用いて、以下の酸性リン脂質及び中性リン脂質(オレイン酸エステル型グリセロリン脂質)(いずれもシグマ社製)の創傷治癒促進効果を比較検討した。
・1−Oleoyl−sn−glycero−3−phosphate sodium salt (以下、「O−LPA」と称する場合がある)
・1、2−Dioleoyl−sn−glycero−3−phosphate sodium salt (以下、「DOPA」と称する場合がある)
・1、2−Dioleoyl−sn−glycero−3−phosphoserine sodium salt (以下、「DOPS」と称する場合がある)
・1、2−Dioleoyl−sn−glycero−3−phosphoinositol sodium salt (以下、「DOPI」と称する場合がある)
・1、2−Dioleoyl−sn−glycero−3−phosphocholine (以下、「DOPC」と称する場合がある)
・1、2−Dioleoyl−sn−glycero−3−phosphoethanolamine (以下、「DOPE」と称する場合がある))
経口摂取用皮膚賦活剤の調製
攪拌装置を備えた500ml容量の4口フラスコに、大豆レシチン(辻製油社製、商品名「SLP−ペースト」)20gを、ヘプタン及び酢酸エチルの混合溶液(ヘプタン:酢酸エチル=1:1、体積比)200mlに溶解した。この混合溶液に、0.2Mの塩化カルシウムを含む0.1Mのトリス・塩酸緩衝液(pH:8.5)100mlを加え、さらに攪拌した。次いで、微生物起源のホスホリパーゼD(名糖産業社製、商品名「Actinomadura」 SP起源)1000ユニットを加え、反応混合物の温度を30℃に保ちながら、14時間攪拌を続けて反応させた。ここまでは、酵素作用工程である。
PC:ホスファチジルコリン
PE:ホスファチジルエタノールアミン
PI:ホスファチジルイノシトール
PA:ホスファチジン酸
PS:ホスファチジルセリン
LPA:リゾホスファチジン酸
経口摂取用皮膚賦活剤の皮膚賦活効果I(創傷治癒促進効果)
上記実施例2で得られた経口摂取用皮膚賦活剤、及び原料の大豆レシチンを適宜混釈し、PA含量がそれぞれ20質量%、30質量%、40質量%、50質量%、60質量%である5種類の経口摂取用皮膚賦活剤を得た。
経口摂取用皮膚賦活剤の皮膚賦活効果II(光老化防止効果)
実施例3で調製したPA含量がそれぞれ20質量%、30質量%、40質量%、50質量%、60質量%である5種類の経口摂取用皮膚賦活剤において、以下のような動物試験により、光老化予防効果をそれぞれ評価した。6週齢のヘアレスマウス(Hos/HR−1、オス、SLCジャパン社製)に,これらのリン脂質混合物をPA量として10mg/day/kg−BWとなるように経口投与した。なお、マウスは各群10匹とした。
コラーゲン加水分解物及び/又はスフィンゴ糖脂質を併用することによる経口摂取用皮膚賦活剤の皮膚賦活効果
上記実施例2で得られた経口摂取用皮膚賦活剤、及び原料の大豆レシチンを、質量比で、(経口摂取用皮膚賦活剤):(原料の大豆レシチン)が42:58になるように配合し、PAの含有量が40質量%である経口摂取用皮膚賦活剤を得た。この経口摂取用皮膚賦活剤に、コラーゲン加水分解物(ゼライス社製、「コラーゲン・トリペプチドHACP―01」)を、質量比で、(コラーゲン加水分解物):(経口摂取用皮膚賦活剤)が9:1になるように配合し、試料Aを得た。
Claims (3)
- 酸性リン脂質の含有量が40質量%以上であり、コラーゲン類及びスフィンゴ糖脂質を更に含むことを特徴とする経口摂取用皮膚賦活剤。
- 酸性リン脂質がホスファチジン酸及び/又はリゾホスファチジン酸であることを特徴とする請求項1に記載の経口摂取用皮膚賦活剤。
- 請求項1又は2に記載の経口摂取用皮膚賦活剤を含有してなる飲食品。
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PCT/JP2011/072507 WO2012043780A1 (ja) | 2010-09-30 | 2011-09-30 | 経口摂取用皮膚賦活剤、及びその製造方法 |
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JP2014162748A (ja) * | 2013-02-25 | 2014-09-08 | Kagawa Univ | 皮膚の光老化抑制剤 |
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KR102155730B1 (ko) * | 2018-02-23 | 2020-09-14 | 경북대학교 산학협력단 | 포스파티딘산을 유효성분으로 포함하는 노화 억제용 조성물 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JPH08332050A (ja) * | 1995-06-06 | 1996-12-17 | Kao Corp | 味覚改質剤 |
WO2009028220A1 (ja) * | 2007-08-28 | 2009-03-05 | Unitika Ltd. | コラーゲン産生促進剤 |
JP2009234931A (ja) * | 2008-03-26 | 2009-10-15 | Nof Corp | トランスグルタミナーゼ遺伝子発現促進剤および、その用途 |
JP2010195752A (ja) * | 2009-02-27 | 2010-09-09 | Unitika Ltd | 骨形成促進剤 |
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH08332050A (ja) * | 1995-06-06 | 1996-12-17 | Kao Corp | 味覚改質剤 |
WO2009028220A1 (ja) * | 2007-08-28 | 2009-03-05 | Unitika Ltd. | コラーゲン産生促進剤 |
JP2009234931A (ja) * | 2008-03-26 | 2009-10-15 | Nof Corp | トランスグルタミナーゼ遺伝子発現促進剤および、その用途 |
JP2010195752A (ja) * | 2009-02-27 | 2010-09-09 | Unitika Ltd | 骨形成促進剤 |
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JPWO2012043780A1 (ja) | 2014-02-24 |
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