JP5827408B2 - 親水性コロイド及び活性炭を有する多層創傷被覆材 - Google Patents
親水性コロイド及び活性炭を有する多層創傷被覆材 Download PDFInfo
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- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00544—Plasters form or structure
- A61F2013/00604—Multilayer
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- A61F13/00—Bandages or dressings; Absorbent pads
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- A61F2013/00676—Plasters adhesive hydrogel
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00902—Plasters containing means
- A61F2013/00914—Plasters containing means with deodorising or perfuming means
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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Description
豚、牛及び/若しくは馬由来、好ましくは豚由来、特に豚皮膚由来であることが好ましい。前述の特性を有するコラーゲン材料は、メディケマ(登録商標)ゲーエムベーハー、ケムニッツ、ドイツを介して商業的に取得可能である。
本発明に係る創傷被覆材と本発明ではない創傷被覆材を比較するために、本発明に係る創傷被覆材のいろいろな例と比較用創傷被覆材が準備された。
・ 創傷被覆材A及びA’は、それぞれ2つのポリアミド系布状材料の間に配置されたコラーゲン層及び活性炭層を有したこと、
・ 同様に、創傷被覆材B及びB’は、それぞれ2つのポリアミド系布状支持材料の間に配置されたコラーゲン層及び活性炭層を有し、さらにコラーゲン層と活性炭層の両方は、オクテニジンで処理されたこと、且つ、
・ 同様に、創傷被覆材Cは、それぞれ2つのポリアミド系布状支持材料の間に配置されたコラーゲン層及び活性炭層を有し、さらにコラーゲン層と活性炭層の両方は、ポリヘキサニドで処理されたこと。
・ 創傷被覆材Dは、標準の活性炭不織布に基づいたものであったこと;
・ 創傷被覆材Eは、ポリヘキサニド含浸ポリウレタン発泡体に基づいたものであったこと;且つ、
・ 創傷被覆材Fは、コラーゲン発泡体のみに基づいたものであったこと。
特に慢性創傷での極端な課題である病院細菌に対するいろいろな創傷被覆材の有効性をテストするために、創傷被覆材の抗菌性能が、抑制地帯テストに関して研究された。
本発明による創傷被覆材と、本発明によらない創傷被覆材の有効性を比較するために、慢性若しくは壊死性の創傷を煩う70歳〜85歳のテスト被験者が、4週間にわたっていずれかで処置された。このために、それぞれの創傷被覆材は、身体の患部に貼り付けられた。処置期間の第1週において、創傷被覆材は、朝と夕とに交換された。2週間を超えて、創傷被覆材の交換は、関連した創傷の状態に基づいて効果をもたらした。さらに、創傷治癒が進むについて被覆材の交換期間を長くし、すべての場合で、被覆材の交換は、いくら遅くとも2日後に実施された。
全体的に、本発明に係る創傷被覆材が、静菌性及び殺菌性処理若しくは特性を介して及び/若しくは活性炭とコラーゲンの組合せを介して、本発明でない創傷被覆材といろいろと比較されて改善されたことが実験例から明らかである。これによって、治療的創傷ケアのための本発明に係る創傷被覆材の使用によって、創傷治癒過程が十分に促進される。さらに、特に病院細菌に対する優れた汚染防護であって、創傷領域における構成物質及びその発生に対して抵抗するものが、治療における例外的な要求を突きつけるものである。さらに本発明に係る創傷被覆材は、良好な臭気吸着特性を有し、上述したものすべては患者の健康のためになるものである。
Claims (13)
- 治療的創傷ケアのための創傷被覆材において、
前記創傷被覆材が、多層構造を有すること、
・該多層構造が、少なくとも1つの親水コロイドを含む少なくとも1つの層、及び
・少なくとも1つの活性炭を含有する層を具備すること、
前記活性炭含有層は、球状活性炭であること、且つ、
前記活性炭含有層の活性炭が、活性炭の合計細孔容量に基づいて、少なくとも60%の2nm以下の細孔直径を有するミクロ細孔から形成されたミクロ細孔容量含有量を有することを特徴とする創傷被覆材。 - 前記親水コロイド層の親水コロイドは、多糖類及びプロテインからなる群から選択されることを特徴とする請求項1記載の創傷被覆材。
- 前記親水コロイド層の親水コロイドは、コラーゲン、セルロース及びセルロース誘導体、グリコサミノグリカン、ペクチン、アラビアゴム、ガラクトマンナン、寒天、カラギーン、アルギン酸塩、ゼラチン、カゼイン塩、キサンタン、デキストラン及びスクレログルカンからなる群から選択されることを特徴とする請求項1又は2記載の創傷被覆材。
- 前記親水コロイド層の親水コロイドは、コラーゲンから選択されることを特徴とする請求項1〜3のいずれか1つに記載の創傷被覆材。
- 親水コロイドを具備する層は、親水コロイド不織布若しくは親水コロイド発泡体を具備することを特徴とする請求項1〜4のいずれか1つに記載の創傷被覆材。
- 親水コロイドを具備する層が、創傷被覆材の外部層を形成すること、且つ、
創傷被覆材の使用状態において、親水コロイドを具備する層は、治療されるべき創傷に対面する創傷被覆材の側面に配置されることを特徴とする請求項1〜5のいずれか1つに記載の創傷被覆材。 - 親水コロイド具備する層は、0.01〜100mmの範囲内の厚さを有すること、且つ、親水コロイドを具備する層が、創傷被覆材の合計厚さの5%〜95%に形成されることを特徴とする請求項1〜6のいずれか1つに記載の創傷被覆材。
- 前記活性炭含有層は、0.01〜3mmの範囲内の絶対粒子サイズを有する球状活性炭を具備すること、且つ、ASTM D2862−97/04による標準測定法によって測定された0.05〜2.5mmの範囲内の平均粒子サイズを有する球状活性炭を具備することを特徴とする請求項1〜7のいずれか1つに記載の創傷被覆材。
- 前記活性炭含有層の活性炭が、
・活性炭の合計細孔容量に基づいて、60%〜95%の範囲内の2nm以下の細孔直径を有するミクロ細孔から形成されたミクロ細孔容量含有量;
・0.40cm3/g〜2cm3/gの範囲内の2nm以下の細孔直径を有するミクロ細孔から形成されたミクロ細孔容量含有量;
・活性炭の特定の合計表面積(BET)に基づいて、少なくとも50%の2nm以下の細孔直径を有する細孔からなる所定のミクロ細孔表面積;
・500〜3,000m2/gの範囲内のBET表面積;
・0.1〜4cm3/gの範囲内の総細孔量;
・10N〜50Nの範囲内の活性炭粒子毎の重量負荷能力;
・少なくとも2.3のフラクタル次元の開放気孔率;
からなる特性の少なくとも1つによって特徴付けられることを特徴とする請求項1〜8のいずれか1つに記載の創傷被覆材。 - 前記活性炭含有層の活性炭は、摩耗抵抗を有し及び埃のない球状活性炭粒子からなること、且つ、
前記活性炭含有層の活性炭は、殺菌性若しくは静菌性効果を有することを特徴とする請求項1〜9のいずれか1つに記載の創傷被覆材。 - 前記活性炭含有層の活性炭は、1〜1,000g/m2の量において存在することを特徴とする請求項1〜10のいずれか1つに記載の創傷被覆材。
- 前記活性炭含有層の活性炭は、平面若しくは三次元布状支持体上に設けられること、又は、
前記活性炭含有層の活性炭は、第1の布状材料及び第2の布状材料の間に配置されることを特徴とする請求項1〜11のいずれか1つに記載の創傷被覆材。 - 前記創傷被覆材は、抗菌作用活性物質、殺菌活性物質、炎症抑制物質、止血活性物質及び創傷治癒促進活性物質の群から選択された少なくとも1つの活性物質を含むことを特徴とする請求項1〜12のいずれか1つに記載の創傷被覆材。
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DE102011120491A DE102011120491A1 (de) | 2011-09-02 | 2011-12-08 | Wundauflage |
PCT/EP2012/003659 WO2013029796A1 (de) | 2011-09-02 | 2012-08-31 | Mehrschichtige wundauflage enthaltend ein hydrocolloid und aktivkohle |
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Families Citing this family (45)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0804654D0 (en) | 2008-03-13 | 2008-04-16 | Smith & Nephew | Vacuum closure device |
US9421132B2 (en) | 2011-02-04 | 2016-08-23 | University Of Massachusetts | Negative pressure wound closure device |
MX358022B (es) | 2011-02-04 | 2018-08-02 | Univ Massachusetts | Dispositivo para cierre de heridas por presión negativa. |
WO2015008054A1 (en) | 2013-07-16 | 2015-01-22 | Smith & Nephew Plc | Apparatus for wound therapy |
WO2013175310A2 (en) | 2012-05-22 | 2013-11-28 | Smith & Nephew Plc | Apparatuses and methods for wound therapy |
EP2852419B1 (en) | 2012-05-22 | 2019-11-20 | Smith & Nephew plc | Wound closure device |
WO2013175309A1 (en) | 2012-05-24 | 2013-11-28 | Smith & Nephew Plc | Devices and methods for treating and closing wounds with negative pressure |
WO2014014922A1 (en) | 2012-07-16 | 2014-01-23 | Smith & Nephew, Inc. | Negative pressure wound closure device |
DE102012019194B4 (de) | 2012-09-24 | 2024-08-01 | Wolfgang Winkelmann | Medizinisches Präparat umfassend einen Träger mit Polyhexanid oder Octenidin |
RU2015142873A (ru) | 2013-03-13 | 2017-04-19 | Смит Энд Нефью Инк. | Устройство и системы для закрытия раны с использованием отрицательного давления, и способы для применения при лечении ран с использованием отрицательного давления |
US10159771B2 (en) | 2013-03-14 | 2018-12-25 | Smith & Nephew Plc | Compressible wound fillers and systems and methods of use in treating wounds with negative pressure |
US20150005391A1 (en) | 2013-06-26 | 2015-01-01 | COLE Research & Design, Inc. | Method of reducing scarring |
MY184693A (en) * | 2013-08-22 | 2021-04-17 | Univ Kebangsaan Malaysia Ukm | Bilayer hydrocolloid films containing therapeutic agents |
CN103394117B (zh) * | 2013-08-28 | 2014-09-03 | 广东泰宝医疗科技股份有限公司 | 一种自粘型复合活性炭纤维敷料及其制备方法 |
WO2015061352A2 (en) | 2013-10-21 | 2015-04-30 | Smith & Nephew, Inc. | Negative pressure wound closure device |
WO2015110409A1 (en) | 2014-01-21 | 2015-07-30 | Smith & Nephew Plc | Wound treatment apparatuses |
EP3096728B1 (en) | 2014-01-21 | 2021-12-15 | Smith & Nephew plc | Collapsible dressing for negative pressure wound treatment |
KR101575178B1 (ko) * | 2014-06-10 | 2015-12-07 | (주)시지바이오 | 차콜 드레싱재 및 그의 제조 방법 |
WO2016057831A1 (en) * | 2014-10-10 | 2016-04-14 | COLE Research & Design, Inc. | Method of reducing scarring |
JP2018519864A (ja) | 2015-04-29 | 2018-07-26 | スミス アンド ネフュー インコーポレイテッド | 陰圧創傷閉鎖デバイス |
CZ28634U1 (cs) | 2015-05-05 | 2015-09-14 | Contipro Pharma A.S. | Dentální přípravek na bázi hyaluronanu a oktenidin dihydrochloridu |
FR3053892A1 (fr) * | 2016-07-12 | 2018-01-19 | Urgo Recherche Innovation Et Developpement | Pansement permettant la liberation controlee et prolongee de la metformine |
US11135351B2 (en) | 2016-08-30 | 2021-10-05 | Smith & Nephew Plc | Systems and methods for applying reduced pressure therapy |
CN106237371A (zh) * | 2016-09-21 | 2016-12-21 | 振德医疗用品股份有限公司 | 双层复合止血海绵、制作双层复合止血海绵的模具及方法 |
US11096832B2 (en) | 2016-09-27 | 2021-08-24 | Smith & Nephew Plc | Wound closure devices with dissolvable portions |
US11617684B2 (en) | 2016-11-02 | 2023-04-04 | Smith & Nephew, Inc. | Wound closure devices |
EP3338813B1 (en) * | 2016-12-20 | 2020-01-29 | BSN Medical GmbH | Multi-layer wound care product with perforated release layer |
EP3634338B1 (en) | 2017-06-07 | 2022-07-27 | KCI USA, Inc. | Wound dressing with odor absorption and increased moisture vapor transmission |
US11324876B2 (en) | 2017-06-13 | 2022-05-10 | Smith & Nephew Plc | Collapsible structure and method of use |
US11872110B2 (en) | 2017-06-13 | 2024-01-16 | Smith & Nephew Plc | Wound closure device and method of use |
US11583623B2 (en) | 2017-06-14 | 2023-02-21 | Smith & Nephew Plc | Collapsible structure for wound closure and method of use |
WO2018231874A1 (en) | 2017-06-14 | 2018-12-20 | Smith & Nephew, Inc. | Control of wound closure and fluid removal management in wound therapy |
CN110678212B (zh) | 2017-06-14 | 2023-01-03 | 史密夫和内修有限公司 | 伤口治疗中的流体去除管理和伤口闭合的控制 |
CN110740715B (zh) | 2017-06-14 | 2022-04-12 | 史密夫及内修公开有限公司 | 用于伤口闭合的可塌缩片材及使用方法 |
EP3658090B1 (en) | 2017-07-27 | 2021-11-10 | Smith & Nephew PLC | Customizable wound closure device |
US12036353B2 (en) | 2017-07-29 | 2024-07-16 | Edward D. Lin | Apparatus and methods for pressure management within a wound chamber |
US11712373B2 (en) * | 2017-07-29 | 2023-08-01 | Edward D. Lin | Wound therapy apparatus with scar modulation properties and related methods |
US11590030B2 (en) | 2017-08-07 | 2023-02-28 | Smith & Nephew Plc | Wound closure device with protective layer and method of use |
EP3675925A1 (en) | 2017-08-29 | 2020-07-08 | Smith & Nephew PLC | Systems and methods for monitoring wound closure |
JP2019107284A (ja) * | 2017-12-19 | 2019-07-04 | 株式会社大木工藝 | 装身具 |
WO2020043665A1 (en) * | 2018-08-27 | 2020-03-05 | Claudia Eder | Antiseptic gel |
EP3893825A1 (en) | 2018-12-13 | 2021-10-20 | University of Massachusetts | Negative pressure wound closure devices and methods |
RU2709462C1 (ru) * | 2019-03-15 | 2019-12-18 | Наталья Васильевна Меньшутина | Ранозаживляющее и гемостатическое средство на основе хитозана и способ его получения |
CN110624127A (zh) * | 2019-10-14 | 2019-12-31 | 河南承东生物科技有限公司 | 一种双重抑菌促愈合液体敷料及其制备方法 |
CN112683014B (zh) * | 2020-12-24 | 2022-07-08 | 杭州协合医疗用品有限公司 | 一种淀粉止血微球中有机溶剂的脱除方法 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0026572B1 (en) * | 1979-09-07 | 1983-10-19 | Kingsdown Medical Consultants Limited | Wound dressing |
NZ203706A (en) * | 1982-04-22 | 1986-03-14 | Squibb & Sons Inc | Occlusive multi-layer wound dressing and hydrocolloidal granules for wound treatment |
EP0227955A3 (en) * | 1982-07-21 | 1987-11-25 | University of Strathclyde | Composite wound dressing |
GB8723447D0 (en) * | 1987-10-06 | 1987-11-11 | Johnson & Johnson Ltd | Wound dressing |
JPH0790147B2 (ja) | 1990-01-08 | 1995-10-04 | 株式会社フジタ | フィルター交換時期判別装置 |
GB9413931D0 (en) * | 1994-07-11 | 1994-08-31 | C V Lab Ltd | Alginate fabric, method of preparation and use |
US5985008A (en) * | 1997-05-20 | 1999-11-16 | Advanced Technology Materials, Inc. | Sorbent-based fluid storage and dispensing system with high efficiency sorbent medium |
US6124521A (en) * | 1999-03-10 | 2000-09-26 | Tri-State Hospital Supply Corporation | Dermal wound window dressing securement system |
US6867287B2 (en) * | 2000-04-25 | 2005-03-15 | The Procter & Gamble Company | Breathable absorbent articles comprising chitosan material |
JP2001333973A (ja) * | 2000-05-26 | 2001-12-04 | Unitika Ltd | 抗菌性活性炭シート及び抗菌性脱臭創傷被覆材 |
US20020168400A1 (en) * | 2001-05-11 | 2002-11-14 | Biocore Medical Technologies, Inc. | Collagen/synthetic resin foam wound dressing |
GB2376632B (en) * | 2001-06-21 | 2004-10-27 | Johnson & Johnson Medical Ltd | Removable cavity wound dressing |
DE10254241A1 (de) | 2002-11-20 | 2004-06-09 | RVG Berlin-Brandenburg Gesellschaft für Verfahrensentwicklung und Recyclingtechnologien mbH | Kugelaktivkohle |
GB2405343A (en) * | 2003-08-29 | 2005-03-02 | Johnson & Johnson Medical Ltd | Charcoal Wound Dressings |
ES2343890T3 (es) * | 2003-09-08 | 2010-08-12 | Fmc Biopolymer As | Espuma gelificada a base de biopolimero. |
CN1720801A (zh) * | 2004-07-12 | 2006-01-18 | 深圳市清华源兴生物医药科技有限公司 | 一种载银杀菌活性炭及其制备方法与应用 |
US7371270B2 (en) | 2004-11-24 | 2008-05-13 | Welland Medical Limited | Odour absorbing filters |
WO2007048099A2 (en) * | 2005-10-18 | 2007-04-26 | Organogenesis, Inc. | Antimicrobial collagenous constructs |
DE202006016821U1 (de) * | 2005-11-02 | 2007-03-29 | Riesinger, Birgit | Absorbierender Körper zur Anbringung an menschliche oder tierische Körperoberflächen |
WO2007051599A1 (de) | 2005-11-02 | 2007-05-10 | Birgit Riesinger | Absorptionskörper zur anbringung an menschliche oder tierische hautoberflächen |
US7517536B2 (en) * | 2005-11-25 | 2009-04-14 | Feng Chia University | Antimicrobial compositions and wound dressings |
TWI354549B (en) | 2005-11-25 | 2011-12-21 | Univ Feng Chia | Antimicrobial compositions and wound dressings |
DE102007009672B4 (de) | 2006-04-07 | 2014-02-20 | Preh Gmbh | Klimabedienteil mit einer Sensoranordnung |
DE102007030931A1 (de) | 2007-07-03 | 2009-01-08 | Birgit Riesinger | Zusammensetzung, enthaltend mindestens einen nutritiven, mindestens einen desinfizierenden bzw. dekontaminierenden und/oder mindestens einen Proteasen hemmend wirkenden Wirkstoff und/oder Wirkstoffkomplex |
EP2072063A1 (en) * | 2007-12-22 | 2009-06-24 | Bayer Innovation GmbH | Infection-resistant cellular hydrophilic prepolymer based polyurethane foams, methods for producing the same and use thereof in antiseptic wound dressings |
DE102009053305A1 (de) | 2009-11-12 | 2011-08-18 | medichema GmbH, 09112 | Verfahren zur Herstellung einer schichtförmigen Wundauflage |
-
2011
- 2011-12-08 DE DE102011120491A patent/DE102011120491A1/de not_active Ceased
- 2011-12-08 DE DE202011108805U patent/DE202011108805U1/de not_active Expired - Lifetime
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2012
- 2012-08-31 PL PL12756104T patent/PL2736542T3/pl unknown
- 2012-08-31 JP JP2014527527A patent/JP5827408B2/ja not_active Expired - Fee Related
- 2012-08-31 ES ES12756104.1T patent/ES2544106T3/es active Active
- 2012-08-31 WO PCT/EP2012/003659 patent/WO2013029796A1/de active Application Filing
- 2012-08-31 EP EP20120756104 patent/EP2736542B1/de active Active
- 2012-08-31 CA CA2846682A patent/CA2846682C/en active Active
- 2012-08-31 CN CN201280053076.XA patent/CN103889468B/zh active Active
- 2012-08-31 US US14/342,463 patent/US9782512B2/en active Active
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Also Published As
Publication number | Publication date |
---|---|
EP2736542B1 (de) | 2015-05-06 |
WO2013029796A1 (de) | 2013-03-07 |
IL231189A (en) | 2017-10-31 |
US9782512B2 (en) | 2017-10-10 |
ES2544106T3 (es) | 2015-08-27 |
DE202011108805U1 (de) | 2012-09-03 |
CA2846682A1 (en) | 2013-03-07 |
US20150157758A1 (en) | 2015-06-11 |
EP2736542A1 (de) | 2014-06-04 |
PL2736542T3 (pl) | 2015-10-30 |
CA2846682C (en) | 2016-03-29 |
JP2014529449A (ja) | 2014-11-13 |
CN103889468B (zh) | 2018-06-29 |
DE102011120491A1 (de) | 2013-03-07 |
CN103889468A (zh) | 2014-06-25 |
IL231189A0 (en) | 2014-04-30 |
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