JP5771206B2 - 分離検出用カラム及びそのキット - Google Patents
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Description
前記連結管としては、例えば、図1に示すように、第一及び第二の固定相の両方の端部に外嵌する合成樹脂製等の非通液性の円管11からなる連結具や、図2に示すように、第一及び第二の固定相の両方の端部に外嵌する非通液性の円管12とその内周面の中央部に周設されるセラミックペーパーやガラスウール等の通液材料13とからなる連結具や、図3に示すように、非通液性の円柱体14とその外周面を被覆する通液材料15とからなり、カラム管や円筒状の支持体に内嵌する連結具が挙げられる。
図4の分離検出用カラムは、紫外線透過性を有する管1と、この管1の一端側に充填される第一の充填剤層2と、管1の他端側に充填される第二の充填剤層3と、第一及び第二の充填剤層2、3の間に介在する通液性を有するスペーサ4と、管1の他端側に詰められたエンドキャップ5とを有する。
2 第一の充填剤層
3 第二の充填剤層
4 スペーサ
5 エンドキャップ
11、12 円管
13、15 通液部材
14 円柱体
Claims (22)
- 通液性を有する柱状又は筒状の第一及び第二の固定相を有し、第一及び第二の固定相の端同士が通液自在に連結され、第一及び第二の固定相の軸方向に移動相を通液させる分離検出用カラムであって、
第一の固定相は、試料中の成分の分離能と、この成分の紫外線又は発色試薬に対する光学応答性と同じ光学応答性と、を有し、
第二の固定相は、前記成分とは異なる光学応答性を有する、分離検出用カラム。 - 前記第二の固定相が前記分離能を有さないことを特徴とする請求項1に記載の分離検出用カラム。
- 前記第一及び第二の固定相が、それぞれ、カラム管中の粒子状の充填剤による充填層、通液性を有する柱状体、又は、非通液性の柱状又は筒状の支持体の周面に形成される、通液性を有する分離剤層、によって構成されることを特徴とする請求項1又は2に記載の分離検出用カラム。
- 前記柱状体の形状が円柱状であり、前記支持体の形状が円柱状又は円筒状であることを特徴とする請求項3に記載の分離検出用カラム。
- 前記第一の固定相が光学異性体用分離剤を含み、前記第二の固定相が光学異性体用分離剤を含まないことを特徴とする請求項1〜4のいずれか一項に記載の分離検出用カラム。
- 前記光学異性体用分離剤が多糖誘導体であることを特徴とする請求項5に記載の分離検出用カラム。
- 前記多糖誘導体が、多糖と、多糖の水酸基或いはアミノ基の一部又は全部と置き換わった芳香族エステル基、芳香族カルバモイル基、及び芳香族エーテル基のいずれかとからなることを特徴とする請求項6に記載の分離検出用カラム。
- 光透過性を有するカラム管と、
試料中の成分の分離能と、この成分の紫外線又は発色試薬に対する光学応答性と同じ光学応答性と、を有する粒子状の第一の充填剤と、
前記成分とは異なる光学応答性を有する粒子状の第二の充填剤と、を含む分離検出用キット。 - 前記第二の充填剤が前記分離能を有さないことを特徴とする請求項8に記載の分離検出用キット。
- 前記第一の充填剤が光学異性体用分離剤を含み、前記第二の充填剤が光学異性体用分離剤を含まないことを特徴とする請求項9に記載の分離検出用キット
- カラム管と、
試料中の成分の分離能と、この成分の紫外線又は発色試薬に対する光学応答性と同じ光学応答性と、を有する粒子状の第一の充填剤と、
前記カラム管に通液自在に連結される第二の円柱体及び第二の薄層クロマトグラフィー棒の一方又は両方と、を含む分離検出用キットであって、
前記第二の円柱体は、前記成分とは異なる光学応答性と通液性とを有し、
前記第二の薄層クロマトグラフィー棒は、非通液性の円柱状又は円筒状の支持体と、この支持体の周面に形成される、前記成分とは異なる光学応答性と通液性とを有する第二の分離剤層と、を有する、分離検出用キット。 - 前記第二の円柱体及び前記第二の分離剤層が前記分離能を有さないことを特徴とする請求項11に記載の分離検出用キット。
- 前記第一の充填剤が光学異性体用分離剤を含み、前記第二の分離剤層が光学異性体用分離剤を含まないことを特徴とする請求項12に記載の分離検出用キット
- 通液性と、試料中の成分の分離能と、この成分の紫外線又は発色試薬に対する光学応答性と同じ光学応答性と、を有する第一の円柱体、及び、非通液性の円柱状の支持体とこの支持体の周面に形成される第一の分離剤層とを有する第一の薄層クロマトグラフィー棒、の一方又は両方と、
光透過性を有し、前記第一の円柱体又は第一の薄層クロマトグラフィー棒と通液自在に連結されるカラム管と、
前記成分とは異なる光学応答性を有する粒子状の第二の充填剤と、を含み、
前記第一の分離剤層が、前記分離能と、前記成分と同じ光学応答性と、通液性と、を有する、分離検出用キット。 - 前記第二の充填剤が前記分離能を有さないことを特徴とする請求項14に記載の分離検出用キット。
- 前記第一の円柱体及び第一の分離剤層が光学異性体用分離剤を含み、前記第二の充填剤が光学異性体用分離剤を含まないことを特徴とする請求項15に記載の分離検出用キット
- 通液性と試料中の成分の分離能と、この成分の紫外線又は発色試薬に対する光学応答性と同じ光学応答性と、を有する第一の柱状体、及び、非通液性の柱状又は筒状の支持体とこの支持体の周面に形成される第一の分離剤層とを有する第一の薄層クロマトグラフィー棒、の一方又は両方と、
前記成分とは異なる光学応答性と通液性とを有する第二の柱状体、及び、非通液性の柱状又は筒状の支持体とこの支持体の周面に形成される第二の分離剤層とを有する第二の薄層クロマトグラフィー棒、の一方又は両方と、
第一の柱状体又は第一の薄層クロマトグラフィー棒と第二の柱状体又は第二の薄層クロマトグラフィー棒とを通液自在に連結する連結具と、を含み、
前記第一の分離剤層が、前記分離能と、前記成分と同じ光学応答性と、通液性と、を有し、
前記第二の分離剤層が、前記成分とは異なる光学応答性と通液性とを有する、分離検出用キット。 - 前記第二の柱状体及び前記第二の分離剤層が前記分離能を有さないことを特徴とする請求項11に記載の分離検出用キット。
- 前記第二の柱状体の形状が円柱状であり、及び前記支持体の形状が円柱状又は円筒状であることを特徴とする請求項11又は14に記載の分離検出用キット。
- 前記第一の柱状体及び第一の分離剤層が光学異性体用分離剤を含み、前記第二の柱状体及び第二の分離剤層が光学異性体用分離剤を含まないことを特徴とする請求項18又は19に記載の分離検出用キット。
- 前記光学異性体用分離剤が多糖誘導体であることを特徴とする請求項10、13、16、及び20のいずれか一項に記載の分離検出用キット。
- 前記多糖誘導体が、多糖と、多糖の水酸基或いはアミノ基の一部又は全部と置き換わった芳香族エステル基、芳香族カルバモイル基、及び芳香族エーテル基のいずれかとからなることを特徴とする請求項21に記載の分離検出用キット。
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US9726650B2 (en) * | 2012-02-03 | 2017-08-08 | Daicel Corporation | Chromatographic medium |
CN106362437B (zh) * | 2016-08-25 | 2018-08-03 | 山东开泰石化丙烯酸有限公司 | 一种用于丙烯酸丁酯生产装置中物料检测的色谱柱 |
JP6847554B2 (ja) * | 2018-08-27 | 2021-03-24 | 卓也 澤田 | ホルダー部材 |
CN117836043A (zh) * | 2021-08-30 | 2024-04-05 | 株式会社大赛璐 | 微流体设备及其制造方法 |
CN114509522B (zh) * | 2021-10-11 | 2024-05-17 | 聚光科技(杭州)股份有限公司 | 基于色谱技术的气体分离装置 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54145191A (en) * | 1978-05-01 | 1979-11-13 | Agency Of Ind Science & Technol | Separating method of mixture |
JPS61201161A (ja) * | 1985-03-05 | 1986-09-05 | Fujikura Ltd | セル付きキヤピラリ−及びその製造方法 |
JP2005017268A (ja) * | 2003-05-30 | 2005-01-20 | Daicel Chem Ind Ltd | 光学異性体用分離剤、その製造方法、及び光学異性体用分離カラム |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4382000A (en) * | 1982-02-26 | 1983-05-03 | Owens-Illinois, Inc. | Chromatography device and method of making chromatography test |
JPS6293660A (ja) * | 1985-10-19 | 1987-04-30 | Mito Kagaku Gijutsu Kenkyusho:Kk | 液体クロマトグラフイ−カラムおよび液体クロマトグラフイ−装置 |
US5178832A (en) * | 1987-09-28 | 1993-01-12 | The Texas A&M University System | Selective immobilization and detection of mycotoxins in solution |
JPH0493336A (ja) | 1990-08-09 | 1992-03-26 | Hitachi Chem Co Ltd | 多孔質体の製造方法 |
JP3140138B2 (ja) * | 1992-02-25 | 2001-03-05 | ダイセル化学工業株式会社 | 薄層クロマトグラム |
JP3317749B2 (ja) | 1993-01-18 | 2002-08-26 | 直弘 曽我 | 無機系多孔質カラム |
JP3397255B2 (ja) | 1993-07-30 | 2003-04-14 | 直弘 曽我 | 無機系多孔質体の製造方法 |
CN2315566Y (zh) * | 1996-09-16 | 1999-04-21 | 北京有色金属研究总院 | 一种新型液相色谱柱 |
JPH11183458A (ja) * | 1997-12-18 | 1999-07-09 | Yazaki Corp | クロマトグラフィー用カラム |
US20050106740A1 (en) * | 2003-11-13 | 2005-05-19 | Boyes Barry E. | Methods, systems and devices for performing analytical protocols |
JP2006159148A (ja) * | 2004-12-10 | 2006-06-22 | Nagoya Institute Of Technology | クロマトグラフィー用カラムおよび電気クロマトグラフィー用カラム |
CA2718301C (en) * | 2005-02-22 | 2014-05-06 | Mecanique Analytique Inc. | Analytical chromatographic method |
ITVE20070034A1 (it) * | 2007-06-01 | 2008-12-02 | Dani Instr Spa | Colonna capillare perfezionata per gascromatografia. |
-
2011
- 2011-07-08 CN CN201180033859.7A patent/CN103038633B/zh active Active
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS54145191A (en) * | 1978-05-01 | 1979-11-13 | Agency Of Ind Science & Technol | Separating method of mixture |
JPS61201161A (ja) * | 1985-03-05 | 1986-09-05 | Fujikura Ltd | セル付きキヤピラリ−及びその製造方法 |
JP2005017268A (ja) * | 2003-05-30 | 2005-01-20 | Daicel Chem Ind Ltd | 光学異性体用分離剤、その製造方法、及び光学異性体用分離カラム |
Non-Patent Citations (3)
Title |
---|
JPN6015007684; Kim KH,Kim HJ, Kang JS, Mar W: 'Determination of metoprolol enantiomers in human urine by coupled achiral-chiral chromatography.' Journal or Pharmaceutical and Biomedecal Analysis 22(2000), 2000, 377-384, Elsevier社(v. Pergamon Press ) * |
JPN6015007686; 'フラッシュチューブ' Wako Organic Square No.8, 200109, 9 * |
JPN6015007687; 'フラッシュチューブ' Wako Organic Square No.13, 200409, 17 * |
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CN103038633A (zh) | 2013-04-10 |
CN103038633B (zh) | 2015-11-25 |
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