JP5677414B2 - ラブ・オン・ア・チップ・システム内の流体流の制御装置および方法ならびにこの装置の製造方法 - Google Patents
ラブ・オン・ア・チップ・システム内の流体流の制御装置および方法ならびにこの装置の製造方法 Download PDFInfo
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- F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
- F16K11/00—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves
- F16K11/02—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit
- F16K11/06—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements
- F16K11/065—Multiple-way valves, e.g. mixing valves; Pipe fittings incorporating such valves with all movable sealing faces moving as one unit comprising only sliding valves, i.e. sliding closure elements with linearly sliding closure members
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- F16K99/00—Subject matter not provided for in other groups of this subclass
- F16K99/0001—Microvalves
- F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
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Description
上述の課題は、このような装置の制御方法に関しては、複数のバルブがそれぞれ、特に少なくとも1つのピストンを介して与えられる押圧力で各バルブを付勢することによって操作され、押圧力で付勢されないときはバルブは開いていてこのバルブを付設されたフローチャネルの中を流体が流れ、バルブが押圧力で付勢されるとそのバルブが閉じてこのバルブを付設されたフローチャネル内で流体流が遮断されることによって解決される(請求項7)。
上述の課題は、このような装置の製造方法に関しては、n個の列Snおよびm個の行Zmへのアレイの複数のバルブの配置に依存して複数のフローチャネルが設けられることによって解決される(請求項12)。
・実質的に平坦なプレートは、バルブアレイの列Snに平行に延びている第1の方向にバルブアレイに対して移動可能に支承されている(請求項2)。
・プレートの平面から突出する複数の***部は、実質的に平坦なプレートが第1の方向に沿ってバルブアレイに対して移動する際に予め定められたプログラムに従って制御されながら個々のバルブが閉じられるとともに他のバルブが開かれるように、n'個の列Sn'およびm'個の行Zm'に配置されている(請求項3)。
・バルブアレイはチップカードに配置され、チップカードはクレジットカード形状のプラスチック材料製の平たい本体を含み、該本体の前面にはフィルム、特に粘着性フィルムが装着され、本体には前面の表面にフローチャネルが切欠きとして配置され、バルブはそれぞれのフローチャネルに少なくとも部分的に隣接して配置されたエラストマー材料を含んでいる(請求項4)。
・本体はポリカーボネートまたはポリプロピレンから構成され、および/またはエラストマーは熱可塑性エラストマー、特にゴム、またはポリプロピレンとエチレン−プロピレン−ジエン−Mクラス−エラストマーとからなる混合物である(請求項5)。
換言すれば、本体はポリカーボネートまたはポリプロピレンから構成され、
または、エラストマーは熱可塑性エラストマー、特にゴム、またはポリプロピレンとエチレン−プロピレン−ジエン−Mクラス−エラストマーとからなる混合物であり、
または、本体はポリカーボネートまたはポリプロピレンから構成され、かつ、エラストマーは熱可塑性エラストマー、特にゴム、またはポリプロピレンとエチレン−プロピレン−ジエン−Mクラス−エラストマーとからなる混合物である。
・チップカードはバルブの操作機構の中にサンドイッチ状に配置され、チップカードの裏面には各バルブに対してそれぞれ機構プレートに各バルブを操作するための1つのピストンが配置され、ピストンはピストンとバルブとの間で押圧力が実質的に生じないように少なくとも1つのばねを介して機構プレートとピストンとの間に初期応力をかけられている(請求項6)。
ラブ・オン・ア・チップ・システム内の流体流の制御装置の制御方法の好ましい実施態様は、次の通りである。
・実質的に平坦なプレートが複数のバルブからなるバルブアレイに対して列Snに平行に移動することによって、バルブの開閉が事前設定されたプログラムに従って行われる(請求項8)。
・実質的に平坦な前記プレートのm'個の行Zm'と、バルブアレイのm個の行Zmとの間の差が、少なくとも1つのバルブが操作されるプロセスステップの数を生じる(請求項9)。
・実質的に平坦な前記プレートはバルブアレイに対して相対的に固定的な速度で移動され、全ての行Zmの相互間隔が等しいときには1つのプロセスステップの時間は行Zm'の相互間隔によって規定され、または、全ての行Zm'の相互間隔が等しいときには1つのプロセスステップの時間は行Zmの相互間隔によって規定される(請求項10)。
・実質的に平坦な前記プレートはバルブアレイに対して相対的にプロセスステップの時間に合わせられた速度で移動され、行Zmはそれぞれ相互に、および行Zm'はそれぞれ相互に、等しい間隔をおいて配置される(請求項11)。
なお、独立請求項の構成要件を従属請求項の構成要件と組み合わせることができ、および、従属請求項の構成要件を相互に組み合わせることができる。
Claims (12)
- n個の列Snおよびm個の行Zmに配置され、フローチャネル(4')内の流体流を制御するようにそれぞれ設計されている複数のバルブからなるバルブアレイを有し、nおよびmは整数であり、さらに前記バルブの操作機構(13)を有し、
前記バルブアレイは少なくとも2つのバルブを含み、各列Snはバルブを有していないかまたは最多でも1つのバルブを有し、各行Zmは0〜n個のバルブを有している、ラブ・オン・ア・チップ・システム内の流体流の制御装置において、
前記バルブの操作機構(13)は、n'個の列Sn'およびm'個の行Zm'に配置され平面から突出する複数の***部を備える1つの平坦なプレート(12)を有し、隣接する列Sn'の間隔はバルブの隣接する列Snの間隔に等しい、ラブ・オン・ア・チップ・システム内の流体流の制御装置。 - 平坦な前記プレート(12)は、前記バルブアレイの列Snに平行に延びている第1の方向に前記バルブアレイに対して移動可能に支承されている請求項1に記載の装置。
- 前記プレート(12)の平面から突出する複数の***部は、平坦な前記プレート(12)が前記第1の方向に沿って前記バルブアレイに対して移動する際に予め定められたプログラムに従って制御されながら個々のバルブが閉じられるとともに他のバルブが開かれるように、n'個の列Sn'およびm'個の行Zm'に配置されている請求項2に記載の装置。
- 前記バルブアレイはチップカードに配置され、前記チップカードはクレジットカード形状のプラスチック材料製の平たい本体(1)を含み、該本体の前面(10)にはフィルム(5)が装着され、前記本体(1)には前記前面(10)の表面にフローチャネル(4')が切欠きとして配置され、バルブはそれぞれの前記フローチャネル(4')に少なくとも部分的に隣接して配置されたエラストマー材料(2)を含んでいる請求項1から3のいずれか1項に記載の装置。
- 前記本体(1)はポリカーボネートまたはポリプロピレンから構成され、および/または前記エラストマー(2)は熱可塑性エラストマー、またはポリプロピレンとエチレン−プロピレン−ジエン−Mクラス−エラストマーとからなる混合物である請求項4に記載の装置。
- 前記チップカードは前記バルブの操作機構(13)の中にサンドイッチ状に配置され、前記チップカードの裏面(11)には各バルブに対してそれぞれ機構プレート(7a)に各バルブを操作するための1つのピストン(8)が配置され、前記ピストン(8)は前記ピストン(8)とバルブとの間で押圧力が生じないように少なくとも1つのばねを介して前記機構プレート(7a)とピストン(8)との間に初期応力をかけられている請求項4または5に記載の装置。
- 請求項1から6のいずれか1項に記載の装置の制御方法において、複数のバルブがそれぞれ押圧力で各バルブを付勢することによって操作され、押圧力で付勢されないときはバルブは開いていてこのバルブを付設されたフローチャネル(4')の中を流体が流れ、バルブが押圧力で付勢されるとそのバルブが閉じてこのバルブを付設されたフローチャネル(4')内で流体流が遮断される、ラブ・オン・ア・チップ・システム内の流体流の制御装置の制御方法。
- 平坦なプレート(12)が複数のバルブからなるバルブアレイに対して列Snに平行に移動することによって、バルブの開閉が事前設定されたプログラムに従って行われる請求項7に記載の方法。
- 平坦な前記プレート(12)のm'個の行Zm'と、前記バルブアレイのm個の行Zmとの間の差が、少なくとも1つのバルブが操作されるプロセスステップの数を生じる請求項8に記載の方法。
- 平坦な前記プレート(12)は前記バルブアレイに対して相対的に固定的な速度で移動され、全ての行Zmの相互間隔が等しいときには1つのプロセスステップの時間は行Zm'の相互間隔によって規定され、または、全ての行Zm'の相互間隔が等しいときには1つのプロセスステップの時間は行Zmの相互間隔によって規定される請求項9に記載の方法。
- 平坦な前記プレート(12)は前記バルブアレイに対して相対的にプロセスステップの時間に合わせられた速度で移動され、行Zmはそれぞれ相互に、および行Zm'はそれぞれ相互に、等しい間隔をおいて配置される請求項9に記載の方法。
- 請求項1から6のいずれか1項に記載の装置の製造方法において、n個の列Snおよびm個の行Zmへのアレイの複数のバルブの配置に依存して複数のフローチャネル(4')が設けられる、ラブ・オン・ア・チップ・システム内の流体流の制御装置の製造方法。
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DE102009023430.6 | 2009-05-29 | ||
PCT/EP2010/055817 WO2010136298A1 (de) | 2009-05-29 | 2010-04-29 | Vorrichtung und verfahren zum steuern von fluidströmen in lab-on-a-chip-systemen sowie verfahren zum herstellen der vorrichtung |
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JP2012528308A (ja) | 2012-11-12 |
US9709179B2 (en) | 2017-07-18 |
DE102009023430B4 (de) | 2013-07-25 |
US9151409B2 (en) | 2015-10-06 |
CN102448611B (zh) | 2014-07-30 |
CN102448611A (zh) | 2012-05-09 |
US20120067433A1 (en) | 2012-03-22 |
US20160051984A1 (en) | 2016-02-25 |
EP2435186B1 (de) | 2018-08-08 |
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