JP5537574B2 - 多血小板血漿の再抗凝固処理のためのシステム及び方法 - Google Patents
多血小板血漿の再抗凝固処理のためのシステム及び方法 Download PDFInfo
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Description
Claims (38)
- 血液アフェレーシスシステムにおける多血小板血漿の再抗凝固のための方法であって、前記方法が
第一の回収コンテナ中に一定量の多血小板血漿を回収するステップ、および前記多血小板血漿が回収されているときに前記第一の回収コンテナへと抗凝固剤を添加するステップを含有する、方法。 - 前記一定量の多血小板血漿が複数のサイクルにおいて回収され、前記抗凝固剤が前記複数のサイクルのそれぞれの間に前記第一の回収コンテナへと添加される、請求項1による方法。
- 一定量の抗凝固剤が前記第一の回収コンテナへと移されるように前記血液アフェレーシスシステムを抗凝固剤によってプライミングするステップと、
前記第一の回収コンテナ中の抗凝固剤を第二の回収コンテナへと移すステップとをさらに含有し、
ここで、前記多血小板血漿が回収されているときに、抗凝固剤が前記第一の回収コンテナへと前記第二の回収コンテナより移される、請求項2による方法。 - 血液アフェレーシスシステムにおける多血小板血漿の再抗凝固のための方法であって、前記方法が
全血を提供するステップ、
前記全血へと抗凝固剤を導入するステップ、
抗凝固処理された前記全血を複数の血液成分へと分離するステップであって、前記複数の血液成分が多血小板血漿を含んでいる、ステップ、
前記複数の血液成分より多血小板血漿を回収コンテナへと回収するステップ、および
前記多血小板血漿を回収するときに前記回収コンテナへと抗凝固剤を添加するステップを含有する、方法。 - 前記多血小板血漿が複数のサイクルにおいて回収され、前記抗凝固剤が前記複数のサイクルのそれぞれの間に前記回収コンテナへと添加される、請求項4による方法。
- 一定量の抗凝固剤が前記回収コンテナへと移されるように前記血液アフェレーシスシステムを抗凝固剤によってプライミングするステップと、
前記回収コンテナ中の抗凝固剤を第二のコンテナへと移すステップとをさらに含有する、請求項5による方法。 - 血液アフェレーシスシステムにおける多血小板血漿の再抗凝固のための方法であって、前記方法が
一定量の抗凝固剤がPRP回収コンテナへと移されるように前記血液アフェレーシスシステムを抗凝固剤によってプライミングするステップ、
前記PRP回収コンテナ中の抗凝固剤を第二のコンテナへと移すステップ、
前記PRP回収コンテナ中の一定量の多血小板血漿を回収するステップであって、前記一定量の多血小板血漿が複数のサイクルによって回収される、ステップ、
前記第二のコンテナから一定量の抗凝固剤の少なくとも一部分を前記PRP回収コンテナへと前記複数のサイクルのそれぞれの間において移すステップを含有する、方法。 - 前記PRP回収コンテナへと移される前記一定量の抗凝固剤の少なくとも一部分が、先行するサイクルにおいて回収される多血小板血漿の量に比例する、請求項7による方法。
- 前記血液アフェレーシスシステムを抗凝固剤によってプライミングするステップが、抗凝固剤ラインおよび全血ラインフィルタを抗凝固剤によってプライミングするステップを含む、請求項7による方法。
- 前記血液アフェレーシスシステムをプライミングするステップが、全血ラインフィルタ中の抗凝固剤を第二のコンテナへと移すステップを含む、請求項9による方法。
- 前記全血ラインフィルタ中の抗凝固剤が前記複数のサイクルの最初の開始時に前記第二のコンテナへと移される、請求項10による方法。
- 前記全血ラインフィルタ中の抗凝固剤が抗凝固剤源へと返却される、請求項9による方法。
- 前記PRP回収コンテナへと移される抗凝固剤の全量が多血小板血漿の目標容量に比例する、請求項7による方法。
- 前記目標容量が前記複数のサイクルのそれぞれにおいて回収される容量の合計である、請求項13による方法。
- 前記複数のサイクルのそれぞれが、
全血を提供するステップ、
前記全血へと抗凝固剤を導入するステップ、
前記抗凝固処理された全血を分離チャンバへと導入するステップであって、ここで前記分離チャンバが前記抗凝固処理された全血を多血小板血漿を含むいくつかの血液成分へと分離する、ステップ、および
前記分離チャンバからPRP回収コンテナへと前記多血小板血漿を抽出するステップを含む、請求項7による方法。 - 前記PRP回収コンテナより前記分離チャンバへと前記多血小板血漿を再導入するステップであって、前記分離チャンバは前記再導入された多血小板血漿を血漿と血漿を減少させた血小板製剤へと分離するステップ、
前記分離チャンバから血小板コンテナへと前記血漿を減少させた血小板を抽出するステップをさらに含有する請求項15による方法。 - 前記全血へと導入される抗凝固剤の量が前記PRP回収コンテナ中の前記一定量の抗凝固剤に比例して減少する、請求項15による方法。
- 血液アフェレーシスシステムにおける多血小板血漿の再抗凝固のためのシステムであって、前記システムが、
回収した多血小板血漿の貯蔵のためのPRPコンテナ、
回収した赤血球の貯蔵のための赤血球コンテナ、
一定量の抗凝固剤がPRPコンテナへと移されるようにシステムを抗凝固剤によってプライミングする手段、
PRPコンテナ中の前記抗凝固剤を前記赤血球コンテナへと移す手段、
前記PRPコンテナ中の一定量の多血小板血漿を回収する手段であって、ここで前記一定量の多血小板血漿が複数のサイクルにおいて回収される、手段、
前記複数のサイクルのそれぞれの間に前記赤血球コンテナから前記PRPコンテナへと前記一定量の抗凝固剤の少なくとも一部分を移す手段を含有する、システム。 - 前記一定量の抗凝固剤の一部分が、先行するサイクルにおいて回収された多血小板血漿の量に比例する、請求項18によるシステム。
- 前記システムを抗凝固剤によってプライミングする手段が、抗凝固剤ラインと全血ラインフィルタを抗凝固剤でプライミングする、請求項18によるシステム。
- 前記システムをプライミングする手段が、前記赤血球ラインフィルタ中の前記抗凝固剤を前記赤血球コンテナへと移す、請求項20によるシステム。
- 前記一定量の抗凝固剤の一部分を移す手段が、前記複数のサイクルの最初の開始時に前記赤血球ラインフィルタ中の前記抗凝固剤を前記赤血球コンテナへと移す、請求項21によるシステム。
- 前記一定量の抗凝固剤の一部分を移す手段が、前記赤血球ラインフィルタ中の抗凝固剤を抗凝固剤源へと返却する、請求項20によるシステム。
- 前記PRPコンテナへと移される前記一定量の抗凝固剤が多血小板血漿の目標容量に比例する、請求項18によるシステム。
- 前記目標容量が、前記複数のサイクルのそれぞれにおいて回収される容量の合計である、請求項24による方法。
- 一定量の多血小板血漿を回収する前記手段が、
全血を提供する手段、
前記全血へと抗凝固剤を導入する手段、
前記抗凝固処理された全血を分離チャンバに導入する手段であって、前記分離チャンバが前記抗凝固処理された全血を多血小板血漿を含むいくつかの血液成分へと分離する、手段
前記分離チャンバより前記PRPコンテナへと前記多血小板血漿を抽出する手段を含む、請求項18によるシステム。 - 前記多血小板血漿を前記PRPコンテナから前記分離チャンバへと再導入する手段であって、ここで前記分離チャンバが再導入された多血小板結晶を血漿と血漿を減少させた血小板製剤へと分離する、手段、および
前記血漿を減少させた血小板製剤を前記分離チャンバより血小板コンテナへと抽出する手段、をさらに含有する請求項26によるシステム。 - 前記全血へと導入される抗凝固剤の量が、PRPコンテナ中の抗凝固剤の量に比例して減少する、請求項26によるシステム。
- 血液アフェレーシスシステムにおける多血小板血漿の再抗凝固のための方法であって、前記方法が
一定量の抗凝固剤がPRP回収コンテナへと移されるように前記血液アフェレーシスシステムを抗凝固剤によってプライミングするステップであって、前記一定量の抗凝固剤が多血小板血漿の目標容量に比例する、ステップ、および
前記目標容量の多血小板血漿を前記PRP回収コンテナへと回収するステップを含有する、方法。 - 前記血液アフェレーシスシステムを抗凝固剤によってプライミングするステップが、抗凝固剤ラインおよび全血ラインフィルタを抗凝固剤によってプライミングするステップを含む、請求項29による方法。
- 前記血液アフェレーシスシステムをプライミングするステップが、全血ラインフィルタ中の抗凝固剤を赤血球コンテナへと移すステップを含む、請求項30による方法。
- 前記全血ラインフィルタ中の抗凝固剤が前記複数のサイクルの最初の開始時に前記赤血球コンテナへと移される、請求項31による方法。
- 前記全血ラインフィルタ中の抗凝固剤が抗凝固剤源へと返却される、請求項31による方法。
- 前記多血小板血漿の目標容量が複数のサイクルにおいて回収される、請求項29による方法。
- 前記目標容量が、前記複数のサイクルのそれぞれにおいて回収される容量の合計である、請求項34による方法。
- 前記複数のサイクルのそれぞれが、
全血を提供するステップ、
前記全血へと抗凝固剤を導入するステップ、
前記抗凝固処理された全血を分離チャンバへと導入するステップであって、ここで前記分離チャンバが前記抗凝固処理された全血を多血小板血漿を含むいくつかの血液成分へと分離する、ステップ、および
前記分離チャンバからPRP回収コンテナへと前記多血小板血漿を抽出するステップを含む、請求34による方法。 - 前記PRP回収コンテナより前記分離チャンバへと前記多血小板血漿を再導入するステップであって、前記分離チャンバは前記再導入された多血小板血漿を血漿と血漿を減少させた血小板製剤へと分離するステップ、
前記分離チャンバから血小板コンテナへと前記血漿を減少させた血小板を抽出するステップをさらに含有する請求項29による方法。 - 前記全血へと導入される抗凝固剤の量が前記PRP回収コンテナ中の前記一定量の抗凝固剤に比例して減少する、請求項29による方法。
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JP2017070794A (ja) * | 2016-12-12 | 2017-04-13 | テルモ株式会社 | 血液成分分離装置および血液成分分離方法 |
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US20100234788A1 (en) | 2010-09-16 |
CN102395392B (zh) | 2015-03-25 |
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JP2012520125A (ja) | 2012-09-06 |
US8834402B2 (en) | 2014-09-16 |
EP2405958B1 (en) | 2016-03-02 |
HK1168815A1 (en) | 2013-01-11 |
CN102395392A (zh) | 2012-03-28 |
EP3034114B1 (en) | 2018-12-19 |
US20160106908A1 (en) | 2016-04-21 |
US9789243B2 (en) | 2017-10-17 |
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US20140356851A1 (en) | 2014-12-04 |
US9248227B2 (en) | 2016-02-02 |
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