JP5182856B2 - 光計測装置 - Google Patents
光計測装置 Download PDFInfo
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- JP5182856B2 JP5182856B2 JP2007314768A JP2007314768A JP5182856B2 JP 5182856 B2 JP5182856 B2 JP 5182856B2 JP 2007314768 A JP2007314768 A JP 2007314768A JP 2007314768 A JP2007314768 A JP 2007314768A JP 5182856 B2 JP5182856 B2 JP 5182856B2
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- Investigating Or Analysing Materials By Optical Means (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Description
Obrig H, Villringer A: Beyond the visible - Imaging the human brain with light. Journal of cerebral blood flow and metabolism 23, 1-18 (2003) Roy CS, Sherrington CS: On the regulation of the blood supply of the brain. J. Physiol., 11, 85-108 (1890) Boas DA, Dale AM, and Franceschini MA, Diffuse optical inaging of brain activation: approaches to optimizing image sensitivity, resolution, and accuracy., Neuro Image, 23, S275-S288, (2004) Okada E, Delpy DT: Near-infrared light propagation in an adult head model. I. Modeling of low-level scattering in the cerebrospinal fluid layer. APPLIED OPTICS 42, 2906-2914, (2003) Matcher SJ, Elwell CE, Cooper CE, Cope M, Delpy DT, Performance Comparison of Several Published Tissue Near-Infrared Spectroscopy Algorithms, Anal. Biochem. 227 (1): 54-68 (1995)
従来、3波長の定常光源を用いて行われてきたfNIRS測定すなわちMBL法における各Hb変化量(Δxo,Δxd)の算出アルゴリズムは、以下のように表される。
fNIRS測定の光プローブおよび制御測定装置には、浜松ホトニクス社製酸素モニターNIRO-200およびマルチプローブアダプターを用いた。サンプリング周波数0.5[Hz]、使用波長776nm,809nm,850nm、プローブ先端開口部径約2mm。プローブホルダーとして図2に示す形状のホルダーを用いた。各照射-受光プローブ(図中の1,3,5,7)間距離は、30mmであり、参照プローブ(図中の2,4,6,8)は、この直線上で照射プローブから20mmの位置に導入した。
motion artifact の検証として、座位安静にした被験者が自発動作により上体を約45°傾けるタスクを課した(以下「MA課題」という。)。タスクデザインは、初期の上体正立
20s に続いて上体傾斜 20s と上体正立 20sのセットの5回繰り返しである。また、機能性信号検出の検証として、同様の***にある被験者に親指と人差し指の対向動作(以下、finger opposition、「FO課題」という。)を課した。タスクデザインは、初期安静 20s に続いて左手指動作 20s , 安静 20s, 右手指動作 20s, 安静 20s の順のセットの5回繰り返しである。
[motion artifact課題時の結果比較]
プローブ配置BでMA課題時に得られる各プローブでのヘモグロビン変化の様子を図3に示す。プローブ1,3,5,7はMBL法で測定される各Hb変化量に相当する。これら各位置でMA課題に相関して各Hbが顕著に変化することが分かる。またこれらの各時系列的変化を詳細に眺めると、ドリフトの有無やドリフト成分と課題相関的成分の大小関係などの面でそれぞれに異なる様相を示していることが分かる。
プローブ配置BでFO課題時に得られる各プローブでのヘモグロビン変化を、左手指運動前10secから課題終了後20secおよび右手指運動前10secから課題終了後20secまでの区間で平均化したデータを図5に示す。プローブ1,3,5,7で得られたMBL法による結果には、運動指の同側/反対側半球いずれの位置でもFO課題に応じたHbの変化が生じていることが分かる。
Claims (1)
- 近赤外光を頭脳の所定の部位に照射し、該所定の部位の近傍において出射してくる光を検出し、生体に関する情報を獲得する光計測装置であって、
該近赤外光の光源と、照射プローブと、受光プローブと、
該照射プローブと該受光プローブを結ぶ直線上で、かつ、該受光プローブと頭皮及び皮下の筋肉組織並びに骨組織からなる層が一様な分光学的変化を示すと見なせる該受光プローブの近傍に、参照プローブとを設け、
該受光プローブにより測定される吸光度変化と該参照プローブにより測定される吸光度変化の、差分に基づいて、脳皮質組織の酸素化ヘモグロビン及び脱酸素化ヘモグロビンの変化量を算出することを特徴とする光計測装置。
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Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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JP5443075B2 (ja) * | 2009-06-30 | 2014-03-19 | 株式会社日立製作所 | ゲームシステム、生体光計測装置 |
JP5641355B2 (ja) * | 2011-05-20 | 2014-12-17 | 独立行政法人産業技術総合研究所 | 生体光計測装置、プログラム及び生体光計測方法 |
CN104244840B (zh) | 2012-04-25 | 2017-04-19 | 株式会社岛津制作所 | 光生物测量装置 |
CN104284629B (zh) * | 2012-05-11 | 2016-04-20 | 株式会社岛津制作所 | 光生物体测量***及其使用方法 |
US10271731B2 (en) * | 2012-07-27 | 2019-04-30 | Shimadzu Corporation | Optical biological measurement device and analysis method using the same |
JP6472145B2 (ja) | 2015-01-07 | 2019-02-20 | 国立研究開発法人産業技術総合研究所 | 脳機能計測装置およびそれを用いた光照射・光検出方法 |
WO2018167854A1 (ja) * | 2017-03-14 | 2018-09-20 | 株式会社日立ハイテクノロジーズ | 解析装置、解析プログラム |
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WO1995015534A1 (en) * | 1993-11-30 | 1995-06-08 | Bell Communications Research, Inc. | Imaging system and method using direct reconstruction of scattered radiation |
JP3310782B2 (ja) * | 1994-07-14 | 2002-08-05 | 株式会社日立製作所 | 吸収物質濃度の空間分布画像化装置 |
JP3359756B2 (ja) * | 1994-10-06 | 2002-12-24 | 株式会社日立製作所 | 生体光計測装置 |
JPH0998972A (ja) * | 1995-10-06 | 1997-04-15 | Hitachi Ltd | 生体光計測装置及び画像作成方法 |
JP3588880B2 (ja) * | 1995-11-17 | 2004-11-17 | 株式会社日立製作所 | 生体光計測装置 |
JP3035791B2 (ja) * | 1996-11-26 | 2000-04-24 | オムロン株式会社 | 生体組織内の吸光物質濃度および生体の介在組織厚の計測方法ならびに計測装置 |
JPH11299760A (ja) * | 1998-04-17 | 1999-11-02 | Mitsubishi Electric Corp | 脳活動計測装置 |
JP2003194714A (ja) * | 2001-12-28 | 2003-07-09 | Omega Wave Kk | 生体組織血液量測定装置 |
JP4483333B2 (ja) * | 2004-02-17 | 2010-06-16 | 株式会社島津製作所 | 光測定装置における測定方法及びチャンネル間偏差測定用標準器 |
JP2005328933A (ja) * | 2004-05-18 | 2005-12-02 | Shimadzu Corp | 経頭蓋的脳機能測定装置 |
JP4625809B2 (ja) * | 2004-07-20 | 2011-02-02 | 俊徳 加藤 | 生体機能診断装置、生体機能診断方法、生体用プローブ、生体用プローブ装着具、生体用プローブ支持具及び生体用プローブ装着支援具 |
JP2006075354A (ja) * | 2004-09-09 | 2006-03-23 | Chunichi Denshi Co Ltd | 組織酸素飽和度測定装置 |
US7865223B1 (en) * | 2005-03-14 | 2011-01-04 | Peter Bernreuter | In vivo blood spectrometry |
JP4696300B2 (ja) * | 2005-10-18 | 2011-06-08 | 独立行政法人産業技術総合研究所 | 近赤外光を用いた生体光計測法のための波長差分を用いたベースライン安定化方法 |
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