JP5173416B2 - コラーゲンに基づく生理活性 - Google Patents
コラーゲンに基づく生理活性 Download PDFInfo
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- JP5173416B2 JP5173416B2 JP2007523011A JP2007523011A JP5173416B2 JP 5173416 B2 JP5173416 B2 JP 5173416B2 JP 2007523011 A JP2007523011 A JP 2007523011A JP 2007523011 A JP2007523011 A JP 2007523011A JP 5173416 B2 JP5173416 B2 JP 5173416B2
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/68—Plantaginaceae (Plantain Family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/01—Hydrolysed proteins; Derivatives thereof
- A61K38/012—Hydrolysed proteins; Derivatives thereof from animals
- A61K38/014—Hydrolysed proteins; Derivatives thereof from animals from connective tissue peptides, e.g. gelatin, collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Nutrition Science (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Food Science & Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Description
Planox L: 1g Planox L 1日1回(10%アクテオシド(=1日100mgアクテオシド)+5gセルロース)
Arthred: 5gコラーゲン加水分解 1日1回
Planox L+Arthred: 1g Planox L+5gコラーゲン加水分解物 1日1回
プラセボ: 5g微晶質セルロース 1日1回
Arthred及びPlanox Lは、単独で投与した場合には改善も有意でない改善も示さなかった(比較試験)。Arthred+Planox Lの組合せからなる本発明の組成物では驚くべき相乗作用が見られ、これは個々の物質の作用を著しく超えるものであった。この組合せ組成物を投与した場合、痛みの状態は有意に軽減され、膝関節の機能状態も著しく高まった。
Claims (15)
- 有効成分Iとしての酵素加水分解コラーゲンと抗酸化性及び/又は抗炎症性を有する非ビタミン種の有効成分IIを含有する、コラーゲンに基づく関節症用の医薬組成物であって、
前記成分IIが少なくとも1つのフェニルエタノイドを含み、
前記フェニルエタノイドは少なくとも1つのアクテオシド及び/又はイソアクテオシドを含み、
前記成分IIが、レモンバーベナ(Aloysia triphylla)の抽出液、凍結乾燥物ならびに/又は画分であることを特徴とする医薬組成物。 - 前記成分Iの平均分子量が1〜10キロダルトンであることを特徴とする、請求項1に記載の医薬組成物。
- 前記成分Iの平均分子量が2〜6キロダルトンであることを特徴とする、請求項2に記載の医薬組成物。
- 前記成分Iの平均分子量が2〜4キロダルトンであることを特徴とする、請求項2に記載の医薬組成物。
- 前記成分Iが動物由来のものであることを特徴とする、請求項1〜4のいずれか一項に記載の医薬組成物。
- 前記成分Iとして冷水に可溶なコラーゲンを含むことを特徴とする、請求項1〜5のいずれか一項に記載の医薬組成物。
- 前記成分IIは、抽出液に基づくものである請求項6に記載の医薬組成物。
- 前記成分Iと前記成分IIをI:IIの重量比1:0.0001〜10で含むことを特徴とする、請求項1〜7のいずれか一項に記載の医薬組成物。
- 主成分IとIIの他に、グルコサミン、コンドロイチン、ヒアルロン酸、メチルスルホニルメタンもしくはクレアチン、ならびに/又は処方剤、安定剤、増量剤、香味剤、色素もしくは甘味剤をさらに含むことを特徴とする、請求項1〜8のいずれか一項に記載の医薬組成物。
- 関節症の予防及び/又は治療を目的とした薬剤の製造のための、請求項1〜7のいずれか一項に記載の医薬組成物の使用。
- プロ競技者、レジャー競技者又はレクリエーション競技者、高齢者又は回復期患者であって、特定の損傷かつ/又は障害のある関節機能を有する者のための、請求項10に記載の使用。
- 得られた薬剤が成分Iの一日用量10g未満に相当する量で投与されることを特徴とする、請求項11に記載の使用。
- 得られた薬剤が2週間〜6か月の期間継続して、投与されることを特徴とする、請求項10〜12のいずれか一項に記載の使用。
- 投与期間が3週間〜3か月である請求項13記載の使用。
- 前記投与が経口で行われる請求項13又は14記載の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004036577 | 2004-07-28 | ||
DE102004036577.6 | 2004-07-28 | ||
PCT/EP2005/008151 WO2006010606A1 (de) | 2004-07-28 | 2005-07-27 | Physiologisch aktive zusammensetzung auf kollagenbasis |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2008508219A JP2008508219A (ja) | 2008-03-21 |
JP5173416B2 true JP5173416B2 (ja) | 2013-04-03 |
Family
ID=35063369
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007523011A Expired - Fee Related JP5173416B2 (ja) | 2004-07-28 | 2005-07-27 | コラーゲンに基づく生理活性 |
Country Status (11)
Country | Link |
---|---|
US (1) | US7678768B2 (ja) |
EP (1) | EP1771200B1 (ja) |
JP (1) | JP5173416B2 (ja) |
KR (1) | KR101238730B1 (ja) |
CN (1) | CN101022823A (ja) |
AT (1) | ATE511853T1 (ja) |
AU (1) | AU2005266505B2 (ja) |
CA (1) | CA2574907C (ja) |
ES (1) | ES2367791T3 (ja) |
NZ (1) | NZ553169A (ja) |
WO (1) | WO2006010606A1 (ja) |
Families Citing this family (43)
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BRPI0715245A2 (pt) * | 2006-09-25 | 2014-03-18 | Haas Inc John I | "método de controle de larvas de insetos, método de controle de fungos método de tratamento ou prevenção de uma infestação de insetos ou fúngica de plantas, composição para tratamento ou prevenção de uma infestação fúngica ou de larvas de insentos, dispositivo de fornecimento de inseticida, dispositivo de fornecimento de fungicida, planta, método de fabricação da composição, kit de tratamento ou prevenção de um infestação fúngica ou de larvas de insetos, método de indentificação de um derivado de lúpulo que controla um inseto, método de identificação de um derivado de lúpulo que controla um fungo e método de identificação de um derivado de lúpulo que repele insetos" |
ES2298071B1 (es) * | 2006-10-25 | 2009-07-28 | Masterfarm,S.L. | Hidrolizado enzimatico de colageno y procedimiento de obtencion. |
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BG1286U1 (bg) * | 2009-10-06 | 2010-03-31 | "Дойч" Еоод | Хранителна добавка |
BG1287U1 (bg) * | 2009-10-15 | 2010-03-31 | "Дойч" Еоод | Хранителна добавка |
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US20010024664A1 (en) * | 1999-03-19 | 2001-09-27 | Obukowicz Mark G. | Selective COX-2 inhibition from edible plant extracts |
US6309675B1 (en) * | 1999-07-21 | 2001-10-30 | Nancy Laning Sobczak | Therapeutic composition including plantain and aloe vera for treatment of arthritis and other afflictions |
CA2393255A1 (en) * | 1999-12-16 | 2001-06-21 | Harry Siskind | Nutritional composition, methods of producing said composition and methods of using said composition |
US20020086070A1 (en) * | 2000-03-11 | 2002-07-04 | Kuhrts Eric Hauser | Anti-inflammatory and connective tissue repair formulations |
DE10047835A1 (de) * | 2000-09-27 | 2002-04-11 | Paper Dietrich H | Verwendung eines Extraktes von Lippia citriodora |
CN1484968A (zh) * | 2002-09-26 | 2004-03-31 | 樗晨 | 一种富硒紫茎女贞叶茶 |
US20040086581A1 (en) * | 2002-11-06 | 2004-05-06 | Jones Edwin B. | Bio-energetic joint and arthritis pain formula |
DE10359384A1 (de) * | 2003-12-18 | 2005-07-28 | Anoxymer Gmbh | Verwendung eines Extraktes von Aloysia triphylla als Matrixprotektor |
-
2005
- 2005-07-27 ES ES05769707T patent/ES2367791T3/es active Active
- 2005-07-27 WO PCT/EP2005/008151 patent/WO2006010606A1/de active Application Filing
- 2005-07-27 EP EP05769707A patent/EP1771200B1/de not_active Not-in-force
- 2005-07-27 CA CA2574907A patent/CA2574907C/en not_active Expired - Fee Related
- 2005-07-27 AT AT05769707T patent/ATE511853T1/de active
- 2005-07-27 AU AU2005266505A patent/AU2005266505B2/en not_active Ceased
- 2005-07-27 US US11/658,437 patent/US7678768B2/en not_active Expired - Fee Related
- 2005-07-27 CN CNA200580031566XA patent/CN101022823A/zh active Pending
- 2005-07-27 KR KR1020077004757A patent/KR101238730B1/ko not_active IP Right Cessation
- 2005-07-27 NZ NZ553169A patent/NZ553169A/en not_active IP Right Cessation
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Also Published As
Publication number | Publication date |
---|---|
ATE511853T1 (de) | 2011-06-15 |
CA2574907A1 (en) | 2006-02-02 |
EP1771200A1 (de) | 2007-04-11 |
KR101238730B1 (ko) | 2013-03-04 |
US7678768B2 (en) | 2010-03-16 |
NZ553169A (en) | 2009-10-30 |
CN101022823A (zh) | 2007-08-22 |
WO2006010606A1 (de) | 2006-02-02 |
JP2008508219A (ja) | 2008-03-21 |
ES2367791T3 (es) | 2011-11-08 |
KR20070054645A (ko) | 2007-05-29 |
EP1771200B1 (de) | 2011-06-08 |
AU2005266505B2 (en) | 2011-10-06 |
US20090005322A1 (en) | 2009-01-01 |
AU2005266505A1 (en) | 2006-02-02 |
CA2574907C (en) | 2015-01-06 |
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