JP5102434B2 - 皮膚品質を改良するための経口投与可能な組成物 - Google Patents
皮膚品質を改良するための経口投与可能な組成物 Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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Description
生き物の生涯には、老化の特徴である様々な徴候は皮膚に現れ、主要な臨床的徴候は細かい線と深い皺の出現であり、これは年齢と共に増加しまたは目立ってくる。更に、皮膚の色は一般に変化し、刺激を拡散し、場合によっては末梢血管拡張がある部分に存在するようになることがある。これらの老化の徴候は、例えば紫外線、汚染物質、フリーラジカルまたは化学物質のような外界からの影響に皮膚を暴露することによって促進される。
従って、第一の態様では、本発明は、ヒトまたは動物の皮膚品質を改良するための経口投与可能な組成物であって、活性成分として細胞のエネルギー代謝を刺激する分子、酸化防止剤、またはそれらの組合せ混合物の有効量を経口的に許容可能なキャリヤー中に含んでなる、組成物を提供することを目的とする。
第一の態様は、皮膚品質を改良するための経口投与可能な組成物であって、活性成分として細胞のエネルギー代謝を刺激する分子、酸化防止剤、またはそれらの組合せ混合物の有効量を経口的に許容可能なキャリヤー中に含んでなる組成物に関する。
研究デザイン:
食餌介入は、12月齢マウスで3ヶ月間であった。総ての動物群は、自由に給餌を受けた。動物の体重を1週間に1回測定した。
雄マウスC57/BL6は、9週齢のものをIFFA credo (フランス)から入手した。3週間の適応後、マウス(12週齢)を1尾ずつ収容して、栄養介入までコントロール食餌Aを与えた。12月齢で、マウスを無作為に10尾ずつ5群(A、B、C、DおよびE)に分けた。食餌介入は3ヶ月間であり、マウスに食物および水を自由に与え、12時間ずつの明暗サイクルを受けさせた。
18%タンパク質(大豆およびホエー)、11%脂肪(大豆油)、59%炭水化物(澱粉+スクロース)および10%セルロースから構成されるコントロール食餌(食餌A)に、イチョウ抽出物(食餌D)、またはビタミンC、ビタミンE、ブドウ種子抽出物およびシステインを含んでなる酸化防止剤のカクテル(食餌B)および/またはL-カルニチン(それぞれ、食餌CおよびE)を追加した。これらの食餌は、下記の通りである:
食餌A-コントロール: 18%タンパク質(大豆およびホエー)、11%脂肪、59%炭水化物、5%セルロース。
食餌B-酸化防止剤のカクテル: 食餌A + 0.19%ビタミンC、0.03% ビタミンE、0.075%ブドウ種子抽出物、0.4%システイン。
食餌C: 食餌A + 0.3% L-カルニチン +食餌Cの酸化防止剤のカクテル。
食餌D: 食餌A + 0.0375%イチョウ抽出物(Linnea)。
食餌E: 食餌A + 0.3% L-カルニチン。
3ヶ月間の食餌介入の後、動物を屠殺して、標準化した生験材料を採取した。背側皮膚(正中線、下背部)皮膜毛を除いて集め、秤量し、0.5x0.5mmの正方形に切り刻んだ。これらをその重量の10倍容積の0.1%酢酸、1M NaCl中で4℃で一定攪拌を行いながら24時間抽出した。試料を、不溶分(残っている皮膜毛、表皮)を遠心分離によって除き、上部の脂質層、溶解した真皮を含む水性層、および不溶分を含むペレットを生じた。水性層を取っておき、タンパク質を測定した。この上清25μlに200μlのBCA試薬(製造業者の指示に従ってBCA試薬AをBCA試薬Bと予備混合, Pierce, Rockford, IL,米国)を追加し、一定攪拌を行いながら30秒間インキュベーションした。顕色を562nmで測定した。タンパク質濃度を、BSA標準曲線から計算した。
12月齢で開始した3ヶ月間の食餌介入の後、4種類の実験用食餌をコントロール食餌と比較した。皮膚を酸性の高塩緩衝液で抽出し、GAG並びに総タンパク質を抽出物測定した。抽出物のGAG含量を、表1に示す。表1は、皮膚のグリコサミノグリカン含量が、コントロール食餌Aと比較して食餌B、C、DおよびEで刺激されることを示している。
これらのデーターから、12月齢マウスでの様々な食餌B、C、DおよびEによる3ヶ月間の食餌介入により、GAG含量の月齢に依存する減少を逆転することができる。食餌介入は、GAG含量を若い皮膚で見られるパターンまで増加させるのに効率的であった。GAGは多量の間質液を結合するための有力な分子であるので、それらは間質水和を増加させ且つ皮膚老化の徴候を元に戻すことができる。
トウモロコシ約58重量%、トウモロコシグルテン約5.5重量%、チキンミール約22重量%、2.5%乾燥チコリー、1%カルニチン、0.1%ビタミンC、ビタミンE(150IU/kg)、0.05%ブドウ種子プロアントシアニジン抽出物、および酸化防止剤としての1%システインであって、残りが塩、ビタミンおよびミネラルであるものから、飼料混合物を作製する。
飼料混合物を、実施例2と同様に2%カルニチンおよび酸化防止剤として0.05%イチョウ抽出物を用いて調製する。次に、飼料混合物を実施例2と同様に加工する。乾燥ドッグフードは、特にイヌの年齢に関連した皮膚の変化を改良しまたは回復することを目的としている。
粉末100gに対して、タンパク質加水分解生成物15%、脂肪25%、炭水化物(マルトデキストリン37%、澱粉6%、スクロース12%を含む) 55%、1日必要量に見合うだけの微量のビタミンおよびオリゴ成分(oligoelements)、2%ミネラル、および3%水分、および2%ピルベート、および酸化防止剤としての1%カルノシンまたはカルノシン前駆体を含む栄養組成物を調製する。
皮膚品質を改良するための、特に皮膚におけるグリコサミノグリカン産生と沈着を刺激する毎日経口投与可能な組成物は、イチョウ抽出物240mgとGlucidex IT 19(マルトデキストリン粉末) QSP 500mgを含む。
Claims (2)
- ヒトの皮膚品質の改良を目的とする経口投与可能な食料栄養補給物を調製するための、L−カルニチン、システイン、ビタミンC、ビタミンE及びブドウ種子抽出物の使用。
- ヒトの皮膚年齢に関係した変化を予防しまたは回復することを目的とする経口投与可能な食料栄養補給物を調製するための、L−カルニチン、システイン、ビタミンC、ビタミンE及びブドウ種子抽出物の使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02078707 | 2002-09-09 | ||
EP02078707.3 | 2002-09-09 | ||
PCT/EP2003/009687 WO2004026287A1 (en) | 2002-09-09 | 2003-09-01 | Orally administrable composition for improving skin quality |
Publications (2)
Publication Number | Publication Date |
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JP2006502176A JP2006502176A (ja) | 2006-01-19 |
JP5102434B2 true JP5102434B2 (ja) | 2012-12-19 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2004536974A Expired - Fee Related JP5102434B2 (ja) | 2002-09-09 | 2003-09-01 | 皮膚品質を改良するための経口投与可能な組成物 |
Country Status (15)
Country | Link |
---|---|
US (1) | US20050249826A1 (ja) |
EP (1) | EP1581199B1 (ja) |
JP (1) | JP5102434B2 (ja) |
KR (1) | KR20050057286A (ja) |
CN (1) | CN1681484B (ja) |
AU (1) | AU2003294667A1 (ja) |
BR (1) | BRPI0314066A8 (ja) |
CA (1) | CA2498141C (ja) |
ES (1) | ES2535778T3 (ja) |
HK (1) | HK1083746A1 (ja) |
MX (1) | MXPA05002652A (ja) |
MY (1) | MY166631A (ja) |
PT (1) | PT1581199E (ja) |
TW (1) | TW200404562A (ja) |
WO (1) | WO2004026287A1 (ja) |
Families Citing this family (22)
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US8034372B2 (en) | 2003-03-05 | 2011-10-11 | Nestec, Ltd. | Dietary supplement for athletic pets |
CN1917779B (zh) * | 2004-01-28 | 2010-06-16 | 雀巢技术公司 | 用于改善皮肤状况和防止皮肤病的营养组合物 |
EP1637149A1 (de) * | 2004-06-09 | 2006-03-22 | Medifood GmbH | Nahrungsergänzungsmittel für den Mann |
WO2006069662A1 (en) * | 2004-12-31 | 2006-07-06 | Dsm Ip Assets B.V. | Pet food |
EP1924160A2 (en) * | 2005-09-02 | 2008-05-28 | Campina Nederland Holding B.V. | Oral composition for moisturising skin |
WO2007062415A1 (en) * | 2005-11-26 | 2007-05-31 | Grinrx | Corporeal delivery of carotenoids |
ES2543808T3 (es) * | 2006-02-01 | 2015-08-24 | Nestec S.A. | Sistema nutricional y métodos para aumentar la longevidad |
AU2007245002B2 (en) * | 2006-03-29 | 2012-05-03 | Société des Produits Nestlé S.A. | Dietary supplements containing probiotics |
ES2562977T3 (es) * | 2006-04-12 | 2016-03-09 | Unilever N.V. | Composición oral con un efecto antienvejecimiento sobre la piel |
EP2004169B1 (en) * | 2006-04-12 | 2012-08-08 | Unilever PLC | Oral composition comprising a polyunsaturated fatty acid and salicylic acid for obtaining an antiinflammatory effect in skin |
US20070286925A1 (en) * | 2006-06-08 | 2007-12-13 | The Procter & Gamble Company | Composition for improving eye health |
JP4922137B2 (ja) * | 2007-11-16 | 2012-04-25 | 株式会社マルハニチロ食品 | ヒアルロン酸産生促進物質 |
WO2011159653A1 (en) * | 2010-06-14 | 2011-12-22 | Abbott Laboratories | Ultrasonically-assisted extrusion methods for manufacturing powdered nutritional products |
MX349209B (es) * | 2010-07-30 | 2017-07-18 | Nestec Sa | Uso de granos de cafe tostados para regular pigmentación de la piel. |
JP2013537528A (ja) * | 2010-07-30 | 2013-10-03 | ネステク ソシエテ アノニム | 皮膚色素沈着を調節するための焙煎及び非焙煎コーヒー豆混合物の使用 |
ES2773723T3 (es) * | 2010-07-30 | 2020-07-14 | Nestle Sa | Uso de café verde y de probióticos para regular la pigmentación de la piel |
BR112013002215B1 (pt) * | 2010-07-30 | 2017-12-19 | L'oreal | Cosmetic use of green coffee grains and method, kit for regulation of skin pigmentation disorders, and non-therapeutic method for cosmetic treatment |
CN102783568B (zh) * | 2012-08-29 | 2014-05-14 | 山东中医药大学 | 一种饲料添加剂 |
CN103385516A (zh) * | 2013-07-29 | 2013-11-13 | 安徽燕之坊食品有限公司 | 一种液体补充物 |
US11767314B2 (en) | 2018-11-02 | 2023-09-26 | Conopco, Inc. | Bioenergetic nicotinic acid glycerol esters, compositions and methods of using same |
WO2020222506A1 (ko) * | 2019-05-02 | 2020-11-05 | 주식회사 넥스모스 | 압타머를 유효성분으로 포함하는 경구용 조성물 |
EP4167747A1 (en) | 2020-06-17 | 2023-04-26 | Société des Produits Nestlé S.A. | Stabilization of lc-pufas by side stream product from green coffee decaffeination |
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US4839159A (en) * | 1988-02-08 | 1989-06-13 | Topicarn, Inc. | Topical L-carnitine composition |
US5686436A (en) * | 1993-05-13 | 1997-11-11 | Hiv Diagnostics, Inc. | Multi-faceted method to repress reproduction of latent viruses in humans and animals |
US5656588A (en) * | 1994-07-19 | 1997-08-12 | Wake Forest University | Wound healing formula |
US6602526B2 (en) * | 1996-02-23 | 2003-08-05 | Medical Doctors Research Institute | Oral compositions containing lotus |
WO1998000024A1 (en) * | 1996-06-28 | 1998-01-08 | Viva America Marketing, Inc. | Nutritional supplement composition and use |
DE19649891C2 (de) * | 1996-12-02 | 1998-12-10 | Mk Produktkontor Gmbh | Verwendung von antioxidativen Zusammensetzungen mit Süßmolkekonzentrat |
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IT1299191B1 (it) * | 1998-06-23 | 2000-02-29 | Sigma Tau Healthscience Spa | Composizione atta a prevenire e trattare l'osteoporosi e le alterazioni legate alla menopausa |
JP4082823B2 (ja) * | 1999-05-06 | 2008-04-30 | 日本メナード化粧品株式会社 | 光毒性抑制剤 |
JP2001098267A (ja) * | 1999-09-30 | 2001-04-10 | Kobayashi Pharmaceut Co Ltd | 抗酸化剤及び活性酸素消去剤 |
EP1250052A1 (en) * | 2000-01-25 | 2002-10-23 | Juvenon, Inc. | Nutritional supplements for aged pets |
WO2002011745A1 (en) * | 2000-08-04 | 2002-02-14 | Angiolab, Inc. | Composition containing ginkgo biloba that inhibit angiogenesis and matrix metalloproteinase |
US20020115710A1 (en) * | 2000-10-31 | 2002-08-22 | Zicker Steven Curtis | Composition and method |
FR2818136B1 (fr) * | 2000-12-15 | 2004-10-15 | Oreal | Composition, notamment cosmetique, comprenant la 7-hydroxy dhea et/ou la 7-ceto dhea et au moins un inhibiteur de no-synthase |
CN1197473C (zh) * | 2001-01-02 | 2005-04-20 | 陈勇 | 胶基可食的功能性口香糖及其制作方法 |
US20030008048A1 (en) * | 2001-06-08 | 2003-01-09 | David Winston | Methods and compositions for helping the body resist the effects of the aging process |
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2003
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- 2003-09-01 BR BRPI0314066A patent/BRPI0314066A8/pt not_active Application Discontinuation
- 2003-09-01 KR KR1020057004051A patent/KR20050057286A/ko not_active Application Discontinuation
- 2003-09-01 AU AU2003294667A patent/AU2003294667A1/en not_active Abandoned
- 2003-09-01 MX MXPA05002652A patent/MXPA05002652A/es active IP Right Grant
- 2003-09-01 WO PCT/EP2003/009687 patent/WO2004026287A1/en active Application Filing
- 2003-09-01 JP JP2004536974A patent/JP5102434B2/ja not_active Expired - Fee Related
- 2003-09-01 US US10/527,097 patent/US20050249826A1/en not_active Abandoned
- 2003-09-01 CA CA2498141A patent/CA2498141C/en not_active Expired - Fee Related
- 2003-09-01 ES ES03785600.2T patent/ES2535778T3/es not_active Expired - Lifetime
- 2003-09-01 PT PT37856002T patent/PT1581199E/pt unknown
- 2003-09-01 CN CN038213354A patent/CN1681484B/zh not_active Expired - Fee Related
- 2003-09-09 TW TW092124912A patent/TW200404562A/zh unknown
- 2003-09-09 MY MYPI20033394A patent/MY166631A/en unknown
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- 2006-03-27 HK HK06103796.4A patent/HK1083746A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2535778T3 (es) | 2015-05-14 |
MY166631A (en) | 2018-07-17 |
AU2003294667A1 (en) | 2004-04-08 |
CN1681484A (zh) | 2005-10-12 |
WO2004026287A1 (en) | 2004-04-01 |
BR0314066A (pt) | 2005-07-05 |
EP1581199B1 (en) | 2015-02-25 |
US20050249826A1 (en) | 2005-11-10 |
CA2498141C (en) | 2012-07-10 |
EP1581199A1 (en) | 2005-10-05 |
CN1681484B (zh) | 2012-06-06 |
JP2006502176A (ja) | 2006-01-19 |
PT1581199E (pt) | 2015-04-27 |
CA2498141A1 (en) | 2004-04-01 |
TW200404562A (en) | 2004-04-01 |
BRPI0314066A8 (pt) | 2017-12-12 |
HK1083746A1 (en) | 2006-07-14 |
KR20050057286A (ko) | 2005-06-16 |
MXPA05002652A (es) | 2006-04-28 |
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