JP5008573B2 - 防腐剤 - Google Patents
防腐剤 Download PDFInfo
- Publication number
- JP5008573B2 JP5008573B2 JP2007553503A JP2007553503A JP5008573B2 JP 5008573 B2 JP5008573 B2 JP 5008573B2 JP 2007553503 A JP2007553503 A JP 2007553503A JP 2007553503 A JP2007553503 A JP 2007553503A JP 5008573 B2 JP5008573 B2 JP 5008573B2
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- hydroxy
- trimethylpentyl
- pyridone
- phenoxyethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003755 preservative agent Substances 0.000 title claims description 74
- 230000002335 preservative effect Effects 0.000 title claims description 72
- 239000000203 mixture Substances 0.000 claims description 116
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims description 42
- 229960005323 phenoxyethanol Drugs 0.000 claims description 42
- -1 4-methyl-6- (2,4,4-trimethylpentyl) -2 (1H) -pyridone aminoethanol salt Chemical compound 0.000 claims description 30
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 150000003839 salts Chemical class 0.000 claims description 29
- 238000002360 preparation method Methods 0.000 claims description 27
- 239000002537 cosmetic Substances 0.000 claims description 26
- 238000009472 formulation Methods 0.000 claims description 22
- 239000000839 emulsion Substances 0.000 claims description 19
- OIQJEQLSYJSNDS-UHFFFAOYSA-N piroctone Chemical compound CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O OIQJEQLSYJSNDS-UHFFFAOYSA-N 0.000 claims description 18
- 239000013543 active substance Substances 0.000 claims description 16
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims description 16
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 14
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 14
- 230000000845 anti-microbial effect Effects 0.000 claims description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 229940126601 medicinal product Drugs 0.000 claims description 12
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims description 10
- 239000005711 Benzoic acid Substances 0.000 claims description 9
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 9
- 235000010199 sorbic acid Nutrition 0.000 claims description 9
- 239000004334 sorbic acid Substances 0.000 claims description 9
- 229940075582 sorbic acid Drugs 0.000 claims description 9
- 239000000126 substance Substances 0.000 claims description 9
- 239000004094 surface-active agent Substances 0.000 claims description 9
- 239000003963 antioxidant agent Substances 0.000 claims description 8
- 235000010233 benzoic acid Nutrition 0.000 claims description 8
- 239000003752 hydrotrope Substances 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 8
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 8
- 235000010234 sodium benzoate Nutrition 0.000 claims description 8
- 239000004299 sodium benzoate Substances 0.000 claims description 8
- UJPKMTDFFUTLGM-UHFFFAOYSA-N 1-aminoethanol Chemical class CC(N)O UJPKMTDFFUTLGM-UHFFFAOYSA-N 0.000 claims description 7
- JUAUJJPBJGQPET-UHFFFAOYSA-N 1-aminoethanol;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one Chemical compound CC(N)O.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O JUAUJJPBJGQPET-UHFFFAOYSA-N 0.000 claims description 7
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 7
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 claims description 7
- 150000007524 organic acids Chemical class 0.000 claims description 7
- 235000010241 potassium sorbate Nutrition 0.000 claims description 7
- 239000004302 potassium sorbate Substances 0.000 claims description 7
- 229940069338 potassium sorbate Drugs 0.000 claims description 7
- 229960004889 salicylic acid Drugs 0.000 claims description 7
- 229960004025 sodium salicylate Drugs 0.000 claims description 7
- 230000000844 anti-bacterial effect Effects 0.000 claims description 6
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims description 6
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims description 6
- 229960002216 methylparaben Drugs 0.000 claims description 6
- 239000002904 solvent Substances 0.000 claims description 6
- 229960004365 benzoic acid Drugs 0.000 claims description 5
- 238000004321 preservation Methods 0.000 claims description 5
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 claims description 4
- 239000000654 additive Substances 0.000 claims description 4
- 235000005985 organic acids Nutrition 0.000 claims description 4
- QUCDWLYKDRVKMI-UHFFFAOYSA-M sodium;3,4-dimethylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1C QUCDWLYKDRVKMI-UHFFFAOYSA-M 0.000 claims description 4
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 3
- JBVOQKNLGSOPNZ-UHFFFAOYSA-N 2-propan-2-ylbenzenesulfonic acid Chemical group CC(C)C1=CC=CC=C1S(O)(=O)=O JBVOQKNLGSOPNZ-UHFFFAOYSA-N 0.000 claims description 3
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 3
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 3
- 229940071118 cumenesulfonate Drugs 0.000 claims description 3
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 3
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims description 3
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 229960003885 sodium benzoate Drugs 0.000 claims description 2
- ZWYIJAODXAWSBE-UHFFFAOYSA-N 6-(2,4,4-trimethylpentyl)-1h-pyridin-2-one Chemical compound CC(C)(C)CC(C)CC1=CC=CC(=O)N1 ZWYIJAODXAWSBE-UHFFFAOYSA-N 0.000 claims 1
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical compound NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 29
- 238000003756 stirring Methods 0.000 description 21
- 229950001046 piroctone Drugs 0.000 description 20
- 150000001298 alcohols Chemical class 0.000 description 14
- 125000003118 aryl group Chemical group 0.000 description 14
- 229940081510 piroctone olamine Drugs 0.000 description 8
- 239000000047 product Substances 0.000 description 8
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
- QFOHBWFCKVYLES-UHFFFAOYSA-N Butylparaben Chemical compound CCCCOC(=O)C1=CC=C(O)C=C1 QFOHBWFCKVYLES-UHFFFAOYSA-N 0.000 description 6
- 230000002421 anti-septic effect Effects 0.000 description 6
- 235000006708 antioxidants Nutrition 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 239000004615 ingredient Substances 0.000 description 6
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 6
- UBQKCCHYAOITMY-UHFFFAOYSA-N pyridin-2-ol Chemical class OC1=CC=CC=N1 UBQKCCHYAOITMY-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000006071 cream Substances 0.000 description 5
- 238000010792 warming Methods 0.000 description 5
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 125000000217 alkyl group Chemical group 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 238000011068 loading method Methods 0.000 description 4
- 229960004063 propylene glycol Drugs 0.000 description 4
- LVDKZNITIUWNER-UHFFFAOYSA-N Bronopol Chemical compound OCC(Br)(CO)[N+]([O-])=O LVDKZNITIUWNER-UHFFFAOYSA-N 0.000 description 3
- XPJVKCRENWUEJH-UHFFFAOYSA-N Isobutylparaben Chemical compound CC(C)COC(=O)C1=CC=C(O)C=C1 XPJVKCRENWUEJH-UHFFFAOYSA-N 0.000 description 3
- CQOVPNPJLQNMDC-UHFFFAOYSA-N N-beta-alanyl-L-histidine Natural products NCCC(=O)NC(C(O)=O)CC1=CN=CN1 CQOVPNPJLQNMDC-UHFFFAOYSA-N 0.000 description 3
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 3
- 229940067596 butylparaben Drugs 0.000 description 3
- 238000001816 cooling Methods 0.000 description 3
- 125000006165 cyclic alkyl group Chemical group 0.000 description 3
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 3
- SOROIESOUPGGFO-UHFFFAOYSA-N diazolidinylurea Chemical compound OCNC(=O)N(CO)C1N(CO)C(=O)N(CO)C1=O SOROIESOUPGGFO-UHFFFAOYSA-N 0.000 description 3
- 229960001083 diazolidinylurea Drugs 0.000 description 3
- WSDISUOETYTPRL-UHFFFAOYSA-N dmdm hydantoin Chemical compound CC1(C)N(CO)C(=O)N(CO)C1=O WSDISUOETYTPRL-UHFFFAOYSA-N 0.000 description 3
- 229960001617 ethyl hydroxybenzoate Drugs 0.000 description 3
- 235000010228 ethyl p-hydroxybenzoate Nutrition 0.000 description 3
- 239000004403 ethyl p-hydroxybenzoate Substances 0.000 description 3
- NUVBSKCKDOMJSU-UHFFFAOYSA-N ethylparaben Chemical compound CCOC(=O)C1=CC=C(O)C=C1 NUVBSKCKDOMJSU-UHFFFAOYSA-N 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 229940093915 gynecological organic acid Drugs 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- ZCTXEAQXZGPWFG-UHFFFAOYSA-N imidurea Chemical compound O=C1NC(=O)N(CO)C1NC(=O)NCNC(=O)NC1C(=O)NC(=O)N1CO ZCTXEAQXZGPWFG-UHFFFAOYSA-N 0.000 description 3
- 239000006210 lotion Substances 0.000 description 3
- 108700019599 monomethylolglycine Proteins 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 3
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 description 3
- 229960003415 propylparaben Drugs 0.000 description 3
- 229940101011 sodium hydroxymethylglycinate Drugs 0.000 description 3
- 235000010268 sodium methyl p-hydroxybenzoate Nutrition 0.000 description 3
- CITBNDNUEPMTFC-UHFFFAOYSA-M sodium;2-(hydroxymethylamino)acetate Chemical compound [Na+].OCNCC([O-])=O CITBNDNUEPMTFC-UHFFFAOYSA-M 0.000 description 3
- OGBHACNFHJJTQT-UHFFFAOYSA-M sodium;4-butoxycarbonylphenolate Chemical compound [Na+].CCCCOC(=O)C1=CC=C([O-])C=C1 OGBHACNFHJJTQT-UHFFFAOYSA-M 0.000 description 3
- QYNMSPKSYXPZHG-UHFFFAOYSA-M sodium;4-ethoxycarbonylphenolate Chemical compound [Na+].CCOC(=O)C1=CC=C([O-])C=C1 QYNMSPKSYXPZHG-UHFFFAOYSA-M 0.000 description 3
- PESXGULMKCKJCC-UHFFFAOYSA-M sodium;4-methoxycarbonylphenolate Chemical compound [Na+].COC(=O)C1=CC=C([O-])C=C1 PESXGULMKCKJCC-UHFFFAOYSA-M 0.000 description 3
- IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 3
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 description 2
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 2
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 2
- MFQARMSJVKMVMG-UHFFFAOYSA-M C(#CC)N(C([O-])=O)CCCC.[I+] Chemical compound C(#CC)N(C([O-])=O)CCCC.[I+] MFQARMSJVKMVMG-UHFFFAOYSA-M 0.000 description 2
- 108010087806 Carnosine Proteins 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
- VYGQUTWHTHXGQB-FFHKNEKCSA-N Retinol Palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-FFHKNEKCSA-N 0.000 description 2
- 102000019197 Superoxide Dismutase Human genes 0.000 description 2
- 108010012715 Superoxide dismutase Proteins 0.000 description 2
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- 239000002253 acid Substances 0.000 description 2
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- ANVAOWXLWRTKGA-XHGAXZNDSA-N all-trans-alpha-carotene Chemical compound CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1C(C)=CCCC1(C)C ANVAOWXLWRTKGA-XHGAXZNDSA-N 0.000 description 2
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- 230000001166 anti-perspirative effect Effects 0.000 description 2
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- 229940064004 antiseptic throat preparations Drugs 0.000 description 2
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 2
- WXBLLCUINBKULX-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1.OC(=O)C1=CC=CC=C1 WXBLLCUINBKULX-UHFFFAOYSA-N 0.000 description 2
- 235000019445 benzyl alcohol Nutrition 0.000 description 2
- CQOVPNPJLQNMDC-ZETCQYMHSA-N carnosine Chemical compound [NH3+]CCC(=O)N[C@H](C([O-])=O)CC1=CNC=N1 CQOVPNPJLQNMDC-ZETCQYMHSA-N 0.000 description 2
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- 125000005131 dialkylammonium group Chemical group 0.000 description 2
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- 150000002148 esters Chemical class 0.000 description 2
- 150000002170 ethers Chemical class 0.000 description 2
- 239000006260 foam Substances 0.000 description 2
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- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 235000013773 glyceryl triacetate Nutrition 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- ZXEKIIBDNHEJCQ-UHFFFAOYSA-N isobutanol Chemical compound CC(C)CO ZXEKIIBDNHEJCQ-UHFFFAOYSA-N 0.000 description 2
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- 150000002632 lipids Chemical class 0.000 description 2
- HCZKYJDFEPMADG-TXEJJXNPSA-N masoprocol Chemical compound C([C@H](C)[C@H](C)CC=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 HCZKYJDFEPMADG-TXEJJXNPSA-N 0.000 description 2
- LVWZTYCIRDMTEY-UHFFFAOYSA-N metamizole Chemical compound O=C1C(N(CS(O)(=O)=O)C)=C(C)N(C)N1C1=CC=CC=C1 LVWZTYCIRDMTEY-UHFFFAOYSA-N 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
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- 238000002156 mixing Methods 0.000 description 2
- 239000002777 nucleoside Substances 0.000 description 2
- 125000003835 nucleoside group Chemical group 0.000 description 2
- 239000002773 nucleotide Substances 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- HLDPLHCMNIULPL-UHFFFAOYSA-M sodium;4-(2-methylpropoxycarbonyl)phenolate Chemical compound [Na+].CC(C)COC(=O)C1=CC=C([O-])C=C1 HLDPLHCMNIULPL-UHFFFAOYSA-M 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
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- 229960002722 terbinafine Drugs 0.000 description 2
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 2
- 150000005621 tetraalkylammonium salts Chemical class 0.000 description 2
- 229930003799 tocopherol Natural products 0.000 description 2
- 239000011732 tocopherol Substances 0.000 description 2
- 229960002622 triacetin Drugs 0.000 description 2
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
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- 150000003573 thiols Chemical class 0.000 description 1
- 229940094937 thioredoxin Drugs 0.000 description 1
- 108060008226 thioredoxin Proteins 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- CRDAMVZIKSXKFV-UHFFFAOYSA-N trans-Farnesol Natural products CC(C)=CCCC(C)=CCCC(C)=CCO CRDAMVZIKSXKFV-UHFFFAOYSA-N 0.000 description 1
- QURCVMIEKCOAJU-UHFFFAOYSA-N trans-isoferulic acid Natural products COC1=CC=C(C=CC(O)=O)C=C1O QURCVMIEKCOAJU-UHFFFAOYSA-N 0.000 description 1
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 1
- LOIYMIARKYCTBW-OWOJBTEDSA-N trans-urocanic acid Chemical compound OC(=O)\C=C\C1=CNC=N1 LOIYMIARKYCTBW-OWOJBTEDSA-N 0.000 description 1
- LOIYMIARKYCTBW-UHFFFAOYSA-N trans-urocanic acid Natural products OC(=O)C=CC1=CNC=N1 LOIYMIARKYCTBW-UHFFFAOYSA-N 0.000 description 1
- 125000005208 trialkylammonium group Chemical group 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- FAGMGMRSURYROS-UHFFFAOYSA-M trihexadecyl(methyl)azanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+](C)(CCCCCCCCCCCCCCCC)CCCCCCCCCCCCCCCC FAGMGMRSURYROS-UHFFFAOYSA-M 0.000 description 1
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 1
- 229940040064 ubiquinol Drugs 0.000 description 1
- QNTNKSLOFHEFPK-UPTCCGCDSA-N ubiquinol-10 Chemical compound COC1=C(O)C(C)=C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)C(O)=C1OC QNTNKSLOFHEFPK-UPTCCGCDSA-N 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 125000005065 undecenyl group Chemical group C(=CCCCCCCCCC)* 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 229940116269 uric acid Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 229940071104 xylenesulfonate Drugs 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 229940043810 zinc pyrithione Drugs 0.000 description 1
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 description 1
- KYNBIEFLVXTQTO-UHFFFAOYSA-L zinc;phenyl sulfate Chemical compound [Zn+2].[O-]S(=O)(=O)OC1=CC=CC=C1.[O-]S(=O)(=O)OC1=CC=CC=C1 KYNBIEFLVXTQTO-UHFFFAOYSA-L 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4926—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having six membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/004—Preparations used to protect coloured hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/06—Preparations for styling the hair, e.g. by temporary shaping or colouring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Description
a) 一種もしくはそれ以上の1−ヒドロキシ−4−メチル−6−アルキル−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩(ただし、アルキルは、炭素原子数1〜12の線状、分枝状もしくは環状アルキル基を意味する)、及び
b) 一つもしくはそれ以上の芳香族基を含む一種もしくはそれ以上のアルコール、
を含む、透明で液状の防腐剤組成物によって解決されることが見出された。
a) 一種もしくはそれ以上の1−ヒドロキシ−4−メチル−6−アルキル−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩(ただし、アルキルは、炭素原子数1〜12の線状、分枝状もしくは環状アルキル基、好ましくは2,4,4−トリメチルペンチルもしくはシクロヘキシルを意味する)、及び
b) 一つもしくはそれ以上の芳香族基を含む一種もしくはそれ以上のアルコール、
を含む、透明液状の防腐剤組成物である。
a)1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩、及び
b)一つもしくはそれ以上、好ましくは一つの芳香族基を含む一種もしくはそれ以上のアルコール、
を含む。
a) 0.1〜20重量%、好ましくは1.1〜10重量%、特に好ましくは1.5〜7重量%、特に5重量%の1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩、及び
b) 35〜99.9重量%、好ましくは80〜99.9重量%の、一つもしくはそれ以上の芳香族基を含む一種もしくはそれ以上のアルコール、
を含む。
a) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドン、及び/またはそれの一種もしくはそれ以上の塩、
b) 一つもしくはそれ以上の芳香族基を含む一種もしくはそれ以上のアルコール、
c) 水、
d) 場合によっては、一種もしくはそれ以上の更に別の抗菌性有効物質、
e) 場合によっては、一種もしくはそれ以上のハイドロトロープ剤、及び
f) 場合によっては、一種もしくはそれ以上の更に別の添加剤、
を含む。
a) 0.1〜20重量%、好ましくは1.1〜10重量%、特に好ましくは1.5〜7重量%、中でも特に好ましくは5重量%の、1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩、
b) 35〜99.8重量%、好ましくは59.8〜99.8重量%の、一つもしくはそれ以上の芳香族基を含む一種もしくはそれ以上のアルコール、
c) 0.1〜35重量%、好ましくは0.1〜20重量%、特に好ましくは0.5〜5重量%、中でも特に好ましくは1〜3重量%の、水、
を含む。
I) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2−(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及びメチルパラベンを含むか、または
II) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及び安息香酸ナトリウムを含むか、または
III) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及び安息香酸を含むか、または
IV) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及びソルビン酸カリウムを含むか、または
V) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及びソルビン酸を含むか、または
VI) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及びサリチル酸ナトリウムを含むか、または
VII) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及びサリチル酸を含む。
a)1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩、及び
b)一つもしくはそれ以上の芳香族基を含む、一種もしくはそれ以上のアルコール、
からなる。
a)1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩、
b)一つもしくはそれ以上の芳香族基を含む一種もしくはそれ以上のアルコール、及び
c)水
からなる。
a)一種もしくはそれ以上の1−ヒドロキシ−4−メチル−6−アルキル−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩、この際、アルキルは、炭素原子数1〜12の線状、分枝状もしくは環状アルキル基、好ましくは2,4,4−トリメチルペンチルもしくはシクロヘキシル、特に好ましくは2,4,4−トリメチルペンチルを意味し、
b)一つもしくはそれ以上の芳香族基を含む、一種もしくはそれ以上のアルコール、及び
c)一種もしくはそれ以上の更に別の抗菌有効物質、
を含む前記化粧用、皮膚用または薬用調合物、並びにこのような防腐剤組成物を含む化粧用、皮膚用または薬用調合物である。
a)一種もしくはそれ以上の1−ヒドロキシ−4−メチル−6−アルキル−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩、この際、アルキルは、炭素原子数1〜12の線状、分枝状もしくは環状アルキル基、好ましくは2,4,4−トリメチルペンチルもしくはシクロヘキシル、特に好ましくは2,4,4−トリメチルペンチルを意味し、
b)一つもしくはそれ以上の芳香族基を含む、一種もしくはそれ以上のアルコール、及び
c)一種もしくはそれ以上の更に別の抗菌有効物質、
を含む、化粧用、皮膚用または薬用調合物である。
a)1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、
b)2−フェノキシエタノール、及び
c)メチルパラベン、安息香酸、安息香酸ナトリウム、ソルビン酸、ソルビン酸カリウム、サリチル酸及びサリチル酸ナトリウムから選択される一種もしくはそれ以上の物質、
を含む化粧用、皮膚用または薬用調合物である。
Octopirox (R) 2重量%
水 1重量%
2-フェノキシエタノール 97重量%
例2: 防腐剤組成物2
Octopirox(R) 5重量%
水 2.5 重量%
2-フェノキシエタノール 92.5重量%
例3: 防腐剤組成物3
Octopirox(R) 5重量%
水 1重量%
2-フェノキシエタノール 94重量%
例4: 防腐剤組成物4
Octopirox(R) 10重量%
水 5重量%
2-フェノキシエタノール 85重量%
例5: 防腐剤組成物5
Octopirox(R) 10重量%
水 2重量%
2-フェノキシエタノール 88重量%
Octopirox(R)を、攪拌下に軽く加温(20〜40℃)しながら、2−フェノキシエタノール中に溶解する。次いで、水を攪拌しながら加える。
Octopirox(R) 5重量%
Nipagin(R)M 15重量%
水 2.5重量%
2-フェノキシエタノール 77.5重量%
例7: 防腐剤組成物7
Octopirox(R) 5重量%
安息香酸ナトリウム 15重量%
水 29重量%
2-フェノキシエタノール 51重量%
例8: 防腐剤組成物8
Octopirox(R) 5重量%
安息香酸 15重量%
水 2.5重量%
2-フェノキシエタノール 77.5重量%
例9: 防腐剤組成物9
Octopirox(R) 5重量%
ソルビン酸カリウム 15重量%
水 25重量%
2-フェノキシエタノール 55重量%
例10: 防腐剤組成物10
Octopirox(R) 5重量%
ソルビン酸 10重量%
プロピレングリコール 45重量%
2-フェノキシエタノール 40重量%
例11: 防腐剤組成物11
Octopirox (R) 5重量%
サリチル酸ナトリウム 15重量%
水 21重量%
2-フェノキシエタノール 59重量%
例12: 防腐剤組成物12
Octopirox (R) 5重量%
サリチル酸 15重量%
水 2.5重量%
2-フェノキシエタノール 77.5重量%
Octopirox (R)及びNipagin (R) Mもしくは上記有機酸を、攪拌下に軽く加温(20〜40℃)しながら、2−フェノキシエタノール中にまたは2−フェノキシエタノール/プロピレングリコール混合物中に溶解する。次いで、場合によっては水を攪拌しながら添加する。
I. 有機酸の塩を、軽く加温(20〜40℃)しながら水中に溶解する。
II. Octopirox(R)を、攪拌下に軽く加温(20〜40℃)しながら2−フェノキシエタノール中に溶解する。
III.攪拌しながらIをIIに加える。
上記水含有防腐剤組成物は0℃、25℃及び40℃で3ヶ月間安定しており、そして結晶化傾向を示さない。
I. AとBを混合
II. CをIに添加
III. Dを用いてpH値を約7に調節
その結果(表3参照)は、表4に記載の成分、すなわちOctopirox(R)及び2-フェノキシエタノール、加えて
−Nipagin(R) M及び水、
−安息香酸及び水、
−ソルビン酸及びプロピレングリコール、または
−サリチル酸及び水、
からなる防腐剤組成物KM III〜KM VIを用いると、表4に記載の成分、すなわちOctopirox(R)、2-フェノキシエタノール及び水からなる防腐剤組成物KM VIIと比較して、かなりより良好な防腐性能が達成できることを示している。
例A
I. 室温でAとBを混合
II. CをI中に混入し、次いでDを添加
III. 得られたエマルションのホモジナイズ
例B
I. Aを約70℃で溶融し、次いでBを添加
II. Cを約70℃に加温
III. IIをI中に混入し、そして室温に冷えるまで攪拌
IV. 約35℃でDをIIIに添加
V. 得られた溶液のホモジナイズ
例C
I. BをAに添加
II. Cを約40℃に加熱
III.攪拌しながらIIをIに加え、そして冷却攪拌(kaltruehen)
例D
I. 75℃でAを溶融
II. Bを75℃に加熱
III. 攪拌しながらIIをIに添加
IV. 冷却攪拌
V. 35℃で、Cの成分をIVに添加
VI. 最後に、DでpH値を4に調節
例E
I. 50℃でAをBに溶解
II. Cの各成分を順次Iに添加
III. Dを用いてpH値を5.5に調節
IV. 最後に、Eを用いて粘度を調節
例F
I. 約85℃に加熱して攪拌しながらAの成分をB中で溶解及び溶融
II. 冷却攪拌
III. Cの成分をIIに添加
IV. 必要に応じてpH値の調製
V. Dの成分をIVに添加
VI. 最後に、Eで粘度を調節
例G
I. 約70℃でAを溶融し、その後Bを添加
II. Cを約70℃に加温
III. IIをIに混ぜ入れ、そして冷却攪拌
IV. 約35℃でDをIIIに添加
V. 最後に、得られたエマルションをホモジナイズ
例H
I. 約80℃でAを溶融
II. Bの低温の溶液をI中に混ぜ入れる
III. 冷却攪拌
IV. 約35℃でCをIIIに添加
例l
I. 約80℃でAを溶融
II. Bを約80℃に加温
III. IIをIに混ぜ入れそして冷却攪拌
IV. 約35℃でCをIIIに添加
例J
I. 約60℃でAを溶融し、その後Bを添加
II. Cを約60℃に加温
III. IIをIに混ぜ入れ、そして冷却攪拌
IV. Dの各成分を約35℃でIIIに順次添加
V. 最後に、得られたエマルションをホモジナイズ
例K
I. Aを約80℃に加熱
II. Bを約80℃に加熱
III. IをIIに混ぜ入れ、そして冷却攪拌
IV. 約35℃で、Cの成分をIIIに添加
例L
I. 攪拌しながらAをB中に溶解
II. 攪拌しながらCをIに加え、均一になるまで攪拌
例M
I. 攪拌しながら軽く加温してBをAに溶解
II. Cの各成分をIに順次添加
III. DでpH値を調節
IV. 最後に、Eで粘度を調節
例N
I. Bの各成分を順次Aに添加
II. 軽く加温したDにCを溶解
III. IIをIに混ぜ入れる
IV. Eの各成分を順次IIIに添加
V. 必要に応じてpH値を調節
VI. 最後にFで粘度を調節
例O
I. 約75℃でAを溶融
II. Bを約75℃に加熱
III. 攪拌しながらIIをIに加え、次いで冷却攪拌
IV. 約30℃で、Cの成分をIIIに添加
V. 最後に、pH値を4.0に調節
例P
I. B中でAを可溶化
II. 加温したD中にCを溶解
III. IIをIに添加
IV. Eの各成分をIIIに添加
V. 約35℃で攪拌しながらFの各成分をIVに添加
例Q
I. Aの成分の混合
II. Bの成分を軽く加温しながら溶解し、放冷しそしてIに添加
III. Cの各成分を順次IIに添加
IV. Dの成分をIIIに添加
V. 最後に、EをIVに加え、均一な調合物が生ずるまで攪拌
例R
I. Aの成分を十分に混合
II. Bの成分を十分に混合し、次いでIIをIに添加
III. Cの成分を十分に混合し、次いでIIIをIIに添加
IV. Dの成分を順次IIIに添加
V. 最後に、EでpH値を4.0に調節
使用した商業製品のINCI名
Claims (24)
- a) 0.1〜20重量%の量の1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩、及び
b) 35〜99.9重量%の量の2−フェノキシエタノール、
を含むことを特徴とする、透明で液状の防腐剤組成物。 - a) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩、
b) 2−フェノキシエタノール、
c) 水、
を含み、更にd)更に別の抗菌有効物質、e)ハイドロトロープ剤、及びf)更に別の添加剤から選択される一種もしくはそれ以上の更なる成分を含むか、または含まない、
ことを特徴とする、請求項1の防腐剤組成物。 - a) 0.1〜20重量%の量の1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩、
b) 35〜99.8重量%の量の2−フェノキシエタノール、
c) 0.1〜35重量%の量の水、
を含むことを特徴とする、請求項1または2の防腐剤組成物。 - 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩を含むことを特徴とする、請求項1〜3のいずれか一つの防腐剤組成物。
- 一種もしくはそれ以上の更に別の抗菌有効物質を含むことを特徴とする、請求項1〜4のいずれか一つの防腐剤組成物。
- 上記の一種もしくはそれ以上の更に別の抗菌有効物質を1〜25重量%の量で含むことを特徴とする、請求項5の防腐剤組成物。
- 上記の一種もしくはそれ以上の更に別の抗菌有効物質が、パラベン類、有機酸、ホルムアルデヒド供与体、及びハロゲン化防腐性物質から選択されることを特徴とする、請求項5または6の防腐剤組成物。
- I) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及びメチルパラベンを含むか、または
II) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及び安息香酸ナトリウムを含むか、または
III) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及び安息香酸を含むか、または
IV) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及びソルビン酸カリウムを含むか、または
V) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及びソルビン酸を含むか、または
VI) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及びサリチル酸ナトリウムを含むか、または
VII) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、2−フェノキシエタノール及びサリチル酸を含む、
ことを特徴とする、請求項7の防腐剤組成物。 - 一種もしくはそれ以上の酸化防止剤を含むことを特徴とする、請求項1〜8のいずれか一つの防腐剤組成物。
- 上記の一種もしくはそれ以上の酸化防止剤が、トコフェリルアセテート、BHT及びEDTAから選択されることを特徴とする、請求項9の防腐剤組成物。
- 一種もしくはそれ以上のハイドロトロープ剤を含むことを特徴とする、請求項1〜10のいずれか一つの防腐剤組成物。
- ハイドロトロープ剤がクメンスルホネートであることを特徴とする、請求項11の防腐剤組成物。
- 一種もしくはそれ以上の可溶化剤を含むことを特徴とする、請求項1〜12のいずれか一つの防腐剤組成物。
- 上記一種もしくはそれ以上の可溶化剤が、トリエチレングリコール、ブチレングリコール及び1,2−プロピレングリコールから選択されることを特徴とする、請求項13の防腐剤組成物。
- a) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドン及び/またはそれの一種もしくはそれ以上の塩、及び
b) 2−フェノキシエタノール、
からなることを特徴とする、請求項1または4の防腐剤組成物。 - a) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドン、及び/またはそれの一種もしくはそれ以上の塩、
b) 2−フェノキシエタノール、及び
c) 水
からなることを特徴とする、請求項1〜4のいずれか一つの防腐剤組成物。 - 皮膚用、化粧用及び薬用製品の防腐のための、請求項1〜16のいずれか一つの組成物の使用。
- ウェットティッシュの防腐のための、請求項1〜16のいずれか一つの組成物の使用。
- エマルションの防腐のための、請求項1〜16のいずれか一つの組成物の使用。
- 化粧用、皮膚用または薬用調合物の製造のための、請求項1〜16のいずれか一つの組成物の使用。
- a) 1−ヒドロキシ−4−メチル−6−(2,4,4−トリメチルペンチル)−2(1H)−ピリドンのアミノエタノール塩、
b) 2−フェノキシエタノール及び
c) 安息香酸、安息香酸ナトリウム、ソルビン酸及びソルビン酸カリウムから選択される一種もしくはそれ以上の物質、
を含むことを特徴とする、化粧用、皮膚用または薬用調合物。 - 成分a)、b)及びc)の各物質が、完成した調合物を基準にして、0.1〜2重量%の量で調合物中に含まれることを特徴とする、請求項21の調合物。
- エマルションであることを特徴とする、請求項21または22の調合物。
- 界面活性剤を含まないエマルションであることを特徴とする、請求項21または22の調合物。
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DE200510005009 DE102005005009A1 (de) | 2005-02-03 | 2005-02-03 | Konservierungsmittel |
DE102005005009.3 | 2005-02-03 | ||
DE200510030762 DE102005030762A1 (de) | 2005-07-01 | 2005-07-01 | Konservierungsmittel |
DE102005030762.0 | 2005-07-01 | ||
PCT/EP2006/000627 WO2006081969A1 (de) | 2005-02-03 | 2006-01-25 | Konservierungsmittel |
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EP (1) | EP1845934B1 (ja) |
JP (1) | JP5008573B2 (ja) |
BR (1) | BRPI0606784B1 (ja) |
DE (1) | DE502006000770D1 (ja) |
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US9610350B2 (en) * | 2009-08-17 | 2017-04-04 | Arch Personal Care Products, L.P. | Broad spectrum preservation blends |
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CN107072910A (zh) * | 2014-08-28 | 2017-08-18 | 路博润先进材料公司 | 调理组合物 |
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CN110139640A (zh) * | 2016-12-27 | 2019-08-16 | 高露洁-棕榄公司 | 珠光剂和珠光组合物 |
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