JP4834291B2 - Stat3活性化幹細胞 - Google Patents
Stat3活性化幹細胞 Download PDFInfo
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- JP4834291B2 JP4834291B2 JP2003568067A JP2003568067A JP4834291B2 JP 4834291 B2 JP4834291 B2 JP 4834291B2 JP 2003568067 A JP2003568067 A JP 2003568067A JP 2003568067 A JP2003568067 A JP 2003568067A JP 4834291 B2 JP4834291 B2 JP 4834291B2
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Description
1.発明の分野
本発明の1つの実施態様は、幹細胞の自己複製と生体内(in vivo)/生体外(培養)(in vitro)増殖を促進させ、その結果組織や器官の再生を高める方法を対象としている。幹細胞中のSTAT3活性を増大させると、未分化幹細胞数が増えると共に幹細胞は自己複製能力を高め、再生作用を増強する。
本発明は、以下に記載する本発明の詳細な説明と、説明のためのみに示した添付図面、つまり本発明に限定されない、から十分に理解されるだろう。その図面についてここで説明する;
Claims (8)
- STAT3-Cを導入した造血幹細胞。
- STAT3-Cを導入していない親細胞の多能性を維持しながら、生体外(培養)(in vitro)における増殖能力が向上した請求項1の造血幹細胞。
- STAT3-Cタンパク質が細胞内に導入されている請求項1又は2の造血幹細胞。
- STAT3-C遺伝子が細胞内に導入されている請求項1又は2の造血幹細胞。
- 請求項1〜4の何れか一の造血幹細胞を増殖させることを含む造血幹細胞集団を増大させる方法。
- 細胞集団が以下の何れか一から選ばれる請求項5の方法:
1)細胞集団が生体外(ex vivo)である、
2)細胞集団が生体外(培養)(in vitro)である。 - STAT3-Cを発現する細胞を造血幹細胞と共培養することを含む請求項5又は6の何れか一の方法。
- 骨髄細胞を損失した患者に投与することを特徴とする請求項1の造血幹細胞を含む治療組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020020008272A KR20030068696A (ko) | 2002-02-15 | 2002-02-15 | 스탓3 (stat3) 분자 활성화에 의한 줄기세포의 생체내이식생착효율 증가 |
KR10-2002-0008272 | 2002-02-15 | ||
PCT/IB2003/000515 WO2003068952A1 (en) | 2002-02-15 | 2003-02-17 | Stat3 activated stem cell |
Publications (3)
Publication Number | Publication Date |
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JP2005517404A JP2005517404A (ja) | 2005-06-16 |
JP2005517404A5 JP2005517404A5 (ja) | 2005-12-22 |
JP4834291B2 true JP4834291B2 (ja) | 2011-12-14 |
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JP2003568067A Expired - Fee Related JP4834291B2 (ja) | 2002-02-15 | 2003-02-17 | Stat3活性化幹細胞 |
Country Status (5)
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US (1) | US7510870B2 (ja) |
JP (1) | JP4834291B2 (ja) |
KR (2) | KR20030068696A (ja) |
AU (1) | AU2003245073A1 (ja) |
WO (1) | WO2003068952A1 (ja) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
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NZ553695A (en) * | 2004-08-16 | 2009-10-30 | Cellres Corp Pte Ltd | Isolation of stem/progenitor cells from amniotic membrane of umbilical cord |
US7838503B2 (en) * | 2005-06-15 | 2010-11-23 | Children's Medical Center Corporation | Methods for extending the replicative lifespan of cells |
US20080242594A1 (en) * | 2005-09-08 | 2008-10-02 | Mckay Ronald D G | Methods for Promoting Stem Cell Proliferation and Survival |
US20110105393A1 (en) * | 2007-08-16 | 2011-05-05 | Andreas Androutsellis-Theotokis | Methods for promoting stem cell proliferation and survival |
US8445517B2 (en) | 2009-12-11 | 2013-05-21 | Dana-Farber Cancer Institute | Stat modulators |
CA2814860C (en) * | 2010-10-22 | 2020-08-25 | Biotime Inc. | Methods of modifying transcriptional regulatory networks in stem cells |
WO2013010045A1 (en) | 2011-07-12 | 2013-01-17 | Biotime Inc. | Novel methods and formulations for orthopedic cell therapy |
KR101935226B1 (ko) * | 2016-04-06 | 2019-01-07 | 가톨릭대학교 산학협력단 | 혈관 내피세포와 중간엽 기질세포의 상호작용을 통한 줄기세포 재생 증진기술 |
US20210222128A1 (en) * | 2020-01-22 | 2021-07-22 | Massachusetts Institute Of Technology | Inducible tissue constructs and uses thereof |
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US4645791A (en) * | 1985-06-24 | 1987-02-24 | Ford Motor Company | Environmentally durable elastomer composition with excellent low temperature dynamic properties |
US6235873B1 (en) * | 1999-07-31 | 2001-05-22 | The Rockefeller University | Constitutively active transcription factors and their uses for identifying modulators of activity including dysproliferative cellular changes |
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2002
- 2002-02-15 KR KR1020020008272A patent/KR20030068696A/ko not_active Application Discontinuation
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2003
- 2003-02-17 KR KR1020047012711A patent/KR101027288B1/ko active IP Right Grant
- 2003-02-17 JP JP2003568067A patent/JP4834291B2/ja not_active Expired - Fee Related
- 2003-02-17 AU AU2003245073A patent/AU2003245073A1/en not_active Abandoned
- 2003-02-17 WO PCT/IB2003/000515 patent/WO2003068952A1/en active Application Filing
- 2003-02-18 US US10/369,053 patent/US7510870B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
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JP2005517404A (ja) | 2005-06-16 |
WO2003068952A1 (en) | 2003-08-21 |
KR20040084918A (ko) | 2004-10-06 |
KR20030068696A (ko) | 2003-08-25 |
US7510870B2 (en) | 2009-03-31 |
US20030157711A1 (en) | 2003-08-21 |
KR101027288B1 (ko) | 2011-04-06 |
AU2003245073A1 (en) | 2003-09-04 |
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