JP4802103B2 - 組成物及び方法 - Google Patents
組成物及び方法 Download PDFInfo
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- JP4802103B2 JP4802103B2 JP2006541371A JP2006541371A JP4802103B2 JP 4802103 B2 JP4802103 B2 JP 4802103B2 JP 2006541371 A JP2006541371 A JP 2006541371A JP 2006541371 A JP2006541371 A JP 2006541371A JP 4802103 B2 JP4802103 B2 JP 4802103B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/111—Aromatic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/733—Fructosans, e.g. inulin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
- A61K36/8998—Hordeum (barley)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Polymers & Plastics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
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- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Nutrition Science (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Fodder In General (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Description
1.猫から得た大便試料をスクリーニングするためのプロトコール:
大便試料を正常で健康な猫及びIBDに関して診断された猫から集めた。正常な猫をサイエンスダイエット(登録商標)フィーラインメンテナンス(登録商標)ドライ(Science Diet (登録商標) Feline maintenance(登録商標) dry)で維持し、一方、IBDを有する猫を治療のための胃腸用の食餌(therapeutic gastrointestinal diet)で維持した。大便試料を分析の前に−70℃に凍結した。分析のために、試料をリン酸緩衝液と1:10(w/w)の比に混合し、ガラスビーズと共に撹拌し、遠心分離して、粒子状物質を除去した。375μlの試料のアリコートを、1.125mlの4%パラホルムアルデヒドを含む管に加え、4℃で4〜5時間放置した。試料を遠心分離し、PBS中で2回洗浄し、次に150μlのろ過済みエタノールと混合し、蛍光インシトゥハイブリダイゼーション分析(微生物計数のためのFISH)の前に−20℃で貯蔵した。属特異的16SrRNA標的プローブを合成し、5’末端で蛍光染料を用いて単一標識して(monolabelled)、発酵媒質中の考察の対象となっている細菌を検出した。総核酸を染色して、総細胞計数を得た。データをlog10細胞/gの大便として表す。FISHは貯蔵した試料の細菌の定量化を可能にし、培養可能な及び非培養可能な多様性の両方を含む。
結果
実施例2:IBD及び正常な猫においてAGがデサルホビブリオに及ぼすインビボ効果
2.供給の研究のためのプロトコール
IBDを有する11匹の猫及び10匹の正常で健康な猫に、ウェスタンラーチから得た0.6%のアラビノガラクタン抽出物と共に1.0%のビートパルプを含むフードを供給した。抽出物は、約90重量%のアラビノガラクタン及び約4重量%のポリフェノールであり、主なポリフェノールはタキシフォリンであり、残りは水分であり、全て2週間の乾物ベースだった。これに続いて、猫を、1.5%のビートパルプを単独で含むフードに切り換えた。大便試料を、0日、14日及び28日に集めた。試料をFISH分析のために次の通り作製した:各大便試料を凍結するために、5.0gの大便を、無菌の袋またはプラスチック容器中、無酸素性のリン酸緩衝食塩水(PBS)中でpH7.3で懸濁して、最終濃度10%(5gの場合45ml)を与えた。スラリーを袋中で均質化/混合して汚染を避けた。異なる容器を各試料につき使用した。5mlのスラリーを等しい量のグリセロールと混合して、50:50混合物を与え、これをFISHによる分析のために凍結した。
結果:
13の完全な組の大便試料を得た。猫が0.6%のAG抽出物を含むフードを摂取した場合、13匹の猫につき4匹は、0.3log単位以上の減少したデサルホビビロspp.(Desulfovibiro spp.)を有した。13匹の猫につき8匹は、デサルホビブリオspp.のレベルの小さな低下を有するかまたは変化がなく、一方、13匹の猫につき1匹のみがデサルホビブリオspp.の増大を有した。猫を、AGを有しないフードに切り換えた場合、13匹の猫につき10匹は、0.3log単位以上のデサルホビブリオspp.の増大したレベルを有し、13匹の猫につき2匹は変化がなく、13匹の猫につき1匹のみがデサルホビブリオspp.の低下したレベルを有した。
実施例3−様々な繊維がデサルホビブリオspp.のレベルを低下したことを示すインビトロ実験
無酸素性のリン酸緩衝媒質を含む発酵容器を用意し、1mlの犬の大便接種材料(10%w/vの大便試料を緩衝させた)を加えた。媒質の組成は、Sunvold GD, Hussein HS, Fahey GC, Merchen NR, and Reinhart GA (1995), In vitro fermentation of selected fiber sources by dogs fecal inoculum and in vivo digestion and metabolism of fiber supplemental diets. J. Animal Sci. 73: 1099-1109 (1995)において説明されている。発酵を39℃で実行した。実験を、様々な繊維を用いてブラインドコード化方法(blind-coded manner)で行った。8時間のインキュベーションの後、1mlの培養流体を除去した。これのアリコートをFISHのために作製した。8時間後に、1mlの培養流体を除去し、PBS中の4%パラホルムアルデヒドと混合し、FISHのために固定した。属特異的16SrRNA標的プローブを合成し、5’末端で蛍光染料を用いて単一標識して、発酵媒質中の考察の対象となっている細菌を検出した。総核酸を染色して、総微生物計数を得た。結果は、幾つかの異なるタイプの繊維は、8時間の発酵の最中デサルホビブリオspp.の増殖を0.5〜1.0log単位減少できることを示した(表2を参照されたい)。
Claims (8)
- 犬または猫のGI管におけるデサルホビブリオ及び/またはヘリコバクターspp.の量を低減する方法であって、前記犬または猫にフードを経口投与することを含み、前記フードは、オリゴ糖、ガラクタン、ベータグルカン及びこれらの混合物からなる群から選択される繊維を乾物ベースで0.1から20重量%含む方法。
- 前記犬または猫は前記投与を必要とする、請求項1に記載の方法。
- 前記犬または猫は、GI管炎症が主な構成要素である疾患を有する、請求項2に記載の方法。
- 前記繊維は、アラビノガラクタン、キシロオリゴ糖、ガラクトオリゴ糖、フルクトオリゴ糖、イヌリン、発芽した大麦及びこれらの混合物からなる群から選択される、請求項3に記載の方法。
- フード中に繊維と共にポリフェノールも存在する、請求項1に記載の方法。
- GI管におけるデサルホビブリオ及び/またはヘリコバクターspp.の高いレベルを有する犬または猫におけるGI管炎症を治療する方法であって、前記犬または猫にフードを経口投与することを含み、前記フードは、オリゴ糖、ガラクタン、ベータグルカン及びこれらの混合物からなる群から選択される繊維を乾物ベースで0.1から20重量%含む方法。
- フード中に繊維と共にポリフェノールも存在する、請求項6に記載の方法。
- デサルホビブリオ及び/またはヘリコバクターspp.の高いレベルを有する犬または猫における腸ガス臭気、大便臭気及び任意のこれらの混合物からなる群から選択される臭気を低減する方法であって、前記犬または猫にフードを経口投与することを含み、前記フードは、オリゴ糖、ガラクタン、ベータグルカン及びこれらの混合物からなる群から選択される繊維を乾物ベースで0.1から20重量%含む方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/719,569 US6936598B2 (en) | 2003-11-21 | 2003-11-21 | Composition and method |
US10/719,569 | 2003-11-21 | ||
PCT/US2004/038697 WO2005051403A1 (en) | 2003-11-21 | 2004-11-19 | Composition and method |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2007512342A JP2007512342A (ja) | 2007-05-17 |
JP4802103B2 true JP4802103B2 (ja) | 2011-10-26 |
Family
ID=34591365
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006541371A Active JP4802103B2 (ja) | 2003-11-21 | 2004-11-19 | 組成物及び方法 |
Country Status (12)
Country | Link |
---|---|
US (1) | US6936598B2 (ja) |
EP (2) | EP3111943B1 (ja) |
JP (1) | JP4802103B2 (ja) |
CN (1) | CN100479827C (ja) |
AU (1) | AU2004292973B2 (ja) |
BR (1) | BRPI0416731A (ja) |
CA (1) | CA2545572C (ja) |
DK (1) | DK1684771T3 (ja) |
ES (1) | ES2604454T3 (ja) |
RU (1) | RU2375065C2 (ja) |
WO (1) | WO2005051403A1 (ja) |
ZA (1) | ZA200604070B (ja) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2006012536A2 (en) | 2004-07-22 | 2006-02-02 | Ritter Andrew J | Methods and compositions for treating lactose intolerance |
EP1877447B1 (en) | 2005-05-05 | 2016-12-21 | Sensient Flavors Inc. | Production of beta-glucans and mannans |
BRPI1008280A2 (pt) | 2009-02-24 | 2015-08-25 | Ritter Pharmaceuticals Inc | Formulações prebióticas e métodos mde uso |
EP2563372A4 (en) | 2010-04-28 | 2013-10-02 | Ritter Pharmaceuticals Inc | PREBIOTIC FORMULATIONS AND METHODS OF USE |
US20130287919A1 (en) * | 2012-04-26 | 2013-10-31 | Flavitpure, Inc. | Method of using dietary ingredients dihydroquercetin (taxifolin), arabinogalactan and arabinogalactan in combination with dihydroquercetin (taxifolin) for applications in food products |
US20130331354A1 (en) * | 2012-06-07 | 2013-12-12 | Flavitpure, Inc. | Method and composition utilizing larch wood extracts in animal feed |
US9145340B2 (en) | 2012-08-13 | 2015-09-29 | Verdesian Life Sciences, Llc | Method of reducing atmospheric ammonia in livestock and poultry containment facilities |
US9961922B2 (en) | 2012-10-15 | 2018-05-08 | Verdesian Life Sciences, Llc | Animal feed and/or water amendments for lowering ammonia concentrations in animal excrement |
US11254620B2 (en) | 2013-08-05 | 2022-02-22 | Verdesian Life Sciences U.S., Llc | Micronutrient-enhanced polymeric seed coatings |
TW201522390A (zh) | 2013-08-27 | 2015-06-16 | 特級肥料產品公司 | 聚陰離子聚合物 |
CA2923561C (en) | 2013-09-05 | 2022-05-03 | Verdesian Life Sciences, Llc | Polymer-boric acid compositions |
US10519070B2 (en) | 2014-05-21 | 2019-12-31 | Verdesian Life Sciences U.S., Llc | Polymer soil treatment compositions including humic acids |
US10822487B2 (en) | 2014-05-22 | 2020-11-03 | Verdesian Life Sciences Llc | Polymeric compositions |
CA3008616A1 (en) * | 2015-12-30 | 2017-07-06 | Hill's Pet Nutrition, Inc. | Pet food compositions comprising fiber and polyphenol |
CN105943463B (zh) * | 2016-06-23 | 2019-03-15 | 金日制药(中国)有限公司 | 一种温和的婴童洗发沐浴泡泡 |
US11260099B2 (en) * | 2016-12-16 | 2022-03-01 | Hills Pet Nutrition, Inc. | Pet food compositions |
US10842809B2 (en) | 2016-12-16 | 2020-11-24 | Hills Pet Nutrition, Inc. | Pet food compositions |
Citations (8)
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JPH05115250A (ja) * | 1991-05-31 | 1993-05-14 | Taiyo Fishery Co Ltd | ペツトフード |
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JPH10215805A (ja) * | 1996-12-24 | 1998-08-18 | Soc Prod Nestle Sa | 糊化された穀物製品およびその製造法 |
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JP2549638B2 (ja) | 1986-10-30 | 1996-10-30 | サントリー株式会社 | ビフイズス菌増殖促進組成物 |
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IT1304170B1 (it) | 1998-12-15 | 2001-03-08 | Novartis Nutrition Ag | Composti organici |
GB9901809D0 (en) * | 1999-01-27 | 1999-03-17 | Scarista Limited | Highly purified ethgyl epa and other epa derivatives for psychiatric and neurological disorderes |
GB9905542D0 (en) * | 1999-03-10 | 1999-05-05 | Mars Uk Ltd | Pet food |
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US6468525B1 (en) | 1999-08-10 | 2002-10-22 | Renew Life, Inc. | Probiotic formulation |
DE10021384A1 (de) | 2000-05-03 | 2001-11-15 | Hora Reiner | Ergänzungsfutter für Haustiere |
US6592863B2 (en) | 2000-08-22 | 2003-07-15 | Nestec S.A. | Nutritional composition |
US20040044988A1 (en) * | 2002-08-29 | 2004-03-04 | Schene Christopher Robin | Generation of compiled code for simulator speed up |
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2003
- 2003-11-21 US US10/719,569 patent/US6936598B2/en not_active Expired - Lifetime
-
2004
- 2004-11-19 JP JP2006541371A patent/JP4802103B2/ja active Active
- 2004-11-19 RU RU2006121995/13A patent/RU2375065C2/ru not_active IP Right Cessation
- 2004-11-19 CA CA2545572A patent/CA2545572C/en not_active Expired - Fee Related
- 2004-11-19 CN CNB2004800344456A patent/CN100479827C/zh not_active Expired - Fee Related
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- 2004-11-19 WO PCT/US2004/038697 patent/WO2005051403A1/en active Application Filing
- 2004-11-19 DK DK04811413.6T patent/DK1684771T3/en active
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Patent Citations (8)
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JPH05115250A (ja) * | 1991-05-31 | 1993-05-14 | Taiyo Fishery Co Ltd | ペツトフード |
US5444054A (en) * | 1994-04-01 | 1995-08-22 | Abbott Labatories | Method of treating ulcerative colitis |
US6087092A (en) * | 1994-07-21 | 2000-07-11 | University Of Montana | Compositions and methods for animal husbandry and for treating gastrointestinal disorders |
JP2001506129A (ja) * | 1996-12-19 | 2001-05-15 | ザ、ユニバーシティ、オブ、ニュー、サウス、ウェイルズ | プレバイオテックスおよびプロバイオテックス |
JPH10215805A (ja) * | 1996-12-24 | 1998-08-18 | Soc Prod Nestle Sa | 糊化された穀物製品およびその製造法 |
US6203797B1 (en) * | 1998-01-06 | 2001-03-20 | Stephen C. Perry | Dietary supplement and method for use as a probiotic, for alleviating the symptons associated with irritable bowel syndrome |
WO2000054788A1 (en) * | 1999-03-15 | 2000-09-21 | Italmed S.N.C. Di Galli G. E Pacini G. | Pharmaceutical composition for medical and veterinary use for regenerating intestinal flora in diarrhoea or dyspeptic syndrome |
FR2815823A1 (fr) * | 2000-10-31 | 2002-05-03 | Colloides Naturels Internat | Methode et preparation de type fibre alimentaire soluble bifidogene pour la mise en oeuvre de ladite methode |
Also Published As
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US6936598B2 (en) | 2005-08-30 |
ZA200604070B (en) | 2007-09-26 |
BRPI0416731A (pt) | 2007-01-16 |
DK1684771T3 (en) | 2016-11-28 |
AU2004292973A1 (en) | 2005-06-09 |
EP1684771A4 (en) | 2010-07-14 |
EP1684771A1 (en) | 2006-08-02 |
WO2005051403A1 (en) | 2005-06-09 |
AU2004292973B2 (en) | 2010-11-25 |
RU2006121995A (ru) | 2007-12-27 |
EP1684771B1 (en) | 2016-08-24 |
ES2604454T3 (es) | 2017-03-07 |
CN100479827C (zh) | 2009-04-22 |
EP3111943B1 (en) | 2019-06-12 |
JP2007512342A (ja) | 2007-05-17 |
RU2375065C2 (ru) | 2009-12-10 |
CN1882351A (zh) | 2006-12-20 |
CA2545572C (en) | 2015-02-10 |
EP3111943A1 (en) | 2017-01-04 |
CA2545572A1 (en) | 2005-06-09 |
US20050113334A1 (en) | 2005-05-26 |
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