JP4797186B2 - 末梢血中への造血幹細胞動員剤 - Google Patents
末梢血中への造血幹細胞動員剤 Download PDFInfo
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- JP4797186B2 JP4797186B2 JP2004296763A JP2004296763A JP4797186B2 JP 4797186 B2 JP4797186 B2 JP 4797186B2 JP 2004296763 A JP2004296763 A JP 2004296763A JP 2004296763 A JP2004296763 A JP 2004296763A JP 4797186 B2 JP4797186 B2 JP 4797186B2
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- peripheral blood
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- hgf
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Description
Becker PS . et al. Spontaneous splenic rupture following administration of granulocyte colony-stimulating factor(G-CSF): occurrence in an allogeneic donor of peripheral blood stem cells. Biol Blood Marrow Transplant 1997; 3: 45-49 一方、肝細胞増殖因子(HGF)は、それ自体、肝細胞を増殖させるサイトカインとして知られているが、肝細胞を増殖させる以外に、サイトカインネットワークを介して、マトリックス分解酵素(MMP)などの他のサイトカインを誘導することが知られている。
このCD34陽性細胞が、マウスの系に特異的でないことを証明するために、肝細胞増殖因子(HGF)発現マウスと異なった系のマウス、B57BL/6(B6)マウスを用いて検討した。B57BL/6(B6)マウスに、肝細胞増殖因子(HGF)発現アデノウイルスを感染させ、末梢血中にCD34陽性細胞が出現するか、また、その末梢血のコロニー形成能を検討した。
Claims (1)
- 肝細胞増殖因子(HGF)を含有し、前記肝細胞増殖因子(HGF)をドナーに投与することで、ドナーの骨髄から、造血幹細胞を、末梢血中に動員し、末梢血中に動員された造血幹細胞を、末梢血中から採取する用途に用いる、末梢血中への造血幹細胞動員剤。
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JP2004296763A JP4797186B2 (ja) | 2004-10-08 | 2004-10-08 | 末梢血中への造血幹細胞動員剤 |
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JP2004296763A JP4797186B2 (ja) | 2004-10-08 | 2004-10-08 | 末梢血中への造血幹細胞動員剤 |
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JP2006104177A JP2006104177A (ja) | 2006-04-20 |
JP4797186B2 true JP4797186B2 (ja) | 2011-10-19 |
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WO2011030847A1 (ja) * | 2009-09-10 | 2011-03-17 | 国立大学法人京都大学 | 造血幹細胞誘導剤組成物 |
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IT1271088B (it) * | 1994-11-24 | 1997-05-26 | Dompe Spa | Uso di fattore di crescita degli epatociti per indurre la proliferazione e differenziazione di cellule emopoietiche |
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