JP4783098B2 - 擬ポリロタキサンおよびポリロタキサンの製造方法 - Google Patents
擬ポリロタキサンおよびポリロタキサンの製造方法 Download PDFInfo
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- 238000004519 manufacturing process Methods 0.000 title claims description 46
- 150000001875 compounds Chemical class 0.000 claims description 58
- 229940126062 Compound A Drugs 0.000 claims description 43
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims description 43
- 238000000034 method Methods 0.000 claims description 27
- 238000002156 mixing Methods 0.000 claims description 25
- 229920000909 polytetrahydrofuran Polymers 0.000 claims description 24
- 239000000203 mixture Substances 0.000 claims description 20
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- 238000004898 kneading Methods 0.000 claims description 12
- 239000007790 solid phase Substances 0.000 claims description 12
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims description 11
- 239000011148 porous material Substances 0.000 claims description 10
- 239000004570 mortar (masonry) Substances 0.000 claims description 9
- 239000002202 Polyethylene glycol Substances 0.000 claims description 8
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- 229920001223 polyethylene glycol Polymers 0.000 claims description 8
- 125000001424 substituent group Chemical group 0.000 claims description 8
- 125000004122 cyclic group Chemical group 0.000 claims description 6
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 3
- 125000005147 toluenesulfonyl group Chemical group C=1(C(=CC=CC1)S(=O)(=O)*)C 0.000 claims description 3
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- -1 methoxy, ethoxy, benzyloxy, diphenylmethoxy, trityloxy, 4-methoxybenzyloxy, methoxymethoxy, 1-ethoxyethoxy, benzyloxymethoxy, 2-trimethylsilylethoxy Chemical group 0.000 description 13
- 238000003746 solid phase reaction Methods 0.000 description 10
- 239000003054 catalyst Substances 0.000 description 9
- 239000003795 chemical substances by application Substances 0.000 description 9
- HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 8
- 238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 8
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- 230000000149 penetrating effect Effects 0.000 description 7
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- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 6
- 150000001266 acyl halides Chemical class 0.000 description 6
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 description 6
- 239000012948 isocyanate Substances 0.000 description 6
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- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
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- IMNIMPAHZVJRPE-UHFFFAOYSA-N triethylenediamine Chemical compound C1CN2CCN1CC2 IMNIMPAHZVJRPE-UHFFFAOYSA-N 0.000 description 4
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- UKLDJPRMSDWDSL-UHFFFAOYSA-L [dibutyl(dodecanoyloxy)stannyl] dodecanoate Chemical compound CCCCCCCCCCCC(=O)O[Sn](CCCC)(CCCC)OC(=O)CCCCCCCCCCC UKLDJPRMSDWDSL-UHFFFAOYSA-L 0.000 description 3
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- LZGZTBZIRWYCJD-UHFFFAOYSA-N (2,2,2-triphenylacetyl) 2,2,2-triphenylacetate Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C=1C=CC=CC=1)C(=O)OC(=O)C(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 LZGZTBZIRWYCJD-UHFFFAOYSA-N 0.000 description 1
- YZMRCMTTYLBDPD-UHFFFAOYSA-N (2,2-diphenylacetyl) 2,2-diphenylacetate Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)C(=O)OC(=O)C(C=1C=CC=CC=1)C1=CC=CC=C1 YZMRCMTTYLBDPD-UHFFFAOYSA-N 0.000 description 1
- AOSWHQDEXHYBMJ-UHFFFAOYSA-N (3,5-dimethylbenzoyl) 3,5-dimethylbenzoate Chemical compound CC1=CC(C)=CC(C(=O)OC(=O)C=2C=C(C)C=C(C)C=2)=C1 AOSWHQDEXHYBMJ-UHFFFAOYSA-N 0.000 description 1
- OIFXTBJKWKJBOQ-UHFFFAOYSA-N (3,5-ditert-butylbenzoyl) 3,5-ditert-butylbenzoate Chemical compound CC(C)(C)C1=CC(C(C)(C)C)=CC(C(=O)OC(=O)C=2C=C(C=C(C=2)C(C)(C)C)C(C)(C)C)=C1 OIFXTBJKWKJBOQ-UHFFFAOYSA-N 0.000 description 1
- UZJQKGKHEQQUTC-UHFFFAOYSA-N (4-tritylbenzoyl) 4-tritylbenzoate Chemical compound C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=C(C=C4)C(=O)OC(=O)C5=CC=C(C=C5)C(C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8 UZJQKGKHEQQUTC-UHFFFAOYSA-N 0.000 description 1
- ZBBLRPRYYSJUCZ-GRHBHMESSA-L (z)-but-2-enedioate;dibutyltin(2+) Chemical compound [O-]C(=O)\C=C/C([O-])=O.CCCC[Sn+2]CCCC ZBBLRPRYYSJUCZ-GRHBHMESSA-L 0.000 description 1
- CZLMRJZAHXYRIX-UHFFFAOYSA-N 1,3-dioxepane Chemical compound C1CCOCOC1 CZLMRJZAHXYRIX-UHFFFAOYSA-N 0.000 description 1
- BYFNSYRFXVKPQE-UHFFFAOYSA-N 1,3-ditert-butyl-5-isocyanatobenzene Chemical compound CC(C)(C)C1=CC(N=C=O)=CC(C(C)(C)C)=C1 BYFNSYRFXVKPQE-UHFFFAOYSA-N 0.000 description 1
- DZSGDHNHQAJZCO-UHFFFAOYSA-N 1-isocyanato-3,5-dimethylbenzene Chemical compound CC1=CC(C)=CC(N=C=O)=C1 DZSGDHNHQAJZCO-UHFFFAOYSA-N 0.000 description 1
- UOZBNMMELVBICG-UHFFFAOYSA-N 2,2,2-triphenylacetyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(C(=O)Cl)C1=CC=CC=C1 UOZBNMMELVBICG-UHFFFAOYSA-N 0.000 description 1
- MSYLETHDEIJMAF-UHFFFAOYSA-N 2,2-diphenylacetyl chloride Chemical compound C=1C=CC=CC=1C(C(=O)Cl)C1=CC=CC=C1 MSYLETHDEIJMAF-UHFFFAOYSA-N 0.000 description 1
- BSKHPKMHTQYZBB-UHFFFAOYSA-N 2-methylpyridine Chemical compound CC1=CC=CC=N1 BSKHPKMHTQYZBB-UHFFFAOYSA-N 0.000 description 1
- ZJIOBDJEKDUUCI-UHFFFAOYSA-N 3,5-dimethylbenzoyl chloride Chemical compound CC1=CC(C)=CC(C(Cl)=O)=C1 ZJIOBDJEKDUUCI-UHFFFAOYSA-N 0.000 description 1
- HZBWOZJDPPOMOM-UHFFFAOYSA-N 3,5-ditert-butylbenzoyl chloride Chemical compound CC(C)(C)C1=CC(C(Cl)=O)=CC(C(C)(C)C)=C1 HZBWOZJDPPOMOM-UHFFFAOYSA-N 0.000 description 1
- HTQOEHLAXWZUJY-UHFFFAOYSA-N 4-tritylbenzoyl chloride Chemical compound C1=CC(C(=O)Cl)=CC=C1C(C=1C=CC=CC=1)(C=1C=CC=CC=1)C1=CC=CC=C1 HTQOEHLAXWZUJY-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
- 238000005698 Diels-Alder reaction Methods 0.000 description 1
- 239000004593 Epoxy Substances 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 239000001116 FEMA 4028 Substances 0.000 description 1
- 239000005062 Polybutadiene Substances 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- GCTFWCDSFPMHHS-UHFFFAOYSA-M Tributyltin chloride Chemical compound CCCC[Sn](Cl)(CCCC)CCCC GCTFWCDSFPMHHS-UHFFFAOYSA-M 0.000 description 1
- APQHKWPGGHMYKJ-UHFFFAOYSA-N Tributyltin oxide Chemical compound CCCC[Sn](CCCC)(CCCC)O[Sn](CCCC)(CCCC)CCCC APQHKWPGGHMYKJ-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
- WQZGKKKJIJFFOK-DVKNGEFBSA-N alpha-D-glucose Chemical group OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-DVKNGEFBSA-N 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 239000003125 aqueous solvent Substances 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
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- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 210000000845 cartilage Anatomy 0.000 description 1
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- 229940097362 cyclodextrins Drugs 0.000 description 1
- GPRSOIDYHMXAGW-UHFFFAOYSA-N cyclopenta-1,3-diene cyclopentanecarboxylic acid iron Chemical compound [CH-]1[CH-][CH-][C-]([CH-]1)C(=O)O.[CH-]1C=CC=C1.[Fe] GPRSOIDYHMXAGW-UHFFFAOYSA-N 0.000 description 1
- RJGHQTVXGKYATR-UHFFFAOYSA-L dibutyl(dichloro)stannane Chemical compound CCCC[Sn](Cl)(Cl)CCCC RJGHQTVXGKYATR-UHFFFAOYSA-L 0.000 description 1
- JGFBRKRYDCGYKD-UHFFFAOYSA-N dibutyl(oxo)tin Chemical compound CCCC[Sn](=O)CCCC JGFBRKRYDCGYKD-UHFFFAOYSA-N 0.000 description 1
- HPYNZHMRTTWQTB-UHFFFAOYSA-N dimethylpyridine Natural products CC1=CC=CN=C1C HPYNZHMRTTWQTB-UHFFFAOYSA-N 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- NJVOZLGKTAPUTQ-UHFFFAOYSA-M fentin chloride Chemical compound C=1C=CC=CC=1[Sn](C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 NJVOZLGKTAPUTQ-UHFFFAOYSA-M 0.000 description 1
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 description 1
- 229940080345 gamma-cyclodextrin Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000002329 infrared spectrum Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000001678 irradiating effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- TXXWBTOATXBWDR-UHFFFAOYSA-N n,n,n',n'-tetramethylhexane-1,6-diamine Chemical compound CN(C)CCCCCCN(C)C TXXWBTOATXBWDR-UHFFFAOYSA-N 0.000 description 1
- 238000000655 nuclear magnetic resonance spectrum Methods 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
- 125000005499 phosphonyl group Chemical group 0.000 description 1
- 238000000053 physical method Methods 0.000 description 1
- 229920003196 poly(1,3-dioxolane) Polymers 0.000 description 1
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- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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- AFCAKJKUYFLYFK-UHFFFAOYSA-N tetrabutyltin Chemical compound CCCC[Sn](CCCC)(CCCC)CCCC AFCAKJKUYFLYFK-UHFFFAOYSA-N 0.000 description 1
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- Materials For Medical Uses (AREA)
- Polyethers (AREA)
- Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
Description
A.Harada,M.Okada,Y.Kawaguchi,Chem.Lett.,34,542(2005)
本発明の擬ポリロタキサンの製造方法は、環状分子構造を有する化合物Aと、鎖状分子構造を有する化合物Bとを反応させて、環状分子構造を有する化合物Aの分子環内を、鎖状分子構造を有する化合物Bの鎖状部分が貫通した構造を有する擬ポリロタキサンを生成する工程(1)を含む方法である。
加圧混合される混合物において、化合物Aと化合物Bの混合割合は、化合物A/化合物Bがモル比で3〜20の割合が好ましく、特に、5〜10の割合が好ましい。この混合割合を調整することによって、得られる擬ポリロタキサンにおける化合物B(軸分子)によって貫通された化合物A(輪分子)の個数n、および化合物Aによる化合物Bの被覆率θを調整することができる。
加圧混合の時間は、特に制限されないが、30分〜2時間程度で十分である。
加圧混合中の反応温度としては、特に限定されるものではないが、室温以上が好ましく、加温することで、ポリロタキサンの収率及びポリマーに対する置換シクロデキストリンの被覆率を向上させることができる。
PM−α−CD490mg(0.360mmol)と、PTHF(Mn=1400)42.0mg(0.0300mmol)とを、メノウ乳鉢に入れ、室温で2時間、乳棒で反応混合物を押し潰すようにして加圧混練した(工程A)。
下記表1に示す数平均分子量を有するPTHFを用い、表1に示すPM−α−CD/PTHFの混合割合とした以外は、実施例1と同様にして、メノウ乳鉢中での加圧混練によって、反応を行った。
得られた反応生成物について、反応生成物の収率、PTHF1分子によって貫通されたPM−α−CDの個数n(平均輪導入数)、および軸分子PTHFが輪分子PM−α−CDによって覆われた部分の長さの割合である被覆率θを求めた。結果を表1に示す。
実施例1で得られた擬ポリロタキサン1.57g(0.10mmol)、4−トリチルフェニルイソシアネート1.09g(3.0mmol)およびジブチル錫ジラウレート3.0μL(5.1×10−3mmol)を、乳鉢中、室温で90分間加圧混合した。次に、混合物をクロロホルムに溶解させ、難溶分を濾別後、エーテル中で1回、メタノール中で1回再沈澱させて白色固体状生成物242mg(収率:22%)を得た。生成物の同定結果と以下に示す。また、反応スキームを図2に示す。
1H NMR(270MHz, CDCl3, VT60℃):δ=7.28-7.04(m, 38H, 末端基のArH), 4.91(s, 7.2×6H, PMα-CDのC(1)H), 3.92-3.05(m, PMα-CDのC(2〜6)H及びO(2,3,6)CH3, PTHFの-CH2CH2CH2CH2O-), 1.53(s, 77H, PTHFの-CH2CH2CH2CH2O-)ppm.
13C NMR(CDCl3):δ=130.7, 127.3, 127.1, 100.2, 82.5, 82.2, 81.3, 71.2, 71.0, 61.7, 58.9, 57.7, 26.7, 26.4ppm.
IR(KBr):1736, 1596, 1527cm-1.
GPC(ポリスチレン基準, 溶離液:クロロホルム,UV):Mw/Mn=1.3,Mn=10100(理論値10935)
DSC:Tg=20.9℃,Td=238℃
図3に示すとおり、軸分子の両末端にメチルスルホニル基を有するポリテトラヒドロフラン(MeSO2PTHF)と、α−CDとを、実施例1と同様にして、加圧混練して固相反応させて擬ポリロタキサンを製造した。
図4に示すとおり、軸分子の両末端にトルエンスルホニル基を有するポリテトラヒドロフラン(Ts−PTHF)と、α−CDとを、実施例1と同様にして、加圧混練して固相反応させて擬ポリロタキサンを製造した。
Claims (6)
- 環状分子構造を有する化合物Aの分子環内を、鎖状分子構造を有する化合物Bの鎖状部分が貫通した構造を有する擬ポリロタキサンの製造方法であって、
前記化合物Aと、前記化合物Bとを含む固相中で両化合物を加圧混合して前記擬ポリロタキサンを生成する工程(1)を含み、
前記化合物Bは、両末端にメチルスルホニル基またはトルエンスルホニル基を有している
ことを特徴とする擬ポリロタキサンの製造方法。 - 前記加圧混合は、前記化合物Aと前記化合物Bとを含む混合物を、2つの面の間に挟持して加圧混練する処理であることを特徴とする請求項1に記載の擬ポリロタキサンの製造方法。
- 前記加圧混合は、前記化合物Aと、前記化合物Bとを含む混合物を、乳鉢中で、乳棒を用いて加圧混練する処理であることを特徴とする請求項2に記載の擬ポリロタキサンの製造方法。
- 前記化合物Bが、ポリエチレングリコールまたはポリテトラヒドロフランであることを特徴とする請求項1〜請求項3のいずれか1項に記載の擬ポリロタキサンの製造方法。
- 前記化合物Aが、シクロデキストリンであることを特徴とする請求項1〜請求項4のいずれか1項に記載の擬ポリロタキサンの製造方法。
- 請求項1〜請求項5のいずれか1項に記載の擬ポリロタキサンの製造方法によって得られる擬ポリロタキサンと、前記化合物Aの分子環の空孔径より嵩高い置換基を有する末端封鎖剤とを反応させて前記擬ポリロタキサンの末端封鎖を行う工程を含むことを特徴とするポリロタキサンの製造方法。
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