JP4549919B2 - 半月板修復スカフォールド - Google Patents
半月板修復スカフォールド Download PDFInfo
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- JP4549919B2 JP4549919B2 JP2005121278A JP2005121278A JP4549919B2 JP 4549919 B2 JP4549919 B2 JP 4549919B2 JP 2005121278 A JP2005121278 A JP 2005121278A JP 2005121278 A JP2005121278 A JP 2005121278A JP 4549919 B2 JP4549919 B2 JP 4549919B2
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- tissue
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- cell growth
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- repair device
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/38—Joints for elbows or knees
- A61F2/3872—Meniscus for implantation between the natural bone surfaces
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/10—Materials or treatment for tissue regeneration for reconstruction of tendons or ligaments
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Vascular Medicine (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Surgical Instruments (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Description
50/50 PDS/VICRYLの不織材料から造られた組織修復インプラントを使って、組織インプラントの滑膜の近傍への配置を比較評価した。インプラントは、約11mm×7mm×1mmの寸法と、236.6mg/mLの密度を持っていた。
(1)生体適合性を有する半月板修復デバイスであって、半月板の欠損部と接触して配置するのに適した、生体適合性を有する組織修復スカフォールドと、当該組織修復スカフォールドに取り付けられており、脛骨表面に接触して、半月板組織欠損部へ生体物質を受け渡すのに適した細胞成長導管フラップとを含んでなる修復デバイス。
(2)前記細胞成長導管フラップが、滑膜から前記組織修復スカフォールドならびに前記半月板組織欠損部への細胞および栄養素の移動を可能とするための導管を提供する、実施態様(1)に記載の修復デバイス。
(3)前記細胞成長導管フラップが滑膜に接触するのに適したものである、実施態様(2)に記載の修復デバイス。
(4)前記組織修復スカフォールドが、生体吸収性物質から造られたものである、実施態様(1)に記載の修復デバイス。
(5)前記組織修復スカフォールドと細胞成長導管フラップとが、相異なる材料から造られている、実施態様(1)に記載の修復デバイス。
(7)前記組織修復スカフォールドと細胞成長導管フラップとが、グリコリド、ラクチドおよびジオキサノンからなる群から選ばれたモノマーに由来する少なくとも一つのポリマーを含んでなる、実施態様(6)に記載の修復デバイス。
(8)前記組織修復スカフォールドと細胞成長導管フラップとがポリジオキサノンを含んでなる、実施態様(1)に記載の修復デバイス。
(9)前記組織修復スカフォールドと細胞成長導管フラップとがグリコリドとL−ラクチドとのコポリマーを含んでなる、実施態様(1)に記載の修復デバイス。
(10)前記組織修復スカフォールドが、天然ポリマー、合成ポリマーおよびこれらの組み合わせからなる群から選ばれた少なくとも一つの材料から形成されたものである、実施態様(1)に記載の修復デバイス。
(12)さらに、細胞の成長を促進するのに有効な少なくとも一つの生理活性物質を含んでなる、実施態様(1)に記載の修復デバイス。
(13)前記生理活性物質が、多血小板血漿、軟骨由来の形態形成タンパク質、ヒトの組み替え成長因子およびこれらの組み合わせからなる群から選ばれたものである、実施態様(12)に記載の修復デバイス。
(14)前記組織修復スカフォールドと細胞成長導管フラップとが単一片から形成されたものである、実施態様(1)に記載の修復デバイス。
(15)前記細胞成長導管フラップが、前記組織修復スカフォールドに対し実質的に垂直方向にあるような向きに配置されている、実施態様(1)に記載の修復デバイス。
(17)前記細胞成長導管フラップと組織修復スカフォールドとが、Lの字状になるように、それぞれに対し配置されている、実施態様(1)に記載の修復デバイス。
(18)前記細胞成長導管フラップが、前記組織修復スカフォールドの厚さより薄い、実施態様(1)に記載の修復デバイス。
(19)前記細胞成長導管フラップの密度が約150mg/mL〜350mg/mLの範囲にある、実施態様(1)に記載の修復デバイス。
(20)前記細胞成長導管フラップの空隙体積が約50%〜95%の範囲にある、実施態様(1)に記載の修復デバイス。
(22)さらに、細胞成長導管フラップを配置する前に半月板にやすり掛けする工程を有する、実施態様(21)に記載の方法。
(23)さらに、細胞成長導管フラップを配置する前に滑膜にやすり掛けする工程を有する、実施態様(21)に記載の方法。
(24)さらに、細胞成長導管フラップを滑膜と接触するように配置することを含む、実施態様(21)に記載の方法。
(25)半月板欠損部の外科的修復方法であって、細胞成長導管フラップを与え、当該細胞成長導管フラップを、半月板組織欠損部と脛骨表面とに接触して配置し、細胞成長導管フラップを適切な場所に固定することを含み、当該細胞成長導管フラップが、細胞および栄養素を半月板欠損部に移動させ、これによって半月板の治癒を促進することが効果的にできる、方法。
(27)前記細胞成長導管フラップが、滑膜から半月板組織欠損部へ細胞および栄養素の移動を可能にする導管を与える、実施態様(25)に記載の方法。
(28)さらに、前記細胞成長導管フラップを配置する前に、半月板にやすり掛けする工程を有する、実施態様(25)に記載の方法。
(29)さらに、前記細胞成長導管フラップを配置する前に、滑膜にやすり掛けする工程有する、実施態様(25)に記載の方法。
12 脛骨
14 大腿骨
18 ホワイトゾーン
19 レッドゾーン
20 半月板修復デバイス
21 断裂
22 組織修復スカフォールド
24 細胞成長導管フラップ
26 交差点
28 縫合糸
30 第一の部分
32 第二の部分
Claims (19)
- 生体適合性を有する半月板修復デバイスであって、
半月板の欠損部と接触して配置するのに適した、生体適合性を有する組織修復スカフォールドと、
当該組織修復スカフォールドに取り付けられており、脛骨表面に接触し、滑膜まで延在する、半月板組織欠損部へ生体物質を受け渡すのに適した細胞成長導管フラップと、
を含んでなり、
前記細胞成長導管フラップは、ボイド空間同士の間が相互連結する開放性の多孔構造を有する、修復デバイス。 - 前記細胞成長導管フラップが、滑膜から前記組織修復スカフォールドならびに前記半月板組織欠損部への細胞および栄養素の移動を可能とするための導管を提供する、請求項1に記載の修復デバイス。
- 前記組織修復スカフォールドが、生体吸収性物質から造られたものである、請求項1または2に記載の修復デバイス。
- 前記組織修復スカフォールドと細胞成長導管フラップとが、相異なる材料から造られている、請求項1〜3のいずれかに記載の修復デバイス。
- 前記組織修復スカフォールドと細胞成長導管フラップとが、同一の材料から造られている、請求項1〜3のいずれかに記載の修復デバイス。
- 前記組織修復スカフォールドと細胞成長導管フラップとが、グリコリド、ラクチドおよびジオキサノンからなる群から選ばれたモノマーに由来する少なくとも一つのポリマーを含んでなる、請求項5に記載の修復デバイス。
- 前記組織修復スカフォールドと細胞成長導管フラップとがポリジオキサノンを含んでなる、請求項1〜6のいずれかに記載の修復デバイス。
- 前記組織修復スカフォールドと細胞成長導管フラップとがグリコリドとL−ラクチドとのコポリマーを含んでなる、請求項1〜6のいずれかに記載の修復デバイス。
- 前記組織修復スカフォールドが、天然ポリマー、合成ポリマーおよびこれらの組み合わせからなる群から選ばれた少なくとも一つの材料から形成されたものである、請求項1〜6のいずれかに記載の修復デバイス。
- 前記組織修復スカフォールド上または組織修復スカフォールド内に配置された生育可能組織であって、組織修復スカフォールドに隣接する本来の組織と一体化するのに有効な生育可能組織をさらに含んでなる、請求項1〜9のいずれかに記載の修復デバイス。
- 細胞の成長を促進するのに有効な少なくとも一つの生理活性物質をさらに含んでなる、請求項1〜10のいずれかに記載の修復デバイス。
- 前記生理活性物質が、多血小板血漿、軟骨由来の形態形成タンパク質、ヒトの組み替え成長因子およびこれらの組み合わせからなる群から選ばれたものである、請求項11に記載の修復デバイス。
- 前記組織修復スカフォールドと細胞成長導管フラップとが単一片から形成されたものである、請求項1に記載の修復デバイス。
- 前記細胞成長導管フラップが、前記組織修復スカフォールドに対し実質的に垂直方向にあるような向きに配置されている、請求項1〜13のいずれかに記載の修復デバイス。
- 前記細胞成長導管フラップと組織修復スカフォールドとが、Tの字状になるように、それぞれに対し配置されている、請求項1〜13のいずれかに記載の修復デバイス。
- 前記細胞成長導管フラップと組織修復スカフォールドとが、Lの字状になるように、それぞれに対し配置されている、請求項1〜13のいずれかに記載の修復デバイス。
- 前記細胞成長導管フラップが、前記組織修復スカフォールドの厚さより薄い、請求項1〜16のいずれかに記載の修復デバイス。
- 前記細胞成長導管フラップの密度が約150mg/mL〜350mg/mLの範囲にある、請求項1〜17のいずれかに記載の修復デバイス。
- 前記細胞成長導管フラップの空隙体積が約50%〜95%の範囲にある、請求項1〜18のいずれかに記載の修復デバイス。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/828,841 US8657881B2 (en) | 2004-04-20 | 2004-04-20 | Meniscal repair scaffold |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2005305162A JP2005305162A (ja) | 2005-11-04 |
JP4549919B2 true JP4549919B2 (ja) | 2010-09-22 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005121278A Expired - Fee Related JP4549919B2 (ja) | 2004-04-20 | 2005-04-19 | 半月板修復スカフォールド |
Country Status (5)
Country | Link |
---|---|
US (1) | US8657881B2 (ja) |
EP (1) | EP1602345B1 (ja) |
JP (1) | JP4549919B2 (ja) |
AU (1) | AU2005201392B8 (ja) |
CA (1) | CA2504397C (ja) |
Cited By (1)
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---|---|---|---|---|
JP2013116324A (ja) * | 2007-04-17 | 2013-06-13 | Board Of Trustees Of The Leland Stanford Jr Univ | ヒドロゲル関節形成装置 |
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AU2005201392B2 (en) | 2006-09-21 |
CA2504397A1 (en) | 2005-10-20 |
EP1602345A1 (en) | 2005-12-07 |
AU2005201392A8 (en) | 2010-04-15 |
CA2504397C (en) | 2010-07-06 |
EP1602345B1 (en) | 2011-05-25 |
AU2005201392B8 (en) | 2010-04-15 |
US20050234549A1 (en) | 2005-10-20 |
US8657881B2 (en) | 2014-02-25 |
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