JP4457002B2 - 超音波診断微小脈管画像化 - Google Patents
超音波診断微小脈管画像化 Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/48—Diagnostic techniques
- A61B8/481—Diagnostic techniques involving the use of contrast agent, e.g. microbubbles introduced into the bloodstream
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
- G01S15/88—Sonar systems specially adapted for specific applications
- G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
- G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
- G01S15/8959—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques using coded signals for correlation purposes
- G01S15/8963—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques using coded signals for correlation purposes using pulse inversion
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- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
- G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
- G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
- G01S7/52023—Details of receivers
- G01S7/52025—Details of receivers for pulse systems
- G01S7/52026—Extracting wanted echo signals
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
- G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
- G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
- G01S7/52023—Details of receivers
- G01S7/52036—Details of receivers using analysis of echo signal for target characterisation
- G01S7/52038—Details of receivers using analysis of echo signal for target characterisation involving non-linear properties of the propagation medium or of the reflective target
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
- G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
- G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
- G01S7/52023—Details of receivers
- G01S7/52036—Details of receivers using analysis of echo signal for target characterisation
- G01S7/52038—Details of receivers using analysis of echo signal for target characterisation involving non-linear properties of the propagation medium or of the reflective target
- G01S7/52039—Details of receivers using analysis of echo signal for target characterisation involving non-linear properties of the propagation medium or of the reflective target exploiting the non-linear response of a contrast enhancer, e.g. a contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S7/00—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00
- G01S7/52—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00
- G01S7/52017—Details of systems according to groups G01S13/00, G01S15/00, G01S17/00 of systems according to group G01S15/00 particularly adapted to short-range imaging
- G01S7/52085—Details related to the ultrasound signal acquisition, e.g. scan sequences
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/06—Measuring blood flow
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
- G01S15/88—Sonar systems specially adapted for specific applications
- G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
- G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
- G01S15/8909—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques using a static transducer configuration
- G01S15/8915—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques using a static transducer configuration using a transducer array
- G01S15/8918—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques using a static transducer configuration using a transducer array the array being linear
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01S—RADIO DIRECTION-FINDING; RADIO NAVIGATION; DETERMINING DISTANCE OR VELOCITY BY USE OF RADIO WAVES; LOCATING OR PRESENCE-DETECTING BY USE OF THE REFLECTION OR RERADIATION OF RADIO WAVES; ANALOGOUS ARRANGEMENTS USING OTHER WAVES
- G01S15/00—Systems using the reflection or reradiation of acoustic waves, e.g. sonar systems
- G01S15/88—Sonar systems specially adapted for specific applications
- G01S15/89—Sonar systems specially adapted for specific applications for mapping or imaging
- G01S15/8906—Short-range imaging systems; Acoustic microscope systems using pulse-echo techniques
- G01S15/8979—Combined Doppler and pulse-echo imaging systems
- G01S15/8981—Discriminating between fixed and moving objects or between objects moving at different speeds, e.g. wall clutter filter
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Description
出力ピクセル(x,y,k) = 最大{abs[入力ピクセル(x,y,k)],(P×出力ピクセル(x,y,k−1))}
に従って動作する。ここで、時定数Pは、レンジが0<P≦1である。時定数Pが1未満の場合には、表示されるマイクロバブル・イベントの痕跡は、明るいイベントとして始まり、その後、時間とともに黒にフェードしていくであろう、崩壊が遅い、速いアタックの明るさを示すであろう。時定数Pが1に等しいときに、残像プロセッサ38は、現在(k)および前の(k−1)ピクセルの明るさの最大輝度投影法を実行するであろう。
速い時間シーケンスを非周期的にインターリーブすることは、造影剤の有無にかかわら
12 アレイ・トランデューサ
14 ビーム成形器
16 直交バンドパス(QBP)フィルタ
20 エコー・プロセッサ
22 流れプロセッサ
30 画像プロセッサ
32 画像バッファ
34 スキャン変換器
36 インター・フレーム・ハイパスフィルタ
37 HPFプロセッサ
38、42 残像プロセッサ
39 リセット制御
40 表示部
44 混合/オーバーレイ・プロセッサ
60、62 ドップラー・フィルタ応答特性
72、74 軌跡
Claims (16)
- 超音波診断装置の作動方法であって、
アレイトランスデューサが被験者の画像領域にパルスを送信することと、
前記アレイトランスデューサが前記画像領域の造影剤からの前記パルスに応答するエコーを受信することと、
所定の時点で前記画像領域の造影剤の位置を検出することと、
異なる時点で前記造影剤の前記位置を示す画像を生成することと、
を備え、
前記画像を生成することは、複数の画像インターバルにわたって持続する前記造影剤の前記位置の表示の残像を生成することを備え、
前記残像の持続時間が、可変の残像時定数により調整され、
前記検出することは、所定の時点での造影剤の前記位置を検出するため、パルス反転による高調波分離を行った後、時間的に異なる画像を時間的ハイパスフィルタリングすることを備える、超音波造影剤による超音波画像化方法。 - 前記時間的ハイパスフィルタリングすることは、時間的に異なる画像フレームの空間基に基づいてフレーム・トゥ・フレーム減算を実行することを備える、請求項1に記載の超音波画像化方法。
- 前記時間的ハイパスフィルタリングすることは、連続した異なる画像フレームの空間基に基づいてフレーム・トゥ・フレーム減算を実行することを備える、請求項2に記載の超音波画像化方法。
- 前記画像を生成することは、前記造影剤の前記位置の最大輝度投影法を表示することを備える、請求項1に記載の超音波画像化方法。
- 前記画像を生成することは、複数の画像インターバルにわたりゆっくり減衰する残像として、所定の時点で、前記造影剤の前記位置を表示することを備える、請求項1に記載の超音波画像化方法。
- 前記画像を生成することは、
出力ピクセル(x,y,k)=最大{abs[入力ピクセル(x,y,k)]、P×出力ピクセル(x,y,k−1)} (ここで、前記xおよび前記yがピクセル座標であり、前記Pは0から1まで変動する時定数であり、かつ、前記kは刻時点である。)に従って、空間基に基づいて画像ピクセル・データを処理することを備える、請求項1に記載の超音波画像化方法。 - 超音波診断装置の作動方法であって、
アレイトランスデューサが被験者の画像領域にパルスを送信することと、
前記アレイトランスデューサが前記画像領域の造影剤からの前記パルスに応答するエコーを受信することと、
第1の時間に、移動している造影剤の位置の第1のデータ群を生成することと、
第2の時間に、前記移動している造影剤の前記位置の第2のデータ群を生成することと、
前記第1および第2の時間に、前記移動している造影剤の前記位置を表す表示のための画像を生成することと、
を備え、
前記表示のための画像を生成することは、所定の時点での造影剤の前記位置を検出するため、パルス反転による高調波分離を行った後、時間的に異なる画像を時間的ハイパスフィルタリングして、造影剤の位置情報を残像処理することを備え、
前記残像の持続時間が、可変の残像時定数により調整される、超音波造影剤を有する超音波画像化方法。 - 前記第1および第2のデータ群を時間的ハイパスフィルタリングすることは、空間基に基づいて前記第1および第2のデータ群の減算を実行することを備える、請求項7に記載の超音波画像化方法。
- 前記造影剤は、高調波造影剤であり、かつ、前記表示のための画像を生成することは、時間と共に前記造影剤の移動のパスを示す画像を生成することを備える、請求項7に記載の超音波画像化方法。
- 超音波診断装置の作動方法であって、
アレイトランスデューサが被験者の画像領域にパルスを送信することと、
前記アレイトランスデューサが前記画像領域の造影剤からの前記パルスに応答するエコーを受信することと、
第1の時間に、移動している高調波造影剤の位置の第1のデータ群を生成することと、
第2の時間に、前記移動している高調波造影剤の前記位置の第2のデータ群を生成することと、
異なる時点で、前記移動している高調波造影剤の前記位置の軌跡を表す表示のための画像を生成することと、
を備え、
前記表示のための画像を生成することは、所定の時点での造影剤の前記位置を検出するため、パルス反転による高調波分離を行った後、時間的に異なる画像を時間的ハイパスフィルタリングして、造影剤の位置情報を残像処理することを備え、
前記残像の持続時間が、可変の残像時定数により調整される、超音波造影剤を有する超音波画像化方法。 - 移動している造影剤を含む画像フィールドに問い合わせるアレイトランスデューサと、
前記移動している造影剤からのコヒーレントのエコー信号を生成する前記アレイトランスデューサに結合されている受信器と、
異なる時点で、前記移動している造影剤の位置を示す画像を生成する、前記受信器に結合されている画像プロセッサと、
前記画像プロセッサに結合されているインター・フレーム・ハイパスフィルタと、
以前の時点で、前記移動している造影剤の前記位置を表す残像を生成する前記インター・フレーム・ハイパスフィルタに結合されている残像プロセッサと、
画像表示部と、
を備え、
前記残像の持続時間が、可変の残像時定数により調整され、
前記ハイパスフィルタに入力される信号が、パルス反転による高調波分離処理が施された後の信号である、高調波造影画像化のための超音波画像化処理システム。 - 前記インター・フレーム・ハイパスフィルタは、フレーム・トゥ・フレームの減算器を備える、請求項11に記載の超音波画像化システム。
- 前記残像時定数が、所定の時点での前記移動している造影剤の前記位置を、無期限に持続させる、請求項11に記載の超音波画像化システム。
- 前記残像時定数が、所定の時点での前記移動している造影剤の前記位置を、遅い減衰で持続させる、請求項11に記載の超音波画像化システム。
- 前記画像表示部は、時間とともに小さい血管を通るマイクロバブルの軌跡を表す画像を表示するために機能する請求項11に記載の超音波画像化システム。
- 更に、前記画像プロセッサに結合されている画像登録プロセッサを備える請求項11に記載の超音波画像化システム。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/170,178 US6676606B2 (en) | 2002-06-11 | 2002-06-11 | Ultrasonic diagnostic micro-vascular imaging |
PCT/IB2003/001982 WO2003103497A1 (en) | 2002-06-11 | 2003-05-16 | Ultrasonic diagnostic microvascular imaging |
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JP2005528949A JP2005528949A (ja) | 2005-09-29 |
JP4457002B2 true JP4457002B2 (ja) | 2010-04-28 |
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JP2004510624A Expired - Lifetime JP4457002B2 (ja) | 2002-06-11 | 2003-05-16 | 超音波診断微小脈管画像化 |
Country Status (8)
Country | Link |
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US (1) | US6676606B2 (ja) |
EP (1) | EP1515639B1 (ja) |
JP (1) | JP4457002B2 (ja) |
CN (1) | CN100401988C (ja) |
AT (1) | ATE454850T1 (ja) |
AU (1) | AU2003224390A1 (ja) |
DE (1) | DE60330963D1 (ja) |
WO (1) | WO2003103497A1 (ja) |
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- 2003-05-16 JP JP2004510624A patent/JP4457002B2/ja not_active Expired - Lifetime
- 2003-05-16 WO PCT/IB2003/001982 patent/WO2003103497A1/en active Application Filing
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JP2005528949A (ja) | 2005-09-29 |
DE60330963D1 (de) | 2010-03-04 |
EP1515639B1 (en) | 2010-01-13 |
CN1658798A (zh) | 2005-08-24 |
WO2003103497A1 (en) | 2003-12-18 |
ATE454850T1 (de) | 2010-01-15 |
US6676606B2 (en) | 2004-01-13 |
AU2003224390A1 (en) | 2003-12-22 |
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