JP4267592B2 - 抗血栓薬薬効試験法 - Google Patents
抗血栓薬薬効試験法 Download PDFInfo
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- JP4267592B2 JP4267592B2 JP2005149183A JP2005149183A JP4267592B2 JP 4267592 B2 JP4267592 B2 JP 4267592B2 JP 2005149183 A JP2005149183 A JP 2005149183A JP 2005149183 A JP2005149183 A JP 2005149183A JP 4267592 B2 JP4267592 B2 JP 4267592B2
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- blood
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- test method
- thromboelastograph
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Hematology (AREA)
- Engineering & Computer Science (AREA)
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- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Urology & Nephrology (AREA)
- Food Science & Technology (AREA)
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- Investigating Or Analysing Biological Materials (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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- Pyrane Compounds (AREA)
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Description
K Rから血塊弾性値の巾が20mmになるまでの時間
MA 血塊弾性値の巾の最大振幅MA値
ANG 血塊弾性の変化のグラフで接線を引いたときの角度
Claims (7)
- 抗血栓薬の投与を受けている患者から採取した血液の一部に抗凝固剤を加えた系(X系血液)、前記血液の一部に抗凝固剤並びにアデノシン二リン酸又はコラーゲンを加えた系(Y系血液)につき、トロンボエラストグラフを測定し、X系血液及びY系血液のR値を比較することを特徴とする抗血栓薬薬効の試験法。
- 前記抗凝固剤がヘパリン又はアルガトロバンであることを特徴とする請求項1に記載の抗血栓薬薬効の試験法。
- 前記X系血液及びY系血液が更に塩化カルシウムを加えたものであることを特徴とする請求項1又は請求項2に記載の抗血栓薬薬効の試験法。
- 前記X系血液が更に生理食塩水を加えたものであることを特徴とする請求項3に記載の抗血栓薬薬効の試験法。
- 前記アデノシン二リン酸の添加量が8.3μM以上、コラーゲンの添加量が10μg/mL以上であることを特徴とする請求項1から請求項4のいずれかに記載の抗血栓薬薬効の試験法。
- 前記抗血栓薬の投与を受けている患者から採取した血液を、カオリン処理することを特徴とする請求項1から請求項5のいずれかに記載の抗血栓薬薬効の試験法。
- 前記カオリン処理が、カオリン塗布バイエルに受け入れることであることを特徴とする請求項6に記載の抗血栓薬薬効の試験法。
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005149183A JP4267592B2 (ja) | 2005-05-23 | 2005-05-23 | 抗血栓薬薬効試験法 |
AT05806150T ATE441866T1 (de) | 2005-05-23 | 2005-11-08 | Verfahren zum testen der wirksamkeit eines antithrombosemittels |
PCT/JP2005/020421 WO2006126290A1 (ja) | 2005-05-23 | 2005-11-08 | 抗血栓薬薬効試験法 |
EP05806150A EP1884778B1 (en) | 2005-05-23 | 2005-11-08 | Method for testing efficacy of antithrombotic agent |
DE602005016465T DE602005016465D1 (de) | 2005-05-23 | 2005-11-08 | Verfahren zum testen der wirksamkeit eines antithrombosemittels |
US11/915,273 US7947505B2 (en) | 2005-05-23 | 2005-11-08 | Method for testing efficacy of antithrombotic agent |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2005149183A JP4267592B2 (ja) | 2005-05-23 | 2005-05-23 | 抗血栓薬薬効試験法 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006329643A JP2006329643A (ja) | 2006-12-07 |
JP4267592B2 true JP4267592B2 (ja) | 2009-05-27 |
Family
ID=37451725
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2005149183A Expired - Fee Related JP4267592B2 (ja) | 2005-05-23 | 2005-05-23 | 抗血栓薬薬効試験法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US7947505B2 (ja) |
EP (1) | EP1884778B1 (ja) |
JP (1) | JP4267592B2 (ja) |
AT (1) | ATE441866T1 (ja) |
DE (1) | DE602005016465D1 (ja) |
WO (1) | WO2006126290A1 (ja) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4267592B2 (ja) | 2005-05-23 | 2009-05-27 | 潤 川崎 | 抗血栓薬薬効試験法 |
WO2008062520A1 (fr) * | 2006-11-22 | 2008-05-29 | Jun Kawasaki | Procédé d'expérimentation efficace de médicaments pour un agent antitrombotique |
WO2009028047A1 (ja) * | 2007-08-28 | 2009-03-05 | Jun Kawasaki | 抗血栓薬薬効試験方法 |
EP2063273A1 (en) * | 2007-11-21 | 2009-05-27 | Pentapharm GmbH | Method for assessing the fibrinogen contribution in coagulation |
US8448499B2 (en) | 2008-12-23 | 2013-05-28 | C A Casyso Ag | Cartridge device for a measuring system for measuring viscoelastic characteristics of a sample liquid, a corresponding measuring system, and a corresponding method |
US8383045B2 (en) | 2009-01-16 | 2013-02-26 | C A Casyso Ag | Measuring unit for measuring characteristics of a sample liquid, in particular viscoelastic characteristics of a blood sample |
EP2371284A1 (en) | 2010-03-24 | 2011-10-05 | C A Casyso AG | Method and apparatus for determining at least one evaluation parameter of a blood sample |
JP5768422B2 (ja) * | 2011-03-17 | 2015-08-26 | ソニー株式会社 | 血液凝固系解析方法および血液凝固系解析装置 |
ES2706995T3 (es) * | 2012-12-18 | 2019-04-02 | Daiichi Sankyo Co Ltd | Procedimiento para medir la generación de trombina |
EP2772763A1 (en) * | 2013-02-28 | 2014-09-03 | Weser-Bissé, Petra | In vitro method, use of an agent and collection device for the inhibition of coagulation in blood |
US10816559B2 (en) | 2014-09-29 | 2020-10-27 | Ca Casyso Ag | Blood testing system and method |
US9897618B2 (en) | 2014-09-29 | 2018-02-20 | C A Casyso Gmbh | Blood testing system |
US10288630B2 (en) | 2014-09-29 | 2019-05-14 | C A Casyso Gmbh | Blood testing system and method |
US10175225B2 (en) | 2014-09-29 | 2019-01-08 | C A Casyso Ag | Blood testing system and method |
US10539579B2 (en) | 2014-09-29 | 2020-01-21 | C A Casyso Gmbh | Blood testing system and method |
USD777343S1 (en) | 2015-05-28 | 2017-01-24 | C A Casyso Ag | Body fluid cartridge device |
US10295554B2 (en) | 2015-06-29 | 2019-05-21 | C A Casyso Gmbh | Blood testing system and method |
US10473674B2 (en) | 2016-08-31 | 2019-11-12 | C A Casyso Gmbh | Controlled blood delivery to mixing chamber of a blood testing cartridge |
US10843185B2 (en) | 2017-07-12 | 2020-11-24 | Ca Casyso Gmbh | Autoplatelet cartridge device |
KR102601619B1 (ko) | 2018-11-12 | 2023-11-13 | 삼성전자주식회사 | 연마 패드 모니터링 방법 및 연마 패드 모니터링 장치 |
CN110514823B (zh) * | 2019-08-28 | 2023-12-05 | 深圳麦科田生物医疗技术股份有限公司 | 一种血小板抑制率检测试剂盒及其制备方法和检测方法 |
CN111937858A (zh) * | 2020-07-06 | 2020-11-17 | 晶准生物医学(深圳)有限公司 | 抗凝组合物、真空采血管 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7179652B2 (en) * | 1999-02-22 | 2007-02-20 | Haemoscope Corporation | Protocol for monitoring platelet inhibition |
US6613573B1 (en) * | 1999-02-22 | 2003-09-02 | Haemoscope Corporation | Method and apparatus for monitoring anti-platelet agents |
EP1212073A4 (en) | 1999-07-23 | 2003-09-03 | Scripps Research Inst | METHOD FOR DETERMINING THE WHOLE BLOOD ACTIVITY |
JP4267592B2 (ja) | 2005-05-23 | 2009-05-27 | 潤 川崎 | 抗血栓薬薬効試験法 |
-
2005
- 2005-05-23 JP JP2005149183A patent/JP4267592B2/ja not_active Expired - Fee Related
- 2005-11-08 DE DE602005016465T patent/DE602005016465D1/de active Active
- 2005-11-08 EP EP05806150A patent/EP1884778B1/en not_active Not-in-force
- 2005-11-08 US US11/915,273 patent/US7947505B2/en not_active Expired - Fee Related
- 2005-11-08 AT AT05806150T patent/ATE441866T1/de not_active IP Right Cessation
- 2005-11-08 WO PCT/JP2005/020421 patent/WO2006126290A1/ja active Application Filing
Also Published As
Publication number | Publication date |
---|---|
JP2006329643A (ja) | 2006-12-07 |
ATE441866T1 (de) | 2009-09-15 |
EP1884778A4 (en) | 2008-08-20 |
EP1884778A1 (en) | 2008-02-06 |
US20090280570A1 (en) | 2009-11-12 |
EP1884778B1 (en) | 2009-09-02 |
DE602005016465D1 (de) | 2009-10-15 |
WO2006126290A1 (ja) | 2006-11-30 |
US7947505B2 (en) | 2011-05-24 |
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