JP4063673B2 - クロマトグラフ高電界非対称波形イオン移動度分光測定の方法および装置 - Google Patents
クロマトグラフ高電界非対称波形イオン移動度分光測定の方法および装置 Download PDFInfo
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- G01N27/624—Differential mobility spectrometry [DMS]; Field asymmetric-waveform ion mobility spectrometry [FAIMS]
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Description
本発明のさらに別の目的は、保持時間データに加えて、差動移動度のスペクトル情報を提供する一種のセンサを提供することである。
10A…ガスクロマトグラフセクション
10B…高電界非対称波形イオン動度分光測定セクション
10C…コントローラ
12a…キャリア・ガス・サンプル
12c…ドリフト・ガス
14…ポンプ
16…入口セクション
17…イオン化セクション
18…イオン源
24…イオン・フィルタ
26…流路
30…フィルタのコントローラ
31…出口セクション
32…検出器
52,54…基板
Claims (46)
- サンプルのクロマトグラフ溶出物を分析する装置であって、
入力部、イオンを濾過するイオン・フィルタ部、出力部、およびそれらを接続する流路、ならびに表示部を備え、
前記流路が前記入力部と出力部の間で前記イオン・フィルタ部を通って延び、前記入力部が前記流路にイオン流れを供給し、前記イオンが前記流路に沿って前記イオン・フィルタ部に流れ、
前記イオン・フィルタ部が、前記流路に前記流路を横切る補償された非対称電界を供給することにより、前記イオン流れから少なくとも1つのイオン種を選択し、前記選択が前記補償された非対称電界中の前記選択されたイオン種の高電界移動度特性に基づいてなされ、前記選択されたイオン種が前記出力部に達して検出され、
前記入力部は前記イオン流れ内で保持時間に渡ってイオン化されたクロマトグラフ溶出物を提供し、この提供された溶出物は、少なくとも1つの濃度ピーク形状をそれぞれが持つ複数の濃度ピークを形成し、各ピークは立上がり区間から前記少なくとも1つのピーク形状を通って立下がり区間にまで広がり、かつピーク持続時間を有し、前記イオン化された溶出物が各ピークについての前記少なくとも1つのピーク形状を表す代表イオン種を含んでおり、
前記イオン・フィルタ部が、各濃度ピークに対する前記代表イオン種を、少なくとも1つの補償電圧を前記イオン・フィルタに印加することによって選択し、前記選択された代表イオン種が各濃度ピークについての前記ピーク持続時間内に、前記イオン・フィルタ部を通り前記出力部に達して、前記溶出物の特性を決定する検出データを生成させ、
前記表示部が、保持時間に対する補償電圧のプロットを表示し、この保持時間に対する補償電圧が前記サンプルの解析に用いられる装置。 - 請求項1において、前記イオン化されたクロマトグラフ溶出物の提供から、前記検出データの生成までの時間の長さが、前記ピーク持続時間より短い装置。
- 請求項1において、前記入力部が前記クロマトグラフ溶出物を前記流路に、時間t0において提供するように配置され、
前記ピーク持続時間が時間t1として表され、前記溶出物ピークが時間t0において、前記立上がり縁で始まり、時間t1において、前記立下り区間で終了し、
前記少なくとも1つのピーク形状の前記流路への提供から、前記検出までの時間の長さが時間t1より短い装置。 - 請求項1において、前記検出データが、(a)前記イオン検出の強度、(b)前記時間の長さ、(c)前記補償された非対称高電界の状態を含む装置。
- 請求項4において、前記イオン流れが反応イオンを含み、前記検出データがさらに(d)保持時間を含む装置。
- 請求項5において、前記入力部がクロマトグラフ出力を含み、
前記溶出物が前記クロマトグラフ出力から前記流路に送り出され、前記溶出物が前記クロマトグラフ内に滞在した時間に関連する保持時間を有し、
前記検出データにより、前記補償状態と保持時間を比較して、溶出物の特性を決定する装置。 - 請求項1において、前記入力部が前記溶出物をイオン化するイオン化セクションを備え、
前記出力部が前記検出データを生成する検出器を備え、
さらに、前記電界補償を走査する、前記フィルタ部分に接続された制御部を備え、
前記溶出物形状を含む前記溶出物が、前記イオン化セクションでイオン化され、前記流路内で前記フィルタ部分に送られる代表イオン流れを発生させ、
前記電界補償を前記制御部により数回走査し、前記代表イオン流れの複数の移動度スペクトルを生成し、
前記数回の走査が、前記ピーク持続時間より短い総合持続時間を有し、前記溶出物中の化学種の特性が決定される装置。 - 請求項1において、前記入力部がガスクロマトグラフと前記流路に組み込まれたイオン化セクションとを備え、前記クロマトグラフが溶出物を前記イオン化セクションに送り出し、
前記イオン化セクションが前記イオン化されたクロマトグラフ溶出物を生成する装置。 - 請求項1において、さらに、デバイス・ハウジングを備え、
前記制御部が、非対称電界発生信号を前記イオン・フィルタ部に供給するための、前記ハウジングに結合された接点を有する装置。 - 請求項1において、前記溶出物ピークが複数のピーク形状を含み、
前記電界補償の走査が前記フィルタ部分で実行されて、前記複数のピーク形状の差動移動度スペクトルを生成し、
前記走査が、前記ピーク持続時間より短い時間内で実行され、前記溶出物中の化学種の特性が決定される装置。 - 請求項10において、さらに、前記補償された非対称電界を制御する制御部を備え、前記制御部が、前記電界に印加する可変DCバイアスを供給して、前記電界補償を走査する装置。
- 請求項10において、さらに、前記フィルタ部分に結合され、このフィルタ部分に非対称RF信号を供給して、前記補償された非対称電界を発生させる制御部を備え、
前記制御部がRF信号の形状を走査して前記補償を走査する装置。 - 請求項12において、前記RF信号の形状がRF信号のデューティ・サイクルである装置。
- 請求項1において、前記入力部がさらに、前記流路内の入口と、ガス・サンプルを前記入口に送り出すキャピラリ・カラムを有するガスクロマトグラフとを備え、
前記ガス・サンプルが、化合物を含むキャリヤ・ガスを含み、
さらに、ドリフト・ガス源を備え、
前記ドリフト・ガス源がドリフト・ガスを前記入口に供給して、前記化合物を含むキャリヤ・ガスを前記流路に沿って前記出力部に移送する装置。 - 請求項14において、さらに、ドリフト・ガス・チューブを備え、
前記キャリヤ・ガスを送り出すカラム出口を有する前記キャピラリ・カラムが前記ドリフト・ガス・チューブ内に収納され、
前記ドリフト・ガス流れが前記カラム出口の位置で前記キャリヤ・ガス流れを囲む装置。 - 請求項1において、前記イオン・フィルタ部が、前記流路の横断方向に一対の電極プレートを備え、
前記補償された非対称電界が前記電極プレート間で発生する装置。 - 請求項16において、前記イオン・フィルタ部が非円筒形である装置。
- 請求項17において、さらに、絶縁基板を備え、
前記電極プレートを前記イオン・フィルタ部の前記基板上に配置して、フィルタ電極を形成する装置。 - 請求項1において、さらに、一対の基板を備え、
前記基板を組み合わせて前記流路を形成し、
前記イオン・フィルタ部が、前記流路の横断方向に対向し、かつ前記基板に組み込まれる一対の間隔を空けた電極を備える装置。 - 請求項19において、前記電界が前記電極間に形成され、前記電界が非収束である装置。
- 請求項20において、前記電極が平板状である装置。
- 請求項20において、前記電極が平行である装置。
- 請求項20において、前記基板がデバイス・ハウジングを形成し、このデバイス・ハウジングが前記入力部、前記流路、および前記出力部を支持している装置。
- 請求項1において、さらに、前記出力部に前記イオン検出を行う検出器を備え、
前記フィルタ部が陽イオンおよび陰イオンを前記検出器まで移送し、
前記検出器が一対の電極を備え、これらの電極がバイアスされ、協働して、前記フィルタ部分により移送された前記陽イオンおよび陰イオンを同時検出する装置。 - 請求項1において、さらに、前記補償された非対称電界を制御する制御部を備え、
前記制御部により、前記電界を通過する前記イオン種の軌道を調整し、
前記出力部がさらに、検出器を備え、
前記検出器が、セグメント化された検出器を形成する連続する複数の電極を備え、各セグメントは前記流路に沿って離間し、前記イオン種の軌道に応じて、前記イオンを空間的に検出する装置。 - 請求項1において、前記流路が大気圧、またはそれに近い気圧で動作する装置。
- 請求項1において、前記イオン・フィルタ部がフィルタ・アレイを備え、各フィルタが前記流路中に一対の電極を備えている装置。
- 請求項1において、さらに、前記流路中にヒータを備えている装置。
- 請求項1において、前記クロマトグラフが、ガスクトマトグラフである装置。
- 請求項1において、前記表示部が、前記出力部に結合され、前記検出されたイオン種を表す少なくとも二次元のデータを表示する装置。
- 請求項1において、さらに、前記イオン・フィルタ部と前記出力部とを結合する分離部を備え、この絶縁部分により前記フィルタ部分と出力部の非導電接続が維持されている装置。
- 請求項1において、さらに、前記イオン・フィルタ部内に配置された一対のイオン・フィルタ電極を含む複数の電極を備えている装置。
- 請求項32において、前記複数の電極が前記流路中に形成された電極アレイを備えている装置。
- 請求項32において、さらに、前記出力部と連通する複数の専用流路を備え、
前記電極の配置が、前記専用流路に設けられたフィルタ電極対のアレイを備えている装置。 - 請求項32において、さらに、複数の専用流路を備え、
電極の前記電極の配置が、前記出力部内に、かつ前記専用流路と連通する検出器電極のアレイを備えている装置。 - 請求項32において、前記電極の前記配置が少なくとも一対の検出器電極を備え、各対の1つの電極が各基板に設けられており、
前記入力部がさらに、イオン化領域を備え、さらに、前記イオン化領域中に少なくとも1つの電極とを備えている装置。 - 請求項32において、前記電極の配置がさらに、複数のセグメントを持つ分割された検出器を形成し、
各セグメントが基板上の少なくとも1つの電極により形成され、
前記セグメントが前記出力部内に、前記流路に沿って長手方向に連続的に形成されている装置。 - 請求項1において、さらに、前記入力部から前記出力部に前記流路を通してガス・サンプルを吸引するフロー・ポンプを備えている装置。
- 請求項38において、前記入力部が、前記ポンプで吸引されるガス・サンプルの前記イオン化を行うイオン化源を備え、さらに、少なくとも1つの流路中の空気を循環させる第2ポンプを備えている装置。
- 請求項1において、前記イオン・フィルタ部が前記流路内に一対の電極プレートを形成し、
前記補償された非対称電界が前記電極プレート間で発生し、
さらに、前記流路の表面を形成する一対の絶縁基板を備え、
前記電極プレートが前記イオン・フィルタ部内の前記基板上に形成されている装置。 - 請求項40において、さらに、第3の基板を備え、前記一対および第3の基板が少なくとも2つの近接する流路を形成している装置。
- 請求項40において、さらに、前記入力部と出力部の間で前記流路に沿って延びるスペーサを備え、
前記イオン・フィルタ部が一対の間隔を空けたフィルタ電極を備えている装置。 - 請求項42において、前記スペーサが前記電極と協働して、前記流路を囲むデバイス・ハウジングを形成している装置。
- 請求項1において、前記検出データが直交検出データを含む装置。
- 請求項1において、前記表示部が、前記検出データの3次元プロットを含む装置。
- クロマトグラフと、請求項1から45のいずれか一項に記載の装置とを備えたシステム。
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US7211791B2 (en) | 2007-05-01 |
CA2440429A1 (en) | 2002-09-12 |
EP1377820A2 (en) | 2004-01-07 |
AU2002306623A1 (en) | 2002-09-19 |
US20010030285A1 (en) | 2001-10-18 |
US20050017163A1 (en) | 2005-01-27 |
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