JP4050748B2 - 粒子測定装置 - Google Patents
粒子測定装置 Download PDFInfo
- Publication number
- JP4050748B2 JP4050748B2 JP2004539450A JP2004539450A JP4050748B2 JP 4050748 B2 JP4050748 B2 JP 4050748B2 JP 2004539450 A JP2004539450 A JP 2004539450A JP 2004539450 A JP2004539450 A JP 2004539450A JP 4050748 B2 JP4050748 B2 JP 4050748B2
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- JP
- Japan
- Prior art keywords
- particle
- flow path
- detection region
- flow cell
- condensing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000002245 particle Substances 0.000 title claims description 55
- 238000001514 detection method Methods 0.000 claims description 31
- 239000012530 fluid Substances 0.000 claims description 11
- 230000001678 irradiating effect Effects 0.000 claims description 4
- 238000011144 upstream manufacturing Methods 0.000 claims description 2
- 238000005259 measurement Methods 0.000 claims 2
- 230000003287 optical effect Effects 0.000 description 15
- 238000006243 chemical reaction Methods 0.000 description 8
- 238000010586 diagram Methods 0.000 description 2
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1434—Optical arrangements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N2015/1493—Particle size
Landscapes
- Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
Description
そこで、散乱光Lsの検出レベルを高めて粒子の検出精度を上げるためには集光レンズ系101の集光角を最大限に利用する必要がある。
また、フローセルの流路の形状を、光学的検出処理手段がその集光角を最大限に利用して散乱光を集光することができるように形成したので、検出レベルを上げることができる。
Claims (2)
- フローセルに光を照射して粒子検出領域を形成し、この粒子検出領域を通過する試料流体に含まれる粒子が発する散乱光などを集光手段で集光し、粒径などの情報を得る粒子測定装置において、前記フローセルは、前記粒子検出領域を形成する流路と、内壁部を前記集光手段の最外縁部に入射する前記散乱光などを妨げないように形成すべく、前記流路に続く中心軸がほぼ一致する四角錐形状又は円錐形状の流路を、前記集光手段を設けた側に備えることを特徴とする粒子測定装置。
- フローセルに光を照射して粒子検出領域を形成し、この粒子検出領域を通過する試料流体に含まれる粒子が発する散乱光などを集光手段で集光し、粒径などの情報を得る粒子測定装置において、前記フローセルは、前記粒子検出領域を形成する流路と、内壁部を前記集光手段の最外縁部に入射する前記散乱光などを妨げないように形成すべく、前記流路の上流側と下流側に中心軸がほぼ一致する四角錐形状又は円錐形状の流路を備え、前記集光手段が前記フローセルを挟んで2つ配置されたことを特徴とする粒子測定装置。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/JP2002/010104 WO2004029589A1 (ja) | 2002-09-27 | 2002-09-27 | フローセル及びそれを用いた粒子測定装置 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007278775A Division JP4064445B1 (ja) | 2007-10-26 | 2007-10-26 | 粒子測定装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2004029589A1 JPWO2004029589A1 (ja) | 2006-01-26 |
JP4050748B2 true JP4050748B2 (ja) | 2008-02-20 |
Family
ID=32040323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2004539450A Expired - Fee Related JP4050748B2 (ja) | 2002-09-27 | 2002-09-27 | 粒子測定装置 |
Country Status (7)
Country | Link |
---|---|
US (1) | US7170601B2 (ja) |
EP (1) | EP1544600B1 (ja) |
JP (1) | JP4050748B2 (ja) |
CN (1) | CN100344956C (ja) |
AU (1) | AU2002343929A1 (ja) |
DE (1) | DE60236967D1 (ja) |
WO (1) | WO2004029589A1 (ja) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8049888B2 (en) * | 2004-03-01 | 2011-11-01 | Firma Cytecs Gmbh | Device for measuring light emitted by microscopically small particles or biological cells |
JP2007071794A (ja) * | 2005-09-09 | 2007-03-22 | Rion Co Ltd | 粒子検出器 |
WO2008042199A2 (en) | 2006-09-29 | 2008-04-10 | Cyberoptics Semiconductor, Inc. | Particles sensor integrated with substrate |
JP4389991B2 (ja) * | 2007-10-26 | 2009-12-24 | ソニー株式会社 | 微小粒子の光学的測定方法及び光学的測定装置 |
US7916293B2 (en) * | 2007-12-04 | 2011-03-29 | Particle Measuring Systems, Inc. | Non-orthogonal particle detection systems and methods |
TWI435080B (zh) | 2011-06-09 | 2014-04-21 | Univ Nat Pingtung Sci & Tech | 細胞或粒子檢測裝置 |
CN107305177A (zh) * | 2016-04-21 | 2017-10-31 | 易幼文 | 一种微粒物可视化装置和便携式微粒物检测*** |
JP6549747B2 (ja) * | 2017-04-14 | 2019-07-24 | リオン株式会社 | 粒子測定装置および粒子測定方法 |
JP7260308B2 (ja) * | 2019-01-24 | 2023-04-18 | リオン株式会社 | 流体中浮遊物質測定用フローセル及び粒子計数装置 |
JP7202904B2 (ja) * | 2019-01-24 | 2023-01-12 | リオン株式会社 | 粒子計数器 |
JP7339070B2 (ja) | 2019-08-29 | 2023-09-05 | リオン株式会社 | 生物粒子測定装置及び生物粒子測定方法 |
US11442000B2 (en) * | 2019-12-16 | 2022-09-13 | Applied Materials, Inc. | In-situ, real-time detection of particulate defects in a fluid |
DE102020001876A1 (de) * | 2020-03-23 | 2021-09-23 | Palas Gmbh Partikel- Und Lasermesstechnik | Verfahren und Aerosol-Messgerät zum Bestimmen der Partikelgeschwindigkeit eines Aerosols |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE793185A (fr) * | 1971-12-23 | 1973-04-16 | Atomic Energy Commission | Appareil pour analyser et trier rapidement des particules telles que des cellules biologiques |
US4276475A (en) * | 1976-10-20 | 1981-06-30 | Waters Associates, Inc. | Novel photometric system |
US4906094A (en) * | 1987-04-23 | 1990-03-06 | Sumitomo Chemical Co. Ltd. | Fine particle measuring method and system and a flow cell for use in the system |
JPH0462455A (ja) * | 1990-06-29 | 1992-02-27 | Shimadzu Corp | 粒度分布測定装置 |
JP2683172B2 (ja) * | 1991-10-01 | 1997-11-26 | キヤノン株式会社 | 検体測定方法及び検体測定装置 |
JPH05240769A (ja) * | 1992-02-29 | 1993-09-17 | Horiba Ltd | 粒子計数装置 |
US5371585A (en) * | 1992-11-10 | 1994-12-06 | Pacific Scientific Company | Particle detecting instrument with sapphire detecting cell defining a rectangular flow path |
JP3328032B2 (ja) * | 1993-11-04 | 2002-09-24 | シスメックス株式会社 | 粒子分析装置 |
JP3290786B2 (ja) * | 1993-11-26 | 2002-06-10 | シスメックス株式会社 | 粒子分析装置 |
CN2251721Y (zh) * | 1995-08-28 | 1997-04-09 | 周定益 | 激光粒度测试仪 |
EP0864855B1 (en) * | 1997-03-10 | 2003-10-29 | Fuji Electric Co., Ltd. | Method and apparatus for measuring turbidity |
JPH1121165A (ja) * | 1997-06-30 | 1999-01-26 | Tokin Corp | フェライトコアの焼成方法及び焼成治具 |
JP4026939B2 (ja) * | 1997-11-14 | 2007-12-26 | 日本分光株式会社 | Hplc用円二色性検出器 |
JP3480669B2 (ja) | 1998-01-26 | 2003-12-22 | リオン株式会社 | 粒子通過位置検出装置 |
JP3480670B2 (ja) * | 1998-01-28 | 2003-12-22 | リオン株式会社 | 光強度分布検出装置 |
US6465802B1 (en) * | 1999-03-18 | 2002-10-15 | Rion Co., Ltd. | Particle measurement apparatus flow cell useful for sample fluids having different refractive indexes |
-
2002
- 2002-09-27 CN CNB028296850A patent/CN100344956C/zh not_active Expired - Lifetime
- 2002-09-27 EP EP02775255A patent/EP1544600B1/en not_active Expired - Lifetime
- 2002-09-27 JP JP2004539450A patent/JP4050748B2/ja not_active Expired - Fee Related
- 2002-09-27 DE DE60236967T patent/DE60236967D1/de not_active Expired - Lifetime
- 2002-09-27 AU AU2002343929A patent/AU2002343929A1/en not_active Abandoned
- 2002-09-27 US US10/528,900 patent/US7170601B2/en not_active Expired - Lifetime
- 2002-09-27 WO PCT/JP2002/010104 patent/WO2004029589A1/ja active Application Filing
Also Published As
Publication number | Publication date |
---|---|
JPWO2004029589A1 (ja) | 2006-01-26 |
EP1544600A4 (en) | 2008-09-10 |
US20060001874A1 (en) | 2006-01-05 |
AU2002343929A1 (en) | 2004-04-19 |
WO2004029589A1 (ja) | 2004-04-08 |
US7170601B2 (en) | 2007-01-30 |
DE60236967D1 (de) | 2010-08-19 |
CN1668910A (zh) | 2005-09-14 |
EP1544600A1 (en) | 2005-06-22 |
CN100344956C (zh) | 2007-10-24 |
EP1544600B1 (en) | 2010-07-07 |
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