JP4013671B2 - ポリメラーゼ連鎖反応容器及びその製造方法 - Google Patents

ポリメラーゼ連鎖反応容器及びその製造方法 Download PDF

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Publication number
JP4013671B2
JP4013671B2 JP2002197038A JP2002197038A JP4013671B2 JP 4013671 B2 JP4013671 B2 JP 4013671B2 JP 2002197038 A JP2002197038 A JP 2002197038A JP 2002197038 A JP2002197038 A JP 2002197038A JP 4013671 B2 JP4013671 B2 JP 4013671B2
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JP
Japan
Prior art keywords
substrate
chain reaction
polymerase chain
cavity
reaction container
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2002197038A
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English (en)
Japanese (ja)
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JP2004033141A (ja
Inventor
将也 中谷
哲男 行政
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Panasonic Corp
Panasonic Holdings Corp
Original Assignee
Panasonic Corp
Matsushita Electric Industrial Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP2002197038A priority Critical patent/JP4013671B2/ja
Application filed by Panasonic Corp, Matsushita Electric Industrial Co Ltd filed Critical Panasonic Corp
Priority to DE60311941T priority patent/DE60311941T2/de
Priority to CNB03800738XA priority patent/CN1309828C/zh
Priority to PCT/JP2003/008467 priority patent/WO2004005507A1/ja
Priority to EP03741179A priority patent/EP1418233B1/de
Priority to US10/485,342 priority patent/US7384782B2/en
Publication of JP2004033141A publication Critical patent/JP2004033141A/ja
Application granted granted Critical
Publication of JP4013671B2 publication Critical patent/JP4013671B2/ja
Priority to US12/149,147 priority patent/US7790441B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1838—Means for temperature control using fluid heat transfer medium
    • B01L2300/185—Means for temperature control using fluid heat transfer medium using a liquid as fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Clinical Laboratory Science (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2002197038A 2002-07-05 2002-07-05 ポリメラーゼ連鎖反応容器及びその製造方法 Expired - Lifetime JP4013671B2 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2002197038A JP4013671B2 (ja) 2002-07-05 2002-07-05 ポリメラーゼ連鎖反応容器及びその製造方法
CNB03800738XA CN1309828C (zh) 2002-07-05 2003-07-03 聚合酶链反应容器及其制造方法
PCT/JP2003/008467 WO2004005507A1 (ja) 2002-07-05 2003-07-03 ポリメラーゼ連鎖反応容器及びその製造方法
EP03741179A EP1418233B1 (de) 2002-07-05 2003-07-03 Behälter für die polymerasekettenreaktion und verfahren zu dessen herstellung
DE60311941T DE60311941T2 (de) 2002-07-05 2003-07-03 Behälter für die polymerasekettenreaktion und verfahren zu dessen herstellung
US10/485,342 US7384782B2 (en) 2002-07-05 2003-07-03 Polymerase chain reaction container and process for producing the same
US12/149,147 US7790441B2 (en) 2002-07-05 2008-04-28 Polymerase chain reaction kit and method of manufacturing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2002197038A JP4013671B2 (ja) 2002-07-05 2002-07-05 ポリメラーゼ連鎖反応容器及びその製造方法

Publications (2)

Publication Number Publication Date
JP2004033141A JP2004033141A (ja) 2004-02-05
JP4013671B2 true JP4013671B2 (ja) 2007-11-28

Family

ID=30112387

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002197038A Expired - Lifetime JP4013671B2 (ja) 2002-07-05 2002-07-05 ポリメラーゼ連鎖反応容器及びその製造方法

Country Status (6)

Country Link
US (2) US7384782B2 (de)
EP (1) EP1418233B1 (de)
JP (1) JP4013671B2 (de)
CN (1) CN1309828C (de)
DE (1) DE60311941T2 (de)
WO (1) WO2004005507A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006035497A1 (ja) * 2004-09-29 2006-04-06 Mukunoki, Akio 核酸増幅反応容器及び核酸増幅反応装置
JP4878200B2 (ja) * 2005-06-29 2012-02-15 キヤノン株式会社 生化学反応カセット
US7629124B2 (en) 2006-06-30 2009-12-08 Canon U.S. Life Sciences, Inc. Real-time PCR in micro-channels
EP2227537A4 (de) * 2007-12-24 2014-05-07 Honeywell Int Inc Reaktor zur quantitativen analyse von nukleinsäuren
JP2010081806A (ja) * 2008-09-29 2010-04-15 Tecnisco Ltd 温度調節流路付きスライド構造
WO2010082279A1 (ja) * 2009-01-15 2010-07-22 パナソニック株式会社 流路構造体およびその製造方法
WO2011088588A1 (en) * 2010-01-20 2011-07-28 Honeywell International, Inc. Reactor for quantitative analysis of nucleic acids
JP2013027844A (ja) * 2011-07-29 2013-02-07 Kyocera Crystal Device Corp マイクロリアクター
JP5735563B2 (ja) * 2013-03-04 2015-06-17 株式会社テクニスコ 温度調節流路付きスライド構造
US10946376B2 (en) 2013-07-05 2021-03-16 Thinxxs Microtechnology Ag Carrier element for introducing a dry substance into a flow cell
EP2821138B2 (de) 2013-07-05 2022-02-09 Thinxxs Microtechnology Ag Flusszelle mit integrierter Trockensubstanz
WO2015138343A1 (en) 2014-03-10 2015-09-17 Click Diagnostics, Inc. Cartridge-based thermocycler
KR20170066498A (ko) 2014-09-29 2017-06-14 칩케어 코포레이션 카트리지 및 유체 칩을 포함하는 세포의 광학적 검출을 위한 장치 및 그 방법
WO2016083898A1 (en) 2014-11-28 2016-06-02 Chipcare Corporation Multiplex bead array assay
AU2015373998A1 (en) 2014-12-31 2017-06-29 Visby Medical, Inc. Devices and methods for molecular diagnostic testing
US10987674B2 (en) 2016-04-22 2021-04-27 Visby Medical, Inc. Printed circuit board heater for an amplification module
WO2017197040A1 (en) 2016-05-11 2017-11-16 Click Diagnostics, Inc. Devices and methods for nucleic acid extraction
CN110325652A (zh) 2016-06-29 2019-10-11 易捷仪器诊断股份有限公司 使用流动池检测分子的装置和方法
USD800331S1 (en) 2016-06-29 2017-10-17 Click Diagnostics, Inc. Molecular diagnostic device
USD800914S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Status indicator for molecular diagnostic device
USD800913S1 (en) 2016-06-30 2017-10-24 Click Diagnostics, Inc. Detection window for molecular diagnostic device
CN109234153B (zh) 2017-07-10 2022-08-09 京东方科技集团股份有限公司 基因测序芯片及其基因测序方法
KR20200079264A (ko) 2017-11-09 2020-07-02 비스비 메디컬, 인코포레이티드 표적 바이러스 검출을 위한 휴대용 분자 진단 디바이스 및 방법
WO2019160072A1 (ja) * 2018-02-16 2019-08-22 京セラ株式会社 流路デバイスおよび計測装置
EP4085149A4 (de) 2020-01-03 2024-03-06 Visby Medical, Inc. Vorrichtungen und verfahren zur prüfung von antibiotischer suszeptibilität
CN115364918B (zh) * 2022-09-05 2023-04-14 鲲鹏基因（北京）科技有限责任公司 基于金属固液转化的聚合酶链式反应分析仪温控装置

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683202A (en) * 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
ZA862335B (en) 1985-03-28 1987-11-25 Cetus Corp Process for amplifying nucleic acid sequences
US5455175A (en) * 1990-06-04 1995-10-03 University Of Utah Research Foundation Rapid thermal cycling device
EP0636413B1 (de) * 1993-07-28 2001-11-14 PE Corporation (NY) Vorrichtung und Verfahren zur Nukleinsäurevervielfältigung
US5725831A (en) 1994-03-14 1998-03-10 Becton Dickinson And Company Nucleic acid amplification apparatus
US6613560B1 (en) * 1994-10-19 2003-09-02 Agilent Technologies, Inc. PCR microreactor for amplifying DNA using microquantities of sample fluid
DE19519015C1 (de) * 1995-05-24 1996-09-05 Inst Physikalische Hochtech Ev Miniaturisierter Mehrkammer-Thermocycler
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
US6136212A (en) * 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
US6143496A (en) * 1997-04-17 2000-11-07 Cytonix Corporation Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
US6977145B2 (en) * 1999-07-28 2005-12-20 Serono Genetics Institute S.A. Method for carrying out a biochemical protocol in continuous flow in a microreactor
JP3790919B2 (ja) * 1999-11-26 2006-06-28 オリンパス株式会社 微量液体の反応装置
JP4442035B2 (ja) * 2001-01-11 2010-03-31 株式会社島津製作所 マイクロチャンネル型チップ
JP2003083965A (ja) 2001-09-10 2003-03-19 Adgene Co Ltd 蛋白・核酸解析用チップ
US20050118584A1 (en) * 2001-10-05 2005-06-02 Sachio Nomura Detection board

Also Published As

Publication number Publication date
CN1309828C (zh) 2007-04-11
CN1537165A (zh) 2004-10-13
DE60311941T2 (de) 2007-09-06
US7790441B2 (en) 2010-09-07
US7384782B2 (en) 2008-06-10
US20080308529A1 (en) 2008-12-18
WO2004005507A1 (ja) 2004-01-15
EP1418233A4 (de) 2005-09-14
EP1418233B1 (de) 2007-02-21
JP2004033141A (ja) 2004-02-05
US20040175713A1 (en) 2004-09-09
EP1418233A1 (de) 2004-05-12
DE60311941D1 (de) 2007-04-05

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