JP3759748B2 - 成長ホルモン放出性を有する化合物 - Google Patents

成長ホルモン放出性を有する化合物 Download PDF

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Publication number: JP3759748B2
Authority: JP; Japan
Prior art keywords: trp; ala; phe; growth hormone; lys
Prior art date: 1993-12-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

JP51711095A

Other languages

English (en)

Japanese (ja)

Other versions

JPH09506873A (ja

Inventor

ランゲランヨハンセン，ニルス

ロー，イェスパー

マズセン，クエルド

フリードリッヒラント，ベレント

セーゲルセン，ヘニング

セヘステズハンセン，ビーギット

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk AS

Original Assignee

Novo Nordisk AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-12-23

Filing date

1994-12-22

Publication date

2006-03-29

1993-12-23 Priority claimed from DK143893A external-priority patent/DK143893D0/da

1994-12-22 Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS

1997-07-08 Publication of JPH09506873A publication Critical patent/JPH09506873A/ja

2006-03-29 Application granted granted Critical

2006-03-29 Publication of JP3759748B2 publication Critical patent/JP3759748B2/ja

2021-03-29 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

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239000005720 sucrose Substances 0.000 description 1
239000004094 surface-active agent Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
229940037128 systemic glucocorticoids Drugs 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
229960001367 tartaric acid Drugs 0.000 description 1
ZJTYRNPLVNMVPQ-GFCCVEGCSA-N tert-butyl n-[(2r)-1-oxo-3-phenylpropan-2-yl]carbamate Chemical compound CC(C)(C)OC(=O)N[C@@H](C=O)CC1=CC=CC=C1 ZJTYRNPLVNMVPQ-GFCCVEGCSA-N 0.000 description 1
YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
230000014616 translation Effects 0.000 description 1
239000012588 trypsin Substances 0.000 description 1
239000002753 trypsin inhibitor Substances 0.000 description 1
238000000825 ultraviolet detection Methods 0.000 description 1
125000005500 uronium group Chemical group 0.000 description 1
229960003726 vasopressin Drugs 0.000 description 1
238000005406 washing Methods 0.000 description 1
239000003643 water by type Substances 0.000 description 1
210000002268 wool Anatomy 0.000 description 1
230000029663 wound healing Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, ***e
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/02—Linear peptides containing at least one abnormal peptide link
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Psychiatry (AREA)
Diabetes (AREA)
Crystallography & Structural Chemistry (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Hospice & Palliative Care (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

JP51711095A 1993-12-23 1994-12-22 成長ホルモン放出性を有する化合物 Expired - Fee Related JP3759748B2 (ja)

Applications Claiming Priority (9)

Application Number	Priority Date	Filing Date	Title
DK143893A DK143893D0 (de)	1993-12-23	1993-12-23
DK1438/93		1993-12-23
DK0075/94		1994-01-17
DK7594		1994-01-17
DK0781/94		1994-06-30
DK78194		1994-06-30
DK1165/94		1994-10-07
DK116594		1994-10-07
PCT/DK1994/000486 WO1995017422A1 (en)	1993-12-23	1994-12-22	Compounds with growth hormone releasing properties

Publications (2)

Publication Number	Publication Date
JPH09506873A JPH09506873A (ja)	1997-07-08
JP3759748B2 true JP3759748B2 (ja)	2006-03-29

Family

ID=27439242

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
JP51711095A Expired - Fee Related JP3759748B2 (ja)	1993-12-23	1994-12-22	成長ホルモン放出性を有する化合物

Country Status (18)

Country	Link
US (1)	US5854211A (de)
EP (1)	EP0736038B1 (de)
JP (1)	JP3759748B2 (de)
CN (1)	CN1052730C (de)
AT (1)	ATE202785T1 (de)
AU (1)	AU683121B2 (de)
CA (1)	CA2179598A1 (de)
CZ (1)	CZ291382B6 (de)
DE (1)	DE69427650T2 (de)
FI (1)	FI962591A (de)
HU (1)	HU221092B1 (de)
IL (1)	IL112111A (de)
NO (1)	NO315611B1 (de)
PL (1)	PL181286B1 (de)
RU (1)	RU2167881C2 (de)
TW (1)	TW438810B (de)
UA (1)	UA45962C2 (de)
WO (1)	WO1995017422A1 (de)

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JP3798024B2 (ja)	1995-12-13	2006-07-19	メルクエンドカンパニーインコーポレーテッド	成長ホルモン分泌促進物質レセプターアッセイ
US6531314B1 (en)	1996-12-10	2003-03-11	Merck & Co., Inc.	Growth hormone secretagogue receptor family
GB2308362A (en) *	1995-12-19	1997-06-25	Lilly Industries Ltd	Pharmaceutical indole derivatives
US6420518B1 (en)	1997-04-04	2002-07-16	Genetech, Inc.	Insulin-like growth factor agonist molecules
US6121416A (en)	1997-04-04	2000-09-19	Genentech, Inc.	Insulin-like growth factor agonist molecules
AU7906998A (en)	1997-06-20	1999-01-04	Novo Nordisk A/S	Compounds with growth hormone releasing properties
DE69921611T2 (de)	1998-01-16	2005-11-03	Novo Nordisk A/S	Verbindungen mit wachstumshormon-freisetzenden eigenschaften
US6682908B1 (en)	1998-07-10	2004-01-27	Merck & Co., Inc.	Mouse growth hormone secretagogue receptor
CA2333857A1 (en)	1998-07-13	2000-01-20	Merck & Co., Inc.	Growth hormone secretagogue related receptors and nucleic acids
EP1112282A4 (de)	1998-08-10	2002-10-31	Merck & Co Inc	Rezeptor des wachstumshormon-sekretionsförderers aus dem hund
ATE284415T1 (de)	1999-01-06	2004-12-15	Genentech Inc	Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i)
KR100699404B1 (ko)	1999-02-18	2007-03-23	가켄 세야쿠 가부시키가이샤	성장 호르몬 분비촉진제로서의 신규 아미드 유도체
AU5630800A (en) *	1999-06-22	2001-01-09	Arno F Spatola	Antimicrobial agents
JP4644402B2 (ja)	1999-07-26	2011-03-02	ベイラーカレッジオブメディスン	超高活性ブタ成長ホルモン放出ホルモン類似体
US7119085B2 (en) *	2000-03-23	2006-10-10	Elan Pharmaceuticals, Inc.	Methods to treat alzheimer's disease
DE60133271T2 (de)	2000-05-16	2009-04-23	Genentech, Inc., South San Francisco	Behandlung von knorpelerkrankungen
EP1159964B1 (de)	2000-05-31	2009-10-28	Pfizer Products Inc.	Verwendung von Wachstumshormonsekretagoga zur Förderung der Beweglichkeit des Verdauungstrakts
US7476653B2 (en)	2003-06-18	2009-01-13	Tranzyme Pharma, Inc.	Macrocyclic modulators of the ghrelin receptor
EP1667521B1 (de)	2003-09-12	2011-12-07	Tercica, Inc.	Verfahren zur behandlung von igf-1 (insulin-like growth factor 1)-mangel
WO2005027913A1 (en) *	2003-09-19	2005-03-31	Pfizer Products Inc.	Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue
UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
CU23558A1 (es)	2006-02-28	2010-07-20	Ct Ingenieria Genetica Biotech	Compuestos análogos a los secretagogos peptidicos de la hormona de crecimiento
AU2008241532A1 (en)	2007-02-09	2008-10-30	Tranzyme Pharma, Inc.	Macrocyclic ghrelin receptor modulators and methods of using the same
US20100099640A1 (en)	2007-05-04	2010-04-22	Joannes Geuns	Tissue degeneration protection
WO2013190520A2 (en)	2012-06-22	2013-12-27	The General Hospital Corporation	Gh-releasing agents in the treatment of vascular stenosis and associated conditions
US9119832B2 (en)	2014-02-05	2015-09-01	The Regents Of The University Of California	Methods of treating mild brain injury
US10328082B2 (en)	2014-05-30	2019-06-25	Pfizer Inc.	Methods of use and combinations
JPWO2016129645A1 (ja)	2015-02-10	2017-10-26	富士フイルム株式会社	光学部材、光学素子、液晶表示装置および近接眼光学部材
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US4803261A (en) *	1986-06-27	1989-02-07	The Administrators Of The Tulane Educational Fund	Method for synthesizing a peptide containing a non-peptide
US5480869A (en) *	1990-01-09	1996-01-02	The Regents Of The University Of California	Anti-inflammatory peptide analogs and treatment to inhibit vascular leakage in injured tissues
US5486505A (en) *	1990-07-24	1996-01-23	Polygen Holding Corporation	Polypeptide compounds having growth hormone releasing activity
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US5663146A (en) *	1991-08-22	1997-09-02	Administrators Of The Tulane Educational Fund	Polypeptide analogues having growth hormone releasing activity
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SE9300012D0 (sv) *	1993-01-05	1993-01-05	Astra Ab	New peptides
US5559209A (en) *	1993-02-18	1996-09-24	The General Hospital Corporation	Regulator regions of G proteins
PL181280B1 (pl) *	1993-12-23	2001-07-31	Novo Nordisk As	oraz zawierajaca je kompozycja farmaceutyczna PL PL PL PL PL PL PL PL

1994
- 1994-12-22 IL IL11211194A patent/IL112111A/xx not_active IP Right Cessation
- 1994-12-22 AU AU13106/95A patent/AU683121B2/en not_active Ceased
- 1994-12-22 HU HU9601740A patent/HU221092B1/hu not_active IP Right Cessation
- 1994-12-22 DE DE69427650T patent/DE69427650T2/de not_active Expired - Fee Related
- 1994-12-22 CN CN94194588A patent/CN1052730C/zh not_active Expired - Fee Related
- 1994-12-22 US US08/464,679 patent/US5854211A/en not_active Expired - Fee Related
- 1994-12-22 UA UA96062484A patent/UA45962C2/uk unknown
- 1994-12-22 PL PL94315114A patent/PL181286B1/pl not_active IP Right Cessation
- 1994-12-22 EP EP95904405A patent/EP0736038B1/de not_active Expired - Lifetime
- 1994-12-22 RU RU96115195/04A patent/RU2167881C2/ru not_active IP Right Cessation
- 1994-12-22 CA CA002179598A patent/CA2179598A1/en not_active Abandoned
- 1994-12-22 JP JP51711095A patent/JP3759748B2/ja not_active Expired - Fee Related
- 1994-12-22 CZ CZ19961833A patent/CZ291382B6/cs not_active IP Right Cessation
- 1994-12-22 AT AT95904405T patent/ATE202785T1/de active
- 1994-12-22 WO PCT/DK1994/000486 patent/WO1995017422A1/en active IP Right Grant
1995
- 1995-01-13 TW TW084100272A patent/TW438810B/zh active
1996
- 1996-06-20 FI FI962591A patent/FI962591A/fi not_active IP Right Cessation
- 1996-06-21 NO NO19962664A patent/NO315611B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU221092B1 (en)	2002-08-28
CN1138334A (zh)	1996-12-18
WO1995017422A1 (en)	1995-06-29
CZ291382B6 (cs)	2003-02-12
DE69427650D1 (de)	2001-08-09
AU683121B2 (en)	1997-10-30
TW438810B (en)	2001-06-07
PL181286B1 (pl)	2001-07-31
IL112111A0 (en)	1995-03-15
DE69427650T2 (de)	2001-11-22
EP0736038B1 (de)	2001-07-04
CZ183396A3 (en)	1997-02-12
JPH09506873A (ja)	1997-07-08
NO962664D0 (no)	1996-06-21
HUT74820A (en)	1997-02-28
FI962591A0 (fi)	1996-06-20
US5854211A (en)	1998-12-29
IL112111A (en)	2000-07-16
UA45962C2 (uk)	2002-05-15
CA2179598A1 (en)	1995-06-29
ATE202785T1 (de)	2001-07-15
NO962664L (no)	1996-08-23
FI962591A (fi)	1996-06-20
RU2167881C2 (ru)	2001-05-27
EP0736038A1 (de)	1996-10-09
AU1310695A (en)	1995-07-10
PL315114A1 (en)	1996-10-14
HU9601740D0 (en)	1996-08-28
CN1052730C (zh)	2000-05-24
NO315611B1 (no)	2003-09-29

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Publication	Publication Date	Title
JP3759748B2 (ja)	2006-03-29	成長ホルモン放出性を有する化合物
KR100354897B1 (ko)	2003-01-06	성장호르몬방출성을갖는화합물
SK155694A3 (en)	1995-05-10	Glucagon-like peptide, insulinotropin derivatives, method of their preparation, pharmaceutical agent containing and using these matters
JPH08510205A (ja)	1996-10-29	Ｙｙペプチドのアナログとその用途
EP0820296A1 (de)	1998-01-28	Analoge von wachstumshormon-freisetzungsfaktor
CZ408197A3 (cs)	1998-05-13	Peptidový derivát, farmaceutický prostředek ho obsahující, jejich použití, způsob stimulace uvolňování růstového hormonu a způsob zvýšení rychlosti a rozsahu růstu zvířat, zvýšení produkce mléka nebo vlny zvířat nebo léčení onemocnění
US5990084A (en)	1999-11-23	Compounds with growth hormone releasing properties
EP0910579A1 (de)	1999-04-28	Substanzen mit wachstumshormon-freisetzenden fähigkeiten.
JP2003501394A (ja)	2003-01-14	延長された重度の疾患の異化状態の処理のための組成物
TW438811B (en)	2001-06-07	Compounds with growth hormone releasing properties
JP4173541B6 (ja)	2009-02-18	成長ホルモン放出特性を有する化合物