ATE284415T1 - Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i) - Google Patents
Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i)Info
- Publication number
- ATE284415T1 ATE284415T1 AT00901397T AT00901397T ATE284415T1 AT E284415 T1 ATE284415 T1 AT E284415T1 AT 00901397 T AT00901397 T AT 00901397T AT 00901397 T AT00901397 T AT 00901397T AT E284415 T1 ATE284415 T1 AT E284415T1
- Authority
- AT
- Austria
- Prior art keywords
- igf
- insulin
- growth factor
- mutated variant
- mutated
- Prior art date
Links
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 title abstract 4
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 1
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 1
- 235000004279 alanine Nutrition 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000008482 dysregulation Effects 0.000 abstract 1
- 208000017169 kidney disease Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/65—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Cardiology (AREA)
- Zoology (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Obesity (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Urology & Nephrology (AREA)
- Nutrition Science (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US11501099P | 1999-01-06 | 1999-01-06 | |
US17026199P | 1999-12-09 | 1999-12-09 | |
PCT/US2000/000199 WO2000040613A1 (en) | 1999-01-06 | 2000-01-05 | Insulin-like growth factor (igf) i mutant variants |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE284415T1 true ATE284415T1 (de) | 2004-12-15 |
Family
ID=26812755
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00901397T ATE284415T1 (de) | 1999-01-06 | 2000-01-05 | Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i) |
Country Status (12)
Country | Link |
---|---|
US (3) | US6403764B1 (de) |
EP (1) | EP1141014B1 (de) |
JP (2) | JP3971108B2 (de) |
AT (1) | ATE284415T1 (de) |
AU (1) | AU762351B2 (de) |
CA (1) | CA2356109C (de) |
DE (1) | DE60016560T2 (de) |
DK (1) | DK1141014T3 (de) |
ES (1) | ES2234560T3 (de) |
IL (2) | IL143866A0 (de) |
PT (1) | PT1141014E (de) |
WO (1) | WO2000040613A1 (de) |
Families Citing this family (45)
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US6875741B2 (en) * | 1998-09-02 | 2005-04-05 | Renuka Pillutla | Insulin and IGF-1 receptor agonists and antagonists |
DE60016560T2 (de) | 1999-01-06 | 2005-12-15 | Genentech, Inc., South San Francisco | Mutierte variante des insulin-ähnlichen wachstumsfaktor-i (igf-i) |
US7250950B2 (en) * | 2001-01-29 | 2007-07-31 | Symyx Technologies, Inc. | Systems, methods and computer program products for determining parameters for chemical synthesis |
US20020143725A1 (en) * | 2001-01-29 | 2002-10-03 | Smith Robin Young | Systems, methods and computer program products for determining parameters for chemical synthesis and for supplying the reagents, equipment and/or chemicals synthesized thereby |
US6849718B2 (en) * | 2001-03-20 | 2005-02-01 | Dana Farber Cancer Institute, Inc. | Muteins of hypoxia inducible factor alpha and methods of use thereof |
US20040048925A1 (en) * | 2002-09-09 | 2004-03-11 | Wiley David B. | Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives |
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US7833513B2 (en) | 2004-12-03 | 2010-11-16 | Rhode Island Hospital | Treatment of Alzheimer's Disease |
EP1674113A1 (de) * | 2004-12-22 | 2006-06-28 | F. Hoffmann-La Roche Ag | Konjugate von insulinähnlichem Wachstumfaktor-1 und Poly(Ethylenglykol) |
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EA200701448A1 (ru) | 2005-01-05 | 2008-02-28 | Байоджен Айдек Эмэй Инк. | Специфически связывающаяся с крипто-антигеном человека молекула (варианты), композиция на ее основе (варианты), способ получения молекулы, способ лечения посредством молекулы (варианты) и способ ингибирования крипто-экспрессии в клетке больного |
JP4988599B2 (ja) | 2005-01-07 | 2012-08-01 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Igf−1融合ポリペプチドおよびその治療的使用 |
TWI406870B (zh) * | 2005-02-21 | 2013-09-01 | Chugai Pharmaceutical Co Ltd | A method of making a protein using hamster IGF-1 |
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CL2007002502A1 (es) | 2006-08-31 | 2008-05-30 | Hoffmann La Roche | Variantes del factor de crecimiento similar a insulina-1 humano (igf-1) pegilados en lisina; metodo de produccion; proteina de fusion que la comprende; y su uso para tratar la enfermedad de alzheimer. |
US8552158B2 (en) * | 2006-08-31 | 2013-10-08 | Hoffmann-La Roche Inc. | Method for the production of insulin-like growth factor-1 |
ES2548009T3 (es) * | 2007-01-25 | 2015-10-13 | F. Hoffmann-La Roche Ag | Uso de IGFBP-7 en la evaluación de la insuficiencia cardíaca |
JP2010520204A (ja) * | 2007-03-02 | 2010-06-10 | アムジェン インコーポレイテッド | 腫瘍疾患を治療するための方法および組成物 |
WO2008153929A1 (en) * | 2007-06-08 | 2008-12-18 | Massachusetts Institute Of Technology | Igf for the treatment of rett syndrome and synaptic disorders |
KR101273187B1 (ko) * | 2008-04-03 | 2013-06-17 | 에프. 호프만-라 로슈 아게 | 신경근 장애의 치료를 위한 폴리(에틸렌글리콜)(peg)-부착된 igf-i 변이체의 용도 |
ATE533060T1 (de) * | 2008-04-03 | 2011-11-15 | Hoffmann La Roche | Assays mit pegylierten insulinähnlichen wachstumsfaktoren |
PL219335B1 (pl) * | 2008-07-04 | 2015-04-30 | Inst Biotechnologii I Antybiotyków | Pochodna insuliny lub jej farmaceutycznie dopuszczalna sól, jej zastosowanie oraz zawierająca ją kompozycja farmaceutyczna |
WO2011011072A2 (en) * | 2009-07-22 | 2011-01-27 | Ipsen Pharma S.A.S. | Analogues of insulin-like growth factor-1 (igf-1) having amino acid substitution at position 59 |
EP2475678B1 (de) | 2009-09-10 | 2014-10-08 | Lonza Biologics Plc. | Verfahren und System zur Polypeptidreinigung |
US20110152188A1 (en) * | 2009-12-23 | 2011-06-23 | Hanns-Christian Mahler | Pharmaceutical compositions of igf/i proteins |
WO2012006635A1 (en) | 2010-07-09 | 2012-01-12 | Biogen Idec Hemophilia Inc. | Processable single chain molecules and polypeptides made using same |
US9738707B2 (en) | 2011-07-15 | 2017-08-22 | Biogen Ma Inc. | Heterodimeric Fc regions, binding molecules comprising same, and methods relating thereto |
PT2802606T (pt) | 2012-01-10 | 2018-07-13 | Biogen Ma Inc | Melhoramento do transporte de moléculas terapêuticas através da barreira hematoencefálica |
MX363021B (es) | 2012-12-18 | 2019-03-05 | Novartis Ag | Polipeptidos estabilizados del factor de crecimiento tipo insulina. |
SG10201707600XA (en) | 2013-03-15 | 2017-11-29 | Biogen Ma Inc | Factor ix polypeptide formulations |
CN104293766A (zh) * | 2013-07-15 | 2015-01-21 | 四川农业大学 | 山羊IGFBP3基因cDNA编码序列克隆的方法 |
US20160271265A1 (en) | 2013-10-02 | 2016-09-22 | Novartis Ag | Insulin-like growth factor mimetics for use in therapy |
UY35874A (es) | 2013-12-12 | 2015-07-31 | Novartis Ag | Un proceso para la preparación de una composición de proteínas pegiladas |
BR112016016578A2 (pt) | 2014-01-20 | 2017-10-03 | Hanmi Pharm Ind Co Ltd | Insulina de ação prolongada e uso daanálogo de insulina, polinucleotídeo, vetor de expressão, transformante, insulina de ação prolongada bem como seu método de preparação e formulação da mesma, conjugado, e uso do mesmo mesma |
US20170248609A1 (en) | 2014-01-27 | 2017-08-31 | Novartis Ag | Biomarkers predictive of muscle atrophy, method and use |
AR100639A1 (es) | 2014-05-29 | 2016-10-19 | Hanmi Pharm Ind Co Ltd | Composición para tratar diabetes que comprende conjugados de análogos de insulina de acción prolongada y conjugados de péptidos insulinotrópicos de acción prolongada |
TWI684458B (zh) | 2014-05-30 | 2020-02-11 | 南韓商韓美藥品股份有限公司 | 包含胰島素及glp-1/昇糖素雙重促效劑之治療糖尿病之組成物 |
ES2893114T3 (es) | 2015-02-04 | 2022-02-08 | Bristol Myers Squibb Co | Métodos para seleccionar moléculas terapéuticas |
DK3253875T3 (da) | 2015-02-04 | 2020-04-14 | H Hoffmann La Roche Ag | Tau-antisense-oligomerer og anvendelser deraf |
UY36870A (es) * | 2015-08-28 | 2017-03-31 | Hanmi Pharm Ind Co Ltd | Análogos de insulina novedosos |
BR112019005637A2 (pt) | 2016-09-23 | 2019-07-30 | Hanmi Pharm Ind Co Ltd | análogos da insulina com afinidade reduzida para o receptor de insulina e seu uso |
CA3054899A1 (en) | 2017-03-23 | 2018-09-27 | Hanmi Pharm. Co., Ltd. | Insulin analog complex with reduced affinity for insulin receptor and use thereof |
CN117384275B (zh) * | 2023-12-13 | 2024-03-15 | 北京科为博生物科技有限公司 | ***突变体igf1m及其应用 |
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-
2000
- 2000-01-05 DE DE60016560T patent/DE60016560T2/de not_active Expired - Lifetime
- 2000-01-05 CA CA002356109A patent/CA2356109C/en not_active Expired - Lifetime
- 2000-01-05 DK DK00901397T patent/DK1141014T3/da active
- 2000-01-05 EP EP00901397A patent/EP1141014B1/de not_active Expired - Lifetime
- 2000-01-05 WO PCT/US2000/000199 patent/WO2000040613A1/en active IP Right Grant
- 2000-01-05 ES ES00901397T patent/ES2234560T3/es not_active Expired - Lifetime
- 2000-01-05 US US09/477,924 patent/US6403764B1/en not_active Expired - Lifetime
- 2000-01-05 PT PT00901397T patent/PT1141014E/pt unknown
- 2000-01-05 AT AT00901397T patent/ATE284415T1/de active
- 2000-01-05 IL IL14386600A patent/IL143866A0/xx unknown
- 2000-01-05 AU AU22245/00A patent/AU762351B2/en not_active Expired
- 2000-01-05 JP JP2000592321A patent/JP3971108B2/ja not_active Expired - Lifetime
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2001
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- 2001-12-19 US US10/028,410 patent/US7105167B2/en not_active Expired - Lifetime
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Also Published As
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CA2356109A1 (en) | 2000-07-13 |
US20020160955A1 (en) | 2002-10-31 |
ES2234560T3 (es) | 2005-07-01 |
EP1141014B1 (de) | 2004-12-08 |
IL143866A0 (en) | 2002-04-21 |
PT1141014E (pt) | 2005-04-29 |
WO2000040613A1 (en) | 2000-07-13 |
AU2224500A (en) | 2000-07-24 |
JP3971108B2 (ja) | 2007-09-05 |
WO2000040613A9 (en) | 2001-05-17 |
US8097587B2 (en) | 2012-01-17 |
DE60016560T2 (de) | 2005-12-15 |
US20110003746A1 (en) | 2011-01-06 |
DE60016560D1 (de) | 2005-01-13 |
IL143866A (en) | 2009-11-18 |
AU762351B2 (en) | 2003-06-26 |
EP1141014A1 (de) | 2001-10-10 |
JP2006328074A (ja) | 2006-12-07 |
JP2002535968A (ja) | 2002-10-29 |
DK1141014T3 (da) | 2005-04-11 |
US6403764B1 (en) | 2002-06-11 |
CA2356109C (en) | 2008-04-22 |
US7105167B2 (en) | 2006-09-12 |
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