JP3679800B2 - グルコース蛍光検査方法 - Google Patents
グルコース蛍光検査方法 Download PDFInfo
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- JP3679800B2 JP3679800B2 JP2004233578A JP2004233578A JP3679800B2 JP 3679800 B2 JP3679800 B2 JP 3679800B2 JP 2004233578 A JP2004233578 A JP 2004233578A JP 2004233578 A JP2004233578 A JP 2004233578A JP 3679800 B2 JP3679800 B2 JP 3679800B2
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- glucose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
- A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0084—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for introduction into the body, e.g. by catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6402—Atomic fluorescence; Laser induced fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0075—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
- A61B5/0082—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes
- A61B5/0088—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence adapted for particular medical purposes for oral or dental tissue
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Veterinary Medicine (AREA)
- Medical Informatics (AREA)
- Biophysics (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Emergency Medicine (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Description
本発明は、グルコース検査装置に実施され、試料中に存在するグルコースの濃度を測定する方法に関するものであって、試料中に存在するグルコースから直接発光される蛍光を検査する。このグルコース検査装置は、励起光で試料を照射し、試料中に存在するグルコースに作用して蛍光を発光させ、該蛍光を検出及び処理して、試料中のグルコースの濃度を測定する。
Claims (6)
- 非生体液である試料中のグルコースの濃度を検査する方法であって、
250ナノメートルから350ナノメートルの間の波長を有する狭帯域励起光を試料に指向し、前記試料中に存在するグルコースによって発光される蛍光を含むリターン光を前記試料から発生させるステップと、
前記リターン光を検査して第1及び第2の信号を発生するステップと、
を備え、前記第1の信号は第1の波長帯域内の前記リターン光の強度を表し、該第1の波長帯域は前記励起光の波長よりも30乃至50ナノメートルほど長波長側の範囲であり、前記第2の信号は第2の波長帯域内の前記リターン光の強度を表し、該第2の波長帯域は380ナノメートルから420ナノメートルの間にわたる波長帯域であり、
前記方法は更に、
前記第1及び第2の信号を処理して、前記試料中のグルコースの濃度を決定するステップを具備することを特徴とする方法。 - 請求項1記載の試料中のグルコースの濃度を検査する方法であって、前記励起光を指向するステップにおいて使用される励起光の波長は308ナノメートルであり、
前記リターン光を検査するステップにおいて使用される第1の波長帯域は335ナノメートルから355の間にわたり、
前記リターン光を検査するステップにおいて使用される第2の波長帯域は380ナノメートルから420ナノメートルの間にわたる方法。 - 請求項1記載の試料中のグルコースの濃度を検査する方法であって、前記試料に励起光を指向するステップが前記励起光を前記試料に誘導するステップを更に含んでなる方法。
- 請求項1記載の試料中のグルコースの濃度を検査する方法であって、前記リターン光を検査するステップが前記試料からの前記リターン光を誘導するステップを更に含んでなる方法。
- 請求項1記載の試料中のグルコースの濃度を検査する方法であって、前記リターン光を検査するステップが
前記第1の波長帯域内のリターン光を検出して前記第1の信号を発生するステップと、
前記第2の波長帯域内のリターン光を検出して前記第2の信号を発生するステップと、
を更に含んでなる方法。 - 請求項5記載の試料中のグルコースの濃度を検査する方法であって、
前記リターン光を検査するステップが、前記リターン光を異なるスペクトル波長に分解して、前記第1及び第2の波長帯域内の光をそれぞれ検出するステップを更に含んでなる方法。
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/043,580 US5341805A (en) | 1993-04-06 | 1993-04-06 | Glucose fluorescence monitor and method |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52240994A Division JP3643842B2 (ja) | 1993-04-06 | 1994-04-01 | グルコース濃度検査装置 |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2004309503A JP2004309503A (ja) | 2004-11-04 |
JP3679800B2 true JP3679800B2 (ja) | 2005-08-03 |
Family
ID=21927895
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52240994A Expired - Lifetime JP3643842B2 (ja) | 1993-04-06 | 1994-04-01 | グルコース濃度検査装置 |
JP2004233578A Expired - Lifetime JP3679800B2 (ja) | 1993-04-06 | 2004-08-10 | グルコース蛍光検査方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP52240994A Expired - Lifetime JP3643842B2 (ja) | 1993-04-06 | 1994-04-01 | グルコース濃度検査装置 |
Country Status (11)
Country | Link |
---|---|
US (1) | US5341805A (ja) |
EP (2) | EP0694165B1 (ja) |
JP (2) | JP3643842B2 (ja) |
AT (2) | ATE243846T1 (ja) |
DE (2) | DE69432869T2 (ja) |
DK (2) | DK0779508T3 (ja) |
ES (2) | ES2113098T3 (ja) |
GR (1) | GR3026579T3 (ja) |
IL (1) | IL109231A (ja) |
PT (1) | PT779508E (ja) |
WO (1) | WO1994023284A1 (ja) |
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- 1994-04-01 DE DE69432869T patent/DE69432869T2/de not_active Expired - Fee Related
- 1994-04-01 WO PCT/US1994/003597 patent/WO1994023284A1/en active IP Right Grant
- 1994-04-01 DK DK94913344.1T patent/DK0694165T3/da active
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WO1994023284A1 (en) | 1994-10-13 |
ATE243846T1 (de) | 2003-07-15 |
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JP3643842B2 (ja) | 2005-04-27 |
PT779508E (pt) | 2003-11-28 |
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DK0779508T3 (da) | 2003-10-20 |
DE69432869D1 (de) | 2003-07-31 |
EP0779508A3 (de) | 1998-03-11 |
ATE164008T1 (de) | 1998-03-15 |
ES2113098T3 (es) | 1998-04-16 |
US5341805A (en) | 1994-08-30 |
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EP0694165B1 (en) | 1998-03-11 |
DE69408976D1 (de) | 1998-04-16 |
ES2202501T3 (es) | 2004-04-01 |
EP0779508A2 (en) | 1997-06-18 |
GR3026579T3 (en) | 1998-07-31 |
DE69408976T2 (de) | 1998-07-09 |
DK0694165T3 (da) | 1998-06-02 |
DE69432869T2 (de) | 2004-05-13 |
JPH08510321A (ja) | 1996-10-29 |
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