JP3418872B2 - 医療用のカテーテル及びその製造方法 - Google Patents

医療用のカテーテル及びその製造方法

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Publication number
JP3418872B2
JP3418872B2 JP51191392A JP51191392A JP3418872B2 JP 3418872 B2 JP3418872 B2 JP 3418872B2 JP 51191392 A JP51191392 A JP 51191392A JP 51191392 A JP51191392 A JP 51191392A JP 3418872 B2 JP3418872 B2 JP 3418872B2
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Prior art keywords
balloon
catheter
layer
polyethylene
layers
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JPH06507101A (ja
Inventor
ジェームス シー． ウォン
ジョージ ティー． ロバーツ
ブリアン エイ． シィニアー ペダーソン
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Boston Scientific Corp
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Boston Scientific Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1027—Making of balloon catheters
    • A61M25/1029—Production methods of the balloon members, e.g. blow-moulding, extruding, deposition or by wrapping a plurality of layers of balloon material around a mandril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
    • A61L29/04—Macromolecular materials
    • A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1027—Making of balloon catheters
    • A61M25/1034—Joining of shaft and balloon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00778—Operations on blood vessels
    • A61B2017/00783—Valvuloplasty
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M2025/1043—Balloon catheters with special features or adapted for special applications
    • A61M2025/1075—Balloon catheters with special features or adapted for special applications having a balloon composed of several layers, e.g. by coating or embedding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M25/00—Catheters; Hollow probes
    • A61M25/10—Balloon catheters
    • A61M25/1027—Making of balloon catheters
    • A61M25/1038—Wrapping or folding devices for use with balloon catheters
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1334—Nonself-supporting tubular film or bag [e.g., pouch, envelope, packet, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/13—Hollow or container type article [e.g., tube, vase, etc.]
    • Y10T428/1352—Polymer or resin containing [i.e., natural or synthetic]
    • Y10T428/139—Open-ended, self-supporting conduit, cylinder, or tube-type article
    • Y10T428/1393—Multilayer [continuous layer]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Manufacturing & Machinery (AREA)
  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Materials For Medical Uses (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Description

【発明の詳細な説明】 発明の背景 本発明は医療器具のために用いるバルーン（風船）及
びこのようなバルーンを用いた医療器具に関するもので
ある。より詳しくは、本発明は、特に血管、弁、泌尿器
管等に用い得るようデザインされた医療用または外科用
のバルーン及びこのようなバルーンを用いたカテーテル
に関するものである。本発明のバルーンは、特殊用途の
ため望まれる拡張機能を有するよう特別に作ることがで
き、所定の直径に膨張でき、ピンホールや漏れを生ずる
ことがない。
従来技術の説明 従来、医療用カテーテルとしてポリエチレン、ポリエ
チレンテレフタレート及びポリアミドのバルーンが用い
られている。ポリエチレンバルーンは、加熱によって同
様の物質に接合でき、先端の直径も比較的に小さいた
め、即ち、バルーンとカテーテル間の接続部を極めて小
さくできるため特に好ましい。また、ポリエチレンバル
ーンは軟らかいため、血管内を傷つけることなくこれを
血管内に通すことができる。更に、ポリエチレンバルー
ンはその壁が厚いためピンホールを形成するおそれがな
い。然しながら逆に厚いため大きくなり、血管内に堅い
病変があればこれを通過せしめるのは極めて困難であ
る。
ポリエチレンテレフタレートのバルーンは抗張力が大
きく、耐破裂強度も高いため、収縮したときの形状を小
さくし、厚さも小さくすることができる。然しながら、
ポリエチレンテレフタレートのバルーンをカテーテルに
接続するには接着剤が必要であり、この接着剤による接
合はしばしば信頼性に欠けることが多く、また接合点で
カテーテルが厚くなる欠点がある。更に、ポリエチレン
テレフタレートのバルーンはその壁が極めて薄いためピ
ンホールが形成される可能性が高い。
発明の要約 本発明者は、従来のポリエチレン及びポリエチレンテ
レフタレートのバルーンの欠点を、異なる重合体材料の
共に押し出され延長された複数の層を積層して形成した
管体より成る積層バルーンを用いることによって除去で
きることを見出した。
本発明の特徴の一つは、欠点のない２つの物質の利点
を組み合わせて多層バルーンとしたことにある。本発明
のバルーンは、ポリエステル類、ポリカーボネート類、
ポリエチレンテレフタレート及びこれらの共重合体等、
またはナイロン等のポリアミド類の比較的に厚い、２軸
配向されたエチレン重合体材料を用いる。これら材料
は、ベース層を構成し、バルーンに抗張力と、耐磨耗性
を与えるようになる。このベース層の厚さは約0.2〜1.0
ミル以上とする。第２の層はベース層と共に押し出さ
れ、共に延長される。この第２の層は、好ましくはポリ
エチレン及びその共重合体類のようなカテーテルと熱融
着でき、従って接着剤を必要としないポリオレフィンと
する。この熱融着可能な第２層はベースの一側、好まし
くは両側に配置する。
本発明の他の特徴は、ベース層としてそれ自体ではポ
リエチレンカテーテル管に容易には熱融着できない材料
を用いることにある。これらの例では、相互に接合可能
な材料のスリーブをカテーテルとバルーン間の接合部分
にかぶせ、スリーブを加熱してバルーンをスリーブに接
合し、同時にスリーブをカテーテルに接合してカテーテ
ルとバルーン間に液密シールを形成せしめる。
多層バルーンにおける第２層は、ベース層上に配置さ
れベース層と共に押し出し形成され、ベース層を環境か
ら守るバリヤーとして機能する。例えば、ナイロン等の
ポリアミドをベース層として用いた場合、プレクサーの
ような無水マレイン酸変性エチレン重合体類の薄層を共
に押し出し形成できる。これらの層をベース層の両側に
配置した場合、ナイロンとしての特性から湿気を防ぐ効
果が得られる。異なる層を互いに結合せしめるため付加
的な層を共に押し出し形成することができる。例えばナ
イロンを用いた場合には、これと熱融着可能な層間に結
合層を必要としない。然しながら他の例として、ベース
層としてポリエステル類やポリカーボネート重合体類を
使用したとき、接着を強める必要がある。このような接
着補強は、紫外線照射であり、または共に押し出し形成
される接着層を用いることである。
バルーンをカテーテルに接続するため多層スリーブを
用いる例では、接着剤を用いなければカテーテルに接合
できない材料の従来の医療用バルーンを用いることがで
きる。少なくともスリーブの内側に配置したポリエチレ
ン層と、バルーンと同じ材料のベース層とによって多層
スリーブを形成することができる。ポリエチレンはカテ
ーテルとバルーンの両者に接着するため熱処理のみによ
って互いに両者を結合できるようになる。
本発明のバルーンは、ポリエチレンとベース層の材料
の両者の利点を有する。ポリエチレンテレフタレートを
ベース層として用いた場合、耐破裂強度の高い極めて薄
い厚さのものとすることができる。例えば、直径3.0mm
の無水マレイン酸変性エチレン重合体をナイロンのベー
ス層上に被覆したとき、バルーンの厚さを0.5ミルとす
ることができ、ポリエチレンテレフタレートのバルーン
と比較可能なほど収縮時形状が小さく、ポリエチレンバ
ルーンよりは極めて小さいものとすることができる。ナ
イロンを用いた場合、この材料は２軸配向でき、ポリエ
チレン材料よりも抗張力を高くでき、その結果耐破裂強
度を弱めることなくより薄いバルーンを得ることができ
る。
本発明の構成のバルーンによれば、そのピンホール形
成に対する抵抗がポリエチレンの場合に比較でき、ポリ
エチレンテレフタレートの場合より秀れたものとなるこ
とが判明した。商標セラーで示す材料と共に押し出した
バルーンはポリエチレンテレフタレートのバルーンに比
べ磨耗に対する抵抗とピンホール形成に対する抵抗がよ
り高い。ポリアミド材料はポリエチレンテレフタレート
とポリエチレン材料よりピンホール形成に対する抵抗が
高い。ポリアミド材料のバルーン自体はポリアミドがポ
リエチレンテレフタレートのように硬くなく柔らかいた
め、血管を通るとき血管を傷つけることはなくポリエチ
レンのものに比較可能である。
本発明による多層押し出しバルーンの好ましい実施例
においては、ベース層上に配置した（またはポリエチレ
ンテレフタレートと混合した）層として上述の商標セラ
ーPT樹脂化合物（このましくはデラウエア州ウイルミン
グトン所在のＥ・Ｔデュポン デネマールスCo.から販
売されているセラーPT4368）を用いる。この場合には、
磨耗に対する抵抗がより大きく、より柔らかいバルーン
を得ることができる。セラーを用いた押し出しによる多
層バルーンによればピンホール形成を減少でき、治療時
の損傷を最小ならしめることができる。更に、セラーを
バルーンの内側層として用いた場合には、内部電極また
は穴あけできるラジオオペークマーカーを共に用いるこ
とができる。
図面の簡単な説明 第１図は多層バルーンとカテーテルの側面図である。
このバルーンは膨張状態のものである。
第２図は収縮状態のカテーテルの説明図である。
第３図はバルーン内の重合体層を示すための、第１図
の３−３線に沿った本発明バルーンの横断面図である。
第４図は収縮された状態のバルーンを示すための、第
２図の４−４線に沿った横断面図である。
第５図は、カテーテルの端部に配置され、スリーブに
よってカテーテルに連結した膨張状態のバルーンの横断
面図である。
好ましい実施例の説明 説明用のカテーテルを第１図と第２図に示す。カテー
テル１は中間部５と、端部６と先端７とを有するカテー
テル管３を含む。端部６と先端７に接続された本発明の
膨張した押出医療用バルーン８を第１図に示す。共に押
し出しによって形成されることは本発明において重要な
ことである。バルーン８の内部はカテーテル管３の少な
くとも１つの通路（図示せず）に接続されている。先端
７（及びバルーン８を支持するための端部６と先端７間
におけるカテーテル部分）を形成するため、カテーテル
管３の一部を切除し、（バルーン８内に点線で示すよう
に）内側ガイドワイヤ14を含む通路のみを残す。
複数の通路がカテーテル管３内を延びている（第３図
及び第４図）。この通路は例えばガイドワイヤ14を囲む
こと、血管内に材料を挿入すること、またはバルーン８
を膨張または収縮せしめること等の種々の機能を果た
す。バルーン８を除き、種々の機能を果たす構成部分は
既知のものである。
使用に際しては、カテーテル１を（第２図に示すよう
に）押し出しバルーン８が閉塞位置に達するまで血管内
に挿入する。この段階では、第１図と第２図の比較から
明らかなようにバルーン８は収縮され、潰されており、
外径は膨張時の直径より小さい。バルーン８が閉塞区域
に移動されたとき、バルーン８を膨張せしめるためカテ
ーテル管３の中間部５に加圧流体を導入する。この流体
は、狭さく部の拡大、また同様の処理の好ましい結果を
得るため体内の所望の位置でバルーン８を半径方向外方
に変形するよう力を加え、バルーン８が比較的に滑らか
な膨張状態になってバルーン８が収縮されないようにす
る。
カテーテル１を動脈内に挿入するためカテーテル管３
はやや可撓性のある材料で作る。カテーテル管３は好ま
しくはポリオレフィン共重合体、例えば従来の高密度ポ
リエチレンにより形成する。管の直径は約12〜16フレン
チとし、水溶液内での滑りを加速するため、内側及び外
側面を例えばシリコンベースの材料で被覆せしめる。
第３図及び第４図に示すように、押し出しバルーン８
は積層構造を有する。この積層構造は厚さ約0.2〜0.5ミ
ルまたはそれ以上であり、２軸配向された重合体、例え
ばポリアミド類、ポリエステル類、ポリカーボネート類
及びこれらの共重合体類の主層8Bを有する。この主層8B
にはプレクサーのような熱融着可能なポリオレフィンの
内層8Cが共に押し出されることによって接合される。プ
レクサーは無水変性ポリエチレンであり、米国オハイオ
州シンシナチのクオータンケミカルコーポレーションか
ら販売されている物の商標名である。この熱融着可能な
内層8Cはカテーテル管３の端部６に直接接続され、熱封
着ジョイント10によってバルーン８に固定される。同様
の熱封着ジョイント11をバルーン８とカテーテルの先端
７間にも形成する。
熱融着可能な内層8Cは主層8Bと共に押し出され、その
厚さは約0.5〜1.0ミルである。好ましくは熱融着可能な
２つの層を主層8Bと共に押し出す。この主層8Bは、カテ
ーテル管３の端部６とバルーン８の主層8B間を熱封着せ
しめるジョイント10としての機能を果たす。２つの層が
主層8Bと共に押し出された場合、内層8Cは熱融着可能な
層を形成し、外層8Aが主層8Bのための保護シースを形成
する。ナイロンのようなポリアミド類を主層8Bとして用
いる場合には、プレクサーを熱融着内層8Cとして用いる
ことができる。外層8Aを同一の材料で造れば、血管を傷
つけることなく血管に通すことができる柔らかさを有
し、また、ピンホール形成に対する抵抗が大きくなる。
第１図に示す構成のものの変形においては、ポリエチ
レンテレフタレートの主層8Bと、ポリエチレンの外層8A
とより成るバルーンをカテーテル管３の端部６の周りに
配置し、次いでナイロンのベース層20Bと高密度のポリ
エチレンの熱融着層より成るスリーブ20をバルーン８の
端部にかぶせ、バルーン８のポリエチレンをスリーブの
ポリエチレンに封着し、ナイロンをカテーテル管３に封
着する。強度が必要な場合には最も内側の層を高密度ポ
リエチレンで形成し、最も外側の層をプレクサーを挟ん
だナイロンによって形成する。
医療用バルーンには磨耗抵抗及びまたは“手ざわり”
が重要であり、このためにはセラー樹脂を押し出すこと
が考えられる。このセラー樹脂は単独で内層及びまたは
外層として用いるか、またはポリエチレンテレフタレー
トと混ぜることができる。セラー樹脂の外層（セラー樹
脂とポリエチレンテレフタレートを50対50で混合したも
の）を有する、気圧6atmで膨張せしめた厚さ1.6ミルの
バルーンを中間グレードの紙やすりで前後にこすりこの
作業をバルーンが破れる迄行った。セラー樹脂、即ち50
対50混合層を用いたバルーンは200回以上のこすり迄破
れなかったが厚さ1.8ミルのポリエチレンテレフタレー
トのバルーンは87回で破れた。セラー樹脂は強度の大き
いポリエチレンテレフタレートであり、既知の技術によ
ってベース層と共に押し出すことができる。
第３図，第４図は押し出されたバルーン８の断面図で
ある。第３図は膨張状態を示し、第４図は収縮状態を示
す。バルーン８の外径はカテーテル管３の略３〜６倍ま
たはそれ以上となし得る。残留液体除去またはバルーン
との化学反応の問題がなければ、バルーンを膨張せしめ
るための加圧流体として既知の流体を使用することがで
きる。かかる流体はバルーンの内部に連通する第１の通
路L1を介してバルーン８内に導入され且つ除去される。
膨張用流体の導入の前に行うカテーテル及びバルーン内
に存在するガスの除去は、カテーテル管３内に形成した
第２の通路L2を介してなされる。好ましくは、通路L1と
L2はジョイント10の部分で消滅せしめ、第３の通路L3の
みが残るようにする。
この第３の通路L3はバルーン８と先端７を通るガイド
ワイヤ14を包んでいる。この第３の通路L3は他の２つの
通路L1とL2とは異なり、バルーン８を通して端部６から
先端７迄延びガイドワイヤ14のさやとなる。他の実施例
においては、バルーン８を膨張及び収縮せしめるための
通路L1とL2の機能を組み合わせた単一の通路を用いるこ
とが好ましい。上記第３の通路L3はガイドワイヤ14を挿
脱自在ならしめる容器を形成する。ガイドワイヤ14はカ
テーテル管３全体とバルーン８（好ましくは第３の通路
L3）を通して延び、（第２図，第３図に示すように）先
端７内の軸孔（図示せず）から先端７外に突き出る。
通路L1,L2,L3の夫々は、既知のようにカテーテル管が
押し出し機から押し出されるとき、押し出し形成される
壁15と16により区劃される。壁15,16の厚さは、既知の
ように0.5〜10ミルである。
第４図に示すように、バルーン８の収縮時の直径は、
カテーテル管３が血管内を容易に通過できるようカテー
テル管３の直径の略等しいか、またはそれ以下とする。
押し出されたカテーテル管３の壁厚は、バルーン８の好
ましい壁厚の６〜12倍である。
バルーン８を共に押し出し形成するため、複数の材料
を押し出し機内で互いに分離して溶融する。溶融したと
き、これらを押し出しヘッド内に分離したまま押し込
み、押し出して複数の層を有する単一の管状の本発明バ
ルーンを形成せしめる。長さ６インチの３層の管を保持
装置内に設置し、ナイロン−プレクサー、またはポリエ
チレン−ポリエチレンテレフタレートバルーンを形成せ
しめる。上記管の左端をタイバーストアダプターに取り
付ける。上記管の右端を熱封着し、加圧流体が漏れるの
を一時的に阻止せしめる。右端を（直径3.0mmのバルー
ンに対しては）少なくとも150グラムの力で引っ張る張
力部材に取り浸ける。この管を100〜400psiの圧力のも
とで約210゜Fに数秒間加熱する。次いで加熱区域を冷却
し、支持枠を僅か拡げ管の所定部分を露出し、バルーン
の再加熱すべき区域を約210゜〜220゜Fの温度に約35秒
間再加熱し、加圧によってバルーンを所望の直径に膨張
せしめる。次いで加圧を止め、デフレクターをバルーン
の端部に摺動し、バルーンを約310゜Fの温度に第３の時
間だけ加熱し、重合体マトリックスを２軸配向せしめ
る。上記第３の時間の加熱によりバルーンの層が薄くな
るのが阻止され、また、設定加熱期間に応じて設定され
た寸法を越えてバルーンが膨張することが阻止される。
この加熱時間は約８秒である。
ナイロン−プレクサーバルーンの場合には、デフレク
ターを管から除去し、加熱されていない他の管をその固
定手段内に取り付ける。カテーテル管をバルーン内に摺
動せしめ、これを熱融着可能なポリエチレン層に係合せ
しめる。バルーンは、ポリエチレン端部とポリエチレン
内層が一体に融着されるに十分な時間約310゜Fに加熱し
てポリエチレン軸に接着せしめる。
上記熱処理工程はカテーテルを多層構造としたとき主
層8Bから熱融着層8C及び8Aが分離するのを防ぐため極め
て重要である。然しながら、ポリエチレンテレフタレー
トとセラー層を有するものでは、薄層化及び層分離の問
題は生じない。
下記請求の範囲に示された本発明の範囲内で種々な変
形を作ることができることは勿論である。
───────────────────────────────────────────────────── フロントページの続き (72)発明者 ロバーツ ジョージ ティー. アメリカ合衆国 マサチューセッツ州 02174 アーリントン ジェイソン ア ベニュー 23 (72)発明者 ペダーソン ブリアン エイ． シィニ アー アメリカ合衆国 マサチューセッツ州 02703 サウスアトレボロ カーティス アベニュー 148 (56)参考文献 特開 昭59−91970（ＪＰ，Ａ) 特開 昭60−92773（ＪＰ，Ａ) 特開 平３−51059（ＪＰ，Ａ) 欧州特許出願公開420448（ＥＰ，Ａ １) (58)調査した分野(Int.Cl.7，ＤＢ名) A61M 25/10

Claims (3)

    (57)【特許請求の範囲】
  1. 【請求項１】端部（６）を有する管状部材（３）と、 この管状部材を貫通する少なくとも１つの通路（L1,L2,
    L3）と、 上記端部にジョイント（10）でかぶさる１つの開放端を
    有する細長いバルーン（８）と、スリーブ（20A,20B）
    とより成り、 上記バルーンの内部が上記通路に連通されており、上記
    バルーンが細長い膨張可能な管状体と、共に押し出され
    る異なる重合体材料の複数の層（8A,8B,8C）より成り、
    これらの層は上記管状体と熱封着不可能であり、 上記スリーブ（20A,20B）が、所定の大きさの直径を有
    し、カテーテルと医療用バルーンを接続するためこの両
    者に接着可能の上記ジョイントに配置される細長い管状
    体より成り、上記スリーブが、共に押し出され延長され
    る異なる重合体材料の複数の層より成る医療用のカテー
    テル。
  2. 【請求項２】上記層の少くとも１つが、ポリエチレンと
    その共重合体類より成る群から選んだ材料のものであ
    る、請求の範囲第１項記載のカテーテル。
  3. 【請求項３】上記バルーンが２つの開放端を有し、上記
    カテーテルが上記バルーン（８）に接着される先端
    （７）を上記開放端の１つに有する請求の範囲第１項ま
    たは第２項記載の医療用のカテーテル。
JP51191392A 1991-04-26 1992-04-23 医療用のカテーテル及びその製造方法 Expired - Lifetime JP3418872B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/691,999 US5195969A (en) 1991-04-26 1991-04-26 Co-extruded medical balloons and catheter using such balloons
US691,999 1991-04-26
PCT/US1992/003351 WO1992019316A1 (en) 1991-04-26 1992-04-23 Co-extruded medical balloons and catheter using such balloons

Related Child Applications (1)

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JP2002202084A Division JP2003047661A (ja) 1991-04-26 2002-07-11 医療用のカテーテル、医療用のバルーン及びその形成方法

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JPH06507101A JPH06507101A (ja) 1994-08-11
JP3418872B2 true JP3418872B2 (ja) 2003-06-23

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JP51191392A Expired - Lifetime JP3418872B2 (ja) 1991-04-26 1992-04-23 医療用のカテーテル及びその製造方法
JP2002202084A Pending JP2003047661A (ja) 1991-04-26 2002-07-11 医療用のカテーテル、医療用のバルーン及びその形成方法
JP2006070432A Expired - Lifetime JP4336689B2 (ja) 1991-04-26 2006-03-15 医療用カテーテル及びその形成方法

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JP2006070432A Expired - Lifetime JP4336689B2 (ja) 1991-04-26 2006-03-15 医療用カテーテル及びその形成方法

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US (5) US5195969A (ja)
EP (3) EP0953364B2 (ja)
JP (3) JP3418872B2 (ja)
CA (1) CA2107690C (ja)
DE (3) DE69233526T2 (ja)
WO (1) WO1992019316A1 (ja)

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US5195969A (en) 1993-03-23
US6136258A (en) 2000-10-24
JPH06507101A (ja) 1994-08-11
EP0742030B1 (en) 2000-06-28
CA2107690A1 (en) 1992-10-27
US20050238833A1 (en) 2005-10-27
DE69217928T2 (de) 1997-07-31
EP0742030A2 (en) 1996-11-13
DE69233526D1 (de) 2005-07-14
CA2107690C (en) 1996-12-24
EP0581873A1 (en) 1994-02-09
EP0953364B2 (en) 2012-02-08
EP0953364B1 (en) 2005-06-08
JP2006204930A (ja) 2006-08-10
US6482348B1 (en) 2002-11-19
DE69231210D1 (de) 2000-08-03
EP0742030A3 (en) 1997-02-05
DE69233526T2 (de) 2005-11-03
US7585289B2 (en) 2009-09-08
DE69231210T2 (de) 2000-11-30
JP4336689B2 (ja) 2009-09-30
JP2003047661A (ja) 2003-02-18
EP0581873B1 (en) 1997-03-05
EP0953364A2 (en) 1999-11-03
EP0953364A3 (en) 2001-10-17
DE69217928D1 (de) 1997-04-10
US5366442A (en) 1994-11-22
WO1992019316A1 (en) 1992-11-12
EP0581873A4 (ja) 1994-03-23

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