JP2513912Y2 - Cooling device for sample container in analyzer - Google Patents
Cooling device for sample container in analyzerInfo
- Publication number
- JP2513912Y2 JP2513912Y2 JP1990025334U JP2533490U JP2513912Y2 JP 2513912 Y2 JP2513912 Y2 JP 2513912Y2 JP 1990025334 U JP1990025334 U JP 1990025334U JP 2533490 U JP2533490 U JP 2533490U JP 2513912 Y2 JP2513912 Y2 JP 2513912Y2
- Authority
- JP
- Japan
- Prior art keywords
- case
- container
- cooling
- flow path
- sample container
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Landscapes
- Automatic Analysis And Handling Materials Therefor (AREA)
Description
【考案の詳細な説明】 〔産業上の利用分野〕 本考案は、例えば酵素免疫分析装置等で使用される試
料容器の冷却装置に関する。DETAILED DESCRIPTION OF THE INVENTION [Industrial field of application] The present invention relates to a cooling device for a sample container used in, for example, an enzyme immunoassay device.
上記の酵素免疫分析装置は、血液中の癌胎生性抗原
（CEA）やフェリチン（FER）、α−フェトプロテイン
（AFP）、リイロキシン結合グロプリン（TBG）等の酵素
免疫の分析に用いられるもので、その測定手法の一つで
ある２ステップサンドイッチ法について説明する。The above enzyme immunoassay device is used for analysis of enzyme immunity such as carcinoembryonic antigen (CEA) and ferritin (FER) in blood, α-fetoprotein (AFP), and lyroxine-binding globulin (TBG). The two-step sandwich method, which is one of the measurement methods, will be described.
この２ステップサンドイッチ法は、底部内面に抗体が
固定された多数本の試料容器をトレイごと冷蔵庫から取
り出して、このトレイを酵素免疫分析装置の所定部位に
セットし、この内の測定項目に応じた抗体が固定された
試料容器を血清注入部に取り出して一定量の血清を注入
すると共に、この試料容器内に希釈液を注入し、かつ、
当該試料容器を恒温振とう器にセットして、体温程度の
恒温下での所定時間にわたる振とうにより免疫第１反応
を行わせる。In this two-step sandwich method, a large number of sample containers each having an antibody immobilized on the inner surface of the bottom are taken out from a refrigerator together with a tray, and the tray is set at a predetermined site of an enzyme immunoassay device, and the measurement items in the tray are set. The sample container with the antibody fixed is taken out to the serum injection part and a fixed amount of serum is injected, and a diluent is injected into the sample container, and
The sample container is set on a constant temperature shaker, and the first immune reaction is performed by shaking for a predetermined time at a constant temperature of about body temperature.
次に、前記試料容器を洗浄部に取り出して当該容器内
を洗浄し、所謂B/F分離を行って後に、測定項目に応じ
た一定量の標識試薬を添加し、かつ、当該試料容器を前
記恒温振とう器にセットして所定時間にわたり免疫第２
反応を行わせる。Next, the sample container is taken out to a cleaning unit to wash the inside of the container, and after so-called B / F separation, a certain amount of a labeling reagent according to a measurement item is added, and the sample container is Set on a constant temperature shaker and immunize for a predetermined time Second
Allow the reaction to take place.
次いで、前記試料容器を取り出して内部を洗浄し、か
つ、一定量の基質試薬を添加して、当該試料容器を再び
前記恒温振とう器にセットし、所定時間にわたり酵素反
応を行わせる。この反応によって試料容器内に過酸化水
素が発生する。Next, the sample container is taken out, the inside is washed, a certain amount of the substrate reagent is added, the sample container is set again on the constant temperature shaker, and the enzymatic reaction is carried out for a predetermined time. Hydrogen peroxide is generated in the sample container by this reaction.
このようにして酵素反応が行われた試料容器を取り出
す一方、予め発光試薬（例えばルミノール液）が注入さ
れた測光部の測光セル内に前記過酸化水素を含む反応液
の所定量を添加し、発光反応を行わせる。While taking out the sample container in which the enzyme reaction has been carried out in this manner, a predetermined amount of the reaction solution containing hydrogen peroxide is added into the photometric cell of the photometric unit in which the luminescent reagent (for example, luminol solution) has been previously injected, Allow the luminescent reaction to occur.
この発光反応時の発光量を電気的に測定し且つコンピ
ューターで演算処理するのであり、これによって酵素免
疫の分析が行われるのである。The amount of luminescence at the time of this luminescence reaction is electrically measured and arithmetically processed by a computer, whereby the enzyme immunoassay is analyzed.
上記の分析に際して従来は、その分析に先立って逐
次、抗体が固定された試料容器の収容トレイを冷蔵庫か
ら取り出して、このトレイを酵素免疫分析装置の所定部
位にセットしており、そして分析を終えたならば、前記
トレイを再び冷蔵庫に戻して試料容器を冷蔵保管してい
る。In the above analysis, conventionally, prior to the analysis, the storage tray of the sample container to which the antibody was immobilized was taken out from the refrigerator, and this tray was set at a predetermined site of the enzyme immunoassay device, and the analysis was completed. Then, the tray is returned to the refrigerator and the sample container is refrigerated.
しかし、分析の度にトレイの出し入れを行わねばなら
ない煩わしさがあるだけでなく、分析の間は試料容器を
保冷することができなくてストック状態にある試料容器
の温度が徐々に高くなり、而して、時間を限って試料容
器を再度冷却処理しなければならないという不都合があ
った。However, not only is it troublesome to move the tray in and out each time the analysis is performed, but it is not possible to keep the sample container cold during the analysis, and the temperature of the sample container in the stock state gradually rises. Then, there is a disadvantage that the sample container has to be cooled again for a limited time.
本考案は、上記の不都合が解消された酵素免疫分析装
置等に装備して好適に使用される試料容器の冷却装置を
提供することを目的としている。An object of the present invention is to provide a cooling device for a sample container which is suitable for use in an enzyme immunoassay device or the like in which the above-mentioned inconvenience is solved.
上記の目的を達成するに至った本考案による分析装置
等における試料容器の冷却装置は、下部側が開放され且
つ上面部には複数個の試料容器の首部を吊り下げ保持す
るための容器保持部が縦横に形成された複数個の容器保
持ケースを、分析装置等の外部に引き出し自在に構成さ
れた冷却ケースの上部に、ケース載置部を介して着脱自
在に設け、前記冷却ケースの中空部を前記容器保持ケー
スの内部空間に連通させる第１流路と、前記前記容器保
持ケースの内部空間を前記冷却ケースの中空部に連通さ
せる第２流路を前記冷却ケースに形成し、かつ、前記冷
却ケースの装置内部への収納状態で冷気吸排気部の吸・
排気口に連通連結される冷気の導出・導入口を前記冷却
ケースに形成する一方、当該冷気の導入口を前記第１流
路に且つ前記第２流路を前記冷気の導出口に連通させる
冷気循環路の構成部材を前記冷却ケースの中空部に設
け、更に、前記第１流路を、前記縦横に形成された容器
保持部の数だけ前記冷却ケースとケース載置部に跨がり
形成し、しかもこのケース載置部の第１流路は、前記複
数個の試料容器の底部側が非接触状態で凹入する凹部を
含む流路により形成されている点に特徴を有する。The cooling device for the sample container in the analyzer and the like according to the present invention which has achieved the above object has a container holding part for opening and holding the neck part of a plurality of sample containers on the upper surface part. A plurality of container holding cases formed vertically and horizontally are provided on the upper part of a cooling case that can be pulled out to the outside of an analyzer or the like so as to be detachable via a case mounting portion, and the hollow part of the cooling case is provided. A first flow path communicating with the internal space of the container holding case and a second flow path communicating the internal space of the container holding case with the hollow part of the cooling case are formed in the cooling case, and the cooling is performed. When the case is stored inside the device, the cool air intake and exhaust
Cold air is formed in the cooling case so as to lead out and introduce cold air in communication with the exhaust port, while cold air is introduced into the first flow passage and the second flow passage is communicated with the cold air delivery port. A component of the circulation path is provided in the hollow portion of the cooling case, and further, the first flow path is formed across the cooling case and the case mounting portion by the number of the container holding portions formed in the vertical and horizontal directions, Moreover, the first flow path of the case mounting portion is characterized in that it is formed by a flow path including a concave portion into which the bottom sides of the plurality of sample containers are recessed in a non-contact state.
上記の特徴構成によれば、容器保持ケースの内部空間
が冷却ケース内の冷気循環路に連通連結されることで、
当該容器保持ケースの内部空間が試料容器に対する冷却
室となり、而して、装置そのものに冷却の機能が装備さ
れたことで、当該装置に試料容器を収納させておけば試
料容器が常に保冷下に置かれる。According to the above characteristic configuration, the internal space of the container holding case is connected to the cold air circulation path in the cooling case,
The internal space of the container holding case serves as a cooling chamber for the sample container, and since the device itself is equipped with a cooling function, if the sample container is stored in the device, the sample container is always kept cool. Placed.
そして、必要に応じて冷却ケースを装置外部に引き出
すことで、容器保持ケース毎の試料容器の交換等が簡易
に行われる。特に、冷却ケースの中空部に設けた冷気循
環路の構成部材により冷気の導入口を第１流路に連通さ
せ、この第１流路を、縦横に形成された容器保持部の数
だけ前記冷却ケースとケース載置部に跨がり形成したの
で、前記冷気の導入口から前記冷却ケースの中空部に導
入される冷気をケース載置部に形成された凹部内の第１
流路に流入でき、前記各試料容器の底部側を直接冷却で
きる。また、前記冷気の導入口から前記冷却ケースの中
空部に導入される冷気は、移動の妨げとなるような試料
容器のような障害物を持たない前記中空部内を移動する
ので、中空部の直上に広がる冷却ケースの第１流路に、
中空部内の冷気を均等に分布させることができる。Then, if necessary, the cooling case is pulled out to the outside of the apparatus, so that the sample container for each container holding case can be easily replaced. In particular, the component for forming the cool air circulation path provided in the hollow portion of the cooling case allows the inlet of the cool air to communicate with the first flow path, and the first flow path is cooled by the number of container holders formed vertically and horizontally. Since it is formed so as to straddle the case and the case mounting portion, the cold air introduced into the hollow portion of the cooling case from the cold air inlet is provided in the first recess in the case mounting portion.
It can flow into the flow channel, and the bottom side of each sample container can be directly cooled. Further, since the cool air introduced into the hollow portion of the cooling case from the cold air introduction port moves in the hollow portion that does not have an obstacle such as a sample container that hinders the movement, it is directly above the hollow portion. In the first flow path of the cooling case that spreads to
The cool air in the hollow portion can be evenly distributed.
以下、本考案の実施例を図面に基づいて説明する。 Hereinafter, embodiments of the present invention will be described with reference to the drawings.
第１図は酵素免疫分析装置の全体を示し、図において、
1,2は装置ケース３の内部空間を上下３つの空間に区画
する仕切板で、第２図に示すように、中央空間P1から上
部空間P2にわたって容器搬送用のエレベータ４が設置さ
れている。FIG. 1 shows the whole enzyme immunoassay device.
Reference numerals 1 and 2 denote partition plates that divide the internal space of the device case 3 into three upper and lower spaces. As shown in FIG. 2, an elevator 4 for container transportation is installed from the central space P 1 to the upper space P 2. There is.
５は容器冷却装置で、詳細については後述するが、下
部空間P3に設置された図示されていない冷却器に連通接
続される冷気吸排気部６と、これに連通連結された冷却
ケース７、及び下記する容器保持ケース10を主体にして
成り、かつ、前記冷却ケース７は前記装置ケース３の前
面側に引き出し自在に構成されている。Reference numeral 5 denotes a container cooling device, the details of which will be described later, but a cool air intake / exhaust part 6 connected to a cooler (not shown) installed in the lower space P 3 , and a cooling case 7 connected to the cool air intake / exhaust part 6, The container holding case 10 described below is mainly used, and the cooling case 7 is configured to be drawn out to the front side of the apparatus case 3.
８は底部内面に抗体が固定され且つ上部開口がアルニ
ウム箔で封じられた第１試料容器、９は希釈液が注入さ
れ且つ上部開口がアルミニウム箔で封じられた希釈液封
入容器で、これらの容器8,9は下部側が開放された容器
保持ケース10に保持され、かつ、冷却風路を形成する状
態で前記冷却ケース７の上面部に着脱自在に載置されて
いる。8 is a first sample container in which an antibody is fixed to the inner surface of the bottom and an upper opening is sealed with an aluminum foil, 9 is a diluent filling container in which a diluent is injected and an upper opening is sealed with an aluminum foil. 8 and 9 are held in a container holding case 10 whose lower side is opened, and are detachably placed on the upper surface of the cooling case 7 in a state of forming a cooling air passage.
11は水平二次元方向に移動自在な容器搬送機構で、容
器チャック11aを昇降自在に備え、前記第１試料容器８
（必要に応じて希釈液封入容器９）を前記エレベータ４
の搬送始端部に搬送する。Reference numeral 11 denotes a container transport mechanism that is movable in the horizontal two-dimensional direction, and is provided with a container chuck 11a that can be moved up and down.
(If necessary, the container for diluting liquid 9) is set in the elevator 4
It is transported to the transport start end.
12は容器保持部ａを備えた恒温振とう器で、この恒温
振とう器12の前部側には、第３図にも示すように、第１
試料容器８の挿通保持孔ｂが形成された第１〜第３ロー
ター13〜15が配置され、かつ、前記第１ローター13の周
部には洗浄器16と希釈液注入器17とが設けられ、第２ロ
ーター14の周部には洗浄器18と基質試薬注入器19とが設
けられ、第３ローター15の周部には洗浄器20と酵素標識
試薬注入器21とが設けられている。Reference numeral 12 denotes a constant temperature shaker equipped with a container holding part a. The front side of the constant temperature shaker 12 has a first
The first to third rotors 13 to 15 in which the insertion holding holes b of the sample container 8 are formed are arranged, and a washing device 16 and a diluting liquid injector 17 are provided around the first rotor 13. A washing device 18 and a substrate reagent injector 19 are provided around the second rotor 14, and a washing device 20 and an enzyme labeling reagent injector 21 are provided around the third rotor 15.
22は容器チャック22aを三次元方向に移動自在に備え
た容器搬送機構で、前記エレベータ４によって搬送され
てきた第１試料容器８を、前記恒温振とう器12と第１〜
第３ローター13〜15、及び、サンプル部23にわたって搬
送する。Reference numeral 22 denotes a container transfer mechanism provided with a container chuck 22a that is movable in three dimensions, and the first sample container 8 transferred by the elevator 4 is transferred to the constant temperature shaker 12 and
It is conveyed over the third rotors 13 to 15 and the sample section 23.
24は試料容器収容部で、試料（血清）が注入された複
数個の第２試料容器25を整列状態で収納した試料容器収
納ケース26が左右方向に並置されている。Reference numeral 24 denotes a sample container storage portion, in which a plurality of second sample containers 25 in which a sample (serum) is injected are stored in an aligned state, and sample container storage cases 26 are arranged side by side in the left-right direction.
27は前記試料容器収納ケース26の上部開口を個々に閉
じる蓋体で、当該蓋体27の容器整列方向一端側には蓋体
開閉機構28が設けられている。27 is a lid that individually closes the upper opening of the sample container storage case 26, and a lid opening / closing mechanism 28 is provided on one end side of the lid 27 in the container alignment direction.
29はピペットチップ30のストック部、31は水平二次元
方向に移動自在な試料注入機構で、上部に吸排気管32が
連通接続されたプローブ33を昇降自在に備え、前記スト
ック部29でのプローブ33の下降運動によって下端部にピ
ペットチップ30を装着し、かつ、吸気によって第２試料
容器25からピペットチップ30内に試料を吸入すると共
に、排気によって第１ローター13に保持された第１試料
容器８内に試料を注入する。29 is a stock portion of the pipette tip 30, 31 is a sample injection mechanism that is movable in two-dimensional horizontal directions, and is equipped with a probe 33 having an intake / exhaust pipe 32 connected in communication therewith so that it can be raised and lowered. The pipette tip 30 is attached to the lower end of the pipette tip 30 by the descending movement of the pipette, the sample is sucked into the pipette tip 30 from the second sample container 25 by suction, and the first sample container 8 held by the first rotor 13 is exhausted. Inject the sample into it.
34は酵素標識試薬が注入された薬液容器35のストック
部である。Reference numeral 34 is a stock portion of the drug solution container 35 in which the enzyme labeling reagent is injected.
36は測光セル37を備えた測光部、38はサンプル部23に
搬送されてきた第１試料容器８内の反応液を前記測光セ
ル37に注入する反応液注入器、39は前記測光セル37内に
発光試薬（例えばルミノール液）を注入する試薬注入
器、40は前記測光セル37に対する洗浄器である。Reference numeral 36 is a photometric unit having a photometric cell 37, 38 is a reaction liquid injector for injecting the reaction liquid in the first sample container 8 conveyed to the sample unit 23 into the photometric cell 37, and 39 is inside the photometric cell 37. Is a reagent injector for injecting a luminescent reagent (for example, a luminol solution), and 40 is a cleaner for the photometric cell 37.
41は第１試料容器８の回収部、42はピペットチップ30
の回収部である。41 is a collecting part of the first sample container 8, 42 is a pipette tip 30
It is a collection part of.
上記構成の酵素免疫分析装置による例えば２ステップ
サンドイッチ法の酵素免疫分析は次のようにして行われ
る。The enzyme immunoassay of, for example, the two-step sandwich method using the enzyme immunoassay device having the above-described configuration is performed as follows.
測定項目に応じた抗体が固定された第１試料容器８
が、下部側の容器搬送機構11とエレベータ４と上部側の
容器搬送機構22とによって第１ローター13の容器保持孔
ｂに取り出される。この容器取り出しの途中で第１試料
容器８の上部開口を封じているアルミニウム箔は破られ
る。The first sample container 8 with the antibody corresponding to the measurement item fixed
Is taken out to the container holding hole b of the first rotor 13 by the lower container transport mechanism 11, the elevator 4, and the upper container transport mechanism 22. The aluminum foil sealing the upper opening of the first sample container 8 is broken during the removal of the container.
一方、前記プローブ33の下端部にピペットチップ30が
装着され、かつ、当該ピペットチップ30内に第２試料容
器25内の試料が吸入されると共に、この試料が前記第１
ローター13に取り出された第１試料容器８内に注入さ
れ、前記ピペットチップ30はピペットチップ回収部42に
廃棄される。On the other hand, the pipette tip 30 is attached to the lower end of the probe 33, and the sample in the second sample container 25 is sucked into the pipette tip 30 and the sample is transferred to the first sample.
It is injected into the first sample container 8 taken out by the rotor 13, and the pipette tip 30 is discarded in the pipette tip collecting section 42.
前記第１ローター13が所定角回動して前記試料が注入
された第１試料容器８内に希釈液が注入され、かつ、当
該第１試料容器８が恒温振とう器12にセットされて、体
温程度の恒温下での所定時間にわたる振とうによって免
疫第１反応が行われる。When the first rotor 13 is rotated by a predetermined angle and the diluent is injected into the first sample container 8 into which the sample is injected, and the first sample container 8 is set on the constant temperature shaker 12, The first immune reaction is performed by shaking for a predetermined time at a constant temperature of about body temperature.
上記の第１試料容器８は第２ローター14に取り出され
て洗浄され、所謂B/F分離が行われて後に、測定項目に
応じた一定量の酵素標識試薬が注入され、再び恒温振と
う器12にセットされて所定時間にわたり免疫第２反応が
行われる。The first sample container 8 is taken out by the second rotor 14 and washed, and after so-called B / F separation is performed, a certain amount of the enzyme labeling reagent corresponding to the measurement item is injected, and the isothermal shaker is again used. It is set to 12 and the second immune reaction is performed for a predetermined time.
次いで、上記の第１試料容器８は第３ローター15に取
り出されて洗浄され、一定量の基質試薬が注入され、か
つ、再び恒温振とう器12にセットされて所定時間にわた
り酵素反応が行われる。この反応によって第１試料容器
８内に過酸化水素が発生する。Next, the above-mentioned first sample container 8 is taken out to the third rotor 15 and washed, a fixed amount of the substrate reagent is injected, and it is set again in the constant temperature shaker 12 to carry out the enzyme reaction for a predetermined time. . Hydrogen peroxide is generated in the first sample container 8 by this reaction.
酵素反応後において、第１試料容器８はサンプル部23
に搬送され、かつ、前記過酸化水素を含む反応液が予め
発光試薬を注入した測光セル37に添加され、ここで発光
反応が行われる。一方、前記第１試料容器８は回収部41
に廃棄される。After the enzymatic reaction, the first sample container 8 has the sample portion 23
And the reaction solution containing hydrogen peroxide is added to the photometric cell 37 into which the luminescent reagent has been previously injected, and the luminescent reaction is carried out there. On the other hand, the first sample container 8 has a collecting section 41.
To be discarded.
上記の発光反応時における発光量が電気的に測定さ
れ、コンピューターで演算処理され、分析結果がモニタ
ー43に表示されると同時にプリンタ44によって記録され
る。The amount of light emission during the above-described light emission reaction is electrically measured, processed by a computer, and the analysis result is displayed on the monitor 43 and simultaneously recorded by the printer 44.
次に、前記容器冷却装置５の具体構造について説明す
ると、この容器冷却装置５は既述したように、図外の冷
却器に連通接続された冷気吸排気部６と、この冷気吸排
気部６に連通連結される冷却ケース７、及び、前記容器
保持ケース10を主体にして成り、前記容器保持ケース10
は、第８図に示すように、下部側を開放した箱形状を呈
し、その上面部には、前記第１試料容器８の首部を吊り
下げ保持するための貫通孔による容器保持部ｃが縦横に
形成されている。そして、この容器保持ケース10には上
蓋ケース51の被嵌が可能であって、当該容器保持ケース
10を流通用のケースとして使用することができるように
なっている。Next, a specific structure of the container cooling device 5 will be described. As described above, the container cooling device 5 includes a cool air intake / exhaust part 6 connected to a cooler (not shown) in communication with the cool air intake / exhaust part 6. The container holding case 10 is mainly composed of a cooling case 7 connected to and connected to the container holding case 10 and the container holding case 10.
As shown in FIG. 8, it has a box shape with an open lower side, and a container holding portion c by a through hole for suspending and holding the neck portion of the first sample container 8 is vertically and horizontally provided on the upper surface thereof. Is formed in. An upper lid case 51 can be fitted into the container holding case 10, and the container holding case
10 can now be used as a distribution case.
一方、前記冷却ケース７は、第４図乃至第８図に示す
ように、左右一対のスライダー52とブラケット53を介し
て前記下部仕切板２上に取り付けられ、前記装置ケース
３の前部側に引き出し自在に構成されている。On the other hand, the cooling case 7 is mounted on the lower partition plate 2 via a pair of left and right sliders 52 and a bracket 53 as shown in FIGS. 4 to 8, and is attached to the front side of the device case 3. It is constructed so that it can be pulled out freely.
そして、この冷却ケース７の上面部には、水平方向へ
の位置ずれを防止する状態で前記容器保持ケース10の複
数個を着脱自在に載置するためのケース載置部54が設け
られ、かつ、当該ケース載置部54の上面部には、前記容
器保持ケース10による吊り下げ保持容器８の底部側を非
接触状態で凹入する凹部ｄが形成されている。The upper surface of the cooling case 7 is provided with a case mounting portion 54 for detachably mounting a plurality of the container holding cases 10 in a state in which the positional displacement in the horizontal direction is prevented, and A recess d is formed on the upper surface of the case mounting portion 54 for recessing the bottom side of the suspension holding container 8 by the container holding case 10 in a non-contact state.
また、前記冷却ケース７とケース載置部54の夫々に
は、前記冷却ケース７の中空部Ｐを容器保持ケース10の
内部空間Ｑに連通させる第１流路ｅが各凹部ｄに対応し
て形成され、かつ、前記内部空間Ｑを中空部Ｐに連通さ
せる第２流路ｆが前記凹部ｄを外れた箇所に形成されて
いる。Further, in each of the cooling case 7 and the case mounting portion 54, a first flow path e for communicating the hollow portion P of the cooling case 7 with the internal space Q of the container holding case 10 corresponds to each recess d. A second flow path f that is formed and connects the internal space Q to the hollow portion P is formed at a location outside the recess d.
更に、前記冷却ケース７の引き出し方向の奥部には、
当該冷却ケース７の引き出し方向奥部への押し込み状態
で、前記冷気吸排気部６の吸・排気口g,hに連通連結さ
れる冷気の導出・導入口i,jが形成され、この内の冷気
導入口ｊを前記第１流路ｅに且つ前記第２流路ｆを冷気
導出口ｉに連通させる冷気循環路Ｒの構成部材55が、前
記冷却ケース７の中空部Ｐに設けられている。尚、第５
図中の56は、前記冷気吸排気部６の内部空間を区画する
仕切板である。Furthermore, in the inner part in the pulling direction of the cooling case 7,
In the state where the cooling case 7 is pushed inward in the pull-out direction, cold air outlet / inlet ports i, j are formed which are connected to the intake / exhaust ports g, h of the cool air intake / exhaust unit 6 and are formed therein. A component 55 of the cold air circulation path R that connects the cold air introduction port j to the first flow path e and the second flow path f to the cold air discharge port i is provided in the hollow portion P of the cooling case 7. . The fifth
Reference numeral 56 in the figure denotes a partition plate that partitions the internal space of the cold air intake / exhaust portion 6.
上記の構成によれば、前記冷却ケース７を引き出し方
向の奥部に押し込むことで、当該冷却ケース７の冷気の
導出・導入口i,jが冷気吸排気部６の吸・排気口g,hに連
通連結され、これによって冷気が第１流路ｅを通して吊
り下げ保持されている第１試料容器８の底部側が直接冷
却され、冷却後の冷気は第２流路ｆから冷気吸排気部６
に還流されるもので、前記ケース載置部54に載置された
容器保持ケース10内の第１試料容器８を、装置内におい
て常に保冷下に置くことができる。According to the above configuration, by pushing the cooling case 7 into the inner part in the pulling-out direction, the cooling air outflow / inlet ports i, j of the cooling case 7 are sucked / exhausted by the cold air intake / exhaust part 6. The bottom side of the first sample container 8 in which the cold air is suspended and held through the first flow path e is directly cooled, and the cool air after cooling is supplied from the second flow path f to the cool air intake / exhaust portion 6
Therefore, the first sample container 8 in the container holding case 10 placed on the case placing portion 54 can be always kept cold in the apparatus.
第９図に容器冷却系の別態様を示す。このものは、上
部側をヒンジにして内方に揺動自在な煽り扉57を前記冷
気吸排気部６の吸・排気口g,hに設けると共に、当該煽
り扉57を閉塞方向に付勢力させる付勢手段58を設け、か
つ、前記冷却ケース７の引き出し方向奥部に、当該冷却
ケース７の押し込みに伴って前記煽り扉57を開放（第10
図参照）させる筒状の冷気導出・導入口i,jを連設する
一方、前記冷気吸排気部６の内部空間を区画する仕切板
56に、両区画室を連通させるバイパス流路ｍを形成し、
このバイパス流路ｍに対する開閉蓋59を一方の煽り扉57
に連通して、当該一方の煽り扉57の付勢閉塞下において
前記バイパス流路ｍが開放されるように構成したもので
ある。FIG. 9 shows another embodiment of the container cooling system. This is provided with a swinging door 57 which is swingable inward with its upper side as a hinge, at the intake / exhaust ports g and h of the cold air intake / exhaust portion 6, and biases the swinging door 57 in the closing direction. A biasing means 58 is provided, and the flap door 57 is opened at the inner part in the pulling-out direction of the cooling case 7 as the cooling case 7 is pushed (10th position).
(See the figure) A partition plate that connects the cold air introduction / introduction ports i and j in series while partitioning the internal space of the cold air intake / exhaust part 6
At 56, a bypass flow passage m that connects both compartments is formed,
The opening / closing lid 59 for this bypass flow path m is attached to the one door 57.
The bypass flow path m is opened under the biased closing of the one flap door 57.
かゝる構成によれば、第11図に示すように、前記冷却
ケース７の装置外部への引き出しに伴って前記吸・排気
口g,hが自動的に閉じられ、かつ、冷気がバイパス流路
ｍに流されるもので、冷熱エネルギーの無駄が防止され
る点に特徴がある。According to such a configuration, as shown in FIG. 11, the intake / exhaust ports g and h are automatically closed when the cooling case 7 is pulled out to the outside of the device, and the cool air is bypassed. It is passed through the path m, and is characterized in that waste of cooling and heating energy is prevented.
尚、前記冷却ケース７の引き出しに連動させて可逆的
に冷却装置５の電気系を開成させることによっても、上
記と同様に冷熱エネルギーの無駄が防止される。By reversibly opening the electric system of the cooling device 5 in conjunction with the pulling out of the cooling case 7, the waste of cold energy can be prevented as in the above case.
以上説明したように本考案は、従来、分析の度に試料
容器の収容トレイを冷蔵庫から取り出して、このトレイ
を分析装置の所定部位にセットしていた箇所に、容器保
持ケースを収容載置するための装置外部への引き出しを
可能とした冷却ケースを設け、かつ、当該冷却ケース内
部の冷気循環路を介して前記容器保持ケースの内部空間
に冷気を導入させて、容器保持ケースの内部空間を試料
容器に対する冷却室に構成した点と、容器保持ケースと
冷却ケースの間にケース載置部を設けた点に特徴を有す
る。As described above, according to the present invention, the storage tray for the sample container is conventionally taken out from the refrigerator every time the analysis is performed, and the container holding case is stored and mounted at the position where the tray is set at a predetermined portion of the analyzer. A cooling case that can be pulled out to the outside of the device is provided, and cold air is introduced into the internal space of the container holding case through the cold air circulation path inside the cooling case, and the internal space of the container holding case is It is characterized in that it is configured as a cooling chamber for the sample container and that a case mounting portion is provided between the container holding case and the cooling case.
而して、装置そのものに冷却の機能が装備されたこと
で、分析装置等に試料容器を常に保冷却貯蔵することが
可能となり、分析の度に試料容器の収容トレイを冷蔵庫
から出し入れする煩わしさがなくなる上、時間を限って
の分析を強いられることもなくなり、勿論、必要に応じ
て冷却ケースを装置外部に引き出すことで、容器保持ケ
ース毎の試料容器の交換等も簡易に行うことができるに
至ったのである。特に、冷却ケースの中空部に設けた冷
気循環路の構成部材により冷気の導入口を第１流路に連
通させ、この第１流路を、縦横に形成された容器保持部
の数だけ前記冷却ケースとケース載置部に跨がり形成し
たので、前記冷気の導入口から前記冷却ケースの中空部
に導入される冷気はケース載置部に形成された凹部内の
第１流路に流入して前記各試料容器の底部側を直接冷却
できる。また、前記冷気の導入口から前記冷却ケースの
中空部に導入される冷気は、移動の妨げとなるような試
料容器のような障害物を持たない前記中空部内を移動す
る。この際、中空部内においては、前記冷気の導入口側
のみならず該導入口側から離れた所でも中空部内の全体
にわたり、前記冷気の導入口から導入される冷気を、一
様に移動させることができる。したがって、中空部の直
上に広がる冷却ケースの第１流路に、中空部内の冷気を
均等に分布させることができる。その結果、ケース載置
部に形成された凹部内の第１流路を介して下部側が開放
された容器保持ケースの容器保持部に保持された複数個
の試料容器の底部側を常に均一に冷却できる。Since the device itself is equipped with a cooling function, it is possible to store the sample container in the analyzer with constant cooling, and it is bothersome to remove the sample container storage tray from the refrigerator each time it is analyzed. In addition, there is no need to perform analysis for a limited time, and of course, by pulling out the cooling case to the outside of the device as needed, it is possible to easily replace the sample container for each container holding case. Was reached. In particular, the component for forming the cool air circulation path provided in the hollow portion of the cooling case allows the inlet of the cool air to communicate with the first flow path, and the first flow path is cooled by the number of container holders formed vertically and horizontally. Since it is formed so as to straddle the case and the case mounting portion, the cool air introduced into the hollow portion of the cooling case from the cold air inlet flows into the first flow path in the recess formed in the case mounting portion. The bottom side of each sample container can be directly cooled. Further, the cold air introduced into the hollow portion of the cooling case from the cold air introduction port moves in the hollow portion that does not have an obstacle such as a sample container that hinders the movement. At this time, in the hollow portion, the cold air introduced from the cold air introduction port should be uniformly moved not only on the cold air introduction port side but also on the entire inside of the hollow part not only at the place away from the introduction port side. You can Therefore, the cold air in the hollow portion can be evenly distributed in the first flow path of the cooling case that spreads immediately above the hollow portion. As a result, the bottom side of the plurality of sample containers held in the container holding part of the container holding case whose lower side is opened through the first channel in the recess formed in the case mounting part is always cooled uniformly. it can.
第１図は内部を透視した酵素免疫分析装置の斜視図、第
２図は一部を破断した主要部の側面図、第３図は主要部
の平面図である。 第４図は要部を破断した容器冷却装置の平面図、第５図
は内部を透視した容器冷却装置の斜視図、第６図は容器
冷却装置の縦断正面図、第７図は容器冷却装置の縦断側
面図、第８図は容器保持ケースと共に冷気の流れを示す
斜視図である。 第９図は容器冷却系の別態様を示す透視斜視図、第10図
および第11図は動作説明図である。 ６……冷気吸排気部、７……冷却ケース、８……試料容
器、10……容器保持ケース、54……ケース載置部、55…
…冷気循環路の構成部材、ｃ……容器保持部（貫通
孔）、ｄ……ケース載置部の凹部、ｅ……第１流路、ｆ
……第２流路、ｇ……冷気吸気口、ｈ……冷気排気口、
ｉ……冷気導出口、ｊ……冷気導入口、Ｐ……中空部、
Ｑ……内部空間、Ｒ……冷気循環路。FIG. 1 is a perspective view of an enzyme immunoassay apparatus with a see-through view, FIG. 2 is a side view of a partially cutaway main part, and FIG. 3 is a plan view of the main part. FIG. 4 is a plan view of the container cooling device in which the main part is broken, FIG. 5 is a perspective view of the container cooling device through which the inside is seen, FIG. 6 is a vertical sectional front view of the container cooling device, and FIG. 7 is a container cooling device. FIG. 8 is a vertical cross-sectional side view, and FIG. 8 is a perspective view showing the flow of cold air together with the container holding case. FIG. 9 is a perspective view showing another embodiment of the container cooling system, and FIGS. 10 and 11 are operation explanatory views. 6 ... Cold air intake / exhaust part, 7 ... Cooling case, 8 ... Sample container, 10 ... Container holding case, 54 ... Case mounting part, 55 ...
... Cold air circulation component, c ... Container holding portion (through hole), d ... Recessed case mounting portion, e ... First flow path, f
...... Second flow path, g ... Cold air intake port, h ... Cold air exhaust port,
i ... Cold air outlet, j ... Cold air inlet, P ... Hollow part,
Q: Internal space, R: Cold air circulation path.
Claims (3)
試料容器の首部を吊り下げ保持するための容器保持部が
縦横に形成された複数個の容器保持ケースを、分析装置
等の外部に引き出し自在に構成された冷却ケースの上部
に、ケース載置部を介して着脱自在に設け、前記冷却ケ
ースの中空部を前記容器保持ケースの内部空間に連通さ
せる第１流路と、前記前記容器保持ケースの内部空間を
前記冷却ケースの中空部に連通させる第２流路を前記冷
却ケースに形成し、かつ、前記冷却ケースの装置内部へ
の収納状態で冷気吸排気部の吸・排気口に連通連結され
る冷気の導出・導入口を前記冷却ケースに形成する一
方、当該冷気の導入口を前記第１流路に且つ前記第２流
路を前記冷気の導出口に連通させる冷気循環路の構成部
材を前記冷却ケースの中空部に設け、更に、前記第１流
路を、前記縦横に形成された容器保持部の数だけ前記冷
却ケースとケース載置部に跨がり形成し、しかもこのケ
ース載置部の第１流路は、前記複数個の試料容器の底部
側が非接触状態で凹入する凹部を含む流路により形成さ
れていることを特徴とする分析装置等における試料容器
の冷却装置。1. A plurality of container holding cases, each of which is open at the lower side and has a container holding portion vertically and horizontally for suspending and holding the necks of a plurality of sample containers on an upper surface thereof, are provided outside an analyzer or the like. A first flow path that is detachably provided on the upper portion of the cooling case configured to be freely drawn out via a case mounting portion, and that communicates the hollow portion of the cooling case with the internal space of the container holding case; A second flow path for communicating the internal space of the container holding case with the hollow part of the cooling case is formed in the cooling case, and the intake / exhaust ports of the cool air intake / exhaust part are stored when the cooling case is housed inside the device. A cold air circulation path that connects the cold air outlet / inlet to the cooling case while connecting the cold air inlet / outlet to the first channel and the second channel to the cold air outlet. The components of the cooling case The first flow path is provided in the hollow portion, and the first flow path is formed across the cooling case and the case mounting portion by the number of the container holding portions formed in the vertical and horizontal directions. A cooling device for a sample container in an analyzer or the like, characterized in that the passage is formed by a flow path including a recess in which the bottom side of the plurality of sample containers is recessed in a non-contact state.
するための貫通孔から成ることをと特徴とする請求項
（１）に記載された分析装置等における試料容器の冷却
装置。2. The cooling device for a sample container in an analyzer and the like according to claim 1, wherein the container holding part is formed of a through hole for suspending and holding the sample container.
してあることを特徴とする請求項（２）に記載された分
析装置等における試料容器の冷却装置。3. A cooling device for a sample container in an analyzer or the like according to claim 2, wherein the first flow path is opened so as to face the container holding portion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1990025334U JP2513912Y2 (en) | 1990-03-13 | 1990-03-13 | Cooling device for sample container in analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP1990025334U JP2513912Y2 (en) | 1990-03-13 | 1990-03-13 | Cooling device for sample container in analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JPH03115855U JPH03115855U (en) | 1991-12-02 |
| JP2513912Y2 true JP2513912Y2 (en) | 1996-10-09 |
Family
ID=31528267
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP1990025334U Expired - Lifetime JP2513912Y2 (en) | 1990-03-13 | 1990-03-13 | Cooling device for sample container in analyzer |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2513912Y2 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4440294A1 (en) * | 1994-11-11 | 1996-05-15 | Boehringer Mannheim Gmbh | System for the incubation of sample liquids |
| JP3609169B2 (en) * | 1995-09-22 | 2005-01-12 | 麒麟麦酒株式会社 | Sampling device |
| JP2006030144A (en) * | 2004-07-21 | 2006-02-02 | Kajikkusu Trading:Kk | Sample tube heat-insulating tray and heat insulating box for multi-well plate |
| JP5697081B2 (en) * | 2010-11-22 | 2015-04-08 | 株式会社堀場製作所 | Reaction tank and measuring device using the reaction tank |
| WO2024142537A1 (en) * | 2022-12-26 | 2024-07-04 | 株式会社日立ハイテク | Automatic analysis device |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6186552A (en) * | 1984-10-03 | 1986-05-02 | 石戸 文也 | Cooling device of apparatus for analysis |
| JPS63109649U (en) * | 1987-01-08 | 1988-07-14 |
-
1990
- 1990-03-13 JP JP1990025334U patent/JP2513912Y2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH03115855U (en) | 1991-12-02 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5455526B2 (en) | Robotic storage device | |
| BR102016010809B1 (en) | apparatus for automatic immunohematological analysis on gel cards | |
| CN112119312A (en) | Full-automatic chemiluminescence immunoassay analyzer | |
| BRPI0901743A2 (en) | apparatus for the automatic analysis of gel card samples | |
| CN207866716U (en) | Chemiluminescence detector | |
| JP5832469B2 (en) | Sample analyzer, transfer device and lid tray | |
| CN109975562A (en) | Chemiluminescence detector and its detection method | |
| JP6882352B2 (en) | Container rack, sample analyzer and sample analysis method | |
| JP2012141226A (en) | Container supply device and sample analysis device | |
| BR9904295B1 (en) | instrument for processing test devices. | |
| JP2513912Y2 (en) | Cooling device for sample container in analyzer | |
| JP2535239B2 (en) | Enzyme immunoassay device | |
| CN1497252B (en) | Processing equipment of measuring element | |
| CN205411328U (en) | Special sales kit (SK) of clinical laboratory | |
| JP3206442B2 (en) | Automatic immunoassay device | |
| CN211140274U (en) | Gene detection kit | |
| CN208248942U (en) | A kind of portable minisize Semiconductors At Low Temperatures sample collection transport apparatus | |
| CN218412576U (en) | Blood coagulation analyzer assembly line, blood coagulation analysis module and sample analyzer assembly line | |
| CN215055772U (en) | Mobile PCR (polymerase chain reaction) shelter laboratory | |
| CN213229625U (en) | Kit for time-resolved fluoroimmunoassay | |
| JPH0736285Y2 (en) | Detachment mechanism of pipette tip to probe | |
| JP2513911Y2 (en) | Opening and closing mechanism of lid for sample container storage case of enzyme immunoassay device | |
| CN219799473U (en) | Melatonin fluorescence method quantitative determination device | |
| JP2584712Y2 (en) | Isothermal shaker in enzyme immunoassay | |
| CN216862416U (en) | Antinuclear antibody spectrum test kit |