JP2023030130A5 - - Google Patents
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- JP2023030130A5 JP2023030130A5 JP2022206897A JP2022206897A JP2023030130A5 JP 2023030130 A5 JP2023030130 A5 JP 2023030130A5 JP 2022206897 A JP2022206897 A JP 2022206897A JP 2022206897 A JP2022206897 A JP 2022206897A JP 2023030130 A5 JP2023030130 A5 JP 2023030130A5
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- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 10
- 235000013305 food Nutrition 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 229930003761 Vitamin B9 Natural products 0.000 claims 5
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 5
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims 5
- 235000019158 vitamin B6 Nutrition 0.000 claims 5
- 239000011726 vitamin B6 Substances 0.000 claims 5
- 235000019159 vitamin B9 Nutrition 0.000 claims 5
- 239000011727 vitamin B9 Substances 0.000 claims 5
- 229940011671 vitamin b6 Drugs 0.000 claims 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 4
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 3
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 claims 3
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 3
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims 3
- 229930003451 Vitamin B1 Natural products 0.000 claims 3
- 229930003471 Vitamin B2 Natural products 0.000 claims 3
- 229930003537 Vitamin B3 Natural products 0.000 claims 3
- 229930003571 Vitamin B5 Natural products 0.000 claims 3
- 229930003756 Vitamin B7 Natural products 0.000 claims 3
- FAPWYRCQGJNNSJ-UBKPKTQASA-L calcium D-pantothenic acid Chemical compound [Ca+2].OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O.OCC(C)(C)[C@@H](O)C(=O)NCCC([O-])=O FAPWYRCQGJNNSJ-UBKPKTQASA-L 0.000 claims 3
- 229960002079 calcium pantothenate Drugs 0.000 claims 3
- 229960003512 nicotinic acid Drugs 0.000 claims 3
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 3
- 229960002477 riboflavin Drugs 0.000 claims 3
- 229960003495 thiamine Drugs 0.000 claims 3
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims 3
- 235000010374 vitamin B1 Nutrition 0.000 claims 3
- 239000011691 vitamin B1 Substances 0.000 claims 3
- 235000019164 vitamin B2 Nutrition 0.000 claims 3
- 239000011716 vitamin B2 Substances 0.000 claims 3
- 235000019160 vitamin B3 Nutrition 0.000 claims 3
- 239000011708 vitamin B3 Substances 0.000 claims 3
- 239000011675 vitamin B5 Substances 0.000 claims 3
- 235000009492 vitamin B5 Nutrition 0.000 claims 3
- 235000011912 vitamin B7 Nutrition 0.000 claims 3
- 239000011735 vitamin B7 Substances 0.000 claims 3
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 2
- 229930003779 Vitamin B12 Natural products 0.000 claims 2
- 229930003268 Vitamin C Natural products 0.000 claims 2
- 229930003316 Vitamin D Natural products 0.000 claims 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 2
- 229930003427 Vitamin E Natural products 0.000 claims 2
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 claims 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 2
- 229960001231 choline Drugs 0.000 claims 2
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 2
- 235000020673 eicosapentaenoic acid Nutrition 0.000 claims 2
- 229960005135 eicosapentaenoic acid Drugs 0.000 claims 2
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 claims 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 2
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 2
- 229940012843 omega-3 fatty acid Drugs 0.000 claims 2
- 229940088594 vitamin Drugs 0.000 claims 2
- 229930003231 vitamin Natural products 0.000 claims 2
- 235000013343 vitamin Nutrition 0.000 claims 2
- 239000011782 vitamin Substances 0.000 claims 2
- 235000019163 vitamin B12 Nutrition 0.000 claims 2
- 239000011715 vitamin B12 Substances 0.000 claims 2
- 235000019154 vitamin C Nutrition 0.000 claims 2
- 239000011718 vitamin C Substances 0.000 claims 2
- 235000019166 vitamin D Nutrition 0.000 claims 2
- 239000011710 vitamin D Substances 0.000 claims 2
- 150000003710 vitamin D derivatives Chemical class 0.000 claims 2
- 235000019165 vitamin E Nutrition 0.000 claims 2
- 239000011709 vitamin E Substances 0.000 claims 2
- 229940046009 vitamin E Drugs 0.000 claims 2
- 229940046008 vitamin d Drugs 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 1
- RHGKLRLOHDJJDR-BYPYZUCNSA-N L-citrulline Chemical compound NC(=O)NCCC[C@H]([NH3+])C([O-])=O RHGKLRLOHDJJDR-BYPYZUCNSA-N 0.000 claims 1
- RHGKLRLOHDJJDR-UHFFFAOYSA-N Ndelta-carbamoyl-DL-ornithine Natural products OC(=O)C(N)CCCNC(N)=O RHGKLRLOHDJJDR-UHFFFAOYSA-N 0.000 claims 1
- 230000032683 aging Effects 0.000 claims 1
- 235000014633 carbohydrates Nutrition 0.000 claims 1
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 229960002173 citrulline Drugs 0.000 claims 1
- 235000013477 citrulline Nutrition 0.000 claims 1
- 230000001149 cognitive effect Effects 0.000 claims 1
- CYQFCXCEBYINGO-IAGOWNOFSA-N delta1-THC Chemical compound C1=C(C)CC[C@H]2C(C)(C)OC3=CC(CCCCC)=CC(O)=C3[C@@H]21 CYQFCXCEBYINGO-IAGOWNOFSA-N 0.000 claims 1
- 239000003925 fat Substances 0.000 claims 1
- 235000019197 fats Nutrition 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000006014 omega-3 oil Substances 0.000 claims 1
- 235000018102 proteins Nutrition 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Images
Claims (6)
- 認知症ではない個体において認知的加齢を軽減するための食品組成物を製造する方法であって、タンパク質、炭水化物、及び脂肪からなる群から選択される少なくとも１種の成分に、ω３脂肪酸と、シトルリンと、ビタミンＢ１２及びコリンとの組み合わせを有効な量で添加することを含み、
前記ω３脂肪酸は、少なくともエイコサペンタエン酸を含み、
前記食品組成物を製造するにあたって、ビタミンＢ１、ビタミンＢ２、ビタミンＢ３、ビタミンＢ５、ビタミンＢ６、ビタミンＢ７及びビタミンＢ９からなる群から少なくとも前記ビタミンＢ６及び前記ビタミンＢ９が選択される少なくとも２種を有効な量で更に添加することを含み、
前記組成物が、１日当たり前記エイコサペンタエン酸を０．５ｇ～１．０ｇの一日用量で投与され、
前記組成物が、米国の１日当たり推奨一日所要量（ＲＤＡ）の０．０１～１０．０倍のコリンを提供する一日用量で投与され、
前記組成物が、米国の１日当たり推奨一日所要量（ＲＤＡ）の０．１～５０倍のビタミンＢ１２を提供する一日用量で投与される、方法。 - 前記食品組成物を製造するにあたって、ビタミンＢ１、ビタミンＢ２、ビタミンＢ３、ビタミンＢ５、ビタミンＢ６、ビタミンＢ７及びビタミンＢ９からなる群から少なくとも前記ビタミンＢ６及び前記ビタミンＢ９が選択される少なくとも６種を有効な量で更に添加することを含む、請求項１に記載の方法。
- 前記組成物が、１日当たり前記ビタミンＢ６を１５ｍｇ～２５ｍｇの一日用量で投与され、
前記組成物が、１日当たり前記ビタミンＢ９を０．１ｍｇ～１．０ｍｇの一日用量で投与される、請求項２に記載の方法。 - 前記食品組成物を製造するにあたって、ビタミンＣ、ビタミンＤ及びビタミンＥからなる群から選択される少なくとも１種を有効な量で更に添加することを含む、請求項３に記載の方法。
- 前記食品組成物を製造するにあたって、ビタミンＣ、ビタミンＤ及びビタミンＥを有効な量で更に添加することを含む、請求項３に記載の方法。
- 前記個体がコンパニオンアニマルである、請求項１～５のいずれか一項に記載の方法。
Applications Claiming Priority (14)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762484119P | 2017-04-11 | 2017-04-11 | |
| US201762484156P | 2017-04-11 | 2017-04-11 | |
| US62/484,156 | 2017-04-11 | ||
| US62/484,119 | 2017-04-11 | ||
| PCT/EP2017/074731 WO2018060396A1 (en) | 2016-09-29 | 2017-09-29 | Omega 3 fatty acids and choline as neuroprotectant in patients with no dementia |
| EPPCT/EP2017/074731 | 2017-09-29 | ||
| EP17193916.8 | 2017-09-29 | ||
| EP17193916.8A EP3388061A1 (en) | 2017-04-11 | 2017-09-29 | Omega 3 fatty acids, no releasing compound, vitamin b12 and choline as neuroprotectant in patients with no dementia |
| US201762580574P | 2017-11-02 | 2017-11-02 | |
| US62/580,574 | 2017-11-02 | ||
| PCT/EP2017/082148 WO2018188771A1 (en) | 2017-04-11 | 2017-12-11 | Omega-3 fatty acid and vitamin d levels to identify and attenuate cognitive aging in individuals |
| EPPCT/EP2017/082148 | 2017-12-11 | ||
| JP2019550713A JP2020516586A (ja) | 2017-04-11 | 2018-04-05 | 認知症ではない個体において、認知的加齢を軽減する組成物及び方法 |
| PCT/EP2018/058710 WO2018189022A1 (en) | 2017-04-11 | 2018-04-05 | Compositions and methods that attenuate cognitive aging in individuals who do not have dementia |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019550713A Division JP2020516586A (ja) | 2017-04-11 | 2018-04-05 | 認知症ではない個体において、認知的加齢を軽減する組成物及び方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023030130A JP2023030130A (ja) | 2023-03-07 |
| JP2023030130A5 true JP2023030130A5 (ja) | 2024-04-04 |
Family
ID=67682482
Family Applications (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019550821A Active JP7270546B2 (ja) | 2017-04-11 | 2017-12-11 | 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル |
| JP2019551444A Active JP7270547B2 (ja) | 2017-04-11 | 2018-04-05 | 個体における認知的加齢を特定及び軽減するためのオメガ－３脂肪酸、ホモシステイン及びビタミンｄのレベル。 |
| JP2019550713A Pending JP2020516586A (ja) | 2017-04-11 | 2018-04-05 | 認知症ではない個体において、認知的加齢を軽減する組成物及び方法 |
| JP2022129345A Active JP7434459B2 (ja) | 2017-04-11 | 2022-08-15 | 個体における認知的加齢を特定及び軽減するためのオメガ－３脂肪酸、ホモシステイン及びビタミンｄのレベル |
| JP2022129344A Active JP7434458B2 (ja) | 2017-04-11 | 2022-08-15 | 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル |
| JP2022206897A Pending JP2023030130A (ja) | 2017-04-11 | 2022-12-23 | 認知症ではない個体において認知的加齢を軽減する組成物の製造方法 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019550821A Active JP7270546B2 (ja) | 2017-04-11 | 2017-12-11 | 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル |
| JP2019551444A Active JP7270547B2 (ja) | 2017-04-11 | 2018-04-05 | 個体における認知的加齢を特定及び軽減するためのオメガ－３脂肪酸、ホモシステイン及びビタミンｄのレベル。 |
| JP2019550713A Pending JP2020516586A (ja) | 2017-04-11 | 2018-04-05 | 認知症ではない個体において、認知的加齢を軽減する組成物及び方法 |
| JP2022129345A Active JP7434459B2 (ja) | 2017-04-11 | 2022-08-15 | 個体における認知的加齢を特定及び軽減するためのオメガ－３脂肪酸、ホモシステイン及びビタミンｄのレベル |
| JP2022129344A Active JP7434458B2 (ja) | 2017-04-11 | 2022-08-15 | 個体における認知的加齢を特定及び軽減するためのオメガ３脂肪酸及びビタミンｄレベル |
Country Status (8)
| Country | Link |
|---|---|
| US (6) | US20210128587A1 (ja) |
| EP (3) | EP3609490A1 (ja) |
| JP (6) | JP7270546B2 (ja) |
| CN (3) | CN110381935A (ja) |
| AU (4) | AU2017408873A1 (ja) |
| BR (3) | BR112019017949A2 (ja) |
| CA (3) | CA3054846A1 (ja) |
| MX (2) | MX2019010484A (ja) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112019017949A2 (pt) * | 2017-04-11 | 2020-05-19 | Nestle Sa | níveis de ácidos graxos ômega-3 e vitamina d para identificar e atenuar o envelhecimento cognitivo em indivíduos |
| CN113252806B (zh) * | 2021-03-25 | 2023-08-29 | 嘉兴学院 | S-腺苷同型半胱氨酸在制备用于诊断或治疗川崎病的产品中的用途 |
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| WO2017053773A1 (en) * | 2015-09-25 | 2017-03-30 | Buck Institute For Research On Aging | Compositions and methods for specific biological cognitive functions in neurodegenerative diseases |
| AU2017270131B2 (en) * | 2016-05-27 | 2023-03-09 | Société des Produits Nestlé S.A. | Nutritional composition for treating or preventing impaired mobility |
| MX2019002827A (es) * | 2016-09-29 | 2019-07-15 | Soc Des Produits Nestle S A Star | Acidos grasos omega 3 y colina como neuroprotectores en pacientes sin demencia. |
| BR112019017949A2 (pt) | 2017-04-11 | 2020-05-19 | Nestle Sa | níveis de ácidos graxos ômega-3 e vitamina d para identificar e atenuar o envelhecimento cognitivo em indivíduos |
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2017
- 2017-12-11 BR BR112019017949A patent/BR112019017949A2/pt active Search and Examination
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2018
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- 2018-04-05 US US16/604,055 patent/US20200054665A1/en not_active Abandoned
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2022
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2023
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2024
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