JP2022546568A - 血液収集容量を画定する疎水性パターンおよび破断ラインを有する媒体 - Google Patents
血液収集容量を画定する疎水性パターンおよび破断ラインを有する媒体 Download PDFInfo
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Abstract
Description
本出願は、2019年9月6日に出願された同時係争中の米国仮特許出願第62/896,715、および2020年8月3日に出願された同時係争中の米国仮特許出願第63/060,279の優先権を主張し、その各々は、参照によってその全体が本明細書に組み込まれる。
診断用試験に使用される血液は、たいてい、皮下注射用針で患者から抽出され、そして試験管に収集される。収集血液はその後、様々な診断用試験が実施される遠隔の研究所に搬送するためにパッケージ化される。しかし、多くの診断用試験で必要となるのは、実際に収集されたサンプルよりも著しく少ない容量である。サンプルからの細胞成分の分離を必要とする試験も存在する。
(620)は、液体試薬リザーバであり、
(621)は、流体チャネルであり、当該流体チャネルは、デバイスを閉じるために一旦キャップがなされると、および/またはキャップが内側にスライドされると、液体試薬リザーバ(621)をサンプル収集ポートに接続し、
(622)は、デバイス中の空領域であり、デバイスが閉じている時には、サンプル収集ポートが当該空領域の中に移動し、
(623)は、ハウジングの液体試薬ポーションの中に延びる側方流動ストリップの下にある剛性支持部であり、
(624)は、上記の実施形態のいずれかに記載されている通りの、1以上の疎水性パターンおよび/または破断ラインを含む媒体(400)によって提供される、側方流動ストリップであり、
(625)は、側方流動ストリップの端部のサンプル吸収パッドであり、そして、
(626)は、乾燥剤タブレットである。
Claims (21)
- 少なくとも1つの疎水性領域によって画定されたチャネルを有する媒体と、
前記チャネルと交差し、そして前記媒体の既定エリアを画定する、少なくとも1つの破断ラインと、を含む、流体サンプル収集デバイス。 - 少なくとも1つの破断ラインは、流体サンプルの収集のための既定容量を提供するエリアを画定する、請求項1に記載の流体サンプル収集デバイス。
- 試薬でコーティングされた前記媒体の、対応する複数のエリアを画定する2以上の破断ラインをさらに含み、そして、少なくとも1つの選択試薬は、別の試薬がコーティングする別のエリアとは異なる選択エリアをコーティングしている、請求項1に記載の流体サンプル収集デバイス。
- 前記疎水性領域は、1以上の流体経路をさらに画定する、請求項1に記載の流体サンプル収集デバイス。
- 前記疎水性領域は、流体の移動の速度を調節する、請求項1に記載の流体サンプル収集デバイス。
- 前記疎水性領域は、前記デバイスを通る流体の移動を減速させるために、蛇行性経路を画定する、請求項5に記載の流体サンプル収集デバイス。
- 前記疎水性領域は、前記流体の移動を減速させ、その後、毛細管作用を減速させるように前記媒体を部分的に飽和させる、請求項5に記載の流体サンプル収集デバイス。
- 前記媒体は、複数の層を含む、請求項1に記載の流体サンプル収集デバイス。
- 第1の層は、疎水性領域によって画定されたチャネルによって、サンプルを第2の層に収集しかつ導く、第1の膜である、請求項8に記載の流体サンプル収集デバイス。
- 前記複数の層のうちの1つは、側方流動ストリップである、請求項8に記載の流体サンプル収集デバイス。
- 前記複数の層のうちの1つは、試薬を含む、請求項8に記載の流体サンプル収集デバイス。
- 前記複数の層のうちの1つは、ろ過媒体を含む、請求項8に記載の流体サンプル収集デバイス。
- 前記複数の層のうちの1つは、疎水性材料または親水性材料の1以上を介して、流体流動を方向転換させる、請求項8に記載の流体サンプル収集デバイス。
- 前記媒体は、膜を含む、請求項1に記載の流体サンプル収集デバイス。
- 前記媒体は、ミクロ構造環境を含む、請求項1に記載の流体サンプル収集デバイス。
- 流体収集デバイスであって、
第1の位置および第2の位置を有するハウジングと、
第1の位置で開いている、生体サンプルを収集するためのサンプルポートと、
前記生体サンプルを吸収し、そして測定するように設計された、構造化ミクロ環境と、
前記ハウジング内に配置された流体制御システムであって、前記生体サンプルが前記第1の位置から前記第2の位置に動かされる時に、前記生体サンプルを前記サンプルポートから前記構造化ミクロ環境に移す、流体制御システムと、を含む、流体収集デバイス。 - 前記構造化ミクロ環境は、膜である、請求項16に記載の流体収集デバイス。
- 前記構造化ミクロ環境は、血漿から赤血球を分離する、請求項16に記載の流体収集デバイス。
- 前記サンプルポート中の流体は、前記構造化ミクロ環境に到達する前に試薬で処理される、請求項16に記載の流体収集デバイス。
- 前記構造化ミクロ環境は、同様の容量を有する2以上のポーションを収集するように構成されている、請求項16に記載の流体収集デバイス。
- 前記ポーションは、単一の流動経路に接続され、そして容易に分離される、請求項20に記載の流体収集デバイス。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962896715P | 2019-09-06 | 2019-09-06 | |
US62/896,715 | 2019-09-06 | ||
US202063060279P | 2020-08-03 | 2020-08-03 | |
US63/060,279 | 2020-08-03 | ||
PCT/US2020/049460 WO2021046391A2 (en) | 2019-09-06 | 2020-09-04 | Medium with hydrophobic patterns and break lines defining a blood collection volume |
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JP2022546568A true JP2022546568A (ja) | 2022-11-04 |
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JP2022514263A Pending JP2022546568A (ja) | 2019-09-06 | 2020-09-04 | 血液収集容量を画定する疎水性パターンおよび破断ラインを有する媒体 |
Country Status (5)
Country | Link |
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US (1) | US20210068730A1 (ja) |
EP (1) | EP4025129A4 (ja) |
JP (1) | JP2022546568A (ja) |
TW (1) | TWI779349B (ja) |
WO (1) | WO2021046391A2 (ja) |
Families Citing this family (1)
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KR20200085783A (ko) | 2017-10-27 | 2020-07-15 | 주노 다이어그노스틱스, 인크. | 초저용량 액체 생검을 위한 장치, 시스템 및 방법 |
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US6770434B2 (en) * | 2000-12-29 | 2004-08-03 | The Provost, Fellows And Scholars Of The College Of The Holy & Undivided Trinity Of Queen Elizabeth Near Dublin | Biological assay method |
US8691161B2 (en) * | 2004-12-13 | 2014-04-08 | Bayer Healthcare Llc | Self-contained test sensor |
WO2007044917A2 (en) * | 2005-10-11 | 2007-04-19 | Handylab, Inc. | Polynucleotide sample preparation device |
US20070122819A1 (en) * | 2005-11-25 | 2007-05-31 | Industrial Technology Research Institute | Analyte assay structure in microfluidic chip for quantitative analysis and method for using the same |
MX2012014620A (es) * | 2010-06-30 | 2013-02-07 | Hoffmann La Roche | Metodos para fabricar una tira reactiva de biosensor dual. |
WO2014018558A1 (en) * | 2012-07-23 | 2014-01-30 | Tasso, Inc. | Methods, systems, and devices relating to open microfluidic channels |
NL2010377C2 (en) * | 2013-03-01 | 2014-09-03 | Micronit Microfluidics Bv | Method for manufacturing microfluidic chips, device for functionalizing microfluidic chips, microfluidic chip and device for holding a microfluidic chip. |
AU2014233184A1 (en) * | 2013-03-15 | 2015-09-17 | Theranos Ip Company, Llc | Methods and devices for sample collection and sample separation |
US10293340B2 (en) * | 2017-10-11 | 2019-05-21 | Fitbit, Inc. | Microfluidic metering and delivery system |
-
2020
- 2020-09-04 JP JP2022514263A patent/JP2022546568A/ja active Pending
- 2020-09-04 EP EP20860541.0A patent/EP4025129A4/en active Pending
- 2020-09-04 WO PCT/US2020/049460 patent/WO2021046391A2/en unknown
- 2020-09-04 US US17/012,191 patent/US20210068730A1/en active Pending
- 2020-09-07 TW TW109130626A patent/TWI779349B/zh active
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EP4025129A2 (en) | 2022-07-13 |
EP4025129A4 (en) | 2024-02-14 |
WO2021046391A2 (en) | 2021-03-11 |
TW202126261A (zh) | 2021-07-16 |
TWI779349B (zh) | 2022-10-01 |
WO2021046391A3 (en) | 2021-04-29 |
US20210068730A1 (en) | 2021-03-11 |
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