JP2022522300A - ロイコノストック・シトレウムwikim0104を含む肥満または脂肪肝疾患の予防、改善または治療用組成物 - Google Patents
ロイコノストック・シトレウムwikim0104を含む肥満または脂肪肝疾患の予防、改善または治療用組成物 Download PDFInfo
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Abstract
Description
キムチ抽出物の原液をMRS培地に塗抹して得た菌単一群集をループで収去してMRS brothに培養した。DNA抽出は、QIAamp DNA Mini Kit(QIAgen、Germany)を使用して抽出した。抽出されたDNAは、1%アガロースゲルを利用して確認し、16S rDNA geneを増幅するために抽出された遺伝体(genomic)DNAを鋳型にして重合酵素連鎖反応(Polymerase Chain Reaction、PCR)を進行し、PCR条件は変性(denaturation)95℃で1分、結合(annealing)45℃で1分、伸長(extension)72℃で1分30秒と30サイクルを行った。得られたPCR産物はマクロゼン(Seoul、Korea)に依頼して配列を分析した。細菌の同定は、16S rDNA配列をNational Center for Biotechnology Information(NCBI、www.ncbi.nlm.nih.gov)のBasic Local Alignment Search Tool(BLAST)検索エンジンの誘導分析を通じて行った。
人体の腸肝軸(gut-liver axis)に類似するようにトランスウェル(transwell)を利用してin vitro実験法を考案した。
5週齢の雄マウス(C57BL/6J)を温度20±2℃、湿度50±5%及び明暗周期(light-dark cycle)12時間単位の条件の飼育室環境下でチャウ食餌療法(chow diet)(CD;Purina、Korea)で1週間適応させた。実験動物は正常食餌(D12450B、Research Diets、New Brunswick、NJ)または総カロリーの45%が脂肪である高脂肪食餌(D12451、Research Diets、New Brunswick、NJ)を摂取させ、1週間の間食餌に適応させた後、実験を行った。実験群は正常食餌摂取群(ND)、高脂肪食餌摂取群(HFD)、高脂肪食餌と共にロイコノストック・シトレウムWiKim0104を2×109CFU/200μl濃度で毎日経口投与した摂取群(HFD+L-LAB1)の総3個のグループで構成し、20週間の間食餌供給を通じて脂肪肝を誘導した。正常食餌摂取群(ND)と高脂肪食餌摂取群(HFD)は、これと同一量のリン酸緩衝食塩水(phosphate buffered saline、PBS)を毎日経口投与した。実験を行ってから20週間後、各実験群の体重を測定した。また、実験群の血中肝機能数値(serum GOT、serum GPT)を測定するために、実験終了16時間前から節食させて腹腔大静脈で採血した後、血清を分離して実験に使用した。
ロイコノストック・シトレウムWiKim0104菌株摂取による肝組織内の脂肪代謝、炎症、肝線維化関連遺伝子の発現水準を調べるために、実験終了後に摘出した肝組織を利用してqPCR(quantitative real time polymerase chain reaction)を実施した。
Claims (12)
- 受託番号KCCM12420Pのロイコノストック・シトレウムWiKim0104{Leuconostoc citreum WiKim0104}。
- ロイコノストック・シトレウムWiKim0104(Leuconostoc citreum WiKim0104;受託番号KCCM12420P)、その培養物、その破砕物またはその抽出物を有効成分として含む炎症、肥満または脂肪肝疾患の予防または改善用組成物。
- 前記脂肪肝疾患は、単純脂肪肝、非アルコール性脂肪肝炎、肝線維化及び肝硬変を含むものである、請求項2に記載の組成物。
- 前記組成物は、食品組成物、食品醗酵用乳酸菌スタータ組成物、飼料または飼料添加剤組成物、または薬学組成物であることを特徴とする、請求項2に記載の組成物。
- 前記食品組成物は、健康機能食品、飲料、バーまたは発酵乳である、請求項4に記載の組成物。
- ロイコノストック・シトレウムWiKim0104(Leuconostoc citreum WiKim0104;受託番号KCCM12420P)、その培養物、その破砕物またはその抽出物の炎症、肥満または脂肪肝疾患の予防、改善または治療用途。
- 前記脂肪肝疾患は、単純脂肪肝、非アルコール性脂肪肝炎、肝線維化及び肝硬変からなる群より選択されたいずれか一つ以上を含む、請求項6に記載の用途。
- 食品組成物、食品醗酵用乳酸菌スタータ組成物、飼料または飼料添加剤組成物、または薬学組成物として使用されることを特徴とする、請求項6に記載の用途。
- 前記食品組成物は、健康機能食品、飲料、バーまたは発酵乳であることを特徴とする、請求項8に記載の用途。
- ロイコノストック・シトレウムWiKim0104 (Leuconostoc citreum WiKim0104;受託番号KCCM12420P)、その培養物、その破砕物またはその抽出物を含む組成物をこれを必要とする個体に投与する段階を含む、炎症、肥満または脂肪肝疾患を予防、改善または治療する方法。
- 前記個体は、ヒトを含む動物であることを特徴とする、請求項10に記載の炎症、肥満または脂肪肝疾患を予防、改善または治療する方法。
- 前記脂肪肝疾患は、単純脂肪肝、非アルコール性脂肪肝炎、肝線維化及び肝硬変からなる群より選択されたいずれか一つを含むものである、請求項10に記載の炎症、肥満または脂肪肝疾患を予防、改善または治療する方法。
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PCT/KR2020/002845 WO2020175940A1 (ko) | 2019-02-28 | 2020-02-27 | 류코노스톡 시트래움 wikim0104를 포함하는 비만 또는 지방간 질환의 예방, 개선 또는 치료용 조성물 |
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KR20220091428A (ko) | 2020-12-23 | 2022-06-30 | 주식회사 리스큐어바이오사이언시스 | 류코노스톡 시트리움 유래 세포밖 소포체를 유효성분으로 포함하는 지방간 개선, 예방 또는 치료용 조성물 |
WO2022139531A1 (ko) * | 2020-12-23 | 2022-06-30 | 주식회사 리스큐어바이오사이언시스 | 류코노스톡 시트리움 유래 세포밖 소포체를 유효성분으로 포함하는 지방간 개선, 예방 또는 치료용 조성물 |
JP2024506625A (ja) * | 2021-02-08 | 2024-02-14 | リスキュア・バイオサイエンシーズ・カンパニー・リミテッド | ロイコノストック・シトレウム菌株を有効成分として含む線維症の予防または治療用医薬組成物 |
CA3207792A1 (en) * | 2021-02-08 | 2022-08-11 | Hwa Sup Chin | Pharmaceutical composition for preventing or treating cholestatic liver injury comprising leuconostoc citreum strain as active ingredient |
US20240091281A1 (en) * | 2021-02-08 | 2024-03-21 | Hwa Sup CHIN | Pharmaceutical composition for preventing or treating intestinal damage comprising leuconostoc citreum strain as active ingredient |
KR102390715B1 (ko) * | 2021-07-13 | 2022-04-29 | 한국식품연구원 | 류코노스톡 시트리움 WiKim0129를 포함하는 암의 예방, 개선 또는 치료용 조성물 |
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Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100872911B1 (ko) * | 2007-10-25 | 2008-12-10 | 두두원발효(주) | 김치유산균으로 발효한 콩 요구르트를 유효성분으로함유하는 비만억제용 조성물 |
KR20100037310A (ko) * | 2008-10-01 | 2010-04-09 | 주식회사 비티엠 | 김치 유산균을 이용한 액상 건강보조식품의 제조방법 |
KR20160108645A (ko) * | 2015-03-04 | 2016-09-20 | 을지대학교 산학협력단 | 발효 두유 쏘이프로 상층액의 항염 효과 기능성 조성물 및 그 제조 방법 |
KR20170000510A (ko) * | 2015-06-24 | 2017-01-03 | 주식회사 대유위니아 | 항비만 유산균의 발생을 위한 김치의 숙성방법 및 이것이 프로그래밍된 냉장고 |
KR101873193B1 (ko) * | 2010-06-08 | 2018-07-02 | 아사히 그룹 홀딩스 가부시키가이샤 | 지질 대사 개선제 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101704126B1 (ko) * | 2014-06-12 | 2017-02-07 | 동국대학교 경주캠퍼스 산학협력단 | 아스퍼질러스 우사미 및 류코노스톡 시트륨 균주를 이용한 진세노사이드 함량이 증가된 홍삼 제제 및 이의 제조방법 |
KR20170032815A (ko) | 2015-09-15 | 2017-03-23 | 경희대학교 산학협력단 | 신규 유산균 및 퇴행성 뇌질환 또는 인지기능의 예방, 개선 또는 치료용 조성물 |
KR101838280B1 (ko) * | 2017-05-30 | 2018-03-14 | 한국식품연구원 | 관절염의 개선 활성을 갖는 류코노스톡 시트리움 wikim56 및 이를 포함하는 조성물 |
KR102390405B1 (ko) | 2017-08-31 | 2022-04-25 | 한화테크윈 주식회사 | 도어벨 장치 |
KR102032982B1 (ko) * | 2019-02-28 | 2019-10-16 | 한국식품연구원 | 류코노스톡 시트래움 WiKim0104를 포함하는 비만 또는 지방간 질환의 예방, 개선 또는 치료용 조성물 |
-
2019
- 2019-02-28 KR KR1020190024254A patent/KR102032982B1/ko active IP Right Grant
-
2020
- 2020-02-27 CA CA3131258A patent/CA3131258A1/en active Pending
- 2020-02-27 EP EP20763924.6A patent/EP3933031A4/en active Pending
- 2020-02-27 BR BR112021016879A patent/BR112021016879A2/pt unknown
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- 2020-02-27 AU AU2020228247A patent/AU2020228247A1/en active Pending
- 2020-02-27 WO PCT/KR2020/002845 patent/WO2020175940A1/ko unknown
- 2020-02-27 US US17/433,427 patent/US20220047652A1/en active Pending
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100872911B1 (ko) * | 2007-10-25 | 2008-12-10 | 두두원발효(주) | 김치유산균으로 발효한 콩 요구르트를 유효성분으로함유하는 비만억제용 조성물 |
KR20100037310A (ko) * | 2008-10-01 | 2010-04-09 | 주식회사 비티엠 | 김치 유산균을 이용한 액상 건강보조식품의 제조방법 |
KR101873193B1 (ko) * | 2010-06-08 | 2018-07-02 | 아사히 그룹 홀딩스 가부시키가이샤 | 지질 대사 개선제 |
KR20160108645A (ko) * | 2015-03-04 | 2016-09-20 | 을지대학교 산학협력단 | 발효 두유 쏘이프로 상층액의 항염 효과 기능성 조성물 및 그 제조 방법 |
KR20170000510A (ko) * | 2015-06-24 | 2017-01-03 | 주식회사 대유위니아 | 항비만 유산균의 발생을 위한 김치의 숙성방법 및 이것이 프로그래밍된 냉장고 |
Non-Patent Citations (1)
Title |
---|
NUTRIENTS, 2018, 10(5):643, JPN6022032078, ISSN: 0004842467 * |
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